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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF717-TMEM254 (FusionGDB2 ID:102813)

Fusion Gene Summary for ZNF717-TMEM254

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF717-TMEM254
Fusion gene ID: 102813
HgeneTgene
Gene symbol

ZNF717

TMEM254

Gene ID

100131827

80195

Gene namezinc finger protein 717transmembrane protein 254
SynonymsOB1|X17|ZNF838C10orf57|bA369J21.6
Cytomap

3p12.3

10q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 717krueppel-like factor X17kruppel-like zinc finger factor X17zinc finger protein 838transmembrane protein 254transmembrane protein C10orf57
Modification date2020031320200313
UniProtAcc.

Q8TBM7

Ensembl transtripts involved in fusion geneENST00000422325, ENST00000477374, 
ENST00000400845, ENST00000491507, 
ENST00000478296, 		ENST00000467529, 
ENST00000372274, ENST00000372275, 
ENST00000372277, ENST00000372281, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 3 X 4=48
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF717 [Title/Abstract] AND TMEM254 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF717(75832457)-TMEM254(81841597), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF717 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM254 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12Q-01AZNF717chr3

75832457

-TMEM254chr10

81841597

+


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Fusion Gene ORF analysis for ZNF717-TMEM254

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000422325ENST00000467529ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5CDS-3UTRENST00000477374ENST00000467529ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000400845ENST00000372274ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000400845ENST00000372275ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000400845ENST00000372277ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000400845ENST00000372281ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000491507ENST00000372274ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000491507ENST00000372275ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000491507ENST00000372277ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3CDSENST00000491507ENST00000372281ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3UTRENST00000400845ENST00000467529ZNF717chr3

75832457

-TMEM254chr10

81841597

+
5UTR-3UTRENST00000491507ENST00000467529ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000422325ENST00000372274ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000422325ENST00000372275ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000422325ENST00000372277ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000422325ENST00000372281ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000477374ENST00000372274ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000477374ENST00000372275ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000477374ENST00000372277ZNF717chr3

75832457

-TMEM254chr10

81841597

+
In-frameENST00000477374ENST00000372281ZNF717chr3

75832457

-TMEM254chr10

81841597

+
intron-3CDSENST00000478296ENST00000372274ZNF717chr3

75832457

-TMEM254chr10

81841597

+
intron-3CDSENST00000478296ENST00000372275ZNF717chr3

75832457

-TMEM254chr10

81841597

+
intron-3CDSENST00000478296ENST00000372277ZNF717chr3

75832457

-TMEM254chr10

81841597

+
intron-3CDSENST00000478296ENST00000372281ZNF717chr3

75832457

-TMEM254chr10

81841597

+
intron-3UTRENST00000478296ENST00000467529ZNF717chr3

75832457

-TMEM254chr10

81841597

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000477374ZNF717chr375832457-ENST00000372277TMEM254chr1081841597+45422911352113
ENST00000477374ZNF717chr375832457-ENST00000372281TMEM254chr1081841597+2154229172513113
ENST00000477374ZNF717chr375832457-ENST00000372275TMEM254chr1081841597+98422911352113
ENST00000477374ZNF717chr375832457-ENST00000372274TMEM254chr1081841597+61522911352113
ENST00000422325ZNF717chr375832457-ENST00000372277TMEM254chr1081841597+60538032360494
ENST00000422325ZNF717chr375832457-ENST00000372281TMEM254chr1081841597+2305380323664113
ENST00000422325ZNF717chr375832457-ENST00000372275TMEM254chr1081841597+113538032354774
ENST00000422325ZNF717chr375832457-ENST00000372274TMEM254chr1081841597+76638032360493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000477374ENST00000372277ZNF717chr375832457-TMEM254chr1081841597+0.845538440.15446153
ENST00000477374ENST00000372281ZNF717chr375832457-TMEM254chr1081841597+0.73289140.26710862
ENST00000477374ENST00000372275ZNF717chr375832457-TMEM254chr1081841597+0.92291260.07708744
ENST00000477374ENST00000372274ZNF717chr375832457-TMEM254chr1081841597+0.797112940.20288709
ENST00000422325ENST00000372277ZNF717chr375832457-TMEM254chr1081841597+0.86257340.13742661
ENST00000422325ENST00000372281ZNF717chr375832457-TMEM254chr1081841597+0.905668740.09433124
ENST00000422325ENST00000372275ZNF717chr375832457-TMEM254chr1081841597+0.979966460.02003356
ENST00000422325ENST00000372274ZNF717chr375832457-TMEM254chr1081841597+0.88644340.1135566

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Fusion Genomic Features for ZNF717-TMEM254


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF717chr375832456-TMEM254chr1081841596+0.0082673240.9917327
ZNF717chr375832456-TMEM254chr1081841596+0.0082673240.9917327

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF717-TMEM254


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:75832457/chr10:81841597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TMEM254

Q8TBM7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722740661_8129119.66666666666667TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722740695_11529119.66666666666667TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722750561_8129229.66666666666666TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722750595_11529229.66666666666666TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722770561_8129104.0TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722770595_11529104.0TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722810461_8129124.0TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722810495_11529124.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-2515_860908.0DomainKRAB
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25202_2240908.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25259_2700908.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25276_2980908.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25304_3260908.0Zinc fingerC2H2-type 4
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25332_3540908.0Zinc fingerC2H2-type 5
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25360_3820908.0Zinc fingerC2H2-type 6
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25388_4100908.0Zinc fingerC2H2-type 7
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25416_4380908.0Zinc fingerC2H2-type 8
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25444_4660908.0Zinc fingerC2H2-type 9
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25472_4940908.0Zinc fingerC2H2-type 10
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25500_5220908.0Zinc fingerC2H2-type 11
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25528_5500908.0Zinc fingerC2H2-type 12
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25556_5780908.0Zinc fingerC2H2-type 13
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25584_6060908.0Zinc fingerC2H2-type 14
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25612_6340908.0Zinc fingerC2H2-type 15
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25642_6590908.0Zinc fingerC2H2-type 16%3B degenerate
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25731_7420908.0Zinc fingerC2H2-type 17%3B degenerate
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25748_7700908.0Zinc fingerC2H2-type 18
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25776_7980908.0Zinc fingerC2H2-type 19
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25804_8260908.0Zinc fingerC2H2-type 20
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25832_8540908.0Zinc fingerC2H2-type 21
HgeneZNF717chr3:75832457chr10:81841597ENST00000400845-25860_8820908.0Zinc fingerC2H2-type 22
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722740615_3529119.66666666666667TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722750515_3529229.66666666666666TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722770515_3529104.0TransmembraneHelical
TgeneTMEM254chr3:75832457chr10:81841597ENST000003722810415_3529124.0TransmembraneHelical


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Fusion Gene Sequence for ZNF717-TMEM254


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102813_102813_1_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372274_length(transcript)=766nt_BP=380nt
GTTTGTATTAGTTGGGTTTCCCGGTGTCTCTTTAGCAAGTGAAGTTTCTGGTTCCCTCCTTCACTGTGTGACCTGCCTAGTCCTCCTGGG
TTGCGTTTACAGAAGTTTATACGAGACCTAGTTTCCAGGGAAGAACTCACTGATGCCGCGAGGGAGATGGGGTACTGGATGATGGTCTTC
AGCCTTAAGGGTACTTCAGTCTTAACCGTGTGTTATAAGGTTTGAAAGGGAGGGTTCCCTATGAATAAGAAGCGCACTTGAAAGAACAGC
CCTCTGGTCTAACCTCCCACTGGTGCTTCAGAGGAGGATAAAAGGTCACAGCTATGTTTCCAGTGTTCTCTGGCTGTTTCCAAGAGCTAC
AAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACT
TGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGT
GCAAGCAAAATGAGCTAAGAATACGGATAAAGATGAGAAAACTGATTCTGAGAGATTCTGAGTGATTTGCCCAGGTCACAGCTGGCATAA
AGGCATCACAAGTGGTCGGGCTCAGCTACTCTGGTTCCTACAGACTTTCTTCTTTGGGATAGCGTCTCTCACCATCTTGATTGCTTACAA

>102813_102813_1_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372274_length(amino acids)=93AA_BP=19
MFPVFSGCFQELQEKNKSLWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKQNELRIRIKMRKLILR

--------------------------------------------------------------
>102813_102813_2_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372275_length(transcript)=1135nt_BP=380nt
GTTTGTATTAGTTGGGTTTCCCGGTGTCTCTTTAGCAAGTGAAGTTTCTGGTTCCCTCCTTCACTGTGTGACCTGCCTAGTCCTCCTGGG
TTGCGTTTACAGAAGTTTATACGAGACCTAGTTTCCAGGGAAGAACTCACTGATGCCGCGAGGGAGATGGGGTACTGGATGATGGTCTTC
AGCCTTAAGGGTACTTCAGTCTTAACCGTGTGTTATAAGGTTTGAAAGGGAGGGTTCCCTATGAATAAGAAGCGCACTTGAAAGAACAGC
CCTCTGGTCTAACCTCCCACTGGTGCTTCAGAGGAGGATAAAAGGTCACAGCTATGTTTCCAGTGTTCTCTGGCTGTTTCCAAGAGCTAC
AAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACT
TGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGT
GCAAATGAGAAAACTGATTCTGAGAGATTCTGAGTGATTTGCCCAGGTCACAGCTGGCATAAAGGCATCACAAGTGGTCGGGCTCAGCTA
CTCTGGTTCCTACAGACTTTCTTCTTTGGGATAGCGTCTCTCACCATCTTGATTGCTTACAAACGGAAGCGCCAAAAACAAACTTGAAGT
TGTCTGAAAGCTTGCTCTACACTTTTACATTCATCCTCACCCTTTTTTTTGTGGGGTAGAGGAGGTGCAGTAATTTACTCAGTGATCTTT
CTACTTTCTAGAAACTGTCCTTCAAAGCTCTTTAAGACCCCCTCGTTAGTCAGTTTTTTCTCTTATATGCTCTGGTTGAGCTTGAATAGA
CCAGTTGTTACTTAAGAAAGAAACAGAGAAAGATTTTAGCTTTTCAATCCTATTTGGCAGAGGACTTCAGCTACCTTCTTACAGTCTTTG
GCTGTGTTGGTACCCTCGTGTGCTCTGAGCTAAGCCACATACTAAACTGACTTTTTGGTTTGTATACCCTTGCTCCCGCCTTCTGATGAA

>102813_102813_2_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372275_length(amino acids)=74AA_BP=19

--------------------------------------------------------------
>102813_102813_3_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372277_length(transcript)=605nt_BP=380nt
GTTTGTATTAGTTGGGTTTCCCGGTGTCTCTTTAGCAAGTGAAGTTTCTGGTTCCCTCCTTCACTGTGTGACCTGCCTAGTCCTCCTGGG
TTGCGTTTACAGAAGTTTATACGAGACCTAGTTTCCAGGGAAGAACTCACTGATGCCGCGAGGGAGATGGGGTACTGGATGATGGTCTTC
AGCCTTAAGGGTACTTCAGTCTTAACCGTGTGTTATAAGGTTTGAAAGGGAGGGTTCCCTATGAATAAGAAGCGCACTTGAAAGAACAGC
CCTCTGGTCTAACCTCCCACTGGTGCTTCAGAGGAGGATAAAAGGTCACAGCTATGTTTCCAGTGTTCTCTGGCTGTTTCCAAGAGCTAC
AAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACT
TGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGT

>102813_102813_3_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372277_length(amino acids)=94AA_BP=19
MFPVFSGCFQELQEKNKSLWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKQNELRIRIKMRKLILR

--------------------------------------------------------------
>102813_102813_4_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372281_length(transcript)=2305nt_BP=380nt
GTTTGTATTAGTTGGGTTTCCCGGTGTCTCTTTAGCAAGTGAAGTTTCTGGTTCCCTCCTTCACTGTGTGACCTGCCTAGTCCTCCTGGG
TTGCGTTTACAGAAGTTTATACGAGACCTAGTTTCCAGGGAAGAACTCACTGATGCCGCGAGGGAGATGGGGTACTGGATGATGGTCTTC
AGCCTTAAGGGTACTTCAGTCTTAACCGTGTGTTATAAGGTTTGAAAGGGAGGGTTCCCTATGAATAAGAAGCGCACTTGAAAGAACAGC
CCTCTGGTCTAACCTCCCACTGGTGCTTCAGAGGAGGATAAAAGGTCACAGCTATGTTTCCAGTGTTCTCTGGCTGTTTCCAAGAGCTAC
AAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACT
TGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGT
GCAAGCATAAAGGCATCACAAGTGGTCGGGCTCAGCTACTCTGGTTCCTACAGACTTTCTTCTTTGGGATAGCGTCTCTCACCATCTTGA
TTGCTTACAAACGGAAGCGCCAAAAACAAACTTGAAGTTGTCTGAAAGCTTGCTCTACACTTTTACATTCATCCTCACCCTTTTTTTTGT
GGGGTAGAGGAGGTGCAGTAATTTACTCAGTGATCTTTCTACTTTCTAGAAACTGTCCTTCAAAGCTCTTTAAGACCCCCTCGTTAGTCA
GTTTTTTCTCTTATATGCTCTGGTTGAGCTTGAATAGACCAGTTGTTACTTAAGAAAGAAACAGAGAAAGATTTTAGCTTTTCAATCCTA
TTTGGCAGAGGACTTCAGCTACCTTCTTACAGTCTTTGGCTGTGTTGGTACCCTCGTGTGCTCTGAGCTAAGCCACATACTAAACTGACT
TTTTGGTTTGTATACCCTTGCTCCCGCCTTCTGATGAAAACACCTTACCCTCACAACCACCATCTTTCCTCTCCTTTCCAAAGCTCTTTC
CACCTTGCTGCACTAAGATAAAGTGACACTTCCACTATATGTCAATTCCACACACATTTATTAGGTACCTGTGAGGTAGGATCCTATCCT
CTCAAACTTCCATTTCTCATGCTACAGAGAAAGATAAGGAAGATGAGCAAGTGCCTGGAATGGGGCAGGCTGAGCAGTCACACAGGCATA
GAGGCACGCTGAGAACCTGGAGGGGAGACTGCAGAGTGCCTTCCCTGATGCTGCAGCCGGAAGTGATCCTTCCCTCCACCTGGCCCCTGG
GACACTGTGCTCTGCAGTGTGCAGGGCCTGATGGCACTGCTAGATTGCTCCTTCAGCTCAGGGCCACAGCTTAAACAGCTTTACCTTTCC
CCTCAGCACCTGTCCCACTATCTTGCACACAGGTGCTCTAACCATGTTTATTGAACAAAGGAGGGAAACTGATTTCACTTTCACTTGTTC
ATTATCATTCCAATTTTTATGTGAAAATGGCACAACCCATTTGGGGTACCCTCACCCCAAAATAAAAGCCCAAGTCTACCTTTGACTGGT
ACCACCTTTTTTGTGGTTTCGTTGGTGAGAAACCTTTATCTTTTTCATACCTTTCTATTCTCAATCACTTCTCCAAAAGTGTGTCTTTCC
AGCTCTGATTTATTCAAAACACAAGCATTTCTGTTTAGAGATTCTAGCCCATGGGTTATCTGGCTAGTTATTACCTCTCCTGTTCACTTA
GTTATACTTTATTATTGCTCACAGGCTGGGGAGGCAGAATGACTCTGTCACCACTAGGAGCCATTAGGGCTTCTTCCCTGGAGGACTGCC
TGCTTGCTTTCTGGGGACACTAGCCCTCATTTCCCTTCTGTGGTACAGTGGGGCAAATTATTTGTATTAAGCAAACATTTATGGGAAACA
ACCCGCTCCCGAAAACGGAGCCCCCAAGTAAAGCACAACCCTGAAAGATTATGAACTATGAATTGTCTCTGGTAGAGATAAATTTCTGCA
AACATATCTCAGTCTTCCCTCTGTTTCTCTGGTGATTAAGAAGTTCCTTTTTGGTAAGGAAAAGGATTTTTAACCATAGAGTTAGGCATC
ATGGAAATTCAAACCAGATTTCTTAATACCTGGTCTTCCTCAAAGAGAAATAATAACAGTAATAGTGGTGCTGGGAACAATATGGCAGAT

>102813_102813_4_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000422325_TMEM254_chr10_81841597_ENST00000372281_length(amino acids)=113AA_BP=19
MFPVFSGCFQELQEKNKSLWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQ

--------------------------------------------------------------
>102813_102813_5_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372274_length(transcript)=615nt_BP=229nt
CGGTCTTGTAGCTGGGCCAGCCTGGGGCTTGGTTCTATGTCCCTGCGGGTCGGTGCGAGGGCGAAGAGGAACCCGTGGGCCCGGGGGATC
CCGGGGGGCCGGACCAGTGTTCCCCAGTTGTGGGAGCAGACGCGTGGGCGCATCGCGGGCGGGCAGGGCCTGAAGTGCAGCTATGTTTCC
AGTGTTCTCTGGCTGTTTCCAAGAGCTACAAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCT
TGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGT
GGGAGAGTCCTTGTATGCCATAGTATTGTGCAAGCAAAATGAGCTAAGAATACGGATAAAGATGAGAAAACTGATTCTGAGAGATTCTGA
GTGATTTGCCCAGGTCACAGCTGGCATAAAGGCATCACAAGTGGTCGGGCTCAGCTACTCTGGTTCCTACAGACTTTCTTCTTTGGGATA

>102813_102813_5_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372274_length(amino acids)=113AA_BP=73
MGQPGAWFYVPAGRCEGEEEPVGPGDPGGPDQCSPVVGADAWAHRGRAGPEVQLCFQCSLAVSKSYKKRINLCGLSSGLRVSLIRTLGPW

--------------------------------------------------------------
>102813_102813_6_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372275_length(transcript)=984nt_BP=229nt
CGGTCTTGTAGCTGGGCCAGCCTGGGGCTTGGTTCTATGTCCCTGCGGGTCGGTGCGAGGGCGAAGAGGAACCCGTGGGCCCGGGGGATC
CCGGGGGGCCGGACCAGTGTTCCCCAGTTGTGGGAGCAGACGCGTGGGCGCATCGCGGGCGGGCAGGGCCTGAAGTGCAGCTATGTTTCC
AGTGTTCTCTGGCTGTTTCCAAGAGCTACAAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCT
TGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGT
GGGAGAGTCCTTGTATGCCATAGTATTGTGCAAATGAGAAAACTGATTCTGAGAGATTCTGAGTGATTTGCCCAGGTCACAGCTGGCATA
AAGGCATCACAAGTGGTCGGGCTCAGCTACTCTGGTTCCTACAGACTTTCTTCTTTGGGATAGCGTCTCTCACCATCTTGATTGCTTACA
AACGGAAGCGCCAAAAACAAACTTGAAGTTGTCTGAAAGCTTGCTCTACACTTTTACATTCATCCTCACCCTTTTTTTTGTGGGGTAGAG
GAGGTGCAGTAATTTACTCAGTGATCTTTCTACTTTCTAGAAACTGTCCTTCAAAGCTCTTTAAGACCCCCTCGTTAGTCAGTTTTTTCT
CTTATATGCTCTGGTTGAGCTTGAATAGACCAGTTGTTACTTAAGAAAGAAACAGAGAAAGATTTTAGCTTTTCAATCCTATTTGGCAGA
GGACTTCAGCTACCTTCTTACAGTCTTTGGCTGTGTTGGTACCCTCGTGTGCTCTGAGCTAAGCCACATACTAAACTGACTTTTTGGTTT

>102813_102813_6_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372275_length(amino acids)=113AA_BP=73
MGQPGAWFYVPAGRCEGEEEPVGPGDPGGPDQCSPVVGADAWAHRGRAGPEVQLCFQCSLAVSKSYKKRINLCGLSSGLRVSLIRTLGPW

--------------------------------------------------------------
>102813_102813_7_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372277_length(transcript)=454nt_BP=229nt
CGGTCTTGTAGCTGGGCCAGCCTGGGGCTTGGTTCTATGTCCCTGCGGGTCGGTGCGAGGGCGAAGAGGAACCCGTGGGCCCGGGGGATC
CCGGGGGGCCGGACCAGTGTTCCCCAGTTGTGGGAGCAGACGCGTGGGCGCATCGCGGGCGGGCAGGGCCTGAAGTGCAGCTATGTTTCC
AGTGTTCTCTGGCTGTTTCCAAGAGCTACAAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCT
TGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGT
GGGAGAGTCCTTGTATGCCATAGTATTGTGCAAGCAAAATGAGCTAAGAATACGGATAAAGATGAGAAAACTGATTCTGAGAGATTCTGA

>102813_102813_7_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372277_length(amino acids)=113AA_BP=73
MGQPGAWFYVPAGRCEGEEEPVGPGDPGGPDQCSPVVGADAWAHRGRAGPEVQLCFQCSLAVSKSYKKRINLCGLSSGLRVSLIRTLGPW

--------------------------------------------------------------
>102813_102813_8_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372281_length(transcript)=2154nt_BP=229nt
CGGTCTTGTAGCTGGGCCAGCCTGGGGCTTGGTTCTATGTCCCTGCGGGTCGGTGCGAGGGCGAAGAGGAACCCGTGGGCCCGGGGGATC
CCGGGGGGCCGGACCAGTGTTCCCCAGTTGTGGGAGCAGACGCGTGGGCGCATCGCGGGCGGGCAGGGCCTGAAGTGCAGCTATGTTTCC
AGTGTTCTCTGGCTGTTTCCAAGAGCTACAAGAAAAGAATAAATCTCTGTGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCT
TGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGT
GGGAGAGTCCTTGTATGCCATAGTATTGTGCAAGCATAAAGGCATCACAAGTGGTCGGGCTCAGCTACTCTGGTTCCTACAGACTTTCTT
CTTTGGGATAGCGTCTCTCACCATCTTGATTGCTTACAAACGGAAGCGCCAAAAACAAACTTGAAGTTGTCTGAAAGCTTGCTCTACACT
TTTACATTCATCCTCACCCTTTTTTTTGTGGGGTAGAGGAGGTGCAGTAATTTACTCAGTGATCTTTCTACTTTCTAGAAACTGTCCTTC
AAAGCTCTTTAAGACCCCCTCGTTAGTCAGTTTTTTCTCTTATATGCTCTGGTTGAGCTTGAATAGACCAGTTGTTACTTAAGAAAGAAA
CAGAGAAAGATTTTAGCTTTTCAATCCTATTTGGCAGAGGACTTCAGCTACCTTCTTACAGTCTTTGGCTGTGTTGGTACCCTCGTGTGC
TCTGAGCTAAGCCACATACTAAACTGACTTTTTGGTTTGTATACCCTTGCTCCCGCCTTCTGATGAAAACACCTTACCCTCACAACCACC
ATCTTTCCTCTCCTTTCCAAAGCTCTTTCCACCTTGCTGCACTAAGATAAAGTGACACTTCCACTATATGTCAATTCCACACACATTTAT
TAGGTACCTGTGAGGTAGGATCCTATCCTCTCAAACTTCCATTTCTCATGCTACAGAGAAAGATAAGGAAGATGAGCAAGTGCCTGGAAT
GGGGCAGGCTGAGCAGTCACACAGGCATAGAGGCACGCTGAGAACCTGGAGGGGAGACTGCAGAGTGCCTTCCCTGATGCTGCAGCCGGA
AGTGATCCTTCCCTCCACCTGGCCCCTGGGACACTGTGCTCTGCAGTGTGCAGGGCCTGATGGCACTGCTAGATTGCTCCTTCAGCTCAG
GGCCACAGCTTAAACAGCTTTACCTTTCCCCTCAGCACCTGTCCCACTATCTTGCACACAGGTGCTCTAACCATGTTTATTGAACAAAGG
AGGGAAACTGATTTCACTTTCACTTGTTCATTATCATTCCAATTTTTATGTGAAAATGGCACAACCCATTTGGGGTACCCTCACCCCAAA
ATAAAAGCCCAAGTCTACCTTTGACTGGTACCACCTTTTTTGTGGTTTCGTTGGTGAGAAACCTTTATCTTTTTCATACCTTTCTATTCT
CAATCACTTCTCCAAAAGTGTGTCTTTCCAGCTCTGATTTATTCAAAACACAAGCATTTCTGTTTAGAGATTCTAGCCCATGGGTTATCT
GGCTAGTTATTACCTCTCCTGTTCACTTAGTTATACTTTATTATTGCTCACAGGCTGGGGAGGCAGAATGACTCTGTCACCACTAGGAGC
CATTAGGGCTTCTTCCCTGGAGGACTGCCTGCTTGCTTTCTGGGGACACTAGCCCTCATTTCCCTTCTGTGGTACAGTGGGGCAAATTAT
TTGTATTAAGCAAACATTTATGGGAAACAACCCGCTCCCGAAAACGGAGCCCCCAAGTAAAGCACAACCCTGAAAGATTATGAACTATGA
ATTGTCTCTGGTAGAGATAAATTTCTGCAAACATATCTCAGTCTTCCCTCTGTTTCTCTGGTGATTAAGAAGTTCCTTTTTGGTAAGGAA
AAGGATTTTTAACCATAGAGTTAGGCATCATGGAAATTCAAACCAGATTTCTTAATACCTGGTCTTCCTCAAAGAGAAATAATAACAGTA

>102813_102813_8_ZNF717-TMEM254_ZNF717_chr3_75832457_ENST00000477374_TMEM254_chr10_81841597_ENST00000372281_length(amino acids)=113AA_BP=19
MFPVFSGCFQELQEKNKSLWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF717-TMEM254


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF717-TMEM254


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF717-TMEM254


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource