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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF91-ASF1B (FusionGDB2 ID:103099)

Fusion Gene Summary for ZNF91-ASF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF91-ASF1B
Fusion gene ID: 103099
HgeneTgene
Gene symbol

ZNF91

ASF1B

Gene ID

7644

55723

Gene namezinc finger protein 91anti-silencing function 1B histone chaperone
SynonymsHPF7|HTF10CIA-II
Cytomap

19p12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10histone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-II
Modification date2020031320200313
UniProtAcc.

Q9NVP2

Ensembl transtripts involved in fusion geneENST00000300619, ENST00000397082, 
ENST00000599743, ENST00000596528, 
ENST00000474890, ENST00000592798, 
ENST00000263382, 
Fusion gene scores* DoF score11 X 8 X 7=6167 X 5 X 6=210
# samples 118
** MAII scorelog2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF91 [Title/Abstract] AND ASF1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF91(23578127)-ASF1B(14232520), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF91

GO:0045892

negative regulation of transcription, DNA-templated

25274305

HgeneZNF91

GO:0070895

negative regulation of transposon integration

25274305

TgeneASF1B

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneASF1B

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across ZNF91 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASF1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-S7-A7WP-01AZNF91chr19

23578127

-ASF1Bchr19

14232520

-


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Fusion Gene ORF analysis for ZNF91-ASF1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300619ENST00000474890ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
5CDS-intronENST00000300619ENST00000592798ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
5CDS-intronENST00000397082ENST00000474890ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
5CDS-intronENST00000397082ENST00000592798ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
5CDS-intronENST00000599743ENST00000474890ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
5CDS-intronENST00000599743ENST00000592798ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
In-frameENST00000300619ENST00000263382ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
In-frameENST00000397082ENST00000263382ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
In-frameENST00000599743ENST00000263382ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
intron-3CDSENST00000596528ENST00000263382ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
intron-intronENST00000596528ENST00000474890ZNF91chr19

23578127

-ASF1Bchr19

14232520

-
intron-intronENST00000596528ENST00000592798ZNF91chr19

23578127

-ASF1Bchr19

14232520

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000599743ZNF91chr1923578127-ENST00000263382ASF1Bchr1914232520-146713325516163
ENST00000300619ZNF91chr1923578127-ENST00000263382ASF1Bchr1914232520-157023620619199
ENST00000397082ZNF91chr1923578127-ENST00000263382ASF1Bchr1914232520-145612214505163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000599743ENST00000263382ZNF91chr1923578127-ASF1Bchr1914232520-0.0176305340.9823695
ENST00000300619ENST00000263382ZNF91chr1923578127-ASF1Bchr1914232520-0.0133168010.9866832
ENST00000397082ENST00000263382ZNF91chr1923578127-ASF1Bchr1914232520-0.01884890.98115104

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Fusion Genomic Features for ZNF91-ASF1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF91-ASF1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:23578127/chr19:14232520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASF1B

Q9NVP2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-1413_84101192.0DomainKRAB
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-1313_84101160.0DomainKRAB
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-141022_1044101192.0Zinc fingerC2H2-type 32
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-141050_1072101192.0Zinc fingerC2H2-type 33
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-141078_1100101192.0Zinc fingerC2H2-type 34
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-141106_1128101192.0Zinc fingerC2H2-type 35
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-141134_1156101192.0Zinc fingerC2H2-type 36
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14154_176101192.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14179_200101192.0Zinc fingerC2H2-type 2
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14208_232101192.0Zinc fingerC2H2-type 3
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14238_260101192.0Zinc fingerC2H2-type 4
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14266_288101192.0Zinc fingerC2H2-type 5
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14294_316101192.0Zinc fingerC2H2-type 6
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14322_344101192.0Zinc fingerC2H2-type 7
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14350_372101192.0Zinc fingerC2H2-type 8
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14378_400101192.0Zinc fingerC2H2-type 9
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14406_428101192.0Zinc fingerC2H2-type 10
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14434_456101192.0Zinc fingerC2H2-type 11
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14462_484101192.0Zinc fingerC2H2-type 12
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14490_512101192.0Zinc fingerC2H2-type 13
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14518_540101192.0Zinc fingerC2H2-type 14%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14546_568101192.0Zinc fingerC2H2-type 15
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14574_596101192.0Zinc fingerC2H2-type 16
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14602_624101192.0Zinc fingerC2H2-type 17
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14630_652101192.0Zinc fingerC2H2-type 18
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14658_680101192.0Zinc fingerC2H2-type 19
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14686_708101192.0Zinc fingerC2H2-type 20
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14714_736101192.0Zinc fingerC2H2-type 21
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14742_764101192.0Zinc fingerC2H2-type 22
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14770_792101192.0Zinc fingerC2H2-type 23
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14798_820101192.0Zinc fingerC2H2-type 24
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14826_848101192.0Zinc fingerC2H2-type 25
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14854_876101192.0Zinc fingerC2H2-type 26
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14885_904101192.0Zinc fingerC2H2-type 27%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14910_932101192.0Zinc fingerC2H2-type 28
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14938_960101192.0Zinc fingerC2H2-type 29
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14966_988101192.0Zinc fingerC2H2-type 30
HgeneZNF91chr19:23578127chr19:14232520ENST00000300619-14994_1016101192.0Zinc fingerC2H2-type 31
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-131022_1044101160.0Zinc fingerC2H2-type 32
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-131050_1072101160.0Zinc fingerC2H2-type 33
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-131078_1100101160.0Zinc fingerC2H2-type 34
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-131106_1128101160.0Zinc fingerC2H2-type 35
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-131134_1156101160.0Zinc fingerC2H2-type 36
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13154_176101160.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13179_200101160.0Zinc fingerC2H2-type 2
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13208_232101160.0Zinc fingerC2H2-type 3
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13238_260101160.0Zinc fingerC2H2-type 4
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13266_288101160.0Zinc fingerC2H2-type 5
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13294_316101160.0Zinc fingerC2H2-type 6
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13322_344101160.0Zinc fingerC2H2-type 7
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13350_372101160.0Zinc fingerC2H2-type 8
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13378_400101160.0Zinc fingerC2H2-type 9
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13406_428101160.0Zinc fingerC2H2-type 10
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13434_456101160.0Zinc fingerC2H2-type 11
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13462_484101160.0Zinc fingerC2H2-type 12
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13490_512101160.0Zinc fingerC2H2-type 13
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13518_540101160.0Zinc fingerC2H2-type 14%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13546_568101160.0Zinc fingerC2H2-type 15
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13574_596101160.0Zinc fingerC2H2-type 16
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13602_624101160.0Zinc fingerC2H2-type 17
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13630_652101160.0Zinc fingerC2H2-type 18
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13658_680101160.0Zinc fingerC2H2-type 19
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13686_708101160.0Zinc fingerC2H2-type 20
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13714_736101160.0Zinc fingerC2H2-type 21
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13742_764101160.0Zinc fingerC2H2-type 22
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13770_792101160.0Zinc fingerC2H2-type 23
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13798_820101160.0Zinc fingerC2H2-type 24
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13826_848101160.0Zinc fingerC2H2-type 25
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13854_876101160.0Zinc fingerC2H2-type 26
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13885_904101160.0Zinc fingerC2H2-type 27%3B degenerate
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13910_932101160.0Zinc fingerC2H2-type 28
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13938_960101160.0Zinc fingerC2H2-type 29
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13966_988101160.0Zinc fingerC2H2-type 30
HgeneZNF91chr19:23578127chr19:14232520ENST00000397082-13994_1016101160.0Zinc fingerC2H2-type 31


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Fusion Gene Sequence for ZNF91-ASF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>103099_103099_1_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000300619_ASF1B_chr19_14232520_ENST00000263382_length(transcript)=1570nt_BP=236nt
ATCTAATCAGGGACGCTGGGCTGGGAACTGTCCAATCAGGCACAAAGCTGGAGCGGACAGGGCGGCTTCCGGGATGTGGCTGGGCCTTTG
TCTCTCGCTGCCGCCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCT
GCAGGTATTGGAGAGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGA
CTGATGCCGTGGGTGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGT
ACCTCAACCCTGAGCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGA
CCCGCTTCCATATCAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCA
ACTGCACTCCTATCAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAAC
CCAGAGTGTCCCAGCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTG
CAATCCAGGTCTGTCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTC
TACAGGCCTATAAGAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCA
CTGTGCACCCTTGAGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGC
TCCAGTCCTGCTGAGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGG
GAATGTTAGTTAGTAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCA
GAGGTGTGATCAGCAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTT
TTCCTGGAGGCTGCCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCT
GGCAGCCTTAACCTGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGC
TCCCCCTCTCTGTGCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAA

>103099_103099_1_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000300619_ASF1B_chr19_14232520_ENST00000263382_length(amino acids)=199AA_BP=72
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMADAPNPSLIPETDAVGVT
VVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDNNMDRLEAIETQDPSLGCGLPLNCTPIKG

--------------------------------------------------------------
>103099_103099_2_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000397082_ASF1B_chr19_14232520_ENST00000263382_length(transcript)=1456nt_BP=122nt
AGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAGAGCCACAGCTA
AGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGG
TCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGA
ACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACA
ACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGG
GGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCAGCACGCCGGGA
GGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTGTCAAACTCAGC
CCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAAGAAGCAGGTAC
TTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTGAGTACCATTGA
TCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTGAGCCAAAGGCT
TTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAGTAGGTAGACTT
AGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAGCAGGATGCTGA
GGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTGCCATGGTTGGA
AGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACCTGTCCTCTGCT
AGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGTGCCCTGGTCCC
CTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGAAAATTAAAAGC

>103099_103099_2_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000397082_ASF1B_chr19_14232520_ENST00000263382_length(amino acids)=163AA_BP=36
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMK

--------------------------------------------------------------
>103099_103099_3_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000599743_ASF1B_chr19_14232520_ENST00000263382_length(transcript)=1467nt_BP=133nt
CCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAG
AGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGG
TGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGA
GCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATAT
CAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTAT
CAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCA
GCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTG
TCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAA
GAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTG
AGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTG
AGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAG
TAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAG
CAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTG
CCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACC
TGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGT
GCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGA

>103099_103099_3_ZNF91-ASF1B_ZNF91_chr19_23578127_ENST00000599743_ASF1B_chr19_14232520_ENST00000263382_length(amino acids)=163AA_BP=36
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF91-ASF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneASF1Bchr19:23578127chr19:14232520ENST00000263382141_15575.0203.0CHAF1B
TgeneASF1Bchr19:23578127chr19:14232520ENST00000263382141_15675.0203.0histone H3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF91-ASF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF91-ASF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource