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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF791-HOOK2 (FusionGDB2 ID:102959)

Fusion Gene Summary for ZNF791-HOOK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF791-HOOK2
Fusion gene ID: 102959
HgeneTgene
Gene symbol

ZNF791

HOOK2

Gene ID

163049

29911

Gene namezinc finger protein 791hook microtubule tethering protein 2
Synonyms-HK2
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 791protein Hook homolog 2h-hook2hHK2hook homolog 2
Modification date2020031320200327
UniProtAcc.

Q96ED9

Ensembl transtripts involved in fusion geneENST00000498389, ENST00000343325, 
ENST00000446165, ENST00000458122, 
ENST00000540038, 		ENST00000264827, 
ENST00000397668, ENST00000589965, 
Fusion gene scores* DoF score7 X 5 X 5=1759 X 10 X 6=540
# samples 912
** MAII scorelog2(9/175*10)=-0.959358015502654
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF791 [Title/Abstract] AND HOOK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF791(12721896)-HOOK2(12874592), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF791 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HOOK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-HE-7130-01AZNF791chr19

12721896

-HOOK2chr19

12874592

-
ChimerDB4KIRPTCGA-HE-7130-01AZNF791chr19

12721896

+HOOK2chr19

12874592

-
ChimerDB4KIRPTCGA-HE-7130ZNF791chr19

12721896

+HOOK2chr19

12874413

-
ChimerDB4KIRPTCGA-HE-7130ZNF791chr19

12721896

+HOOK2chr19

12874592

-


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Fusion Gene ORF analysis for ZNF791-HOOK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000498389ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874592

-
3UTR-3CDSENST00000498389ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874413

-
3UTR-3CDSENST00000498389ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874592

-
3UTR-3CDSENST00000498389ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874413

-
3UTR-intronENST00000498389ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874592

-
3UTR-intronENST00000498389ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5CDS-intronENST00000343325ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5CDS-intronENST00000343325ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5CDS-intronENST00000446165ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5CDS-intronENST00000446165ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-3CDSENST00000458122ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-3CDSENST00000458122ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-3CDSENST00000458122ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-3CDSENST00000458122ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-3CDSENST00000540038ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-3CDSENST00000540038ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-3CDSENST00000540038ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-3CDSENST00000540038ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-intronENST00000458122ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-intronENST00000458122ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874413

-
5UTR-intronENST00000540038ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874592

-
5UTR-intronENST00000540038ENST00000589965ZNF791chr19

12721896

+HOOK2chr19

12874413

-
In-frameENST00000343325ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874592

-
In-frameENST00000343325ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874413

-
In-frameENST00000343325ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874592

-
In-frameENST00000343325ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874413

-
In-frameENST00000446165ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874592

-
In-frameENST00000446165ENST00000264827ZNF791chr19

12721896

+HOOK2chr19

12874413

-
In-frameENST00000446165ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874592

-
In-frameENST00000446165ENST00000397668ZNF791chr19

12721896

+HOOK2chr19

12874413

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000446165ZNF791chr1912721896+ENST00000397668HOOK2chr1912874592-777165681328117
ENST00000446165ZNF791chr1912721896+ENST00000264827HOOK2chr1912874592-776165681328117
ENST00000343325ZNF791chr1912721896+ENST00000397668HOOK2chr1912874592-777165681328117
ENST00000343325ZNF791chr1912721896+ENST00000264827HOOK2chr1912874592-776165681328117
ENST00000446165ZNF791chr1912721896+ENST00000397668HOOK2chr1912874413-666165570217117
ENST00000446165ZNF791chr1912721896+ENST00000264827HOOK2chr1912874413-665165570217117
ENST00000343325ZNF791chr1912721896+ENST00000397668HOOK2chr1912874413-666165570217117
ENST00000343325ZNF791chr1912721896+ENST00000264827HOOK2chr1912874413-665165570217117

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000446165ENST00000397668ZNF791chr1912721896+HOOK2chr1912874592-0.125105590.8748944
ENST00000446165ENST00000264827ZNF791chr1912721896+HOOK2chr1912874592-0.130382930.86961704
ENST00000343325ENST00000397668ZNF791chr1912721896+HOOK2chr1912874592-0.125105590.8748944
ENST00000343325ENST00000264827ZNF791chr1912721896+HOOK2chr1912874592-0.130382930.86961704
ENST00000446165ENST00000397668ZNF791chr1912721896+HOOK2chr1912874413-0.326504050.673496
ENST00000446165ENST00000264827ZNF791chr1912721896+HOOK2chr1912874413-0.339842560.6601575
ENST00000343325ENST00000397668ZNF791chr1912721896+HOOK2chr1912874413-0.326504050.673496
ENST00000343325ENST00000264827ZNF791chr1912721896+HOOK2chr1912874413-0.339842560.6601575

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Fusion Genomic Features for ZNF791-HOOK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF791-HOOK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12721896/chr19:12874592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOOK2

Q96ED9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+144_901577.0DomainKRAB
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+144_901577.0DomainKRAB
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14100_1221577.0Zinc fingerC2H2-type 1
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14132_1541577.0Zinc fingerC2H2-type 2
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14160_1821577.0Zinc fingerC2H2-type 3
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14188_2101577.0Zinc fingerC2H2-type 4
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14216_2381577.0Zinc fingerC2H2-type 5
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14244_2661577.0Zinc fingerC2H2-type 6
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14272_2941577.0Zinc fingerC2H2-type 7
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14300_3221577.0Zinc fingerC2H2-type 8
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14328_3501577.0Zinc fingerC2H2-type 9
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14356_3781577.0Zinc fingerC2H2-type 10
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14384_4061577.0Zinc fingerC2H2-type 11
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14412_4341577.0Zinc fingerC2H2-type 12
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14440_4621577.0Zinc fingerC2H2-type 13
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14468_4901577.0Zinc fingerC2H2-type 14
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14496_5181577.0Zinc fingerC2H2-type 15
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14524_5461577.0Zinc fingerC2H2-type 16
HgeneZNF791chr19:12721896chr19:12874413ENST00000343325+14552_5741577.0Zinc fingerC2H2-type 17
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14100_1221577.0Zinc fingerC2H2-type 1
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14132_1541577.0Zinc fingerC2H2-type 2
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14160_1821577.0Zinc fingerC2H2-type 3
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14188_2101577.0Zinc fingerC2H2-type 4
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14216_2381577.0Zinc fingerC2H2-type 5
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14244_2661577.0Zinc fingerC2H2-type 6
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14272_2941577.0Zinc fingerC2H2-type 7
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14300_3221577.0Zinc fingerC2H2-type 8
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14328_3501577.0Zinc fingerC2H2-type 9
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14356_3781577.0Zinc fingerC2H2-type 10
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14384_4061577.0Zinc fingerC2H2-type 11
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14412_4341577.0Zinc fingerC2H2-type 12
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14440_4621577.0Zinc fingerC2H2-type 13
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14468_4901577.0Zinc fingerC2H2-type 14
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14496_5181577.0Zinc fingerC2H2-type 15
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14524_5461577.0Zinc fingerC2H2-type 16
HgeneZNF791chr19:12721896chr19:12874592ENST00000343325+14552_5741577.0Zinc fingerC2H2-type 17
TgeneHOOK2chr19:12721896chr19:12874413ENST000002648271922180_427644718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874413ENST000002648271922455_607644718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874413ENST000003976682023180_427646720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874413ENST000003976682023455_607646720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874592ENST000002648271822180_427607718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874592ENST000002648271822455_607607718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874592ENST000003976681923180_427609720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874592ENST000003976681923455_607609720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12721896chr19:12874413ENST0000026482719226_122644718.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12721896chr19:12874413ENST0000039766820236_122646720.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12721896chr19:12874592ENST0000026482718226_122607718.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12721896chr19:12874592ENST0000039766819236_122609720.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12721896chr19:12874413ENST0000026482719221_161644718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874413ENST000002648271922533_719644718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874413ENST0000039766820231_161646720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874413ENST000003976682023533_719646720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874592ENST0000026482718221_161607718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874592ENST000002648271822533_719607718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874592ENST0000039766819231_161609720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12721896chr19:12874592ENST000003976681923533_719609720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation


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Fusion Gene Sequence for ZNF791-HOOK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102959_102959_1_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874413_ENST00000264827_length(transcript)=665nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGATGGACTTTGAGAAA
AGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAG
CGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTG
AACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCG
CCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGG
GAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGA

>102959_102959_1_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874413_ENST00000264827_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

--------------------------------------------------------------
>102959_102959_2_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874413_ENST00000397668_length(transcript)=666nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGATGGACTTTGAGAAA
AGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAG
CGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTG
AACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCG
CCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGG
GAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGA

>102959_102959_2_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874413_ENST00000397668_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

--------------------------------------------------------------
>102959_102959_3_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874592_ENST00000264827_length(transcript)=776nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGGTCATGCAGACCATG
GAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCCTGAGGACACAGCTCCGAGAACGGGATGTCCGCATCCGACAC
CTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTG
CAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCC
TTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGG
CTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAG
ATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATG

>102959_102959_3_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874592_ENST00000264827_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

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>102959_102959_4_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874592_ENST00000397668_length(transcript)=777nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGGTCATGCAGACCATG
GAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCCTGAGGACACAGCTCCGAGAACGGGATGTCCGCATCCGACAC
CTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTG
CAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCC
TTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGG
CTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAG
ATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATG

>102959_102959_4_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000343325_HOOK2_chr19_12874592_ENST00000397668_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

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>102959_102959_5_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874413_ENST00000264827_length(transcript)=665nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGATGGACTTTGAGAAA
AGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAG
CGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTG
AACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCG
CCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGG
GAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGA

>102959_102959_5_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874413_ENST00000264827_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

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>102959_102959_6_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874413_ENST00000397668_length(transcript)=666nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGATGGACTTTGAGAAA
AGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAG
CGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTG
AACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCG
CCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGG
GAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGA

>102959_102959_6_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874413_ENST00000397668_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

--------------------------------------------------------------
>102959_102959_7_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874592_ENST00000264827_length(transcript)=776nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGGTCATGCAGACCATG
GAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCCTGAGGACACAGCTCCGAGAACGGGATGTCCGCATCCGACAC
CTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTG
CAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCC
TTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGG
CTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAG
ATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATG

>102959_102959_7_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874592_ENST00000264827_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

--------------------------------------------------------------
>102959_102959_8_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874592_ENST00000397668_length(transcript)=777nt_BP=165nt
GCAAATGCGTGCTACGTCACTGTGCGATCGGGTTGTGCTTAGCTTGGGGTCTCCTGGCCCCTTGACGCGTCAGGTTGCTGTACCCCTGCA
TCGGATGCGCTGTACCCTGCGCTGGCTCCGTGAACCTTAGGGACAACACCGGGACACCCGCGAGGCCGGAAAATGGTCATGCAGACCATG
GAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCCTGAGGACACAGCTCCGAGAACGGGATGTCCGCATCCGACAC
CTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTG
CAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCCTGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCC
TTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGACAGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGG
CTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAG
ATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAGCAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATG

>102959_102959_8_ZNF791-HOOK2_ZNF791_chr19_12721896_ENST00000446165_HOOK2_chr19_12874592_ENST00000397668_length(amino acids)=117AA_BP=
MLKRTGLYLPPALPPHQSGRGKSRDHGLKALEHLAEAQCWAPCELEEARVGGAQAGLIVRSVSACQWGEGSEMPGVPRVHGENWLPAAAV

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Fusion Gene PPI Analysis for ZNF791-HOOK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF791-HOOK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF791-HOOK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource