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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF677-ACYP1 (FusionGDB2 ID:102702)

Fusion Gene Summary for ZNF677-ACYP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF677-ACYP1
Fusion gene ID: 102702
HgeneTgene
Gene symbol

ZNF677

ACYP1

Gene ID

342926

97

Gene namezinc finger protein 677acylphosphatase 1
Synonyms-ACYPE
Cytomap

19q13.42

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 677hypothetical protein MGC48625acylphosphatase-1acylphosphatase 1, erythrocyte (common) typeacylphosphatase, erythrocyte isozymeacylphosphatase, organ-common type isozymeacylphosphate phosphohydrolase 1
Modification date2020031320200313
UniProtAcc.

P07311

Ensembl transtripts involved in fusion geneENST00000333952, ENST00000594681, 
ENST00000598513, ENST00000598806, 
ENST00000599012, ENST00000595293, 
ENST00000601413, ENST00000601828, 
ENST00000553302, ENST00000555135, 
ENST00000238618, ENST00000555694, 
ENST00000357971, ENST00000555463, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF677 [Title/Abstract] AND ACYP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF677(53746996)-ACYP1(75520362), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF677-ACYP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF677-ACYP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF677 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACYP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer211NZNF677chr19

53746996

-ACYP1chr14

75520362

-


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Fusion Gene ORF analysis for ZNF677-ACYP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333952ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000333952ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000594681ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000594681ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000598513ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000598513ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000598806ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000598806ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000599012ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
5CDS-intronENST00000599012ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000333952ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000333952ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000594681ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000594681ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598513ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598513ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598513ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598806ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598806ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000598806ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000599012ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000599012ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
Frame-shiftENST00000599012ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000333952ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000333952ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000594681ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000594681ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000598513ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000598806ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
In-frameENST00000599012ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000595293ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000595293ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000595293ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000595293ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601413ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601413ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601413ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601413ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601828ENST00000238618ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601828ENST00000357971ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601828ENST00000555463ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-3CDSENST00000601828ENST00000555694ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000595293ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000595293ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000601413ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000601413ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000601828ENST00000553302ZNF677chr19

53746996

-ACYP1chr14

75520362

-
intron-intronENST00000601828ENST00000555135ZNF677chr19

53746996

-ACYP1chr14

75520362

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333952ZNF677chr1953746996-ENST00000555463ACYP1chr1475520362-7583354231141
ENST00000333952ZNF677chr1953746996-ENST00000357971ACYP1chr1475520362-7523354231141
ENST00000598513ZNF677chr1953746996-ENST00000555694ACYP1chr1475520362-7373204081136
ENST00000599012ZNF677chr1953746996-ENST00000555694ACYP1chr1475520362-7393224100137
ENST00000594681ZNF677chr1953746996-ENST00000555463ACYP1chr1475520362-9515286162205
ENST00000594681ZNF677chr1953746996-ENST00000357971ACYP1chr1475520362-9455286162205
ENST00000598806ZNF677chr1953746996-ENST00000555694ACYP1chr1475520362-7583414291143

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333952ENST00000555463ZNF677chr1953746996-ACYP1chr1475520362-0.296741040.703259
ENST00000333952ENST00000357971ZNF677chr1953746996-ACYP1chr1475520362-0.299889830.70011014
ENST00000598513ENST00000555694ZNF677chr1953746996-ACYP1chr1475520362-0.339792040.660208
ENST00000599012ENST00000555694ZNF677chr1953746996-ACYP1chr1475520362-0.277021860.7229781
ENST00000594681ENST00000555463ZNF677chr1953746996-ACYP1chr1475520362-0.369740550.63025945
ENST00000594681ENST00000357971ZNF677chr1953746996-ACYP1chr1475520362-0.379090550.62090945
ENST00000598806ENST00000555694ZNF677chr1953746996-ACYP1chr1475520362-0.380221640.61977834

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Fusion Genomic Features for ZNF677-ACYP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF677-ACYP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:53746996/chr14:75520362)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACYP1

P07311

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Its physiological role is not yet clear.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-478_90563323.3333333333335DomainKRAB
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-458_9056585.0DomainKRAB
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47263_285563323.3333333333335Zinc fingerC2H2-type 1
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47291_313563323.3333333333335Zinc fingerC2H2-type 2
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47319_341563323.3333333333335Zinc fingerC2H2-type 3
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47347_369563323.3333333333335Zinc fingerC2H2-type 4
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47375_397563323.3333333333335Zinc fingerC2H2-type 5
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47403_425563323.3333333333335Zinc fingerC2H2-type 6
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47431_453563323.3333333333335Zinc fingerC2H2-type 7
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47459_481563323.3333333333335Zinc fingerC2H2-type 8
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47487_509563323.3333333333335Zinc fingerC2H2-type 9
HgeneZNF677chr19:53746996chr14:75520362ENST00000333952-47515_537563323.3333333333335Zinc fingerC2H2-type 10
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45263_28556585.0Zinc fingerC2H2-type 1
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45291_31356585.0Zinc fingerC2H2-type 2
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45319_34156585.0Zinc fingerC2H2-type 3
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45347_36956585.0Zinc fingerC2H2-type 4
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45375_39756585.0Zinc fingerC2H2-type 5
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45403_42556585.0Zinc fingerC2H2-type 6
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45431_45356585.0Zinc fingerC2H2-type 7
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45459_48156585.0Zinc fingerC2H2-type 8
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45487_50956585.0Zinc fingerC2H2-type 9
HgeneZNF677chr19:53746996chr14:75520362ENST00000598513-45515_53756585.0Zinc fingerC2H2-type 10
TgeneACYP1chr19:53746996chr14:75520362ENST00000238618139_9928100.0DomainAcylphosphatase-like
TgeneACYP1chr19:53746996chr14:75520362ENST00000357971249_995456.0DomainAcylphosphatase-like
TgeneACYP1chr19:53746996chr14:75520362ENST00000555694139_9928100.0DomainAcylphosphatase-like


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Fusion Gene Sequence for ZNF677-ACYP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102702_102702_1_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000333952_ACYP1_chr14_75520362_ENST00000357971_length(transcript)=752nt_BP=335nt
GACCCGGAAGCGGATCTCGCGGGGCTACTGGCGCTCTCGGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGATGAACTGTGATGA
TCCACTTCTTCTTAATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAATGGCTCTTTCTCA
GGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGA
CGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAAAAGCTGGGATTGG
TAGGCTGGGTCCAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATGCAGGAATGGCTTG
AAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAA
TTGTAAAATAATGGCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAACTATTGTGTGTTA
ATATTAGCATTAGTCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGATTACCACTGTACA

>102702_102702_1_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000333952_ACYP1_chr14_75520362_ENST00000357971_length(amino acids)=141AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF

--------------------------------------------------------------
>102702_102702_2_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000333952_ACYP1_chr14_75520362_ENST00000555463_length(transcript)=758nt_BP=335nt
GACCCGGAAGCGGATCTCGCGGGGCTACTGGCGCTCTCGGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGATGAACTGTGATGA
TCCACTTCTTCTTAATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAATGGCTCTTTCTCA
GGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGA
CGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAAAAGCTGGGATTGG
TAGGCTGGGTCCAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATGCAGGAATGGCTTG
AAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAA
TTGTAAAATAATGGCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAACTATTGTGTGTTA
ATATTAGCATTAGTCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGATTACCACTGTACA

>102702_102702_2_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000333952_ACYP1_chr14_75520362_ENST00000555463_length(amino acids)=141AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF

--------------------------------------------------------------
>102702_102702_3_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000594681_ACYP1_chr14_75520362_ENST00000357971_length(transcript)=945nt_BP=528nt
GAGTCTCCGTCTTTCGGGTTCAAGCCTGCGCCTCGCGGGCCACAGGTTCCCACGCTCCGCTGTCGGGTTTTGGGGTCGCCCTGTAGGTTA
AAACCCCGAACCTGCTCATTCCTCTCGCGGCGTGGCCCTAAGACGTTCCCAGTCCCGTCGCTCCGAGAGGGTCTAGAGATCTGCGTCCAT
TTCGGATTAAAATCGTTCTGAAGTGGGTACTGGCCCCGACCTTTTTGCTTTAGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGA
TGAACTGTGATGATCCACTTCTTCTTAATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAA
TGGCTCTTTCTCAGGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGG
CCTTGTACAGGGACGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAA
AAGCTGGGATTGGTAGGCTGGGTCCAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATG
CAGGAATGGCTTGAAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTAC
TCAGACTTCCAAATTGTAAAATAATGGCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAA
CTATTGTGTGTTAATATTAGCATTAGTCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGA

>102702_102702_3_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000594681_ACYP1_chr14_75520362_ENST00000357971_length(amino acids)=205AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF
FLSSSSEFLSQVSQSFIKKKWIITVHLPRILPEVILCGLKQKGRGQYPLQNDFNPKWTQISRPSRSDGTGNVLGPRRERNEQVRGFNLQG

--------------------------------------------------------------
>102702_102702_4_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000594681_ACYP1_chr14_75520362_ENST00000555463_length(transcript)=951nt_BP=528nt
GAGTCTCCGTCTTTCGGGTTCAAGCCTGCGCCTCGCGGGCCACAGGTTCCCACGCTCCGCTGTCGGGTTTTGGGGTCGCCCTGTAGGTTA
AAACCCCGAACCTGCTCATTCCTCTCGCGGCGTGGCCCTAAGACGTTCCCAGTCCCGTCGCTCCGAGAGGGTCTAGAGATCTGCGTCCAT
TTCGGATTAAAATCGTTCTGAAGTGGGTACTGGCCCCGACCTTTTTGCTTTAGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGA
TGAACTGTGATGATCCACTTCTTCTTAATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAA
TGGCTCTTTCTCAGGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGG
CCTTGTACAGGGACGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAA
AAGCTGGGATTGGTAGGCTGGGTCCAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATG
CAGGAATGGCTTGAAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTAC
TCAGACTTCCAAATTGTAAAATAATGGCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAA
CTATTGTGTGTTAATATTAGCATTAGTCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGA

>102702_102702_4_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000594681_ACYP1_chr14_75520362_ENST00000555463_length(amino acids)=205AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF
FLSSSSEFLSQVSQSFIKKKWIITVHLPRILPEVILCGLKQKGRGQYPLQNDFNPKWTQISRPSRSDGTGNVLGPRRERNEQVRGFNLQG

--------------------------------------------------------------
>102702_102702_5_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000598513_ACYP1_chr14_75520362_ENST00000555694_length(transcript)=737nt_BP=320nt
CTCGCGGGGCTACTGGCGCTCTCGGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGATGAACTGTGATGATCCACTTCTTCTTAA
TGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAATGGCTCTTTCTCAGGGACTGTTTACATT
CAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGACGTGATGTTGGAGAA
CTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAAAAGCTGGGATTGGTAGGCTGGGTCCAGA
ACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATGCAGGAATGGCTTGAAACAAGAGGAAGTC
CTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAATTGTAAAATAATGGC
CTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAACTATTGTGTGTTAATATTAGCATTAGTC
AATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGATTACCACTGTACACAAATCTAATCAATA

>102702_102702_5_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000598513_ACYP1_chr14_75520362_ENST00000555694_length(amino acids)=136AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF

--------------------------------------------------------------
>102702_102702_6_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000598806_ACYP1_chr14_75520362_ENST00000555694_length(transcript)=758nt_BP=341nt
CCTGCCGACCCGGAAGCGGATCTCGCGGGGCTACTGGCGCTCTCGGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGATGAACTG
TGATGATCCACTTCTTCTTAATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAATGGCTCT
TTCTCAGGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTA
CAGGGACGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAAAAGCTGG
GATTGGTAGGCTGGGTCCAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATGCAGGAAT
GGCTTGAAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACT
TCCAAATTGTAAAATAATGGCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAACTATTGT
GTGTTAATATTAGCATTAGTCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGATTACCAC

>102702_102702_6_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000598806_ACYP1_chr14_75520362_ENST00000555694_length(amino acids)=143AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF

--------------------------------------------------------------
>102702_102702_7_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000599012_ACYP1_chr14_75520362_ENST00000555694_length(transcript)=739nt_BP=322nt
ATCTCGCGGGGCTACTGGCGCTCTCGGCCCACACAATATGACCTCGGGGAGGATGCGAGGAAGATGAACTGTGATGATCCACTTCTTCTT
AATGAATGACTGACTTACCTGAGAAAGAAACTCAGAGGAAGAGGAAAGAAAGAAGAGGAGGGAATGGCTCTTTCTCAGGGACTGTTTACA
TTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGTGGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGACGTGATGTTGGAG
AACTACAGGAACCTGCTTTCTCTCGATGAGGATAACATCCCTCCAGAAGATGGCTGAGGGTAAAAAGCTGGGATTGGTAGGCTGGGTCCA
GAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCCATCTCCAAGGTGCGTCATATGCAGGAATGGCTTGAAACAAGAGGAAG
TCCTAAATCACACATCGACAAAGCAAACTTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAATTGTAAAATAATG
GCCTGAATTTAAGTTTTCTAAGATAAACTCAGTGGTTTGGTTTTTATTATTAATAGAGATAGAACTATTGTGTGTTAATATTAGCATTAG
TCAATAAGTTATTTTAATGTCAGATTTTTGAATGTTATTATATATTACCTGTATGATGGAAGGATTACCACTGTACACAAATCTAATCAA

>102702_102702_7_ZNF677-ACYP1_ZNF677_chr19_53746996_ENST00000599012_ACYP1_chr14_75520362_ENST00000555694_length(amino acids)=137AA_BP=1
MEMGPCNCPCTVPRSVFWTQPTNPSFLPSAIFWRDVILIERKQVPVVLQHHVPVQGPLGRVQALPLLLREFYGHILECKQSLRKSHSLLF

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Fusion Gene PPI Analysis for ZNF677-ACYP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF677-ACYP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF677-ACYP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource