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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF77-LPCAT2 (FusionGDB2 ID:102909)

Fusion Gene Summary for ZNF77-LPCAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF77-LPCAT2
Fusion gene ID: 102909
HgeneTgene
Gene symbol

ZNF77

LPCAT2

Gene ID

58492

54947

Gene namezinc finger protein 77lysophosphatidylcholine acyltransferase 2
SynonymspT1AGPAT11|AYTL1|LysoPAFAT
Cytomap

19p13.3

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 77ZNFpT1lysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2
Modification date2020031320200313
UniProtAcc.

Q7L5N7

Ensembl transtripts involved in fusion geneENST00000314531, ENST00000588050, 
ENST00000565056, ENST00000262134, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 9 X 4=216
# samples 49
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF77 [Title/Abstract] AND LPCAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF77(2944836)-LPCAT2(55559420), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPCAT2

GO:0036151

phosphatidylcholine acyl-chain remodeling

21498505


check buttonFusion gene breakpoints across ZNF77 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPCAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1XL-01AZNF77chr19

2944836

-LPCAT2chr16

55559420

+
ChimerDB4BRCATCGA-D8-A1XLZNF77chr19

2944835

-LPCAT2chr16

55559419

+


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Fusion Gene ORF analysis for ZNF77-LPCAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314531ENST00000565056ZNF77chr19

2944836

-LPCAT2chr16

55559420

+
5CDS-intronENST00000314531ENST00000565056ZNF77chr19

2944835

-LPCAT2chr16

55559419

+
5UTR-3CDSENST00000588050ENST00000262134ZNF77chr19

2944836

-LPCAT2chr16

55559420

+
5UTR-3CDSENST00000588050ENST00000262134ZNF77chr19

2944835

-LPCAT2chr16

55559419

+
5UTR-intronENST00000588050ENST00000565056ZNF77chr19

2944836

-LPCAT2chr16

55559420

+
5UTR-intronENST00000588050ENST00000565056ZNF77chr19

2944835

-LPCAT2chr16

55559419

+
In-frameENST00000314531ENST00000262134ZNF77chr19

2944836

-LPCAT2chr16

55559420

+
In-frameENST00000314531ENST00000262134ZNF77chr19

2944835

-LPCAT2chr16

55559419

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314531ZNF77chr192944836-ENST00000262134LPCAT2chr1655559420+513296211559512
ENST00000314531ZNF77chr192944835-ENST00000262134LPCAT2chr1655559419+513296211559512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314531ENST00000262134ZNF77chr192944836-LPCAT2chr1655559420+0.0001359950.999864
ENST00000314531ENST00000262134ZNF77chr192944835-LPCAT2chr1655559419+0.0001359950.999864

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Fusion Genomic Features for ZNF77-LPCAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF77chr192944835-LPCAT2chr1655559419+4.92E-070.9999995
ZNF77chr192944835-LPCAT2chr1655559419+4.92E-070.9999995
ZNF77chr192944835-LPCAT2chr1655559419+4.92E-070.9999995
ZNF77chr192944835-LPCAT2chr1655559419+4.92E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF77-LPCAT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:2944836/chr16:55559420)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPCAT2

Q7L5N7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q8BYI6, ECO:0000269|PubMed:17182612, ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014404_41557545.0Calcium binding1
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014441_45257545.0Calcium binding2
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014404_41557545.0Calcium binding1
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014441_45257545.0Calcium binding2
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014391_42657545.0DomainEF-hand 1
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014428_46357545.0DomainEF-hand 2
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014391_42657545.0DomainEF-hand 1
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014428_46357545.0DomainEF-hand 2
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014146_15157545.0MotifHXXXXD motif
TgeneLPCAT2chr19:2944835chr16:55559419ENST00000262134014220_22357545.0MotifNote=EGTC motif
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014146_15157545.0MotifHXXXXD motif
TgeneLPCAT2chr19:2944836chr16:55559420ENST00000262134014220_22357545.0MotifNote=EGTC motif
TgeneLPCAT2chr19:2944835chr16:55559419ENST0000026213401479_54457545.0Topological domainLumenal
TgeneLPCAT2chr19:2944836chr16:55559420ENST0000026213401479_54457545.0Topological domainLumenal
TgeneLPCAT2chr19:2944835chr16:55559419ENST0000026213401458_7857545.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneLPCAT2chr19:2944836chr16:55559420ENST0000026213401458_7857545.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-144_991546.0DomainKRAB
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-144_991546.0DomainKRAB
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14212_2341546.0Zinc fingerC2H2-type 1
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14240_2621546.0Zinc fingerC2H2-type 2
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14268_2901546.0Zinc fingerC2H2-type 3
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14296_3181546.0Zinc fingerC2H2-type 4
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14324_3461546.0Zinc fingerC2H2-type 5
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14352_3741546.0Zinc fingerC2H2-type 6
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14380_4021546.0Zinc fingerC2H2-type 7
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14408_4301546.0Zinc fingerC2H2-type 8
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14436_4581546.0Zinc fingerC2H2-type 9
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14464_4861546.0Zinc fingerC2H2-type 10
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14492_5141546.0Zinc fingerC2H2-type 11
HgeneZNF77chr19:2944835chr16:55559419ENST00000314531-14520_5421546.0Zinc fingerC2H2-type 12
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14212_2341546.0Zinc fingerC2H2-type 1
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14240_2621546.0Zinc fingerC2H2-type 2
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14268_2901546.0Zinc fingerC2H2-type 3
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14296_3181546.0Zinc fingerC2H2-type 4
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14324_3461546.0Zinc fingerC2H2-type 5
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14352_3741546.0Zinc fingerC2H2-type 6
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14380_4021546.0Zinc fingerC2H2-type 7
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14408_4301546.0Zinc fingerC2H2-type 8
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14436_4581546.0Zinc fingerC2H2-type 9
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14464_4861546.0Zinc fingerC2H2-type 10
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14492_5141546.0Zinc fingerC2H2-type 11
HgeneZNF77chr19:2944836chr16:55559420ENST00000314531-14520_5421546.0Zinc fingerC2H2-type 12
TgeneLPCAT2chr19:2944835chr16:55559419ENST000002621340141_5757545.0Topological domainCytoplasmic
TgeneLPCAT2chr19:2944836chr16:55559420ENST000002621340141_5757545.0Topological domainCytoplasmic


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Fusion Gene Sequence for ZNF77-LPCAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102909_102909_1_ZNF77-LPCAT2_ZNF77_chr19_2944835_ENST00000314531_LPCAT2_chr16_55559419_ENST00000262134_length(transcript)=5132nt_BP=96nt
ACCCCGAGCGGCTCAGGTGTCCTGTCGTGCTCACCTGCGCCGGTCGCTGGACCGCGGGGCGCTAACCCTGGAGAGCCCAGGAGCGGGCGG
GACATGATTGTCCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCA
ATTTCAACAGTATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGT
CGTGCTATGTTCTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCT
CATTCAACATTCTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATT
GGCAGACTGTTACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGA
ACAACATCAGGAGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGA
GCCTTCATTCCAGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACA
TTCATTCAGCTTTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGTTTATGCCAGTTCAAGTACCAAATGATGAAGAA
AAAAATGATCCTGTCCTTTTTGCCAATAAAGTCCGGAATTTAATGGCAGAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGAC
TGCAGATTGATGATTTCAGCAGGACAGCTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTA
GATTGGGATGGTGTTCGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCC
AAGTATTTAAAGTTGCCTGTTTCAGATGTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAG
TATGTGATTGGCCTGGCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGAT
GGCTACATAACGGAGGAAGAGTTCTCCACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATA
GCCCAAGGGGACTCAATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGAC
CTCCAGACGTGCCATGTGTTTTCATTACCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAA
GAGAGTACCTCAGACAAAAAAGATGACTGAAAGCAGTATTTCCAATAAGGAAAACACAGTAGCTTTTGCTTGAAATTGTAAAGGCACTTA
TTGATAATACTTTTAATGTGTTGGTAATGATGTTTAAAATTGAAAGATTTTTAAAACAAAAATGATAGATTTTCTTACTAAAAATGTTTT
TATTAACCTTGCTTTTATTGGAAAAAATCAAGCAATATTTCGTTTTCTTTTGTGTTATATTGTACTTTACTGATTCATTTACTGGTGATA
CATATGTTTTTATGGATTTTCCAGTTTAATTTGCATATACAAATGAATGCAATGGTCTATTGGTGAGCATTGAGCAACACTGTATAAAGT
TTTAAAAATGTAAACACTTTTTAATCTACTTTCCTCTAAAAATCAATAATATTCTATTATTTCTAATCCTTTTCCACTTGGGAAATAACA
ATGAAGAATCTGAGAATTTGACATCTATAACTTTACAGATTCATTTTTCCATTTAAATTTCAGTTTCTTGGATCACTGAATATGGGAAGG
GAGAGCTTCACTAATTAGACGCAGCTTCTTAAGAACTTATATTCTCTTTGACATACATCTCTATTGTAGTTTTTTGTTTTGTTTTGTTTT
TTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGAT
TCTCGTACCTCAGACTCCCGAGTAGTTGGGATTACAGGTGCCCACCACCACACCCGACTAATTTTTGTATTTTTAGTAGCCATGTGGTTT
TGCCATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC
CACCGTTCCCGGCCTATTGTAGATTTTCTTAACTACTTGCTAAGGAAATCATATCCTTTTACATGAACTACAGGTTTAGAACTTGGTTTT
AAGACAACTGCTATGGCCAGAAGGTAAATGGGAATTGCCTTATTGAAGGTAACATTGATTGCCTAATAAGAAAATGAATTGTTTGCCACA
GAGTTGAATTTAATTTGAGTTAGATAGTTCAGAATGTAGCACTTGCCCTATAAATGAATCAGATTTGTTCTATTTATATAATATTAGAAT
TAATATATTATCATGTAAGTGGGAATTTTATTTTGTTAAGTGGACTCTCAAATTTTAGAACTTGTGTGAAATATCTCCCAGAAAACACAA
AAGGTTTCAAGGTATCACCCAAAGCTAGGGAATCAACAAACGTACTTTATTAATGCAAGACCACAATTTAAGCCCCAGGCAGGAATCCAA
CAGTAACATTTTTCCTTTAGGTTAAGCAGTAATTTTTTTGAATTGTCATTTTTAATGGGTCTCACACATGCATATTGCTAATATCATTCA
TGTTTGAGGTTTTCAACAAAGAACCAATTTATTAATATAATGTACAAAAATAGTTGGTTCATTTTCTGAATTCAGTCTTTGAAATAAAAC
TCCTTGTTTTGGCCGTGTTTCTGAATGTATTGGTGATTCACCCCCAAGCTAATTTTTTAAAGTCATTTTTGAAGTTGGGAAGTCTCATGA
GAGATGTTGAAGTATGTATTTAATCAAGAGTCATGATTTCAAACTAGTTTTACATATTAAGCAGTTAGTGTTCTAATTTAATGGGTAAAT
GTGTGTTTGGATAAATATCTGAAAATTTTATCCTTAAGTATATATAATTATTTGCCTCTTATATGTCTTAAAGCTATTTAAACAAGGTGT
TAAATGAGCCAAAACAATTAAGTAATTAGAACAGTACATTTTTATCAGAGTGTCTGTCATATGCAATGAATGTATGTAATACTAAAAAAT
CATGACTACTTTTATCAAAGAAAAACCACACATTAATCCTATTAATCATGAAAGCGTAGCATTGTAAATTAAAGGTTTTCTTTGAGGCTC
TTGAAAGTGATCCCATTGCTTTCCTGTTTTAAAAATATTTTATGCTCTTTATTTCCACTTCTGTGAATGTGATATTTCTATTTTGTGATT
ATGTTACTGAATAAACAAACTTGCTACATAAAATTCTTAGCAATTAAAAAAATTCTGATTCTGCCATTTTGTCTCAAATGTAATATACCC
TTTTAATATCATATGTTTACATATTTATGAATGATTAATCATTTTTGTTTGCATTAAACTTTATGAAATGTCAGAAATGATTTTACTCTA
ATGAAACTCAAATTTTGCCCAAAGTAGCAATATTCTTAAAGATGTTGAATTTTGACTGGTTGAATTTTATATAGTAACACACAAGTCGTG
ATCATCAATATTATTGCAGACCAGGACTCTGCTTATATGCCTTGCTAACAAAGATTTCTTTCACAGAGGCTTTTCTCCTCTCAAGACTTA
AAGTAAGAATTACATTTTATTAAGTCAGTTAAATGCACCATGGCTTCATATAGTAATATAAAAAAACTCTTTGAAGTGAGAAATATTATA
TCCTAAAACCTCTAAACCACAAACATTCAATTGAAAGAGTTCTGTTGAAGGATAATGACATACTGACTGCTTACAGACCAAGTTGCTTGC
ATTTTGTATGTTTAGCCCTCCTTTGCCACTGCTTTTAGAGCCTTGGAAGGCTAAGTGTGATAGTAATGCTAGCTCTAATGCATATTTAAA
GGAGACTGCCTCGCTTTTAGAAGACATCTGGTCTGCTCTCTGCATGAGGCACAGCAGTAAAGCTCTTTGATTCCCAGAATCAAGAACTCT
CCCCTTCAGACTATTACCGAATGCAAGGTGGTTAATTGAAGGCCACTAATTGATGCTCAAATAGAAGGATATTGACTATATTGGAACAGA
TGGAGTCTCTACTACAAAAGTCTTTGGGTATTTGTTTCTTACATAGAAAATGCTAACATGAATAGAAAGATACTGGTGCAAGACCATTCC
CGGGAAAGTAGACATACTTACATTTTTTTCCTTTTCTGCTCATTTGAATGAACTCAATTTTATGTTAAATTGTTATATCAGAGTGACAAA
TAAGTGCTATGGCTTGATAGAAGTGAAGCTCTTCACATATATTCAAAATACATATCACAAACTTTGGTAAATAGGATAGTAATCTGAAGA
ACTTTTGCCCTTTTTACCCCATTTACTGTAACTCTTGTTTCTAGGTAATCGTTCTCTCTCAACAAACTTCTCAAGCGTCTGTGTAACAAG
CCACATGTTCTAACAAATTGTCTCCATCGCACTTCAACAGCCAGGTCCCTATTTTTTATAACGTATTAACCTTATTATTTTCTTATTATT
TTAAAAGAATCTATGCACATTAGCAAAATTTAAAAGATAGAGAAAAATATAAACAGAAAAAATTATGTTTACTTCTACCACCCTAAATCA
ACTATTATCAATTTTATACATATTTTACTCCATCTTTTTTCAAAGTTTCTTACATTTTCCAATGTCATTAAAATTCTCTGTGAATGTAAA
TTTTAAAAACTGTACCTACTGTTTTTTGGAAATCTGTAACAAGCTATGTGTAATCATTCTTCTAATATTAAACATATTGTGTCCAGAATT

>102909_102909_1_ZNF77-LPCAT2_ZNF77_chr19_2944835_ENST00000314531_LPCAT2_chr16_55559419_ENST00000262134_length(amino acids)=512AA_BP=25
MSCSPAPVAGPRGANPGEPRSGRDMIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSM
GFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEW
PQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLF
ANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPV
SDVLRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSIS

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>102909_102909_2_ZNF77-LPCAT2_ZNF77_chr19_2944836_ENST00000314531_LPCAT2_chr16_55559420_ENST00000262134_length(transcript)=5132nt_BP=96nt
ACCCCGAGCGGCTCAGGTGTCCTGTCGTGCTCACCTGCGCCGGTCGCTGGACCGCGGGGCGCTAACCCTGGAGAGCCCAGGAGCGGGCGG
GACATGATTGTCCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCA
ATTTCAACAGTATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGT
CGTGCTATGTTCTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCT
CATTCAACATTCTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATT
GGCAGACTGTTACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGA
ACAACATCAGGAGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGA
GCCTTCATTCCAGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACA
TTCATTCAGCTTTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGTTTATGCCAGTTCAAGTACCAAATGATGAAGAA
AAAAATGATCCTGTCCTTTTTGCCAATAAAGTCCGGAATTTAATGGCAGAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGAC
TGCAGATTGATGATTTCAGCAGGACAGCTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTA
GATTGGGATGGTGTTCGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCC
AAGTATTTAAAGTTGCCTGTTTCAGATGTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAG
TATGTGATTGGCCTGGCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGAT
GGCTACATAACGGAGGAAGAGTTCTCCACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATA
GCCCAAGGGGACTCAATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGAC
CTCCAGACGTGCCATGTGTTTTCATTACCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAA
GAGAGTACCTCAGACAAAAAAGATGACTGAAAGCAGTATTTCCAATAAGGAAAACACAGTAGCTTTTGCTTGAAATTGTAAAGGCACTTA
TTGATAATACTTTTAATGTGTTGGTAATGATGTTTAAAATTGAAAGATTTTTAAAACAAAAATGATAGATTTTCTTACTAAAAATGTTTT
TATTAACCTTGCTTTTATTGGAAAAAATCAAGCAATATTTCGTTTTCTTTTGTGTTATATTGTACTTTACTGATTCATTTACTGGTGATA
CATATGTTTTTATGGATTTTCCAGTTTAATTTGCATATACAAATGAATGCAATGGTCTATTGGTGAGCATTGAGCAACACTGTATAAAGT
TTTAAAAATGTAAACACTTTTTAATCTACTTTCCTCTAAAAATCAATAATATTCTATTATTTCTAATCCTTTTCCACTTGGGAAATAACA
ATGAAGAATCTGAGAATTTGACATCTATAACTTTACAGATTCATTTTTCCATTTAAATTTCAGTTTCTTGGATCACTGAATATGGGAAGG
GAGAGCTTCACTAATTAGACGCAGCTTCTTAAGAACTTATATTCTCTTTGACATACATCTCTATTGTAGTTTTTTGTTTTGTTTTGTTTT
TTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGAT
TCTCGTACCTCAGACTCCCGAGTAGTTGGGATTACAGGTGCCCACCACCACACCCGACTAATTTTTGTATTTTTAGTAGCCATGTGGTTT
TGCCATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC
CACCGTTCCCGGCCTATTGTAGATTTTCTTAACTACTTGCTAAGGAAATCATATCCTTTTACATGAACTACAGGTTTAGAACTTGGTTTT
AAGACAACTGCTATGGCCAGAAGGTAAATGGGAATTGCCTTATTGAAGGTAACATTGATTGCCTAATAAGAAAATGAATTGTTTGCCACA
GAGTTGAATTTAATTTGAGTTAGATAGTTCAGAATGTAGCACTTGCCCTATAAATGAATCAGATTTGTTCTATTTATATAATATTAGAAT
TAATATATTATCATGTAAGTGGGAATTTTATTTTGTTAAGTGGACTCTCAAATTTTAGAACTTGTGTGAAATATCTCCCAGAAAACACAA
AAGGTTTCAAGGTATCACCCAAAGCTAGGGAATCAACAAACGTACTTTATTAATGCAAGACCACAATTTAAGCCCCAGGCAGGAATCCAA
CAGTAACATTTTTCCTTTAGGTTAAGCAGTAATTTTTTTGAATTGTCATTTTTAATGGGTCTCACACATGCATATTGCTAATATCATTCA
TGTTTGAGGTTTTCAACAAAGAACCAATTTATTAATATAATGTACAAAAATAGTTGGTTCATTTTCTGAATTCAGTCTTTGAAATAAAAC
TCCTTGTTTTGGCCGTGTTTCTGAATGTATTGGTGATTCACCCCCAAGCTAATTTTTTAAAGTCATTTTTGAAGTTGGGAAGTCTCATGA
GAGATGTTGAAGTATGTATTTAATCAAGAGTCATGATTTCAAACTAGTTTTACATATTAAGCAGTTAGTGTTCTAATTTAATGGGTAAAT
GTGTGTTTGGATAAATATCTGAAAATTTTATCCTTAAGTATATATAATTATTTGCCTCTTATATGTCTTAAAGCTATTTAAACAAGGTGT
TAAATGAGCCAAAACAATTAAGTAATTAGAACAGTACATTTTTATCAGAGTGTCTGTCATATGCAATGAATGTATGTAATACTAAAAAAT
CATGACTACTTTTATCAAAGAAAAACCACACATTAATCCTATTAATCATGAAAGCGTAGCATTGTAAATTAAAGGTTTTCTTTGAGGCTC
TTGAAAGTGATCCCATTGCTTTCCTGTTTTAAAAATATTTTATGCTCTTTATTTCCACTTCTGTGAATGTGATATTTCTATTTTGTGATT
ATGTTACTGAATAAACAAACTTGCTACATAAAATTCTTAGCAATTAAAAAAATTCTGATTCTGCCATTTTGTCTCAAATGTAATATACCC
TTTTAATATCATATGTTTACATATTTATGAATGATTAATCATTTTTGTTTGCATTAAACTTTATGAAATGTCAGAAATGATTTTACTCTA
ATGAAACTCAAATTTTGCCCAAAGTAGCAATATTCTTAAAGATGTTGAATTTTGACTGGTTGAATTTTATATAGTAACACACAAGTCGTG
ATCATCAATATTATTGCAGACCAGGACTCTGCTTATATGCCTTGCTAACAAAGATTTCTTTCACAGAGGCTTTTCTCCTCTCAAGACTTA
AAGTAAGAATTACATTTTATTAAGTCAGTTAAATGCACCATGGCTTCATATAGTAATATAAAAAAACTCTTTGAAGTGAGAAATATTATA
TCCTAAAACCTCTAAACCACAAACATTCAATTGAAAGAGTTCTGTTGAAGGATAATGACATACTGACTGCTTACAGACCAAGTTGCTTGC
ATTTTGTATGTTTAGCCCTCCTTTGCCACTGCTTTTAGAGCCTTGGAAGGCTAAGTGTGATAGTAATGCTAGCTCTAATGCATATTTAAA
GGAGACTGCCTCGCTTTTAGAAGACATCTGGTCTGCTCTCTGCATGAGGCACAGCAGTAAAGCTCTTTGATTCCCAGAATCAAGAACTCT
CCCCTTCAGACTATTACCGAATGCAAGGTGGTTAATTGAAGGCCACTAATTGATGCTCAAATAGAAGGATATTGACTATATTGGAACAGA
TGGAGTCTCTACTACAAAAGTCTTTGGGTATTTGTTTCTTACATAGAAAATGCTAACATGAATAGAAAGATACTGGTGCAAGACCATTCC
CGGGAAAGTAGACATACTTACATTTTTTTCCTTTTCTGCTCATTTGAATGAACTCAATTTTATGTTAAATTGTTATATCAGAGTGACAAA
TAAGTGCTATGGCTTGATAGAAGTGAAGCTCTTCACATATATTCAAAATACATATCACAAACTTTGGTAAATAGGATAGTAATCTGAAGA
ACTTTTGCCCTTTTTACCCCATTTACTGTAACTCTTGTTTCTAGGTAATCGTTCTCTCTCAACAAACTTCTCAAGCGTCTGTGTAACAAG
CCACATGTTCTAACAAATTGTCTCCATCGCACTTCAACAGCCAGGTCCCTATTTTTTATAACGTATTAACCTTATTATTTTCTTATTATT
TTAAAAGAATCTATGCACATTAGCAAAATTTAAAAGATAGAGAAAAATATAAACAGAAAAAATTATGTTTACTTCTACCACCCTAAATCA
ACTATTATCAATTTTATACATATTTTACTCCATCTTTTTTCAAAGTTTCTTACATTTTCCAATGTCATTAAAATTCTCTGTGAATGTAAA
TTTTAAAAACTGTACCTACTGTTTTTTGGAAATCTGTAACAAGCTATGTGTAATCATTCTTCTAATATTAAACATATTGTGTCCAGAATT

>102909_102909_2_ZNF77-LPCAT2_ZNF77_chr19_2944836_ENST00000314531_LPCAT2_chr16_55559420_ENST00000262134_length(amino acids)=512AA_BP=25
MSCSPAPVAGPRGANPGEPRSGRDMIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSM
GFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEW
PQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLF
ANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPV
SDVLRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSIS

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Fusion Gene PPI Analysis for ZNF77-LPCAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF77-LPCAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF77-LPCAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource