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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNRF2-ARMC10 (FusionGDB2 ID:103151)

Fusion Gene Summary for ZNRF2-ARMC10

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNRF2-ARMC10
Fusion gene ID: 103151
HgeneTgene
Gene symbol

ZNRF2

ARMC10

Gene ID

223082

83787

Gene namezinc and ring finger 2armadillo repeat containing 10
SynonymsRNF202PNAS-112|PNAS112|PSEC0198|SVH
Cytomap

7p14.3

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZNRF2RING finger protein 202RING-type E3 ubiquitin transferase ZNRF2protein Ells2zinc and ring finger 2, E3 ubiquitin protein ligasezinc finger/RING finger 2zinc/RING finger protein 2armadillo repeat-containing protein 10specific splicing variant involved in hepatocarcinogenesissplicing variant involved in hepatocarcinogenesis protein
Modification date2020031320200313
UniProtAcc.

Q8N2F6

Ensembl transtripts involved in fusion geneENST00000323037, ENST00000459998, 
ENST00000323716, ENST00000425331, 
ENST00000428183, ENST00000441711, 
ENST00000454559, ENST00000541300, 
Fusion gene scores* DoF score7 X 5 X 5=1754 X 4 X 3=48
# samples 84
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNRF2 [Title/Abstract] AND ARMC10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNRF2(30363353)-ARMC10(102724129), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNRF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARMC10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8631-01AZNRF2chr7

30363353

+ARMC10chr7

102724129

+


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Fusion Gene ORF analysis for ZNRF2-ARMC10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000323037ENST00000323716ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
In-frameENST00000323037ENST00000425331ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
In-frameENST00000323037ENST00000428183ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
In-frameENST00000323037ENST00000441711ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
In-frameENST00000323037ENST00000454559ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
In-frameENST00000323037ENST00000541300ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000323716ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000425331ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000428183ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000441711ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000454559ZNRF2chr7

30363353

+ARMC10chr7

102724129

+
intron-3CDSENST00000459998ENST00000541300ZNRF2chr7

30363353

+ARMC10chr7

102724129

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323037ZNRF2chr730363353+ENST00000425331ARMC10chr7102724129+352816169042331475
ENST00000323037ZNRF2chr730363353+ENST00000541300ARMC10chr7102724129+335116169042154416
ENST00000323037ZNRF2chr730363353+ENST00000428183ARMC10chr7102724129+342516169042226440
ENST00000323037ZNRF2chr730363353+ENST00000441711ARMC10chr7102724129+360916169042403499
ENST00000323037ZNRF2chr730363353+ENST00000454559ARMC10chr7102724129+343216169042226440
ENST00000323037ZNRF2chr730363353+ENST00000323716ARMC10chr7102724129+360916169042403499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323037ENST00000425331ZNRF2chr730363353+ARMC10chr7102724129+0.0014409010.99855906
ENST00000323037ENST00000541300ZNRF2chr730363353+ARMC10chr7102724129+0.0018634160.9981365
ENST00000323037ENST00000428183ZNRF2chr730363353+ARMC10chr7102724129+0.0019285510.9980715
ENST00000323037ENST00000441711ZNRF2chr730363353+ARMC10chr7102724129+0.0011744260.9988256
ENST00000323037ENST00000454559ZNRF2chr730363353+ARMC10chr7102724129+0.0019066920.9980933
ENST00000323037ENST00000323716ZNRF2chr730363353+ARMC10chr7102724129+0.0011744260.9988256

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Fusion Genomic Features for ZNRF2-ARMC10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNRF2chr730363353+ARMC10chr7102724128+8.88E-070.99999917
ZNRF2chr730363353+ARMC10chr7102724128+8.88E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNRF2-ARMC10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:30363353/chr7:102724129)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARMC10

Q8N2F6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNRF2chr7:30363353chr7:102724129ENST00000323037+25124_127188289.0Compositional biasNote=Poly-Gly
HgeneZNRF2chr7:30363353chr7:102724129ENST00000323037+2536_40188289.0Compositional biasNote=Poly-Gly
HgeneZNRF2chr7:30363353chr7:102724129ENST00000323037+2541_97188289.0Compositional biasNote=Ala-rich
TgeneARMC10chr7:30363353chr7:102724129ENST0000032371617138_18081344.0RepeatNote=ARM
TgeneARMC10chr7:30363353chr7:102724129ENST0000042533105138_18046285.0RepeatNote=ARM
TgeneARMC10chr7:30363353chr7:102724129ENST0000042818316138_18081285.0RepeatNote=ARM
TgeneARMC10chr7:30363353chr7:102724129ENST0000044171106138_18046309.0RepeatNote=ARM
TgeneARMC10chr7:30363353chr7:102724129ENST0000045455905138_18046250.0RepeatNote=ARM
TgeneARMC10chr7:30363353chr7:102724129ENST0000054130004138_18046226.0RepeatNote=ARM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNRF2chr7:30363353chr7:102724129ENST00000323037+25199_240188289.0Zinc fingerRING-type%3B atypical
TgeneARMC10chr7:30363353chr7:102724129ENST00000323716175_2781344.0TransmembraneHelical
TgeneARMC10chr7:30363353chr7:102724129ENST00000425331055_2746285.0TransmembraneHelical
TgeneARMC10chr7:30363353chr7:102724129ENST00000428183165_2781285.0TransmembraneHelical
TgeneARMC10chr7:30363353chr7:102724129ENST00000441711065_2746309.0TransmembraneHelical
TgeneARMC10chr7:30363353chr7:102724129ENST00000454559055_2746250.0TransmembraneHelical
TgeneARMC10chr7:30363353chr7:102724129ENST00000541300045_2746226.0TransmembraneHelical


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Fusion Gene Sequence for ZNRF2-ARMC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>103151_103151_1_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000323716_length(transcript)=3609nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGATATACATCAGTCAAGTATGTGAGGATGTCTTCTCTGGTCCTCTGAACTCTGCTGTGCAGCTGGCTGGACTGACATTGTT
GACAAACATGACTGTTACCAATGACCACCAGCACATGCTTCACAGTTACATTACAGACCTGTTCCAGGTGTTACTTACTGGAAATGGAAA
CACGAAGGTGCAAGTTTTGAAACTGCTTTTGAATTTGTCTGAAAATCCAGCCATGACAGAAGGACTTCTCCGTGCCCAAGTGGATTCATC
ATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAATATAAAGAACTGCCTCAAAAT
AGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGAATGTGCCCAGAAAATAAGAGC
TTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGTCATATTTTTCCAAAGAGTAAT
GCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACAGTAAATATCACATTTTGTCAT
TAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAGAGCTTGTACTGAAACCATTTA
TTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCACATTTAAGCTACCCTTCTACC
TTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACTGAATAGTCTTGTTCTTTTAGT
AGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTTTCTCATCAGTAGAATCTATTT
TGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCATTCAATGTTATATATAAAATA
GTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCGTGCTGGGCGCGGTGGCTCTTG
CCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGCCTGACCAATATGGAGAAACCC
TGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATTGCTT
GAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAA
AAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAACACAAAAATTATAGAATATGG
GATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGATACCCAAACTCCTGGAGTGGG
AGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTATAATCTTTTTTTAATAAAGGGG

>103151_103151_1_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000323716_length(amino acids)=499AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLT
NMTVTNDHQHMLHSYITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEILLRVLTLFQNIKNCLKIE

--------------------------------------------------------------
>103151_103151_2_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000425331_length(transcript)=3528nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGATATACATCAGTCAAGTATGTGAGGATGTCTTCTCTGGTCCTCTGAACTCTGCTGTGCAGCTGGCTGGACTGACATTGTT
GACAAACATGACTGTTACCAATGACCACCAGCACATGCTTCACAGTTACATTACAGACCTGTTCCAGGTGTTACTTACTGGAAATGGAAA
CACGAAGGTGGATTCATCATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAATAT
AAAGAACTGCCTCAAAATAGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGAATG
TGCCCAGAAAATAAGAGCTTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGTCAT
ATTTTTCCAAAGAGTAATGCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACAGTA
AATATCACATTTTGTCATTAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAGAGC
TTGTACTGAAACCATTTATTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCACAT
TTAAGCTACCCTTCTACCTTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACTGAA
TAGTCTTGTTCTTTTAGTAGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTTTCT
CATCAGTAGAATCTATTTTGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCATTC
AATGTTATATATAAAATAGTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCGTGC
TGGGCGCGGTGGCTCTTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGCCTG
ACCAATATGGAGAAACCCTGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCC
GAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAA
ACTCTGTCTCAAAAAAAAAAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAACAC
AAAAATTATAGAATATGGGATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGATAC
CCAAACTCCTGGAGTGGGAGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTATAAT

>103151_103151_2_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000425331_length(amino acids)=475AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLT
NMTVTNDHQHMLHSYITDLFQVLLTGNGNTKVDSSFLSLYDSHVAKEILLRVLTLFQNIKNCLKIEGHLAVQPTFTEGSLFFLLHGEECA

--------------------------------------------------------------
>103151_103151_3_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000428183_length(transcript)=3425nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGGTGCAAGTTTTGAAACTGCTTTTGAATTTGTCTGAAAATCCAGCCATGACAGAAGGACTTCTCCGTGCCCAAGTGGATTC
ATCATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAATATAAAGAACTGCCTCAA
AATAGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGAATGTGCCCAGAAAATAAG
AGCTTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGTCATATTTTTCCAAAGAGT
AATGCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACAGTAAATATCACATTTTGT
CATTAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAGAGCTTGTACTGAAACCAT
TTATTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCACATTTAAGCTACCCTTCT
ACCTTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACTGAATAGTCTTGTTCTTTT
AGTAGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTTTCTCATCAGTAGAATCTA
TTTTGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCATTCAATGTTATATATAAA
ATAGTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCGTGCTGGGCGCGGTGGCTC
TTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGCCTGACCAATATGGAGAAA
CCCTGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATTG
CTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAA
AAAAAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAACACAAAAATTATAGAATA
TGGGATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGATACCCAAACTCCTGGAGT
GGGAGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTATAATCTTTTTTTAATAAAG

>103151_103151_3_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000428183_length(amino acids)=440AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKVQVLKLLLNLSENPAMTEGLLRAQVDSS

--------------------------------------------------------------
>103151_103151_4_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000441711_length(transcript)=3609nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGATATACATCAGTCAAGTATGTGAGGATGTCTTCTCTGGTCCTCTGAACTCTGCTGTGCAGCTGGCTGGACTGACATTGTT
GACAAACATGACTGTTACCAATGACCACCAGCACATGCTTCACAGTTACATTACAGACCTGTTCCAGGTGTTACTTACTGGAAATGGAAA
CACGAAGGTGCAAGTTTTGAAACTGCTTTTGAATTTGTCTGAAAATCCAGCCATGACAGAAGGACTTCTCCGTGCCCAAGTGGATTCATC
ATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAATATAAAGAACTGCCTCAAAAT
AGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGAATGTGCCCAGAAAATAAGAGC
TTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGTCATATTTTTCCAAAGAGTAAT
GCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACAGTAAATATCACATTTTGTCAT
TAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAGAGCTTGTACTGAAACCATTTA
TTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCACATTTAAGCTACCCTTCTACC
TTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACTGAATAGTCTTGTTCTTTTAGT
AGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTTTCTCATCAGTAGAATCTATTT
TGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCATTCAATGTTATATATAAAATA
GTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCGTGCTGGGCGCGGTGGCTCTTG
CCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGCCTGACCAATATGGAGAAACCC
TGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATTGCTT
GAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAA
AAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAACACAAAAATTATAGAATATGG
GATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGATACCCAAACTCCTGGAGTGGG
AGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTATAATCTTTTTTTAATAAAGGGG

>103151_103151_4_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000441711_length(amino acids)=499AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLT
NMTVTNDHQHMLHSYITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEILLRVLTLFQNIKNCLKIE

--------------------------------------------------------------
>103151_103151_5_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000454559_length(transcript)=3432nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGGTGCAAGTTTTGAAACTGCTTTTGAATTTGTCTGAAAATCCAGCCATGACAGAAGGACTTCTCCGTGCCCAAGTGGATTC
ATCATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAATATAAAGAACTGCCTCAA
AATAGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGAATGTGCCCAGAAAATAAG
AGCTTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGTCATATTTTTCCAAAGAGT
AATGCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACAGTAAATATCACATTTTGT
CATTAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAGAGCTTGTACTGAAACCAT
TTATTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCACATTTAAGCTACCCTTCT
ACCTTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACTGAATAGTCTTGTTCTTTT
AGTAGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTTTCTCATCAGTAGAATCTA
TTTTGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCATTCAATGTTATATATAAA
ATAGTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCGTGCTGGGCGCGGTGGCTC
TTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGCCTGACCAATATGGAGAAA
CCCTGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATTG
CTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAA
AAAAAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAACACAAAAATTATAGAATA
TGGGATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGATACCCAAACTCCTGGAGT
GGGAGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTATAATCTTTTTTTAATAAAG

>103151_103151_5_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000454559_length(amino acids)=440AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKVQVLKLLLNLSENPAMTEGLLRAQVDSS

--------------------------------------------------------------
>103151_103151_6_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000541300_length(transcript)=3351nt_BP=1616nt
GCGGGCCACGTGCGGGAGGAGGGGCCGCCTTCTGGTTGGCGCCCGGTGTCCGTTCCTCCTATCGGCGTAGGCCCCGCGAGGAAGACAAGG
GCGCGCCCTGGCTGGGAGGGCGTGGCCAGAGACCTGTCCATCACCGAGTCCACGAGTGGCAGCACCTACCACACCGCAGTACCTTGGCGA
GGCGGAGCAGGGGCAGGCAGGTCGCGGAAGGGGGAGGCGGAGCAAGGCCGGCGGGAGCCAATCGGCCTGGCGGCACGAGGGGGCGGGGGC
GGGGTCAACGCGCGCGACCCAAACACACGGGCCGGGCGCACCCTGCAGCCGCGCCGCTCCGCGGCCTTCCGGCGCGGGGCCGGGGAACCT
CCTCCCCATCTGCGCACCCCCCGCCTTCGCGGCCCAGATCCTCCCGCCAGCCCGGCCCCTCCTTCGCAGGGGGAGCGAGGCGACGGTTGC
CGGGAAGCGCGCGCCACCTCTCCCTCCCATTTTTCGTTCTCCCCTCGCGCGCCACCCGTTTTTCCTCTTTCTCCGTTAATAACAGCTGGG
TGGCTGGGGGAGGAGGGAAGGTGGCCCCGGCGGAGTCTGGGCGGGCGCCTCCCACTCAGCCGCCAGCCGCCGTGGGAGCCGGAGGATGGC
GGCGGTAGCAGCGGCCGCCCGAGAGGAGGCGGTGCCGAGATCGGGGGCGCCGAGCGCGGCAGCAGAGAGCGGTAGCGGCCCGTCGTGGCG
CACCAGAACCGAAACCAGCGGCAGCCGCACGGCCACTTGAGCCGCCCCTTCCTGCTGGAGCCAGCGAGGGGTGCCTGCAGCCGGGACCCC
TTCCTCTCCGCGTCTCCTCGTCTCCCGCGCCCGCGTCAGGCCGTCGGCCTCGCCCGCCGCCCCAAGAAGAGCGCGCCGGGCGCCGACTGC
CCCTCTGGACGCCGGGCGGCGGCCCTGGACGTGCGGGGGCCTCTCTGGGCCGGCCGCGGCGCCTGGGCCCTGCCCTCTAGCTCCCGCGCT
CGCTCCCGCCCTCCCGGCTCTCGGGGCGCAGCGCGCGGGCCCGGCCCGGGGCAGGGCGGACATGGGCGCCAAACAGAGCGGCCCGGCCGC
CGCTAACGGCCGCACGCGCGCGTACTCGGGCTCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGG
CGCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGCGCCTCCGGCGGCGCCGCGGCGGCCGCGGC
GGCCCCGGCAGCCCCGGCGGCCCCGCGCAGCCGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCC
CTTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGCCCTGAGGACGGCGGCGGCGGCCGGGACCG
GCCGGTGGGCGGGAGCCCCGGCGGGCCGCGCCTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTG
CCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAAGA
CTTAACTGATGGTTCATATGATGATGTTCTAAATGCTGAACAACTTCAGAAACTCCTTTACCTGCTGGAGTCAACGGAGGATCCTGTAAT
TATTGAAAGAGCTTTGATTACTTTGGGTAACAATGCAGCCTTTTCAGTTAACCAAGCTATTATTCGTGAATTGGGTGGTATTCCAATTGT
TGCAAACAAAATCAACCATTCCAACCAGAGTATTAAAGAGAAAGCTTTAAATGCACTAAATAACCTGAGTGTGAATGTTGAAAATCAAAT
CAAGATAAAGGTGGATTCATCATTCCTTTCCCTTTATGACAGCCACGTAGCAAAGGAGATTCTTCTTCGAGTACTTACGCTATTTCAGAA
TATAAAGAACTGCCTCAAAATAGAAGGCCATTTAGCTGTGCAGCCTACTTTCACTGAAGGTTCATTGTTTTTCCTGTTACATGGAGAAGA
ATGTGCCCAGAAAATAAGAGCTTTAGTTGATCACCATGATGCAGAGGTGAAGGAAAAGGTTGTAACAATAATACCCAAAATCTGATTGGT
CATATTTTTCCAAAGAGTAATGCAGTCTGGATATAAACGTATTTTCTGTCTTCCTTATAAGGGGATTCTCCCAGCTGCTAAATTTAAACA
GTAAATATCACATTTTGTCATTAACACAGCTATAACTTGCCGTGGTTCTCAGATTTATTTTGGACTATTTTGATGCCAAGTGAATATAAG
AGCTTGTACTGAAACCATTTATTTCTTTCTATTTTGCTATTTGCAAATGCTTGTTATCTTCCCTACATGAAGTGGCAGTAACCTTTTTCA
CATTTAAGCTACCCTTCTACCTTTTGAAGTGATTTGCAGTTACTCATCTGAGACAGCATCAGTATTTGACTAAATCATTGTTTCACAACT
GAATAGTCTTGTTCTTTTAGTAGCAACGAAATCCTAAGCTCTTGAGGCCATTCACCTGCCAACCTGACCATACTGCTTTCAAAAGTCTTT
TCTCATCAGTAGAATCTATTTTGGTCACTTCTAGTCAATGAAAAATGTAAACTTTTAGGAGAGAATGTTTCTTAGGACTCACCCACTCCA
TTCAATGTTATATATAAAATAGTGTGATCAATCACAATGTCCATCTTTAGACAGTTGGTTAAATAAATTATCTGGTCTTTGAAAAGACCG
TGCTGGGCGCGGTGGCTCTTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGATCGGGAGTTTGAGACCAAGC
CTGACCAATATGGAGAAACCCTGTCTCTACTAAGAACACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAG
GCCGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGC
AAAACTCTGTCTCAAAAAAAAAAAAAAATGATGGAGCTCCGAATGTGCTTAAGTGGAAAGATATCTATGAAATATGGTGGTTTTTTAAAA
CACAAAAATTATAGAATATGGGATCCCGTGTGTGTGTGTGTGTGTTTGAATGAAAAATGCTTATGTATTGACAGAACACTTCTAGAATGA
TACCCAAACTCCTGGAGTGGGAGTGGGGAATGCCTTCTACGTACACACTGTTCTACTGTTTGAATTTTTTAATATGAGCCCAAATTGTAT

>103151_103151_6_ZNRF2-ARMC10_ZNRF2_chr7_30363353_ENST00000323037_ARMC10_chr7_102724129_ENST00000541300_length(amino acids)=416AA_BP=235
MDAGRRPWTCGGLSGPAAAPGPCPLAPALAPALPALGAQRAGPARGRADMGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGA
RAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRP
VGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVII
ERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKVDSSFLSLYDSHVAKEILLRVLTLFQNI

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Fusion Gene PPI Analysis for ZNRF2-ARMC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNRF2-ARMC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNRF2-ARMC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource