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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF793-GRAMD1B (FusionGDB2 ID:102967)

Fusion Gene Summary for ZNF793-GRAMD1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF793-GRAMD1B
Fusion gene ID: 102967
HgeneTgene
Gene symbol

ZNF793

GRAMD1B

Gene ID

390927

57476

Gene namezinc finger protein 793GRAM domain containing 1B
Synonyms-LINC01059
Cytomap

19q13.12

11q24.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 793protein Aster-BGRAM domain-containing protein 1Blong intergenic non-protein coding RNA 1059
Modification date2020031320200313
UniProtAcc.

Q3KR37

Ensembl transtripts involved in fusion geneENST00000445217, ENST00000542455, 
ENST00000587143, ENST00000587986, 
ENST00000588578, ENST00000589319, 
ENST00000322282, ENST00000450171, 
ENST00000456860, ENST00000529750, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 2=60
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/60*10)=0
Context

PubMed: ZNF793 [Title/Abstract] AND GRAMD1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF793(38009174)-GRAMD1B(123214841), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF793 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRAMD1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA225273ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+


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Fusion Gene ORF analysis for ZNF793-GRAMD1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000445217ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000445217ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000445217ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000445217ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000542455ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000542455ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000542455ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000542455ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587143ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587143ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587143ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587143ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587986ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587986ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587986ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000587986ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000588578ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000588578ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000588578ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000588578ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000589319ENST00000322282ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000589319ENST00000450171ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000589319ENST00000456860ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+
intron-intronENST00000589319ENST00000529750ZNF793chr19

38009174

+GRAMD1Bchr11

123214841

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF793-GRAMD1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF793-GRAMD1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38009174/:123214841)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRAMD1B

Q3KR37

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF793-GRAMD1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF793-GRAMD1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF793-GRAMD1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF793-GRAMD1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource