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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF695-SMYD3 (FusionGDB2 ID:102729)

Fusion Gene Summary for ZNF695-SMYD3

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF695-SMYD3
	Fusion gene ID: 102729
		Hgene	Tgene
	Gene symbol	ZNF695	SMYD3
	Gene ID	57116	64754
	Gene name	zinc finger protein 695	SET and MYND domain containing 3
	Synonyms	SBZF3	KMT3E\|ZMYND1\|ZNFN3A1\|bA74P14.1
	Cytomap	1q44	1q44
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 695zinc finger protein SBZF3	histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000339986, ENST00000487338, ENST00000498046,	ENST00000366517, ENST00000403792, ENST00000388985, ENST00000490107, ENST00000541742,
Fusion gene scores	* DoF score	1 X 1 X 1=1	29 X 14 X 17=6902
	# samples	1	47
	** MAII score	log2(1/1*10)=3.32192809488736	log2(47/6902*10)=-3.87628181187052 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF695 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMYD3(246670356)-ZNF695(247131094), # samples:3 ZNF695(247171208)-SMYD3(246093239), # samples:1
Anticipated loss of major functional domain due to fusion event.	SMYD3-ZNF695 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SMYD3-ZNF695 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. SMYD3-ZNF695 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF695 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMYD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-4369-01A	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-

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Fusion Gene ORF analysis for ZNF695-SMYD3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000339986	ENST00000366517	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5CDS-5UTR	ENST00000487338	ENST00000366517	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5CDS-intron	ENST00000339986	ENST00000403792	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5CDS-intron	ENST00000487338	ENST00000403792	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5UTR-3CDS	ENST00000498046	ENST00000388985	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5UTR-3CDS	ENST00000498046	ENST00000490107	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5UTR-3CDS	ENST00000498046	ENST00000541742	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5UTR-5UTR	ENST00000498046	ENST00000366517	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
5UTR-intron	ENST00000498046	ENST00000403792	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000339986	ENST00000388985	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000339986	ENST00000490107	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000339986	ENST00000541742	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000487338	ENST00000388985	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000487338	ENST00000490107	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-
In-frame	ENST00000487338	ENST00000541742	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000487338	ZNF695	chr1	247171208	-	ENST00000541742	SMYD3	chr1	246093239	-	1167	188	26	943	305
ENST00000487338	ZNF695	chr1	247171208	-	ENST00000490107	SMYD3	chr1	246093239	-	1165	188	26	943	305
ENST00000487338	ZNF695	chr1	247171208	-	ENST00000388985	SMYD3	chr1	246093239	-	944	188	26	943	306
ENST00000339986	ZNF695	chr1	247171208	-	ENST00000541742	SMYD3	chr1	246093239	-	1130	151	1	906	301
ENST00000339986	ZNF695	chr1	247171208	-	ENST00000490107	SMYD3	chr1	246093239	-	1128	151	1	906	301
ENST00000339986	ZNF695	chr1	247171208	-	ENST00000388985	SMYD3	chr1	246093239	-	907	151	1	906	302

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000487338	ENST00000541742	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.002439091	0.99756086
ENST00000487338	ENST00000490107	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.002512837	0.9974872
ENST00000487338	ENST00000388985	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.00201842	0.99798155
ENST00000339986	ENST00000541742	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.002194058	0.9978059
ENST00000339986	ENST00000490107	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.00230377	0.9976962
ENST00000339986	ENST00000388985	ZNF695	chr1	247171208	-	SMYD3	chr1	246093239	-	0.00159474	0.9984053

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Fusion Genomic Features for ZNF695-SMYD3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF695-SMYD3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246670356/chr1:247131094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000388985

205_206

177

429.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000490107

205_206

118

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000541742

205_206

118

370.0

Region

S-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

4_87

516.0

Domain

KRAB

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

4_87

173.0

Domain

KRAB

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

156_178

516.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

184_206

516.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

212_234

516.0

Zinc finger

C2H2-type 3%3B atypical

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

240_262

516.0

Zinc finger

C2H2-type 4%3B degenerate

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

268_290

516.0

Zinc finger

C2H2-type 5

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

296_318

516.0

Zinc finger

C2H2-type 6

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

324_346

516.0

Zinc finger

C2H2-type 7

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

352_374

516.0

Zinc finger

C2H2-type 8

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

380_402

516.0

Zinc finger

C2H2-type 9

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

408_430

516.0

Zinc finger

C2H2-type 10

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

436_458

516.0

Zinc finger

C2H2-type 11

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

464_486

516.0

Zinc finger

C2H2-type 12

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000339986

492_514

516.0

Zinc finger

C2H2-type 13

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

156_178

173.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

184_206

173.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

212_234

173.0

Zinc finger

C2H2-type 3%3B atypical

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

240_262

173.0

Zinc finger

C2H2-type 4%3B degenerate

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

268_290

173.0

Zinc finger

C2H2-type 5

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

296_318

173.0

Zinc finger

C2H2-type 6

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

324_346

173.0

Zinc finger

C2H2-type 7

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

352_374

173.0

Zinc finger

C2H2-type 8

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

380_402

173.0

Zinc finger

C2H2-type 9

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

408_430

173.0

Zinc finger

C2H2-type 10

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

436_458

173.0

Zinc finger

C2H2-type 11

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

464_486

173.0

Zinc finger

C2H2-type 12

Hgene

ZNF695

chr1:247171208

chr1:246093239

ENST00000487338

492_514

173.0

Zinc finger

C2H2-type 13

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000388985

4_240

177

429.0

Domain

SET

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000490107

4_240

118

370.0

Domain

SET

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000541742

4_240

118

370.0

Domain

SET

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000388985

14_16

177

429.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000490107

14_16

118

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000541742

14_16

118

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000388985

49_87

177

429.0

Zinc finger

MYND-type

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000490107

49_87

118

370.0

Zinc finger

MYND-type

Tgene

SMYD3

chr1:247171208

chr1:246093239

ENST00000541742

49_87

118

370.0

Zinc finger

MYND-type

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Fusion Gene Sequence for ZNF695-SMYD3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102729_102729_1_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000388985_length(transcript)=907nt_BP=151nt
TTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGAGAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGT
GGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCTGGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAA
TGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAA
TGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGA
GGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAAC
TGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGC
CATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGC
CTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCC
CGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTT
TGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGC

>102729_102729_1_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=302AA_BP=50
LSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFN
GPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLA
MCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAF

--------------------------------------------------------------
>102729_102729_2_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000490107_length(transcript)=1128nt_BP=151nt
TTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGAGAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGT
GGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCTGGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAA
TGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAA
TGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGA
GGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAAC
TGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGC
CATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGC
CTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCC
CGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTT
TGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGC
ATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGT
GTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGT

>102729_102729_2_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=301AA_BP=50
LSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFN
GPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLA
MCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAF

--------------------------------------------------------------
>102729_102729_3_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000541742_length(transcript)=1130nt_BP=151nt
TTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGAGAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGT
GGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCTGGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAA
TGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAA
TGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGA
GGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAAC
TGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGC
CATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGC
CTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCC
CGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTT
TGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGC
ATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGT
GTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGT

>102729_102729_3_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000339986_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=301AA_BP=50
LSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFN
GPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLA
MCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAF

--------------------------------------------------------------
>102729_102729_4_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000388985_length(transcript)=944nt_BP=188nt
AGAGAGGAAGGGGCGGCCTTGGGGATCTGGCGGGGCCTTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGA
GAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGTGGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCT
GGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCA
ATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGC
TCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCC
GTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAG
AACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACA
TCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCA
TGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCA
TGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGA

>102729_102729_4_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=306AA_BP=54
MAGPLSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCS
IVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWE
QVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNL

--------------------------------------------------------------
>102729_102729_5_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000490107_length(transcript)=1165nt_BP=188nt
AGAGAGGAAGGGGCGGCCTTGGGGATCTGGCGGGGCCTTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGA
GAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGTGGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCT
GGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCA
ATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGC
TCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCC
GTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAG
AACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACA
TCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCA
TGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCA
TGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGA
TTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGC
CTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGG

>102729_102729_5_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=305AA_BP=54
MAGPLSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCS
IVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWE
QVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNL

--------------------------------------------------------------
>102729_102729_6_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000541742_length(transcript)=1167nt_BP=188nt
AGAGAGGAAGGGGCGGCCTTGGGGATCTGGCGGGGCCTTTGTCTCCTTGCGGCCGGCGGGGTGCTGGGTTCCCGTCTGCTGCCTCTCGGA
GAGTCCCGGGTGACTGCCGCAGGCTCCATCGCCCTGTGGCCTGCAGGTATTGCGAGATTTATAGGGAGGACGCTGGGACCCCCAAAAGCT
GGGAAATGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCA
ATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGC
TCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCC
GTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAG
AACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACA
TCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCA
TGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCA
TGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGA
TTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGC
CTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGG

>102729_102729_6_ZNF695-SMYD3_ZNF695_chr1_247171208_ENST00000487338_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=305AA_BP=54
MAGPLSPCGRRGAGFPSAASRRVPGDCRRLHRPVACRYCEIYREDAGTPKSWEMVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCS
IVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWE
QVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF695-SMYD3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF695-SMYD3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF695-SMYD3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source