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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF788-ZNF763 (FusionGDB2 ID:102943)

Fusion Gene Summary for ZNF788-ZNF763

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF788-ZNF763
	Fusion gene ID: 102943
		Hgene	Tgene
	Gene symbol	ZNF788	ZNF763
	Gene ID	388507	284390
	Gene name	zinc finger family member 788, pseudogene	zinc finger protein 763
	Synonyms	ZNF788	ZNF\|ZNF440L
	Cytomap	19p13.2	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	putative KRAB domain-containing protein ZNF788KRAB domain-containing protein ZNF788zinc finger family member 788zinc finger protein 788	zinc finger protein 763DNA-binding proteinzinc finger protein 440 like
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000430298, ENST00000596883, ENST00000339302, ENST00000397755, ENST00000397759,	ENST00000343949, ENST00000358987, ENST00000545530, ENST00000591944, ENST00000592625, ENST00000538752, ENST00000590798,
Fusion gene scores	* DoF score	2 X 2 X 2=8	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/8*10)=1.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: ZNF788 [Title/Abstract] AND ZNF763 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF788(12221246)-ZNF763(12088185), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF788 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF763 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	SPNT_100	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
ChimerDB4	Non-Cancer	SPNT_231	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+

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Fusion Gene ORF analysis for ZNF788-ZNF763

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000430298	ENST00000343949	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000430298	ENST00000358987	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000430298	ENST00000545530	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000430298	ENST00000591944	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000430298	ENST00000592625	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000596883	ENST00000343949	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000596883	ENST00000358987	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000596883	ENST00000545530	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000596883	ENST00000591944	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5CDS-intron	ENST00000596883	ENST00000592625	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-3CDS	ENST00000339302	ENST00000538752	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-3CDS	ENST00000339302	ENST00000590798	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-intron	ENST00000339302	ENST00000343949	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-intron	ENST00000339302	ENST00000358987	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-intron	ENST00000339302	ENST00000545530	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-intron	ENST00000339302	ENST00000591944	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
5UTR-intron	ENST00000339302	ENST00000592625	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
In-frame	ENST00000430298	ENST00000538752	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
In-frame	ENST00000430298	ENST00000590798	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
In-frame	ENST00000596883	ENST00000538752	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
In-frame	ENST00000596883	ENST00000590798	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-3CDS	ENST00000397755	ENST00000538752	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-3CDS	ENST00000397755	ENST00000590798	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-3CDS	ENST00000397759	ENST00000538752	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-3CDS	ENST00000397759	ENST00000590798	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397755	ENST00000343949	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397755	ENST00000358987	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397755	ENST00000545530	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397755	ENST00000591944	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397755	ENST00000592625	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397759	ENST00000343949	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397759	ENST00000358987	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397759	ENST00000545530	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397759	ENST00000591944	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+
intron-intron	ENST00000397759	ENST00000592625	ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000430298

ZNF788

chr19

12221246

ENST00000590798

ZNF763

chr19

12088185

1571

335

139

1389

416

ENST00000430298

ZNF788

chr19

12221246

ENST00000538752

ZNF763

chr19

12088185

1571

335

139

1389

416

ENST00000596883

ZNF788

chr19

12221246

ENST00000590798

ZNF763

chr19

12088185

1513

277

1331

436

ENST00000596883

ZNF788

chr19

12221246

ENST00000538752

ZNF763

chr19

12088185

1513

277

1331

436

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ZNF788-ZNF763

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+	3.24E-06	0.9999968
ZNF788	chr19	12221246	+	ZNF763	chr19	12088185	+	3.24E-06	0.9999968

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF788-ZNF763

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12221246/chr19:12088185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

144_166

398.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

172_194

398.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

200_222

398.0

Zinc finger

C2H2-type 3

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

228_250

398.0

Zinc finger

C2H2-type 4

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

256_278

398.0

Zinc finger

C2H2-type 5

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

284_306

398.0

Zinc finger

C2H2-type 6

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

312_334

398.0

Zinc finger

C2H2-type 7

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

340_362

398.0

Zinc finger

C2H2-type 8

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

144_166

395.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

172_194

395.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

200_222

395.0

Zinc finger

C2H2-type 3

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

228_250

395.0

Zinc finger

C2H2-type 4

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

256_278

395.0

Zinc finger

C2H2-type 5

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

284_306

395.0

Zinc finger

C2H2-type 6

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

312_334

395.0

Zinc finger

C2H2-type 7

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

340_362

395.0

Zinc finger

C2H2-type 8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF788

chr19:12221246

chr19:12088185

ENST00000339302

24_82

616.0

Domain

KRAB

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000343949

4_86

398.0

Domain

KRAB

Tgene

ZNF763

chr19:12221246

chr19:12088185

ENST00000358987

4_86

395.0

Domain

KRAB

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Fusion Gene Sequence for ZNF788-ZNF763

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102943_102943_1_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000430298_ZNF763_chr19_12088185_ENST00000538752_length(transcript)=1571nt_BP=335nt
AACTTTTTTCGGGGAAGGAGACGGCTGCAAGCCCGCGGTCTCTTGTTGCTGTGCTAACGACCGTTGGAACCCTCTTTCTGGCTCTTGGAA
CGCTCGGCTCTGAGAGGCTCCAGGTTTCTCCGCCAGAGCTCCTGTCGCTCTGTCAGTTGCGCTGTGTTCCTCTCTAGTCACAAGAGCCTT
GGGGAAGACAGTTGGAAGCTCAGACATGGACTCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCCAGACGAGTGGGCTTTGCTGGA
TCCTTCCCAAAAGAATCTCTACCGAGAAGTGATGCAAGAAACCTTGAGGAACTTGGCCTCTATAGGGAAAAAGTGGAAAGACCAGAACAT
TGAATATGAGTACCAAAACCCCAGGAGAAACTTCAGGAGTCTCATAGAAGGGAATGTCAATGAAATTAAAGAAGACAGTCATTGTGGAGA
AACTTTTACCCAGGTTCCAGATGACAGGCTGAACTTCCAGGAGAAGAAAGCTTCTCCTGAAGCAAAATCATGTGATAACTTTGTATGTGG
AGAAGTTGGCATAGGTAACTCATCTTTTAATATGAACATCAGAGGTGACATTGGGCACAAGGCATACGAGTATCAGGACTATGCACCAAA
GCCATATAAGTGTCAACAACCTAAGAAAGCCTTCAGATATCACCCCTCCTTTAGAACACAAGAAAGGAATCACACCGGAGAGAAACCCTA
TGCTTGTAAAGAATGTGGAAAAACCTTTATTTCCCATTCAGGCATTCGAAGACGCATGGTAATGCACAGTGGGGATGGACCTTATAAATG
TAAGTTTTGTGGGAAAGCTGTCCATTGTCTCAGATTATATCTTATCCATGAAAGAACTCACACTGGAGAGAAACCGTATGAATGTAAACA
ATGTGTTAAATCCTTTAGTTATTCTGCTACCCATCGAATACATGAAAGAACTCACACTGGAGAAAAGCCTTATGAATGTCAGCAATGTGG
GAAAGCATTCCATAGTTCCAGTTCTTTTCAAGCACATAAAAGAACCCACACTGGGGGAAAGCCATATGAATGTAAACAATGTGGCAAATC
CTTCAGTTGGTGTCATTCCTTTCAAATACATGAAAGAACTCACACTGGGGAGAAGCCCTGTGAATGTAGCAAATGTAATAAAGCATTCCG
TAGTTACAGATCCTATCTTAGACATAAAAGGAGTCACACGGGAGAGAAGCCTTATCAATGTAAGGAATGTAGAAAAGCATTCACGTATCC
CAGTTCCCTTCGTAGACATGAAAGGACCCACTCTGCGAAAAAACCTTATGAATGTAAGCAGTGTGGGAAAGCATTATCTTATAAGTTTTC
AAACACACCTAAGAATGCGCTCTGGAGAAAGACCTTATAAATGTTAGATATGTGGGAAAGGCCTTTATTCTGCCAAGTCATTTCGAAGAC
ATGAAAAAACTCACACTGGAGAGAAACCCTATAAATGCATGCCATGTGGTAAAGCCTTCAATCTTTCCAGTTCCTTTCAGTATCATGAAA

>102943_102943_1_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000430298_ZNF763_chr19_12088185_ENST00000538752_length(amino acids)=416AA_BP=23
MSVALCSSLVTRALGKTVGSSDMDSVAFEDVAVNFTPDEWALLDPSQKNLYREVMQETLRNLASIGKKWKDQNIEYEYQNPRRNFRSLIE
GNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPS
FRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHER
THTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEK

--------------------------------------------------------------
>102943_102943_2_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000430298_ZNF763_chr19_12088185_ENST00000590798_length(transcript)=1571nt_BP=335nt
AACTTTTTTCGGGGAAGGAGACGGCTGCAAGCCCGCGGTCTCTTGTTGCTGTGCTAACGACCGTTGGAACCCTCTTTCTGGCTCTTGGAA
CGCTCGGCTCTGAGAGGCTCCAGGTTTCTCCGCCAGAGCTCCTGTCGCTCTGTCAGTTGCGCTGTGTTCCTCTCTAGTCACAAGAGCCTT
GGGGAAGACAGTTGGAAGCTCAGACATGGACTCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCCAGACGAGTGGGCTTTGCTGGA
TCCTTCCCAAAAGAATCTCTACCGAGAAGTGATGCAAGAAACCTTGAGGAACTTGGCCTCTATAGGGAAAAAGTGGAAAGACCAGAACAT
TGAATATGAGTACCAAAACCCCAGGAGAAACTTCAGGAGTCTCATAGAAGGGAATGTCAATGAAATTAAAGAAGACAGTCATTGTGGAGA
AACTTTTACCCAGGTTCCAGATGACAGGCTGAACTTCCAGGAGAAGAAAGCTTCTCCTGAAGCAAAATCATGTGATAACTTTGTATGTGG
AGAAGTTGGCATAGGTAACTCATCTTTTAATATGAACATCAGAGGTGACATTGGGCACAAGGCATACGAGTATCAGGACTATGCACCAAA
GCCATATAAGTGTCAACAACCTAAGAAAGCCTTCAGATATCACCCCTCCTTTAGAACACAAGAAAGGAATCACACCGGAGAGAAACCCTA
TGCTTGTAAAGAATGTGGAAAAACCTTTATTTCCCATTCAGGCATTCGAAGACGCATGGTAATGCACAGTGGGGATGGACCTTATAAATG
TAAGTTTTGTGGGAAAGCTGTCCATTGTCTCAGATTATATCTTATCCATGAAAGAACTCACACTGGAGAGAAACCGTATGAATGTAAACA
ATGTGTTAAATCCTTTAGTTATTCTGCTACCCATCGAATACATGAAAGAACTCACACTGGAGAAAAGCCTTATGAATGTCAGCAATGTGG
GAAAGCATTCCATAGTTCCAGTTCTTTTCAAGCACATAAAAGAACCCACACTGGGGGAAAGCCATATGAATGTAAACAATGTGGCAAATC
CTTCAGTTGGTGTCATTCCTTTCAAATACATGAAAGAACTCACACTGGGGAGAAGCCCTGTGAATGTAGCAAATGTAATAAAGCATTCCG
TAGTTACAGATCCTATCTTAGACATAAAAGGAGTCACACGGGAGAGAAGCCTTATCAATGTAAGGAATGTAGAAAAGCATTCACGTATCC
CAGTTCCCTTCGTAGACATGAAAGGACCCACTCTGCGAAAAAACCTTATGAATGTAAGCAGTGTGGGAAAGCATTATCTTATAAGTTTTC
AAACACACCTAAGAATGCGCTCTGGAGAAAGACCTTATAAATGTTAGATATGTGGGAAAGGCCTTTATTCTGCCAAGTCATTTCGAAGAC
ATGAAAAAACTCACACTGGAGAGAAACCCTATAAATGCATGCCATGTGGTAAAGCCTTCAATCTTTCCAGTTCCTTTCAGTATCATGAAA

>102943_102943_2_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000430298_ZNF763_chr19_12088185_ENST00000590798_length(amino acids)=416AA_BP=23
MSVALCSSLVTRALGKTVGSSDMDSVAFEDVAVNFTPDEWALLDPSQKNLYREVMQETLRNLASIGKKWKDQNIEYEYQNPRRNFRSLIE
GNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPS
FRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHER
THTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEK

--------------------------------------------------------------
>102943_102943_3_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000596883_ZNF763_chr19_12088185_ENST00000538752_length(transcript)=1513nt_BP=277nt
TCCGCCAGAGCTCCTGTCGCTCTGTCAGTTGCGCTGTGTTCCTCTCTAGTCACAAGAGCCTTGGGGAAGACAGTTGGAAGCTCAGACATG
AGAAATATGATTCCACAGGACAATGAAAACCCACCCCAACAGGGTGAAGCAAATCAAAATGACTCAGTGGCCTTTGAGGATGTGGCTGTG
AACTTCACCCCAGACGAGTGGGCTTTGCTGGATCCTTCCCAAAAGAATCTCTACCGAGAAGTGATGCAAGAAACCTTGAGGAACTTGGCC
TCTATAGGGAAAAAGTGGAAAGACCAGAACATTGAATATGAGTACCAAAACCCCAGGAGAAACTTCAGGAGTCTCATAGAAGGGAATGTC
AATGAAATTAAAGAAGACAGTCATTGTGGAGAAACTTTTACCCAGGTTCCAGATGACAGGCTGAACTTCCAGGAGAAGAAAGCTTCTCCT
GAAGCAAAATCATGTGATAACTTTGTATGTGGAGAAGTTGGCATAGGTAACTCATCTTTTAATATGAACATCAGAGGTGACATTGGGCAC
AAGGCATACGAGTATCAGGACTATGCACCAAAGCCATATAAGTGTCAACAACCTAAGAAAGCCTTCAGATATCACCCCTCCTTTAGAACA
CAAGAAAGGAATCACACCGGAGAGAAACCCTATGCTTGTAAAGAATGTGGAAAAACCTTTATTTCCCATTCAGGCATTCGAAGACGCATG
GTAATGCACAGTGGGGATGGACCTTATAAATGTAAGTTTTGTGGGAAAGCTGTCCATTGTCTCAGATTATATCTTATCCATGAAAGAACT
CACACTGGAGAGAAACCGTATGAATGTAAACAATGTGTTAAATCCTTTAGTTATTCTGCTACCCATCGAATACATGAAAGAACTCACACT
GGAGAAAAGCCTTATGAATGTCAGCAATGTGGGAAAGCATTCCATAGTTCCAGTTCTTTTCAAGCACATAAAAGAACCCACACTGGGGGA
AAGCCATATGAATGTAAACAATGTGGCAAATCCTTCAGTTGGTGTCATTCCTTTCAAATACATGAAAGAACTCACACTGGGGAGAAGCCC
TGTGAATGTAGCAAATGTAATAAAGCATTCCGTAGTTACAGATCCTATCTTAGACATAAAAGGAGTCACACGGGAGAGAAGCCTTATCAA
TGTAAGGAATGTAGAAAAGCATTCACGTATCCCAGTTCCCTTCGTAGACATGAAAGGACCCACTCTGCGAAAAAACCTTATGAATGTAAG
CAGTGTGGGAAAGCATTATCTTATAAGTTTTCAAACACACCTAAGAATGCGCTCTGGAGAAAGACCTTATAAATGTTAGATATGTGGGAA
AGGCCTTTATTCTGCCAAGTCATTTCGAAGACATGAAAAAACTCACACTGGAGAGAAACCCTATAAATGCATGCCATGTGGTAAAGCCTT

>102943_102943_3_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000596883_ZNF763_chr19_12088185_ENST00000538752_length(amino acids)=436AA_BP=43
MSVALCSSLVTRALGKTVGSSDMRNMIPQDNENPPQQGEANQNDSVAFEDVAVNFTPDEWALLDPSQKNLYREVMQETLRNLASIGKKWK
DQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQD
YAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPY
ECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCN

--------------------------------------------------------------
>102943_102943_4_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000596883_ZNF763_chr19_12088185_ENST00000590798_length(transcript)=1513nt_BP=277nt
TCCGCCAGAGCTCCTGTCGCTCTGTCAGTTGCGCTGTGTTCCTCTCTAGTCACAAGAGCCTTGGGGAAGACAGTTGGAAGCTCAGACATG
AGAAATATGATTCCACAGGACAATGAAAACCCACCCCAACAGGGTGAAGCAAATCAAAATGACTCAGTGGCCTTTGAGGATGTGGCTGTG
AACTTCACCCCAGACGAGTGGGCTTTGCTGGATCCTTCCCAAAAGAATCTCTACCGAGAAGTGATGCAAGAAACCTTGAGGAACTTGGCC
TCTATAGGGAAAAAGTGGAAAGACCAGAACATTGAATATGAGTACCAAAACCCCAGGAGAAACTTCAGGAGTCTCATAGAAGGGAATGTC
AATGAAATTAAAGAAGACAGTCATTGTGGAGAAACTTTTACCCAGGTTCCAGATGACAGGCTGAACTTCCAGGAGAAGAAAGCTTCTCCT
GAAGCAAAATCATGTGATAACTTTGTATGTGGAGAAGTTGGCATAGGTAACTCATCTTTTAATATGAACATCAGAGGTGACATTGGGCAC
AAGGCATACGAGTATCAGGACTATGCACCAAAGCCATATAAGTGTCAACAACCTAAGAAAGCCTTCAGATATCACCCCTCCTTTAGAACA
CAAGAAAGGAATCACACCGGAGAGAAACCCTATGCTTGTAAAGAATGTGGAAAAACCTTTATTTCCCATTCAGGCATTCGAAGACGCATG
GTAATGCACAGTGGGGATGGACCTTATAAATGTAAGTTTTGTGGGAAAGCTGTCCATTGTCTCAGATTATATCTTATCCATGAAAGAACT
CACACTGGAGAGAAACCGTATGAATGTAAACAATGTGTTAAATCCTTTAGTTATTCTGCTACCCATCGAATACATGAAAGAACTCACACT
GGAGAAAAGCCTTATGAATGTCAGCAATGTGGGAAAGCATTCCATAGTTCCAGTTCTTTTCAAGCACATAAAAGAACCCACACTGGGGGA
AAGCCATATGAATGTAAACAATGTGGCAAATCCTTCAGTTGGTGTCATTCCTTTCAAATACATGAAAGAACTCACACTGGGGAGAAGCCC
TGTGAATGTAGCAAATGTAATAAAGCATTCCGTAGTTACAGATCCTATCTTAGACATAAAAGGAGTCACACGGGAGAGAAGCCTTATCAA
TGTAAGGAATGTAGAAAAGCATTCACGTATCCCAGTTCCCTTCGTAGACATGAAAGGACCCACTCTGCGAAAAAACCTTATGAATGTAAG
CAGTGTGGGAAAGCATTATCTTATAAGTTTTCAAACACACCTAAGAATGCGCTCTGGAGAAAGACCTTATAAATGTTAGATATGTGGGAA
AGGCCTTTATTCTGCCAAGTCATTTCGAAGACATGAAAAAACTCACACTGGAGAGAAACCCTATAAATGCATGCCATGTGGTAAAGCCTT

>102943_102943_4_ZNF788-ZNF763_ZNF788_chr19_12221246_ENST00000596883_ZNF763_chr19_12088185_ENST00000590798_length(amino acids)=436AA_BP=43
MSVALCSSLVTRALGKTVGSSDMRNMIPQDNENPPQQGEANQNDSVAFEDVAVNFTPDEWALLDPSQKNLYREVMQETLRNLASIGKKWK
DQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQD
YAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPY
ECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF788-ZNF763

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF788-ZNF763

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF788-ZNF763

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source