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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF736-FAM120B (FusionGDB2 ID:102854)

Fusion Gene Summary for ZNF736-FAM120B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF736-FAM120B
Fusion gene ID: 102854
HgeneTgene
Gene symbol

ZNF736

FAM120B

Gene ID

728927

84498

Gene namezinc finger protein 736family with sequence similarity 120B
Synonyms-CCPG|KIAA1838|PGCC1|SAN1|dJ894D12.1
Cytomap

7q11.21

6q27

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 736KRAB-containing zinc-finger repressor proteinconstitutive coactivator of peroxisome proliferator-activated receptor gammaPPARG constitutive coactivator 1PPARgamma constitutive coactivator 1constitutive coactivator of PPAR-gammasenataxin-associated nuclease 1
Modification date2020032020200313
UniProtAcc.

Q96EK7

Ensembl transtripts involved in fusion geneENST00000355095, ENST00000423484, 
ENST00000465343, 		ENST00000496635, 
ENST00000252510, ENST00000476287, 
ENST00000537664, ENST00000540480, 
Fusion gene scores* DoF score6 X 4 X 4=9610 X 9 X 6=540
# samples 710
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF736 [Title/Abstract] AND FAM120B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF736(63797360)-FAM120B(170704575), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF736 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM120B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0219-01AZNF736chr7

63797360

+FAM120Bchr6

170704575

+


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Fusion Gene ORF analysis for ZNF736-FAM120B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355095ENST00000496635ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
5CDS-intronENST00000423484ENST00000496635ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000355095ENST00000252510ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000355095ENST00000476287ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000355095ENST00000537664ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000355095ENST00000540480ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000423484ENST00000252510ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000423484ENST00000476287ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000423484ENST00000537664ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
In-frameENST00000423484ENST00000540480ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
intron-3CDSENST00000465343ENST00000252510ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
intron-3CDSENST00000465343ENST00000476287ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
intron-3CDSENST00000465343ENST00000537664ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
intron-3CDSENST00000465343ENST00000540480ZNF736chr7

63797360

+FAM120Bchr6

170704575

+
intron-intronENST00000465343ENST00000496635ZNF736chr7

63797360

+FAM120Bchr6

170704575

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355095ZNF736chr763797360+ENST00000540480FAM120Bchr6170704575+1279548940464158
ENST00000355095ZNF736chr763797360+ENST00000537664FAM120Bchr6170704575+1007548940464158
ENST00000355095ZNF736chr763797360+ENST00000476287FAM120Bchr6170704575+2996548940464158
ENST00000355095ZNF736chr763797360+ENST00000252510FAM120Bchr6170704575+1573548940464158
ENST00000423484ZNF736chr763797360+ENST00000540480FAM120Bchr6170704575+1079348740264158
ENST00000423484ZNF736chr763797360+ENST00000537664FAM120Bchr6170704575+807348740264158
ENST00000423484ZNF736chr763797360+ENST00000476287FAM120Bchr6170704575+2796348740264158
ENST00000423484ZNF736chr763797360+ENST00000252510FAM120Bchr6170704575+1373348740264158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355095ENST00000540480ZNF736chr763797360+FAM120Bchr6170704575+0.086270150.9137298
ENST00000355095ENST00000537664ZNF736chr763797360+FAM120Bchr6170704575+0.100419460.8995805
ENST00000355095ENST00000476287ZNF736chr763797360+FAM120Bchr6170704575+0.089531880.9104681
ENST00000355095ENST00000252510ZNF736chr763797360+FAM120Bchr6170704575+0.087341150.9126589
ENST00000423484ENST00000540480ZNF736chr763797360+FAM120Bchr6170704575+0.084028940.9159711
ENST00000423484ENST00000537664ZNF736chr763797360+FAM120Bchr6170704575+0.0844585150.9155415
ENST00000423484ENST00000476287ZNF736chr763797360+FAM120Bchr6170704575+0.065531380.9344686
ENST00000423484ENST00000252510ZNF736chr763797360+FAM120Bchr6170704575+0.071323090.92867684

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Fusion Genomic Features for ZNF736-FAM120B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF736chr763797360+FAM120Bchr6170704574+0.0002493320.9997507
ZNF736chr763797360+FAM120Bchr6170704574+0.0002493320.9997507

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF736-FAM120B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:63797360/chr6:170704575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM120B

Q96EK7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+454_7575428.0DomainKRAB
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+344_7575428.0DomainKRAB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45145_16775428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45173_19575428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45201_22375428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45229_25175428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45257_27975428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45285_30775428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45313_33575428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45341_36375428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45369_39175428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797360chr6:170704575ENST00000355095+45397_41975428.0Zinc fingerC2H2-type 10
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34145_16775428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34173_19575428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34201_22375428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34229_25175428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34257_27975428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34285_30775428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34313_33575428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34341_36375428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34369_39175428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797360chr6:170704575ENST00000423484+34397_41975428.0Zinc fingerC2H2-type 10


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Fusion Gene Sequence for ZNF736-FAM120B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102854_102854_1_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000252510_length(transcript)=1573nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGGAGGTGGGGAAGACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGA
CCAGGGACCAGGAAGCAGACAGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCAC
ACCTGGACGCAGAGCCCTGCCAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAA
GAAGGAACGATGCCTTTTTCAATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTG
TGGCCCAAAACAATCATTGTTAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAA
TAAATGGGAATCTGTTGTATTCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTA
TACAGTAGTCCTCCCTTATCTGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTAT
ACCTTGGCTTTTTCCTCTACGTACATACCATGATAAAGCTTAACAAAGAACAGTGAGAGATTAACAGCAACCAATAACTAATAAAAGCTA
TGTGAATGTGGTCTCTGTCAAAATATCGTGCTGTAATCACCCTTCTTGCTATCTGAAAACCAAGAAGACCACTAAGTGACTAATGGTCAG
AGAAGCTGGATGAGGGGCTGATTCATGTCCTGGGCATGACAGAGCGGGAGGCACAAGGTTTCATCACACTATTCACAATGGCGAGCAAGT
TAAAACGGATTTCCCATTTAATTTAATTTTCAGACTTCAGTTGACCATGAGTAACCGAAACCACAGAAAGTGAAGCTGGGGATATTTCAG

>102854_102854_1_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000252510_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_2_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000476287_length(transcript)=2996nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGGAGGTGGGGAAGACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGA
CCAGGGACCAGGAAGCAGACAGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCAC
ACCTGGACGCAGAGCCCTGCCAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAA
GAAGGAACGATGCCTTTTTCAATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTG
TGGCCCAAAACAATCATTGTTAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAA
TAAATGGGAATCTGTTGTATTCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTA
TACAGTAGTCCTCCCTTATCTGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTAT
ACCTTGGCTTTTTCCTCTACGTACATACCATGATAAAGCTTAACAAAGAACAGTGAGAGATTAACAGCAACCAATAACTAATAAAAGCTA
TGTGAATGTGGTCTCTGTCAAAATATCGTGCTGTAATCACCCTTCTTGCTATCTGAAAACCAAGAAGACCACTAAGTGACTAATGGTCAG
AGAAGCTGGATGAGGGGCTGATTCATGTCCTGGGCATGACAGAGCGGGAGGCACAAGGTTTCATCACACTATTCACAATGGCGAGCAAGT
TAAAACGGATTTCCCATTTAATTTAATTTTCAGACTTCAGTTGACCATGAGTAACCGAAACCACAGAAAGTGAAGCTGGGGATATTTCAG
AAATTCTTTTCTAATCAGAAATTCTAATCAAACATAAGTTTCCAACTATGTGTTCTCTTGGTCCTCAGAAGTGTTTGAATAGAAAAGTAA
CAACTAACTTCCCATCTTTCTGGTGGAAGAGTTAATTCTGCCTGGAGGGTTCTGCCTGGGAGACATGACAGCATGTGTGTGACTCCTGTG
TCTGTTTCTGTGGGGTCATCCCTTTCGTTTCATTTTGCCAGGGCCTGGCTCAGGATTTTTTATGGCAGTGCCTGTGAAGACAAGCCTGGC
CCTCCATCCAGTCACACAGGAAATCCACAGAGAGCATGCTGAGAGCAGCCAGCGGCTGGGCTGCCATCAGGCCTGGTTTATGATGCCACA
AGTGAATGGCACGTTTGTTCCTCTTTATCTCTGAGCATTGAAGGACTTTTGGTTAAAAAAAAAAATTAAGTTCAGAGTAATCCTTTTCAT
GGAAGAATCTTCAGGTCACCAAAGAATTGAAATTTTAAGCCCCAGATTGTACTGAGCTGTACCTGTGGGAAAAGGAATGGCCAGGGTATT
GATGATGGAAAAGATTCAAATGAGGAGTTAGAAGGCAAGCCCTCTGTGGGCAGCCGTCTTCCAGAAACCTCGAACTTATGTCTGTCTCCA
CCTGAGAAAGGAGAAGAAAAGCTGGTGGTGACCCCTGCTCCTGCTGGGCCATGCCATGGCTCTGAAGATGCCCCGTGTTCTTAGGAGGTG
CTCACCCCTGGCACCTAAAGACATTTCCTTCTGGTTGTTGCTCTTTAAAAACAAAATAAGCCCCTGAACGTGCTTGCAGGCCAGTTTGTG
TGCCTGCACTTGACGAATTACCTTGACCAACGGGCCAAAGGCACAGAGCTCCAAGGCATCATCTTTCCTTAAAATCCTGAGTGTTTATTA
AAAAGGGACATGGTCTCTAGGTATCTTATTACATTTGTATTTCTTACATTTGAAATATCCTAACCGCTCCCTTCGGTTTCTTCTTAAGAA
CATTTACATCTAATTATTTTTCGTGCAAGTCTTGTAGGACCCACATGTTTTCCTAGCTTTGGAAATCGATTTTTTTCATTCCTCTTATGA
GGATTTCCCTATGTCAGTAAACATTAACTTTCTATTTCTTCCATTTTTGCTCATTTGAAACCCCTGCTGCTTCTAGATCTATTTCTTTGC
ACTTGTATAACTTTGAAATAAATTCCTCATCCCTTAGACTAAGAGAGTGGGTGTCTGTGAAAATTGTTTTCTCCTTCATAATACCTAAAT
TCTAGTTTGTCAGTAAAATATTTGTGTTTGGTTAACAAGCTCTTATTTAAGCCATTGAGTTAGTATAATCTTTATTACCTTTGAAAAACC
AGAGAGCTGAATTTTTTGTCATTCTAAGTTGTAAGTAACACTGCAGTCAAGTCTTCTGATGAAATTTCCATATATCAAATTGAAAATAAA

>102854_102854_2_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000476287_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_3_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000537664_length(transcript)=1007nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGGAGGTGGGGAAGACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGA
CCAGGGACCAGGAAGCAGACAGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCAC
ACCTGGACGCAGAGCCCTGCCAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAA
GAAGGAACGATGCCTTTTTCAATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTG
TGGCCCAAAACAATCATTGTTAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAA

>102854_102854_3_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000537664_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_4_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000540480_length(transcript)=1279nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGGAGGTGGGGAAGACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGA
CCAGGGACCAGGAAGCAGACAGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCAC
ACCTGGACGCAGAGCCCTGCCAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAA
GAAGGAACGATGCCTTTTTCAATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTG
TGGCCCAAAACAATCATTGTTAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAA
TAAATGGGAATCTGTTGTATTCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTA
TACAGTAGTCCTCCCTTATCTGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTAT
ACCTTGGCTTTTTCCTCTACGTACATACCATGATAAAGCTTAACAAAGAACAGTGAGAGATTAACAGCAACCAATAACTAATAAAAGCTA

>102854_102854_4_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000355095_FAM120B_chr6_170704575_ENST00000540480_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_5_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000252510_length(transcript)=1373nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGGAGGTGGGGAA
GACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGACCAGGGACCAGGAAGCAGAC
AGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCACACCTGGACGCAGAGCCCTGC
CAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAAGAAGGAACGATGCCTTTTTC
AATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTGTGGCCCAAAACAATCATTGT
TAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAATAAATGGGAATCTGTTGTAT
TCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTATACAGTAGTCCTCCCTTATC
TGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTATACCTTGGCTTTTTCCTCTAC
GTACATACCATGATAAAGCTTAACAAAGAACAGTGAGAGATTAACAGCAACCAATAACTAATAAAAGCTATGTGAATGTGGTCTCTGTCA
AAATATCGTGCTGTAATCACCCTTCTTGCTATCTGAAAACCAAGAAGACCACTAAGTGACTAATGGTCAGAGAAGCTGGATGAGGGGCTG
ATTCATGTCCTGGGCATGACAGAGCGGGAGGCACAAGGTTTCATCACACTATTCACAATGGCGAGCAAGTTAAAACGGATTTCCCATTTA
ATTTAATTTTCAGACTTCAGTTGACCATGAGTAACCGAAACCACAGAAAGTGAAGCTGGGGATATTTCAGAAATTCTTTTCTAATCAGAA

>102854_102854_5_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000252510_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_6_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000476287_length(transcript)=2796nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGGAGGTGGGGAA
GACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGACCAGGGACCAGGAAGCAGAC
AGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCACACCTGGACGCAGAGCCCTGC
CAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAAGAAGGAACGATGCCTTTTTC
AATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTGTGGCCCAAAACAATCATTGT
TAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAATAAATGGGAATCTGTTGTAT
TCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTATACAGTAGTCCTCCCTTATC
TGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTATACCTTGGCTTTTTCCTCTAC
GTACATACCATGATAAAGCTTAACAAAGAACAGTGAGAGATTAACAGCAACCAATAACTAATAAAAGCTATGTGAATGTGGTCTCTGTCA
AAATATCGTGCTGTAATCACCCTTCTTGCTATCTGAAAACCAAGAAGACCACTAAGTGACTAATGGTCAGAGAAGCTGGATGAGGGGCTG
ATTCATGTCCTGGGCATGACAGAGCGGGAGGCACAAGGTTTCATCACACTATTCACAATGGCGAGCAAGTTAAAACGGATTTCCCATTTA
ATTTAATTTTCAGACTTCAGTTGACCATGAGTAACCGAAACCACAGAAAGTGAAGCTGGGGATATTTCAGAAATTCTTTTCTAATCAGAA
ATTCTAATCAAACATAAGTTTCCAACTATGTGTTCTCTTGGTCCTCAGAAGTGTTTGAATAGAAAAGTAACAACTAACTTCCCATCTTTC
TGGTGGAAGAGTTAATTCTGCCTGGAGGGTTCTGCCTGGGAGACATGACAGCATGTGTGTGACTCCTGTGTCTGTTTCTGTGGGGTCATC
CCTTTCGTTTCATTTTGCCAGGGCCTGGCTCAGGATTTTTTATGGCAGTGCCTGTGAAGACAAGCCTGGCCCTCCATCCAGTCACACAGG
AAATCCACAGAGAGCATGCTGAGAGCAGCCAGCGGCTGGGCTGCCATCAGGCCTGGTTTATGATGCCACAAGTGAATGGCACGTTTGTTC
CTCTTTATCTCTGAGCATTGAAGGACTTTTGGTTAAAAAAAAAAATTAAGTTCAGAGTAATCCTTTTCATGGAAGAATCTTCAGGTCACC
AAAGAATTGAAATTTTAAGCCCCAGATTGTACTGAGCTGTACCTGTGGGAAAAGGAATGGCCAGGGTATTGATGATGGAAAAGATTCAAA
TGAGGAGTTAGAAGGCAAGCCCTCTGTGGGCAGCCGTCTTCCAGAAACCTCGAACTTATGTCTGTCTCCACCTGAGAAAGGAGAAGAAAA
GCTGGTGGTGACCCCTGCTCCTGCTGGGCCATGCCATGGCTCTGAAGATGCCCCGTGTTCTTAGGAGGTGCTCACCCCTGGCACCTAAAG
ACATTTCCTTCTGGTTGTTGCTCTTTAAAAACAAAATAAGCCCCTGAACGTGCTTGCAGGCCAGTTTGTGTGCCTGCACTTGACGAATTA
CCTTGACCAACGGGCCAAAGGCACAGAGCTCCAAGGCATCATCTTTCCTTAAAATCCTGAGTGTTTATTAAAAAGGGACATGGTCTCTAG
GTATCTTATTACATTTGTATTTCTTACATTTGAAATATCCTAACCGCTCCCTTCGGTTTCTTCTTAAGAACATTTACATCTAATTATTTT
TCGTGCAAGTCTTGTAGGACCCACATGTTTTCCTAGCTTTGGAAATCGATTTTTTTCATTCCTCTTATGAGGATTTCCCTATGTCAGTAA
ACATTAACTTTCTATTTCTTCCATTTTTGCTCATTTGAAACCCCTGCTGCTTCTAGATCTATTTCTTTGCACTTGTATAACTTTGAAATA
AATTCCTCATCCCTTAGACTAAGAGAGTGGGTGTCTGTGAAAATTGTTTTCTCCTTCATAATACCTAAATTCTAGTTTGTCAGTAAAATA
TTTGTGTTTGGTTAACAAGCTCTTATTTAAGCCATTGAGTTAGTATAATCTTTATTACCTTTGAAAAACCAGAGAGCTGAATTTTTTGTC
ATTCTAAGTTGTAAGTAACACTGCAGTCAAGTCTTCTGATGAAATTTCCATATATCAAATTGAAAATAAAGCAAAATATATTTATTACTC

>102854_102854_6_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000476287_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_7_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000537664_length(transcript)=807nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGGAGGTGGGGAA
GACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGACCAGGGACCAGGAAGCAGAC
AGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCACACCTGGACGCAGAGCCCTGC
CAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAAGAAGGAACGATGCCTTTTTC
AATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTGTGGCCCAAAACAATCATTGT

>102854_102854_7_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000537664_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------
>102854_102854_8_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000540480_length(transcript)=1079nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGGAGGTGGGGAA
GACAGGGCTCCAGCTACCACAGGACGGGCTCTGGGTATAGCCGTTCCAGTCAGGGACAGCCGTGGAGAGACCAGGGACCAGGAAGCAGAC
AGTATGAGCATGACCAGTGGAGAAGGTACTAGTCAACCTCCAGAAAGAGTATGGAGAGAAAAAGAGGCACACCTGGACGCAGAGCCCTGC
CAGCGCCCTCCTCTGCTGTTGCAGCTGCAAGGAGACCATGCCTGTGGGAGCCAGGCCTCGCTTGCATGAAGAAGGAACGATGCCTTTTTC
AATGGTGTCTCCCTCCCATTGTGCAGAAGAGCTTTTGTTGGCTTCTCTCCCGAGCTTGTGCCTGATTCTGTGGCCCAAAACAATCATTGT
TAACATCTTCATGTGTTTCATTCTGATCTTTCATTCATATATATGATGCCTAGCTAATTTCATTTTAAAATAAATGGGAATCTGTTGTAT
TCTGATTTTTTATTAGCAACACTAGATTATGAGGGGTTATCTCCTGTTATTAAAAAGTCAGAAAACACTATACAGTAGTCCTCCCTTATC
TGCGGGGGAGACATCCCAAGACCCTCAGTGGATGCCTGAGACTGGATAGTATGGAATCCTACATATCTATACCTTGGCTTTTTCCTCTAC

>102854_102854_8_ZNF736-FAM120B_ZNF736_chr7_63797360_ENST00000423484_FAM120B_chr6_170704575_ENST00000540480_length(amino acids)=158AA_BP=0
MKHMKMLTMIVLGHRIRHKLGREANKSSSAQWEGDTIEKGIVPSSCKRGLAPTGMVSLQLQQQRRALAGLCVQVCLFFSPYSFWRLTSTF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF736-FAM120B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF736-FAM120B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF736-FAM120B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource