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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNRF3-PI4KA (FusionGDB2 ID:103178)

Fusion Gene Summary for ZNRF3-PI4KA

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNRF3-PI4KA
Fusion gene ID: 103178
HgeneTgene
Gene symbol

ZNRF3

PI4KA

Gene ID

84133

5297

Gene namezinc and ring finger 3phosphatidylinositol 4-kinase alpha
SynonymsBK747E2.3|RNF203PI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230
Cytomap

22q12.1

22q11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3phosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, a
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332811, ENST00000402174, 
ENST00000406323, ENST00000544604, 
ENST00000572273, ENST00000414196, 
ENST00000466162, ENST00000255882, 
Fusion gene scores* DoF score26 X 11 X 18=514811 X 11 X 5=605
# samples 3911
** MAII scorelog2(39/5148*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/605*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNRF3 [Title/Abstract] AND PI4KA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNRF3(29383189)-PI4KA(21193019), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNRF3

GO:0016567

protein ubiquitination

22575959

TgenePI4KA

GO:0016310

phosphorylation

25327288


check buttonFusion gene breakpoints across ZNRF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PI4KA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3578ZNRF3chr22

29383189

+PI4KAchr22

21193019

-


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Fusion Gene ORF analysis for ZNRF3-PI4KA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000332811ENST00000572273ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-5UTRENST00000402174ENST00000572273ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-5UTRENST00000406323ENST00000572273ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-5UTRENST00000544604ENST00000572273ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000332811ENST00000414196ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000332811ENST00000466162ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000402174ENST00000414196ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000402174ENST00000466162ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000406323ENST00000414196ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000406323ENST00000466162ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000544604ENST00000414196ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
5CDS-intronENST00000544604ENST00000466162ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
In-frameENST00000332811ENST00000255882ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
In-frameENST00000402174ENST00000255882ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
In-frameENST00000406323ENST00000255882ZNRF3chr22

29383189

+PI4KAchr22

21193019

-
In-frameENST00000544604ENST00000255882ZNRF3chr22

29383189

+PI4KAchr22

21193019

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544604ZNRF3chr2229383189+ENST00000255882PI4KAchr2221193019-711060117567532192
ENST00000332811ZNRF3chr2229383189+ENST00000255882PI4KAchr2221193019-68002915764432128
ENST00000402174ZNRF3chr2229383189+ENST00000255882PI4KAchr2221193019-67282199363712092
ENST00000406323ZNRF3chr2229383189+ENST00000255882PI4KAchr2221193019-66591502463022092

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544604ENST00000255882ZNRF3chr2229383189+PI4KAchr2221193019-0.0028115750.9971884
ENST00000332811ENST00000255882ZNRF3chr2229383189+PI4KAchr2221193019-0.0023742220.99762577
ENST00000402174ENST00000255882ZNRF3chr2229383189+PI4KAchr2221193019-0.002223240.9977768
ENST00000406323ENST00000255882ZNRF3chr2229383189+PI4KAchr2221193019-0.0021491970.9978508

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Fusion Genomic Features for ZNRF3-PI4KA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNRF3-PI4KA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29383189/chr22:21193019)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePI4KAchr22:29383189chr22:21193019ENST000004141960231530_17180855.0DomainPIK helical
TgenePI4KAchr22:29383189chr22:21193019ENST000004141960231846_20790855.0DomainPI3K/PI4K
TgenePI4KAchr22:29383189chr22:21193019ENST000005722730551530_171802045.0DomainPIK helical
TgenePI4KAchr22:29383189chr22:21193019ENST000005722730551846_207902045.0DomainPI3K/PI4K

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNRF3chr22:29383189chr22:21193019ENST00000332811+29241_93642837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29383189chr22:21193019ENST00000332811+2956_21942837.0Topological domainExtracellular
HgeneZNRF3chr22:29383189chr22:21193019ENST00000402174+29241_93642837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29383189chr22:21193019ENST00000402174+2956_21942837.0Topological domainExtracellular
HgeneZNRF3chr22:29383189chr22:21193019ENST00000406323+18241_93642837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29383189chr22:21193019ENST00000406323+1856_21942837.0Topological domainExtracellular
HgeneZNRF3chr22:29383189chr22:21193019ENST00000544604+29241_936142937.0Topological domainCytoplasmic
HgeneZNRF3chr22:29383189chr22:21193019ENST00000544604+2956_219142937.0Topological domainExtracellular
HgeneZNRF3chr22:29383189chr22:21193019ENST00000332811+29220_24042837.0TransmembraneHelical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000402174+29220_24042837.0TransmembraneHelical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000406323+18220_24042837.0TransmembraneHelical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000544604+29220_240142937.0TransmembraneHelical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000332811+29293_33442837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000402174+29293_33442837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000406323+18293_33442837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29383189chr22:21193019ENST00000544604+29293_334142937.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for ZNRF3-PI4KA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>103178_103178_1_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000332811_PI4KA_chr22_21193019_ENST00000255882_length(transcript)=6800nt_BP=291nt
GCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGAGGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACC
ACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCTCAGCGCCGAGGGCGAGATCGTGCAGATGCACCCACTGGGC
CTATGTAATAACAATGACGAAGAGGACTTGTATGAATATGGCTGGGTAGGAGTGGTGAAGCTGGAACAGCCAGAATTGGACCCGAAACCA
TGCCTCACTGTCCTAGGCAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGATGAAAGACGGAGA
GATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTTCGACTTCTCAAA
GGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTCAGCTTCTGCTTG
GTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTGCATGTCCTCTTG
GGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCGCGAGCATTTGGG
CGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAAGAGCTTGAAGGT
GTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTGAAGAGGAAAACC
AGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTTCACTACTTTGAA
GCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCTCCCCTTTTCAAC
GGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAGGAGGCTGTTCTC
AAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGACCCTCTCTACCTG
ACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGATTTTGTGCTGGAG
CAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTCAAACTGCGCTGT
CAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAGCTATCTGAGAAG
CTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGCCTGTGCGAGAGG
TTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTCTACAAGTACCAC
AGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTCATGTCGGGTAAG
AAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTGACGGTGGACCCA
GTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTGATTCCCGACCAC
ACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTACAGCAGAAATTC
TGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATCTATCAGGAAGTG
TGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGCTATAGGCATTGC
TCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATGAACCTGTTGGAG
TTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCTAGCAGTGCAGGG
AACTTGGGAGTACTCATTCCTGTAATAGCTGTGCTCACCCGACGACTGCCACCCATCAAAGAAGCTAAGCCTCGGTTACAGAAGCTCTTC
CGAGACTTCTGGCTGTATTCCGTTCTGATGGGATTCGCTGTGGAGGGCTCAGGACTCTGGCCAGAAGAATGGTACGAGGGGGTCTGTGAA
ATAGCCACTAAGTCCCCCTTGCTCACCTTTCCCAGCAAGGAGCCACTGCGGTCCGTCCTCCAGTATAACTCAGCCATGAAGAATGACACG
GTCACCCCCGCTGAGCTGAGTGAGCTCCGCAGCACTATCATCAACCTGCTGGACCCCCCTCCCGAGGTGTCCGCACTCATCAACAAGCTG
GACTTCGCCATGTCCACCTACCTCCTCTCTGTGTACCGGCTGGAGTACATGAGGGTACTGCGTTCAACAGATCCTGATCGCTTCCAGGTA
ATGTTCTGCTACTTTGAGGATAAAGCTATTCAGAAAGACAAATCTGGGATGATGCAGTGTGTGATTGCAGTCGCGGACAAAGTATTCGAT
GCCTTCCTGAACATGATGGCGGATAAAGCCAAGACCAAGGAGAACGAGGAGGAGCTGGAGCGGCACGCTCAGTTCCTGTTGGTGAACTTC
AACCACATCCACAAGAGGATAAGGAGGGTGGCAGACAAGTATCTATCTGGTCTGGTGGATAAGTTTCCCCACTTGCTCTGGAGCGGGACT
GTGCTGAAGACCATGCTGGACATCCTGCAGACCCTGTCACTGTCACTGAGCGCTGATATTCACAAGGATCAGCCTTACTATGACATCCCC
GACGCCCCCTACCGGATCACGGTTCCTGACACGTACGAAGCCCGTGAGAGCATTGTGAAGGACTTCGCTGCACGCTGTGGGATGATCCTC
CAGGAGGCCATGAAGTGGGCACCTACCGTCACCAAGTCCCACCTGCAGGAATATCTGAACAAACATCAGAACTGGGTATCGGGACTGTCC
CAGCACACGGGGCTGGCCATGGCCACTGAGAGCATCCTTCACTTTGCTGGCTACAACAAGCAGAACACAACTCTTGGGGCAACTCAGCTG
AGCGAGCGCCCGGCCTGTGTGAAGAAAGACTACTCCAACTTCATGGCATCCCTGAATCTGCGCAACCGCTACGCGGGCGAGGTGTATGGA
ATGATTCGGTTCTCAGGCACCACAGGCCAGATGTCTGACCTGAACAAAATGATGGTCCAGGATCTACATTCAGCTTTAGACCGCAGTCAT
CCTCAGCACTACACGCAGGCCATGTTCAAGCTGACCGCAATGCTCATTAGCAGTAAAGATTGTGACCCGCAGCTCCTTCATCATCTGTGC
TGGGGTCCCCTCCGGATGTTCAATGAGCATGGCATGGAGACGGCCCTGGCCTGCTGGGAGTGGCTGCTGGCTGGCAAGGATGGAGTGGAA
GTGCCGTTCATGCGGGAGATGGCAGGGGCCTGGCACATGACGGTGGAGCAGAAATTTGGCCTGTTTTCTGCTGAGATAAAGGAAGCAGAC
CCCCTGGCTGCCTCGGAAGCAAGTCAACCCAAACCCTGTCCCCCCGAAGTGACCCCCCACTACATCTGGATCGACTTCCTGGTGCAGCGG
TTTGAGATCGCCAAGTACTGCAGCTCTGACCAAGTGGAGATCTTCTCCAGCCTGCTGCAGCGCTCCATGTCCCTGAACATCGGCGGGGCC
AAGGGGAGCATGAACCGGCACGTGGCGGCCATCGGGCCCCGCTTCAAGCTGCTGACCCTGGGGCTGTCCCTCCTGCATGCCGATGTGGTT
CCAAATGCAACCATCCGCAATGTGCTTCGCGAGAAGATCTACTCCACTGCCTTTGACTACTTCAGCTGTCCCCCAAAGTTCCCTACTCAA
GGAGAGAAGCGGCTGCGTGAAGACATAAGCATCATGATTAAATTTTGGACCGCCATGTTCTCAGATAAGAAGTACCTGACCGCCAGCCAG
CTTGTTCCCCCAGATAATCAGGACACCCGGAGCAACCTGGACATAACTGTCGGCTCTCGGCAACAAGCCACCCAAGGCTGGATCAACACA
TACCCCCTGTCCAGCGGCATGTCCACCATCTCCAAGAAATCAGGCATGTCTAAGAAAACCAACCGGGGCTCCCAGCTGCACAAATACTAC
ATGAAGCGCAGGACGCTGCTGCTGTCCCTGCTGGCCACTGAGATCGAGCGTCTCATCACATGGTACAACCCGCTGTCAGCCCCGGAACTG
GAACTAGACCAGGCCGGAGAGAACAGCGTGGCCAACTGGAGATCTAAGTACATCAGCCTGAGTGAGAAGCAGTGGAAGGACAACGTGAAC
CTCGCCTGGAGCATCTCTCCCTACCTAGCCGTGCAGCTGCCTGCCAGGTTTAAGAACACAGAAGCCATTGGGAACGAAGTGACCCGTCTC
GTTCGGTTGGACCCGGGAGCCGTTAGTGATGTGCCTGAAGCAATCAAGTTCCTGGTCACCTGGCACACCATCGACGCCGATGCTCCAGAG
CTCAGCCATGTGCTGTGCTGGGCGCCCACGGACCCACCCACAGGCCTCTCCTACTTCTCCAGCATGTACCCGCCGCACCCTCTCACGGCG
CAGTACGGGGTGAAAGTCCTGCGGTCCTTCCCTCCGGACGCCATCCTCTTCTACATCCCCCAGATTGTGCAGGCCCTCAGGTACGACAAG
ATGGGCTATGTGCGGGAGTATATTCTGTGGGCAGCGTCTAAATCCCAGCTTCTGGCACACCAGTTCATCTGGAACATGAAGACTAACATT
TATCTAGATGAAGAGGGCCACCAGAAAGACCCTGACATCGGCGACCTCCTGGATCAGTTGGTAGAGGAGATCACAGGCTCCTTGTCCGGC
CCAGCGAAGGACTTTTACCAGCGGGAGTTTGATTTCTTTAACAAGATCACCAACGTGTCGGCTATCATCAAGCCCTACCCTAAAGGCGAC
GAGAGAAAGAAGGCTTGTCTGTCGGCCCTGTCTGAAGTGAAGGTGCAGCCGGGCTGCTACCTGCCCAGCAACCCTGAGGCCATTGTGCTG
GACATCGACTACAAGTCTGGGACCCCGATGCAGAGTGCTGCAAAAGCCCCATATCTGGCCAAGTTCAAGGTGAAGCGATGTGGAGTTAGT
GAACTTGAAAAAGAAGGTCTGCGGTGCCGCTCAGACTCCGAGGATGAGTGCAGCACGCAGGAGGCCGACGGCCAGAAGATCTCCTGGCAG
GCAGCCATCTTCAAGGTGGGAGACGACTGCCGGCAGGACATGCTGGCCCTGCAGATCATCGACCTCTTCAAGAACATCTTCCAGCTGGTC
GGCCTGGACCTCTTTGTTTTTCCCTACCGCGTGGTGGCCACTGCCCCTGGGTGCGGGGTGATCGAGTGCATCCCCGACTGCACCTCCCGG
GACCAGCTGGGCCGCCAGACAGACTTCGGCATGTACGACTACTTCACACGCCAGTACGGGGATGAGTCCACTCTGGCCTTCCAGCAGGCC
CGCTACAACTTCATCCGAAGCATGGCCGCCTACAGCCTCCTGCTGTTCCTGCTGCAGATCAAGGACAGACACAACGGCAACATTATGCTG
GACAAGAAGGGTCATATCATCCACATCGACTTTGGCTTCATGTTTGAAAGCTCGCCGGGCGGCAATCTCGGCTGGGAACCCGACATCAAG
CTGACGGATGAGATGGTGATGATCATGGGGGGCAAGATGGAGGCCACACCCTTCAAGTGGTTCATGGAGATGTGTGTCCGAGGCTACCTG
GCTGTGCGGCCCTACATGGACGCGGTCGTCTCCCTGGTCACTCTCATGTTGGACACGGGCCTGCCCTGTTTTCGCGGCCAGACAATCAAG
CTCTTGAAGCACAGGTTTAGCCCCAACATGACTGAGCGCGAGGCTGCAAATTTCATCATGAAGGTCATCCAGAGCTGCTTCCTCAGCAAC
AGGAGCCGGACCTACGACATGATCCAGTACTATCAGAATGACATCCCCTACTGAGGAGGGGACCTTCGAGGGCCTCTGCCCCATGTGCCC
TCAAAGCTGTCCCACAATCATGGAGCCCTGCGACCTCCCTGCCCTGCCGCCACATGCAGTGGAGGAGAGGCCTGTGGCCCAAAGAACCTG
GTAGCGCCTCCTGGGGCAGCACGTGGGTGGCGCAGCCTTGGTAACGCCATGGACTGCAGCGACAATCAATGGATGGTGCTGTCTATGCAC
AGGTGTGAGTCCTCTGTTTGCACTGGACATATTCCCTACCTGTCTTATTTCATAGGTACATGAAGTATTGTGTATAAAAAAAGAGATAAG

>103178_103178_1_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000332811_PI4KA_chr22_21193019_ENST00000255882_length(amino acids)=2128AA_BP=78
MFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKVQKLLCMCPVDF
HGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEIL
EVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLT
VCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLN
LVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRI
HNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIP
SPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQE
SDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSAT
KDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPI
KEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDP
PPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEEL
ERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIV
KDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLN
LRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACW
EWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLL
QRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAM
FSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLI
TWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLV
TWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLA
HQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGC
YLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQI
IDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQ
IKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDT

--------------------------------------------------------------
>103178_103178_2_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000402174_PI4KA_chr22_21193019_ENST00000255882_length(transcript)=6728nt_BP=219nt
GCACAGAAGTTTGCTGCATCACTGGTGAGCTGGGGAGTGTCCTGTGTGGTGTCCACTTAATCTTACTAGGAAGGATCCCCTCATTTCAAC
AAGATGCACCCACTGGGCCTATGTAATAACAATGACGAAGAGGACTTGTATGAATATGGCTGGGTAGGAGTGGTGAAGCTGGAACAGCCA
GAATTGGACCCGAAACCATGCCTCACTGTCCTAGGCAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAG
TTAGATGAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTAC
CTTCTTCGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAG
AGCTTCAGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAG
GTTTTGCATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGA
ATCTCGCGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTC
CTGGAAGAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGT
ACCCTGAAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCT
GCCTTTCACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCA
GTCTCTCCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATC
GTTGAGGAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTC
AGTGACCCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATC
CATGATTTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGC
CCCCTCAAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGC
ATCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTG
GGCCGCCTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTG
AAGCTCTACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTG
AACGTCATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCT
GGATTGACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCT
CACTTGATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAG
ATCCTACAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAA
TACATCTATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGAC
CACGGCTATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTG
CTCATGAACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAG
GCTTCTAGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCTCACCCGACGACTGCCACCCATCAAAGAAGCTAAGCCT
CGGTTACAGAAGCTCTTCCGAGACTTCTGGCTGTATTCCGTTCTGATGGGATTCGCTGTGGAGGGCTCAGGACTCTGGCCAGAAGAATGG
TACGAGGGGGTCTGTGAAATAGCCACTAAGTCCCCCTTGCTCACCTTTCCCAGCAAGGAGCCACTGCGGTCCGTCCTCCAGTATAACTCA
GCCATGAAGAATGACACGGTCACCCCCGCTGAGCTGAGTGAGCTCCGCAGCACTATCATCAACCTGCTGGACCCCCCTCCCGAGGTGTCC
GCACTCATCAACAAGCTGGACTTCGCCATGTCCACCTACCTCCTCTCTGTGTACCGGCTGGAGTACATGAGGGTACTGCGTTCAACAGAT
CCTGATCGCTTCCAGGTAATGTTCTGCTACTTTGAGGATAAAGCTATTCAGAAAGACAAATCTGGGATGATGCAGTGTGTGATTGCAGTC
GCGGACAAAGTATTCGATGCCTTCCTGAACATGATGGCGGATAAAGCCAAGACCAAGGAGAACGAGGAGGAGCTGGAGCGGCACGCTCAG
TTCCTGTTGGTGAACTTCAACCACATCCACAAGAGGATAAGGAGGGTGGCAGACAAGTATCTATCTGGTCTGGTGGATAAGTTTCCCCAC
TTGCTCTGGAGCGGGACTGTGCTGAAGACCATGCTGGACATCCTGCAGACCCTGTCACTGTCACTGAGCGCTGATATTCACAAGGATCAG
CCTTACTATGACATCCCCGACGCCCCCTACCGGATCACGGTTCCTGACACGTACGAAGCCCGTGAGAGCATTGTGAAGGACTTCGCTGCA
CGCTGTGGGATGATCCTCCAGGAGGCCATGAAGTGGGCACCTACCGTCACCAAGTCCCACCTGCAGGAATATCTGAACAAACATCAGAAC
TGGGTATCGGGACTGTCCCAGCACACGGGGCTGGCCATGGCCACTGAGAGCATCCTTCACTTTGCTGGCTACAACAAGCAGAACACAACT
CTTGGGGCAACTCAGCTGAGCGAGCGCCCGGCCTGTGTGAAGAAAGACTACTCCAACTTCATGGCATCCCTGAATCTGCGCAACCGCTAC
GCGGGCGAGGTGTATGGAATGATTCGGTTCTCAGGCACCACAGGCCAGATGTCTGACCTGAACAAAATGATGGTCCAGGATCTACATTCA
GCTTTAGACCGCAGTCATCCTCAGCACTACACGCAGGCCATGTTCAAGCTGACCGCAATGCTCATTAGCAGTAAAGATTGTGACCCGCAG
CTCCTTCATCATCTGTGCTGGGGTCCCCTCCGGATGTTCAATGAGCATGGCATGGAGACGGCCCTGGCCTGCTGGGAGTGGCTGCTGGCT
GGCAAGGATGGAGTGGAAGTGCCGTTCATGCGGGAGATGGCAGGGGCCTGGCACATGACGGTGGAGCAGAAATTTGGCCTGTTTTCTGCT
GAGATAAAGGAAGCAGACCCCCTGGCTGCCTCGGAAGCAAGTCAACCCAAACCCTGTCCCCCCGAAGTGACCCCCCACTACATCTGGATC
GACTTCCTGGTGCAGCGGTTTGAGATCGCCAAGTACTGCAGCTCTGACCAAGTGGAGATCTTCTCCAGCCTGCTGCAGCGCTCCATGTCC
CTGAACATCGGCGGGGCCAAGGGGAGCATGAACCGGCACGTGGCGGCCATCGGGCCCCGCTTCAAGCTGCTGACCCTGGGGCTGTCCCTC
CTGCATGCCGATGTGGTTCCAAATGCAACCATCCGCAATGTGCTTCGCGAGAAGATCTACTCCACTGCCTTTGACTACTTCAGCTGTCCC
CCAAAGTTCCCTACTCAAGGAGAGAAGCGGCTGCGTGAAGACATAAGCATCATGATTAAATTTTGGACCGCCATGTTCTCAGATAAGAAG
TACCTGACCGCCAGCCAGCTTGTTCCCCCAGATAATCAGGACACCCGGAGCAACCTGGACATAACTGTCGGCTCTCGGCAACAAGCCACC
CAAGGCTGGATCAACACATACCCCCTGTCCAGCGGCATGTCCACCATCTCCAAGAAATCAGGCATGTCTAAGAAAACCAACCGGGGCTCC
CAGCTGCACAAATACTACATGAAGCGCAGGACGCTGCTGCTGTCCCTGCTGGCCACTGAGATCGAGCGTCTCATCACATGGTACAACCCG
CTGTCAGCCCCGGAACTGGAACTAGACCAGGCCGGAGAGAACAGCGTGGCCAACTGGAGATCTAAGTACATCAGCCTGAGTGAGAAGCAG
TGGAAGGACAACGTGAACCTCGCCTGGAGCATCTCTCCCTACCTAGCCGTGCAGCTGCCTGCCAGGTTTAAGAACACAGAAGCCATTGGG
AACGAAGTGACCCGTCTCGTTCGGTTGGACCCGGGAGCCGTTAGTGATGTGCCTGAAGCAATCAAGTTCCTGGTCACCTGGCACACCATC
GACGCCGATGCTCCAGAGCTCAGCCATGTGCTGTGCTGGGCGCCCACGGACCCACCCACAGGCCTCTCCTACTTCTCCAGCATGTACCCG
CCGCACCCTCTCACGGCGCAGTACGGGGTGAAAGTCCTGCGGTCCTTCCCTCCGGACGCCATCCTCTTCTACATCCCCCAGATTGTGCAG
GCCCTCAGGTACGACAAGATGGGCTATGTGCGGGAGTATATTCTGTGGGCAGCGTCTAAATCCCAGCTTCTGGCACACCAGTTCATCTGG
AACATGAAGACTAACATTTATCTAGATGAAGAGGGCCACCAGAAAGACCCTGACATCGGCGACCTCCTGGATCAGTTGGTAGAGGAGATC
ACAGGCTCCTTGTCCGGCCCAGCGAAGGACTTTTACCAGCGGGAGTTTGATTTCTTTAACAAGATCACCAACGTGTCGGCTATCATCAAG
CCCTACCCTAAAGGCGACGAGAGAAAGAAGGCTTGTCTGTCGGCCCTGTCTGAAGTGAAGGTGCAGCCGGGCTGCTACCTGCCCAGCAAC
CCTGAGGCCATTGTGCTGGACATCGACTACAAGTCTGGGACCCCGATGCAGAGTGCTGCAAAAGCCCCATATCTGGCCAAGTTCAAGGTG
AAGCGATGTGGAGTTAGTGAACTTGAAAAAGAAGGTCTGCGGTGCCGCTCAGACTCCGAGGATGAGTGCAGCACGCAGGAGGCCGACGGC
CAGAAGATCTCCTGGCAGGCAGCCATCTTCAAGGTGGGAGACGACTGCCGGCAGGACATGCTGGCCCTGCAGATCATCGACCTCTTCAAG
AACATCTTCCAGCTGGTCGGCCTGGACCTCTTTGTTTTTCCCTACCGCGTGGTGGCCACTGCCCCTGGGTGCGGGGTGATCGAGTGCATC
CCCGACTGCACCTCCCGGGACCAGCTGGGCCGCCAGACAGACTTCGGCATGTACGACTACTTCACACGCCAGTACGGGGATGAGTCCACT
CTGGCCTTCCAGCAGGCCCGCTACAACTTCATCCGAAGCATGGCCGCCTACAGCCTCCTGCTGTTCCTGCTGCAGATCAAGGACAGACAC
AACGGCAACATTATGCTGGACAAGAAGGGTCATATCATCCACATCGACTTTGGCTTCATGTTTGAAAGCTCGCCGGGCGGCAATCTCGGC
TGGGAACCCGACATCAAGCTGACGGATGAGATGGTGATGATCATGGGGGGCAAGATGGAGGCCACACCCTTCAAGTGGTTCATGGAGATG
TGTGTCCGAGGCTACCTGGCTGTGCGGCCCTACATGGACGCGGTCGTCTCCCTGGTCACTCTCATGTTGGACACGGGCCTGCCCTGTTTT
CGCGGCCAGACAATCAAGCTCTTGAAGCACAGGTTTAGCCCCAACATGACTGAGCGCGAGGCTGCAAATTTCATCATGAAGGTCATCCAG
AGCTGCTTCCTCAGCAACAGGAGCCGGACCTACGACATGATCCAGTACTATCAGAATGACATCCCCTACTGAGGAGGGGACCTTCGAGGG
CCTCTGCCCCATGTGCCCTCAAAGCTGTCCCACAATCATGGAGCCCTGCGACCTCCCTGCCCTGCCGCCACATGCAGTGGAGGAGAGGCC
TGTGGCCCAAAGAACCTGGTAGCGCCTCCTGGGGCAGCACGTGGGTGGCGCAGCCTTGGTAACGCCATGGACTGCAGCGACAATCAATGG
ATGGTGCTGTCTATGCACAGGTGTGAGTCCTCTGTTTGCACTGGACATATTCCCTACCTGTCTTATTTCATAGGTACATGAAGTATTGTG

>103178_103178_2_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000402174_PI4KA_chr22_21193019_ENST00000255882_length(amino acids)=2092AA_BP=42
MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYL
LRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGI
SRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSA
FHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFS
DPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCI
KLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLN
VMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQI
LQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELL
MNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWY
EGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDP
DRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHL
LWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNW
VSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSA
LDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAE
IKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLL
HADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQ
GWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQW
KDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPP
HPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEIT
GSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVK
RCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIP
DCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGW
EPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQS

--------------------------------------------------------------
>103178_103178_3_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000406323_PI4KA_chr22_21193019_ENST00000255882_length(transcript)=6659nt_BP=150nt
TTTTCTTTCCATTTTATTTCCTAGATGCACCCACTGGGCCTATGTAATAACAATGACGAAGAGGACTTGTATGAATATGGCTGGGTAGGA
GTGGTGAAGCTGGAACAGCCAGAATTGGACCCGAAACCATGCCTCACTGTCCTAGGCAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTG
GATTTCCATGGGATCTTCCAGTTAGATGAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCAC
AAAGATTGTGTGGTTCCTTACCTTCTTCGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGA
GGTGCCCTCCCGGTTGCAGAGAGCTTCAGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAG
ATTTTAGAGGTGCTTTTGCAGGTTTTGCATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTAT
GCTATCCCATGCCTGATAGGAATCTCGCGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATC
CCTCCTCATTCCCTCCGTGTCCTGGAAGAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTG
CTGACTGTCTGTCAGGAGGGTACCCTGAAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCT
CCCAGTTCCCCTGGAGGATCTGCCTTTCACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCA
ACCATCAGCTCCAGCTTCTCAGTCTCTCCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTC
TTAAACCTGGTGAAGAAGATCGTTGAGGAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCT
GATCTCTACTACACTTCCTTCAGTGACCCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCG
ACCTCTTTTGTGAAGGAGATCCATGATTTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGAC
CGGATCCACAATGAGCTGAGCCCCCTCAAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAG
CAGGGTGCAGAAAACCTTTGCATCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTG
ATCTGCTGTCTGCAGGGTTTGGGCCGCCTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTC
ATCCCGTCCCCAGTTCTGGTGAAGCTCTACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAAT
GAGCATTCCGAGTCAACCCTGAACGTCATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAAC
ATCTGCAGGTGCCTGAAGGCTGGATTGACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCT
CAGGAGAGCGACAAGGACGCTCACTTGATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAG
GTCATGGAGCCCATTCTGCAGATCCTACAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGC
CTGGTTATCACCGGAAATCAATACATCTATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCA
GCCACCAAAGATTACAAGGACCACGGCTATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGAC
GAGCACCTGGTGGATGAGCTGCTCATGAACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGC
GAGAAGGGCCCTGCCCTAAAGGCTTCTAGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCTCACCCGACGACTGCCA
CCCATCAAAGAAGCTAAGCCTCGGTTACAGAAGCTCTTCCGAGACTTCTGGCTGTATTCCGTTCTGATGGGATTCGCTGTGGAGGGCTCA
GGACTCTGGCCAGAAGAATGGTACGAGGGGGTCTGTGAAATAGCCACTAAGTCCCCCTTGCTCACCTTTCCCAGCAAGGAGCCACTGCGG
TCCGTCCTCCAGTATAACTCAGCCATGAAGAATGACACGGTCACCCCCGCTGAGCTGAGTGAGCTCCGCAGCACTATCATCAACCTGCTG
GACCCCCCTCCCGAGGTGTCCGCACTCATCAACAAGCTGGACTTCGCCATGTCCACCTACCTCCTCTCTGTGTACCGGCTGGAGTACATG
AGGGTACTGCGTTCAACAGATCCTGATCGCTTCCAGGTAATGTTCTGCTACTTTGAGGATAAAGCTATTCAGAAAGACAAATCTGGGATG
ATGCAGTGTGTGATTGCAGTCGCGGACAAAGTATTCGATGCCTTCCTGAACATGATGGCGGATAAAGCCAAGACCAAGGAGAACGAGGAG
GAGCTGGAGCGGCACGCTCAGTTCCTGTTGGTGAACTTCAACCACATCCACAAGAGGATAAGGAGGGTGGCAGACAAGTATCTATCTGGT
CTGGTGGATAAGTTTCCCCACTTGCTCTGGAGCGGGACTGTGCTGAAGACCATGCTGGACATCCTGCAGACCCTGTCACTGTCACTGAGC
GCTGATATTCACAAGGATCAGCCTTACTATGACATCCCCGACGCCCCCTACCGGATCACGGTTCCTGACACGTACGAAGCCCGTGAGAGC
ATTGTGAAGGACTTCGCTGCACGCTGTGGGATGATCCTCCAGGAGGCCATGAAGTGGGCACCTACCGTCACCAAGTCCCACCTGCAGGAA
TATCTGAACAAACATCAGAACTGGGTATCGGGACTGTCCCAGCACACGGGGCTGGCCATGGCCACTGAGAGCATCCTTCACTTTGCTGGC
TACAACAAGCAGAACACAACTCTTGGGGCAACTCAGCTGAGCGAGCGCCCGGCCTGTGTGAAGAAAGACTACTCCAACTTCATGGCATCC
CTGAATCTGCGCAACCGCTACGCGGGCGAGGTGTATGGAATGATTCGGTTCTCAGGCACCACAGGCCAGATGTCTGACCTGAACAAAATG
ATGGTCCAGGATCTACATTCAGCTTTAGACCGCAGTCATCCTCAGCACTACACGCAGGCCATGTTCAAGCTGACCGCAATGCTCATTAGC
AGTAAAGATTGTGACCCGCAGCTCCTTCATCATCTGTGCTGGGGTCCCCTCCGGATGTTCAATGAGCATGGCATGGAGACGGCCCTGGCC
TGCTGGGAGTGGCTGCTGGCTGGCAAGGATGGAGTGGAAGTGCCGTTCATGCGGGAGATGGCAGGGGCCTGGCACATGACGGTGGAGCAG
AAATTTGGCCTGTTTTCTGCTGAGATAAAGGAAGCAGACCCCCTGGCTGCCTCGGAAGCAAGTCAACCCAAACCCTGTCCCCCCGAAGTG
ACCCCCCACTACATCTGGATCGACTTCCTGGTGCAGCGGTTTGAGATCGCCAAGTACTGCAGCTCTGACCAAGTGGAGATCTTCTCCAGC
CTGCTGCAGCGCTCCATGTCCCTGAACATCGGCGGGGCCAAGGGGAGCATGAACCGGCACGTGGCGGCCATCGGGCCCCGCTTCAAGCTG
CTGACCCTGGGGCTGTCCCTCCTGCATGCCGATGTGGTTCCAAATGCAACCATCCGCAATGTGCTTCGCGAGAAGATCTACTCCACTGCC
TTTGACTACTTCAGCTGTCCCCCAAAGTTCCCTACTCAAGGAGAGAAGCGGCTGCGTGAAGACATAAGCATCATGATTAAATTTTGGACC
GCCATGTTCTCAGATAAGAAGTACCTGACCGCCAGCCAGCTTGTTCCCCCAGATAATCAGGACACCCGGAGCAACCTGGACATAACTGTC
GGCTCTCGGCAACAAGCCACCCAAGGCTGGATCAACACATACCCCCTGTCCAGCGGCATGTCCACCATCTCCAAGAAATCAGGCATGTCT
AAGAAAACCAACCGGGGCTCCCAGCTGCACAAATACTACATGAAGCGCAGGACGCTGCTGCTGTCCCTGCTGGCCACTGAGATCGAGCGT
CTCATCACATGGTACAACCCGCTGTCAGCCCCGGAACTGGAACTAGACCAGGCCGGAGAGAACAGCGTGGCCAACTGGAGATCTAAGTAC
ATCAGCCTGAGTGAGAAGCAGTGGAAGGACAACGTGAACCTCGCCTGGAGCATCTCTCCCTACCTAGCCGTGCAGCTGCCTGCCAGGTTT
AAGAACACAGAAGCCATTGGGAACGAAGTGACCCGTCTCGTTCGGTTGGACCCGGGAGCCGTTAGTGATGTGCCTGAAGCAATCAAGTTC
CTGGTCACCTGGCACACCATCGACGCCGATGCTCCAGAGCTCAGCCATGTGCTGTGCTGGGCGCCCACGGACCCACCCACAGGCCTCTCC
TACTTCTCCAGCATGTACCCGCCGCACCCTCTCACGGCGCAGTACGGGGTGAAAGTCCTGCGGTCCTTCCCTCCGGACGCCATCCTCTTC
TACATCCCCCAGATTGTGCAGGCCCTCAGGTACGACAAGATGGGCTATGTGCGGGAGTATATTCTGTGGGCAGCGTCTAAATCCCAGCTT
CTGGCACACCAGTTCATCTGGAACATGAAGACTAACATTTATCTAGATGAAGAGGGCCACCAGAAAGACCCTGACATCGGCGACCTCCTG
GATCAGTTGGTAGAGGAGATCACAGGCTCCTTGTCCGGCCCAGCGAAGGACTTTTACCAGCGGGAGTTTGATTTCTTTAACAAGATCACC
AACGTGTCGGCTATCATCAAGCCCTACCCTAAAGGCGACGAGAGAAAGAAGGCTTGTCTGTCGGCCCTGTCTGAAGTGAAGGTGCAGCCG
GGCTGCTACCTGCCCAGCAACCCTGAGGCCATTGTGCTGGACATCGACTACAAGTCTGGGACCCCGATGCAGAGTGCTGCAAAAGCCCCA
TATCTGGCCAAGTTCAAGGTGAAGCGATGTGGAGTTAGTGAACTTGAAAAAGAAGGTCTGCGGTGCCGCTCAGACTCCGAGGATGAGTGC
AGCACGCAGGAGGCCGACGGCCAGAAGATCTCCTGGCAGGCAGCCATCTTCAAGGTGGGAGACGACTGCCGGCAGGACATGCTGGCCCTG
CAGATCATCGACCTCTTCAAGAACATCTTCCAGCTGGTCGGCCTGGACCTCTTTGTTTTTCCCTACCGCGTGGTGGCCACTGCCCCTGGG
TGCGGGGTGATCGAGTGCATCCCCGACTGCACCTCCCGGGACCAGCTGGGCCGCCAGACAGACTTCGGCATGTACGACTACTTCACACGC
CAGTACGGGGATGAGTCCACTCTGGCCTTCCAGCAGGCCCGCTACAACTTCATCCGAAGCATGGCCGCCTACAGCCTCCTGCTGTTCCTG
CTGCAGATCAAGGACAGACACAACGGCAACATTATGCTGGACAAGAAGGGTCATATCATCCACATCGACTTTGGCTTCATGTTTGAAAGC
TCGCCGGGCGGCAATCTCGGCTGGGAACCCGACATCAAGCTGACGGATGAGATGGTGATGATCATGGGGGGCAAGATGGAGGCCACACCC
TTCAAGTGGTTCATGGAGATGTGTGTCCGAGGCTACCTGGCTGTGCGGCCCTACATGGACGCGGTCGTCTCCCTGGTCACTCTCATGTTG
GACACGGGCCTGCCCTGTTTTCGCGGCCAGACAATCAAGCTCTTGAAGCACAGGTTTAGCCCCAACATGACTGAGCGCGAGGCTGCAAAT
TTCATCATGAAGGTCATCCAGAGCTGCTTCCTCAGCAACAGGAGCCGGACCTACGACATGATCCAGTACTATCAGAATGACATCCCCTAC
TGAGGAGGGGACCTTCGAGGGCCTCTGCCCCATGTGCCCTCAAAGCTGTCCCACAATCATGGAGCCCTGCGACCTCCCTGCCCTGCCGCC
ACATGCAGTGGAGGAGAGGCCTGTGGCCCAAAGAACCTGGTAGCGCCTCCTGGGGCAGCACGTGGGTGGCGCAGCCTTGGTAACGCCATG
GACTGCAGCGACAATCAATGGATGGTGCTGTCTATGCACAGGTGTGAGTCCTCTGTTTGCACTGGACATATTCCCTACCTGTCTTATTTC

>103178_103178_3_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000406323_PI4KA_chr22_21193019_ENST00000255882_length(amino acids)=2092AA_BP=42
MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYL
LRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGI
SRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSA
FHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFS
DPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCI
KLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLN
VMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQI
LQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELL
MNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWY
EGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDP
DRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHL
LWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNW
VSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSA
LDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAE
IKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLL
HADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQ
GWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQW
KDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPP
HPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEIT
GSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVK
RCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIP
DCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGW
EPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQS

--------------------------------------------------------------
>103178_103178_4_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000544604_PI4KA_chr22_21193019_ENST00000255882_length(transcript)=7110nt_BP=601nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGATGCACCCACTGGGCCTATGTAATAACAATGACGAAGAGGACTTGTATGAATATGGCTGGGTAGG
AGTGGTGAAGCTGGAACAGCCAGAATTGGACCCGAAACCATGCCTCACTGTCCTAGGCAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGT
GGATTTCCATGGGATCTTCCAGTTAGATGAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCA
CAAAGATTGTGTGGTTCCTTACCTTCTTCGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAG
AGGTGCCCTCCCGGTTGCAGAGAGCTTCAGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGA
GATTTTAGAGGTGCTTTTGCAGGTTTTGCATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTA
TGCTATCCCATGCCTGATAGGAATCTCGCGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAAT
CCCTCCTCATTCCCTCCGTGTCCTGGAAGAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCT
GCTGACTGTCTGTCAGGAGGGTACCCTGAAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCC
TCCCAGTTCCCCTGGAGGATCTGCCTTTCACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTC
AACCATCAGCTCCAGCTTCTCAGTCTCTCCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACT
CTTAAACCTGGTGAAGAAGATCGTTGAGGAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGC
TGATCTCTACTACACTTCCTTCAGTGACCCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCC
GACCTCTTTTGTGAAGGAGATCCATGATTTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGA
CCGGATCCACAATGAGCTGAGCCCCCTCAAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGA
GCAGGGTGCAGAAAACCTTTGCATCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCT
GATCTGCTGTCTGCAGGGTTTGGGCCGCCTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGT
CATCCCGTCCCCAGTTCTGGTGAAGCTCTACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAA
TGAGCATTCCGAGTCAACCCTGAACGTCATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAA
CATCTGCAGGTGCCTGAAGGCTGGATTGACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTC
TCAGGAGAGCGACAAGGACGCTCACTTGATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAA
GGTCATGGAGCCCATTCTGCAGATCCTACAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTG
CCTGGTTATCACCGGAAATCAATACATCTATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTC
AGCCACCAAAGATTACAAGGACCACGGCTATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGA
CGAGCACCTGGTGGATGAGCTGCTCATGAACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAG
CGAGAAGGGCCCTGCCCTAAAGGCTTCTAGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCTCACCCGACGACTGCC
ACCCATCAAAGAAGCTAAGCCTCGGTTACAGAAGCTCTTCCGAGACTTCTGGCTGTATTCCGTTCTGATGGGATTCGCTGTGGAGGGCTC
AGGACTCTGGCCAGAAGAATGGTACGAGGGGGTCTGTGAAATAGCCACTAAGTCCCCCTTGCTCACCTTTCCCAGCAAGGAGCCACTGCG
GTCCGTCCTCCAGTATAACTCAGCCATGAAGAATGACACGGTCACCCCCGCTGAGCTGAGTGAGCTCCGCAGCACTATCATCAACCTGCT
GGACCCCCCTCCCGAGGTGTCCGCACTCATCAACAAGCTGGACTTCGCCATGTCCACCTACCTCCTCTCTGTGTACCGGCTGGAGTACAT
GAGGGTACTGCGTTCAACAGATCCTGATCGCTTCCAGGTAATGTTCTGCTACTTTGAGGATAAAGCTATTCAGAAAGACAAATCTGGGAT
GATGCAGTGTGTGATTGCAGTCGCGGACAAAGTATTCGATGCCTTCCTGAACATGATGGCGGATAAAGCCAAGACCAAGGAGAACGAGGA
GGAGCTGGAGCGGCACGCTCAGTTCCTGTTGGTGAACTTCAACCACATCCACAAGAGGATAAGGAGGGTGGCAGACAAGTATCTATCTGG
TCTGGTGGATAAGTTTCCCCACTTGCTCTGGAGCGGGACTGTGCTGAAGACCATGCTGGACATCCTGCAGACCCTGTCACTGTCACTGAG
CGCTGATATTCACAAGGATCAGCCTTACTATGACATCCCCGACGCCCCCTACCGGATCACGGTTCCTGACACGTACGAAGCCCGTGAGAG
CATTGTGAAGGACTTCGCTGCACGCTGTGGGATGATCCTCCAGGAGGCCATGAAGTGGGCACCTACCGTCACCAAGTCCCACCTGCAGGA
ATATCTGAACAAACATCAGAACTGGGTATCGGGACTGTCCCAGCACACGGGGCTGGCCATGGCCACTGAGAGCATCCTTCACTTTGCTGG
CTACAACAAGCAGAACACAACTCTTGGGGCAACTCAGCTGAGCGAGCGCCCGGCCTGTGTGAAGAAAGACTACTCCAACTTCATGGCATC
CCTGAATCTGCGCAACCGCTACGCGGGCGAGGTGTATGGAATGATTCGGTTCTCAGGCACCACAGGCCAGATGTCTGACCTGAACAAAAT
GATGGTCCAGGATCTACATTCAGCTTTAGACCGCAGTCATCCTCAGCACTACACGCAGGCCATGTTCAAGCTGACCGCAATGCTCATTAG
CAGTAAAGATTGTGACCCGCAGCTCCTTCATCATCTGTGCTGGGGTCCCCTCCGGATGTTCAATGAGCATGGCATGGAGACGGCCCTGGC
CTGCTGGGAGTGGCTGCTGGCTGGCAAGGATGGAGTGGAAGTGCCGTTCATGCGGGAGATGGCAGGGGCCTGGCACATGACGGTGGAGCA
GAAATTTGGCCTGTTTTCTGCTGAGATAAAGGAAGCAGACCCCCTGGCTGCCTCGGAAGCAAGTCAACCCAAACCCTGTCCCCCCGAAGT
GACCCCCCACTACATCTGGATCGACTTCCTGGTGCAGCGGTTTGAGATCGCCAAGTACTGCAGCTCTGACCAAGTGGAGATCTTCTCCAG
CCTGCTGCAGCGCTCCATGTCCCTGAACATCGGCGGGGCCAAGGGGAGCATGAACCGGCACGTGGCGGCCATCGGGCCCCGCTTCAAGCT
GCTGACCCTGGGGCTGTCCCTCCTGCATGCCGATGTGGTTCCAAATGCAACCATCCGCAATGTGCTTCGCGAGAAGATCTACTCCACTGC
CTTTGACTACTTCAGCTGTCCCCCAAAGTTCCCTACTCAAGGAGAGAAGCGGCTGCGTGAAGACATAAGCATCATGATTAAATTTTGGAC
CGCCATGTTCTCAGATAAGAAGTACCTGACCGCCAGCCAGCTTGTTCCCCCAGATAATCAGGACACCCGGAGCAACCTGGACATAACTGT
CGGCTCTCGGCAACAAGCCACCCAAGGCTGGATCAACACATACCCCCTGTCCAGCGGCATGTCCACCATCTCCAAGAAATCAGGCATGTC
TAAGAAAACCAACCGGGGCTCCCAGCTGCACAAATACTACATGAAGCGCAGGACGCTGCTGCTGTCCCTGCTGGCCACTGAGATCGAGCG
TCTCATCACATGGTACAACCCGCTGTCAGCCCCGGAACTGGAACTAGACCAGGCCGGAGAGAACAGCGTGGCCAACTGGAGATCTAAGTA
CATCAGCCTGAGTGAGAAGCAGTGGAAGGACAACGTGAACCTCGCCTGGAGCATCTCTCCCTACCTAGCCGTGCAGCTGCCTGCCAGGTT
TAAGAACACAGAAGCCATTGGGAACGAAGTGACCCGTCTCGTTCGGTTGGACCCGGGAGCCGTTAGTGATGTGCCTGAAGCAATCAAGTT
CCTGGTCACCTGGCACACCATCGACGCCGATGCTCCAGAGCTCAGCCATGTGCTGTGCTGGGCGCCCACGGACCCACCCACAGGCCTCTC
CTACTTCTCCAGCATGTACCCGCCGCACCCTCTCACGGCGCAGTACGGGGTGAAAGTCCTGCGGTCCTTCCCTCCGGACGCCATCCTCTT
CTACATCCCCCAGATTGTGCAGGCCCTCAGGTACGACAAGATGGGCTATGTGCGGGAGTATATTCTGTGGGCAGCGTCTAAATCCCAGCT
TCTGGCACACCAGTTCATCTGGAACATGAAGACTAACATTTATCTAGATGAAGAGGGCCACCAGAAAGACCCTGACATCGGCGACCTCCT
GGATCAGTTGGTAGAGGAGATCACAGGCTCCTTGTCCGGCCCAGCGAAGGACTTTTACCAGCGGGAGTTTGATTTCTTTAACAAGATCAC
CAACGTGTCGGCTATCATCAAGCCCTACCCTAAAGGCGACGAGAGAAAGAAGGCTTGTCTGTCGGCCCTGTCTGAAGTGAAGGTGCAGCC
GGGCTGCTACCTGCCCAGCAACCCTGAGGCCATTGTGCTGGACATCGACTACAAGTCTGGGACCCCGATGCAGAGTGCTGCAAAAGCCCC
ATATCTGGCCAAGTTCAAGGTGAAGCGATGTGGAGTTAGTGAACTTGAAAAAGAAGGTCTGCGGTGCCGCTCAGACTCCGAGGATGAGTG
CAGCACGCAGGAGGCCGACGGCCAGAAGATCTCCTGGCAGGCAGCCATCTTCAAGGTGGGAGACGACTGCCGGCAGGACATGCTGGCCCT
GCAGATCATCGACCTCTTCAAGAACATCTTCCAGCTGGTCGGCCTGGACCTCTTTGTTTTTCCCTACCGCGTGGTGGCCACTGCCCCTGG
GTGCGGGGTGATCGAGTGCATCCCCGACTGCACCTCCCGGGACCAGCTGGGCCGCCAGACAGACTTCGGCATGTACGACTACTTCACACG
CCAGTACGGGGATGAGTCCACTCTGGCCTTCCAGCAGGCCCGCTACAACTTCATCCGAAGCATGGCCGCCTACAGCCTCCTGCTGTTCCT
GCTGCAGATCAAGGACAGACACAACGGCAACATTATGCTGGACAAGAAGGGTCATATCATCCACATCGACTTTGGCTTCATGTTTGAAAG
CTCGCCGGGCGGCAATCTCGGCTGGGAACCCGACATCAAGCTGACGGATGAGATGGTGATGATCATGGGGGGCAAGATGGAGGCCACACC
CTTCAAGTGGTTCATGGAGATGTGTGTCCGAGGCTACCTGGCTGTGCGGCCCTACATGGACGCGGTCGTCTCCCTGGTCACTCTCATGTT
GGACACGGGCCTGCCCTGTTTTCGCGGCCAGACAATCAAGCTCTTGAAGCACAGGTTTAGCCCCAACATGACTGAGCGCGAGGCTGCAAA
TTTCATCATGAAGGTCATCCAGAGCTGCTTCCTCAGCAACAGGAGCCGGACCTACGACATGATCCAGTACTATCAGAATGACATCCCCTA
CTGAGGAGGGGACCTTCGAGGGCCTCTGCCCCATGTGCCCTCAAAGCTGTCCCACAATCATGGAGCCCTGCGACCTCCCTGCCCTGCCGC
CACATGCAGTGGAGGAGAGGCCTGTGGCCCAAAGAACCTGGTAGCGCCTCCTGGGGCAGCACGTGGGTGGCGCAGCCTTGGTAACGCCAT
GGACTGCAGCGACAATCAATGGATGGTGCTGTCTATGCACAGGTGTGAGTCCTCTGTTTGCACTGGACATATTCCCTACCTGTCTTATTT
CATAGGTACATGAAGTATTGTGTATAAAAAAAGAGATAAGATTTAACCAACATCAACAAAATAAAAACCCAAAATAGTGCTGTGTTGGAA

>103178_103178_4_ZNRF3-PI4KA_ZNRF3_chr22_29383189_ENST00000544604_PI4KA_chr22_21193019_ENST00000255882_length(amino acids)=2192AA_BP=31
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
QHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGM
PPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT
PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI
QDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVE
GSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLE
YMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYL
SGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHL
QEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLN
KMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV
EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRF
KLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI
TVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRS
KYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTG
LSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGD
LLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAK
APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATA
PGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMF
ESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNRF3-PI4KA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNRF3-PI4KA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNRF3-PI4KA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource