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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF772-ERCC2 (FusionGDB2 ID:102899)

Fusion Gene Summary for ZNF772-ERCC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF772-ERCC2
Fusion gene ID: 102899
HgeneTgene
Gene symbol

ZNF772

ERCC2

Gene ID

400720

2068

Gene namezinc finger protein 772ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms-COFS2|EM9|TFIIH|TTD|TTD1|XPD
Cytomap

19q13.43

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 772general transcription and DNA repair factor IIH helicase subunit XPDBTF2 p80CXPDDNA excision repair protein ERCC-2DNA repair protein complementing XP-D cellsTFIIH 80 kDa subunitTFIIH basal transcription factor complex 80 kDa subunitTFIIH basal tran
Modification date2020031320200315
UniProtAcc.

P18074

Ensembl transtripts involved in fusion geneENST00000343280, ENST00000356584, 
ENST00000425074, ENST00000600175, 
ENST00000427512, ENST00000601768, 
ENST00000221481, ENST00000391940, 
ENST00000485403, ENST00000391944, 
ENST00000391945, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 3=36
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF772 [Title/Abstract] AND ERCC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF772(57978327)-ERCC2(45860957), # samples:1
ZNF772(57988002)-ERCC2(45860801), # samples:1
ZNF772(57988002)-ERCC2(45860957), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF772-ERCC2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF772-ERCC2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC2

GO:0006283

transcription-coupled nucleotide-excision repair

8663148

TgeneERCC2

GO:0006366

transcription by RNA polymerase II

9852112

TgeneERCC2

GO:0045893

positive regulation of transcription, DNA-templated

8692842

TgeneERCC2

GO:0045944

positive regulation of transcription by RNA polymerase II

8692841


check buttonFusion gene breakpoints across ZNF772 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ERCC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-1970-01AZNF772chr19

57978327

-ERCC2chr19

45860957

-
ChimerDB4GBMTCGA-32-1970-01AZNF772chr19

57988002

-ERCC2chr19

45860801

-
ChimerDB4GBMTCGA-32-1970-01AZNF772chr19

57988002

-ERCC2chr19

45860957

-


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Fusion Gene ORF analysis for ZNF772-ERCC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343280ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000343280ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000343280ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000343280ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000343280ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000343280ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000356584ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000356584ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000356584ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000356584ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000356584ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000356584ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000425074ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000425074ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000425074ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000425074ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000425074ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000425074ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000600175ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000600175ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000600175ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000600175ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
5CDS-intronENST00000600175ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
5CDS-intronENST00000600175ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000343280ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000343280ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000343280ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000343280ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000356584ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000356584ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000356584ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000356584ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000425074ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000425074ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000425074ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000425074ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000600175ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000600175ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
Frame-shiftENST00000600175ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
Frame-shiftENST00000600175ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-3CDSENST00000343280ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000343280ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000356584ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000356584ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000425074ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000425074ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000427512ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000427512ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-3CDSENST00000427512ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-3CDSENST00000427512ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000427512ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-3CDSENST00000427512ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-3CDSENST00000600175ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000600175ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000601768ENST00000391944ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000601768ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-3CDSENST00000601768ENST00000391944ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-3CDSENST00000601768ENST00000391945ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-3CDSENST00000601768ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-3CDSENST00000601768ENST00000391945ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000343280ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000343280ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000343280ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000356584ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000356584ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000356584ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000425074ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000425074ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000425074ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000427512ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000427512ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000427512ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000427512ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000600175ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000600175ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000600175ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000221481ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000601768ENST00000221481ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000391940ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000601768ENST00000391940ZNF772chr19

57988002

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000485403ZNF772chr19

57978327

-ERCC2chr19

45860957

-
intron-intronENST00000601768ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860801

-
intron-intronENST00000601768ENST00000485403ZNF772chr19

57988002

-ERCC2chr19

45860957

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF772-ERCC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF772-ERCC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57978327/:45860957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERCC2

P18074

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF772-ERCC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF772-ERCC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF772-ERCC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF772-ERCC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource