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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNRF3-PREPL (FusionGDB2 ID:103179)

Fusion Gene Summary for ZNRF3-PREPL

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNRF3-PREPL
Fusion gene ID: 103179
HgeneTgene
Gene symbol

ZNRF3

PREPL

Gene ID

84133

9581

Gene namezinc and ring finger 3prolyl endopeptidase like
SynonymsBK747E2.3|RNF203CMS22
Cytomap

22q12.1

2p21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3prolyl endopeptidase-likeputative prolyl oligopeptidase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000544604, ENST00000332811, 
ENST00000402174, ENST00000406323, 
ENST00000540817, ENST00000260648, 
ENST00000378511, ENST00000378520, 
ENST00000409272, ENST00000409411, 
ENST00000409936, ENST00000409957, 
ENST00000410081, ENST00000541738, 
Fusion gene scores* DoF score26 X 11 X 18=51484 X 3 X 3=36
# samples 394
** MAII scorelog2(39/5148*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNRF3 [Title/Abstract] AND PREPL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNRF3(29280054)-PREPL(44556251), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNRF3

GO:0016567

protein ubiquitination

22575959


check buttonFusion gene breakpoints across ZNRF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PREPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-1665-01BZNRF3chr22

29280054

+PREPLchr2

44556251

-
ChimerDB4OVTCGA-09-1665ZNRF3chr22

29280054

+PREPLchr2

44556251

-


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Fusion Gene ORF analysis for ZNRF3-PREPL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000544604ENST00000540817ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000260648ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000378511ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000378520ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000409272ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000409411ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000409936ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000409957ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000410081ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-3CDSENST00000332811ENST00000541738ZNRF3chr22

29280054

+PREPLchr2

44556251

-
5UTR-intronENST00000332811ENST00000540817ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000260648ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000378511ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000378520ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000409272ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000409411ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000409936ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000409957ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000410081ZNRF3chr22

29280054

+PREPLchr2

44556251

-
In-frameENST00000544604ENST00000541738ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000260648ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000378511ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000378520ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000409272ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000409411ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000409936ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000409957ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000410081ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000402174ENST00000541738ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000260648ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000378511ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000378520ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000409272ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000409411ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000409936ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000409957ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000410081ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-3CDSENST00000406323ENST00000541738ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-intronENST00000402174ENST00000540817ZNRF3chr22

29280054

+PREPLchr2

44556251

-
intron-intronENST00000406323ENST00000540817ZNRF3chr22

29280054

+PREPLchr2

44556251

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544604ZNRF3chr2229280054+ENST00000541738PREPLchr244556251-50514751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000409411PREPLchr244556251-38994751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000409957PREPLchr244556251-38994751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000409936PREPLchr244556251-38964751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000260648PREPLchr244556251-18354751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000409272PREPLchr244556251-18354751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000410081PREPLchr244556251-17404751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000378520PREPLchr244556251-15944751751305376
ENST00000544604ZNRF3chr2229280054+ENST00000378511PREPLchr244556251-15894751751305376

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544604ENST00000541738ZNRF3chr2229280054+PREPLchr244556251-0.0002772080.9997228
ENST00000544604ENST00000409411ZNRF3chr2229280054+PREPLchr244556251-0.000278810.9997212
ENST00000544604ENST00000409957ZNRF3chr2229280054+PREPLchr244556251-0.000278810.9997212
ENST00000544604ENST00000409936ZNRF3chr2229280054+PREPLchr244556251-0.0002824540.99971753
ENST00000544604ENST00000260648ZNRF3chr2229280054+PREPLchr244556251-0.0011273720.9988726
ENST00000544604ENST00000409272ZNRF3chr2229280054+PREPLchr244556251-0.0011273720.9988726
ENST00000544604ENST00000410081ZNRF3chr2229280054+PREPLchr244556251-0.0013052960.9986947
ENST00000544604ENST00000378520ZNRF3chr2229280054+PREPLchr244556251-0.0013421040.9986578
ENST00000544604ENST00000378511ZNRF3chr2229280054+PREPLchr244556251-0.0013274980.9986725

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Fusion Genomic Features for ZNRF3-PREPL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNRF3-PREPL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29280054/chr2:44556251)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNRF3chr22:29280054chr2:44556251ENST00000332811+19241_9360837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr2:44556251ENST00000332811+1956_2190837.0Topological domainExtracellular
HgeneZNRF3chr22:29280054chr2:44556251ENST00000402174+19241_9360837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr2:44556251ENST00000402174+1956_2190837.0Topological domainExtracellular
HgeneZNRF3chr22:29280054chr2:44556251ENST00000406323+18241_9360837.0Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr2:44556251ENST00000406323+1856_2190837.0Topological domainExtracellular
HgeneZNRF3chr22:29280054chr2:44556251ENST00000544604+19241_936100937.0Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr2:44556251ENST00000544604+1956_219100937.0Topological domainExtracellular
HgeneZNRF3chr22:29280054chr2:44556251ENST00000332811+19220_2400837.0TransmembraneHelical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000402174+19220_2400837.0TransmembraneHelical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000406323+18220_2400837.0TransmembraneHelical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000544604+19220_240100937.0TransmembraneHelical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000332811+19293_3340837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000402174+19293_3340837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000406323+18293_3340837.0Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr2:44556251ENST00000544604+19293_334100937.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for ZNRF3-PREPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>103179_103179_1_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000260648_length(transcript)=1835nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG

>103179_103179_1_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000260648_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_2_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000378511_length(transcript)=1589nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA

>103179_103179_2_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000378511_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_3_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000378520_length(transcript)=1594nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA

>103179_103179_3_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000378520_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_4_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409272_length(transcript)=1835nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG

>103179_103179_4_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409272_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_5_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409411_length(transcript)=3899nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG
CTATCTGAATAAAGTTATAAGCTCCTATAAGCCATAATTTACTTTTAAACATTTTATTTTTTTCAAAACATTTGAGAACCTTTCTTAAAG
CAGTTACATTCAAGCTACAGAAATATCGAAGAATTAATGATTGTTCACCAAGCAGCATGCTGTACATGAAGCTATTACAAATGCTTACAA
TCCCACTGAAATGCCAGTGTCTTCATCTCTTCATAAAGGTGCCTAACACGAGGTATACAGTATGTTCAGTACACTGGAATAGCATGCTCG
ATTGGAAACAAAGCATCTATCTCTGAAAGCTGTTTGGCGATGAAGGAGATTCTTCGTGTTGTGTTCAAAGATGAGTCCCTCTCCCTTGTC
CAGAAAAATGCCACTTGTATCAACTTTACTGCCTTTGTCGGCAGAATTGGTACTTAACCTTATTCTCATTTTAGCGGGAAGGCCCGAAAT
CATATTATGTAGATTTAACAGTGTTGATTCTCCAAAATTCAGAACCACGATAAAGATTCTGTCGATGCCATCCAGCTCTCTTGTGTACAC
AACATAGTGGCTGTCATTCCTCAAATGGCAAAACCAGCCCCTGTTGAGGAGTAGCTCATTGGCATGAAGTAGACTTAAATCTTGATATAA
CTTCAAAGCCGATCTGGGCTGAGTCTTTTGGACCTATTTTTTTAAAAAAGTATTTACGTAAGTGTTTGATTCTAAGAATTGTTTGTAAGT
ATTTTTAATATATTGTAAGGAGTTATTTACCCAAAACACTTGCTCCAATTTTGCCCCTTATAATTGCCAAATTGTAAGCATCAATAAGTA
GGTAAGAACAATTTATATAAAAACTGATAGAAATGACAAATTCGGGGTTTCGGCTTGTCTGGGAGTCAATAAGTACGCACAGTGCTCTGC
TACATTGTAGAGTTTCTGTAGAGATCAAATTTGACTCCACTTTAGGAGTCCCAAAGCAAATGTCCATGTCTAAGATGAATATTTAACTTG
CATAGTCATTCTGTGCTATATTGTAACTGCCAGATGGCCAGAAAGAAGGCAACAGTGGACTCAGACTTCTGAGGAATTTGGGTTTGTTCC
CCTTTGTAGACTAATGTGTAGGTTGCTGTTGTGCGAAGATCGTGTAACTTTAGCAGACATGTATTTCTTGCACAGCTAATAGAAGACAAA
GTTGAAAAAAAGGATGCAAAATAAAAAGCTGCCTAAGGTGAAAGTTAGAAATTGTAGACTTTTTTTTACCATAATAGTATGTGTTCATTA
AAGATGATTTGGGTTTATTTTACAGCTATATAAAACATAATTTGATGATGTACTTCTAACCTTTCAAGCATTTTCTGTTATTGACTATAT
AATATAGCCTCCATAAATGTTTTTAATGACAATATTCTGTTGAACGGTTGTACCATACTCAGCCATGCCCTTTCATTTTGACGATAGTGT
TTCTAATATTTTGTATTTTTATTCCCCTCCCCCCATTTTTGTATTACTTAAGATAGATTATCAGAAAGACAGTTACTTTGTCAAAGAGTA
TGGGCACTTGATACATAATGCCAAATTATTCTTCATAAGAGCTGTTGCCAAATCAGTGATAATGTTCATTTAATTGTATTCTTGCCAGCC
ATGTTTACTGGGGTGATAGTTGTTATTGTGGTTGTTATTGTTCTTTAGGGGTAGGTTCCCAATATGTGGTCTTTAAATAATTATCTAATG
GTGTTTAAAAAGATGTTTATTCTGTTTGTCAGGTACAAAGATATTTATGATACATGTATGACTTGTCTAAGTTATTAACATTTTCTCTAG
CCTTAGGTAATGCATGAAAGCACATGTTTCAGTGCCACTCACATAAGAAGTGCCCGGTAAGTGTTAGCTATTATTGTCTACTTGAGTTAC
TACTTTCTAAAAGTATGTTGAAGTCTTTTTCTGTAATTGCAGATTTGTTGATTTTGCATTTGAGTATTTTCTATATTTTGAAGCTGTTAG
ATGCGTAGTCATGATTTTTGGTGGAATGTTTTATCAATTTTTGAAAATTGCCTTTGTCTCATATAATGCTTTTCATATTGAACTATATTT

>103179_103179_5_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409411_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_6_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409936_length(transcript)=3896nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG
CTATCTGAATAAAGTTATAAGCTCCTATAAGCCATAATTTACTTTTAAACATTTTATTTTTTTCAAAACATTTGAGAACCTTTCTTAAAG
CAGTTACATTCAAGCTACAGAAATATCGAAGAATTAATGATTGTTCACCAAGCAGCATGCTGTACATGAAGCTATTACAAATGCTTACAA
TCCCACTGAAATGCCAGTGTCTTCATCTCTTCATAAAGGTGCCTAACACGAGGTATACAGTATGTTCAGTACACTGGAATAGCATGCTCG
ATTGGAAACAAAGCATCTATCTCTGAAAGCTGTTTGGCGATGAAGGAGATTCTTCGTGTTGTGTTCAAAGATGAGTCCCTCTCCCTTGTC
CAGAAAAATGCCACTTGTATCAACTTTACTGCCTTTGTCGGCAGAATTGGTACTTAACCTTATTCTCATTTTAGCGGGAAGGCCCGAAAT
CATATTATGTAGATTTAACAGTGTTGATTCTCCAAAATTCAGAACCACGATAAAGATTCTGTCGATGCCATCCAGCTCTCTTGTGTACAC
AACATAGTGGCTGTCATTCCTCAAATGGCAAAACCAGCCCCTGTTGAGGAGTAGCTCATTGGCATGAAGTAGACTTAAATCTTGATATAA
CTTCAAAGCCGATCTGGGCTGAGTCTTTTGGACCTATTTTTTTAAAAAAGTATTTACGTAAGTGTTTGATTCTAAGAATTGTTTGTAAGT
ATTTTTAATATATTGTAAGGAGTTATTTACCCAAAACACTTGCTCCAATTTTGCCCCTTATAATTGCCAAATTGTAAGCATCAATAAGTA
GGTAAGAACAATTTATATAAAAACTGATAGAAATGACAAATTCGGGGTTTCGGCTTGTCTGGGAGTCAATAAGTACGCACAGTGCTCTGC
TACATTGTAGAGTTTCTGTAGAGATCAAATTTGACTCCACTTTAGGAGTCCCAAAGCAAATGTCCATGTCTAAGATGAATATTTAACTTG
CATAGTCATTCTGTGCTATATTGTAACTGCCAGATGGCCAGAAAGAAGGCAACAGTGGACTCAGACTTCTGAGGAATTTGGGTTTGTTCC
CCTTTGTAGACTAATGTGTAGGTTGCTGTTGTGCGAAGATCGTGTAACTTTAGCAGACATGTATTTCTTGCACAGCTAATAGAAGACAAA
GTTGAAAAAAAGGATGCAAAATAAAAAGCTGCCTAAGGTGAAAGTTAGAAATTGTAGACTTTTTTTTACCATAATAGTATGTGTTCATTA
AAGATGATTTGGGTTTATTTTACAGCTATATAAAACATAATTTGATGATGTACTTCTAACCTTTCAAGCATTTTCTGTTATTGACTATAT
AATATAGCCTCCATAAATGTTTTTAATGACAATATTCTGTTGAACGGTTGTACCATACTCAGCCATGCCCTTTCATTTTGACGATAGTGT
TTCTAATATTTTGTATTTTTATTCCCCTCCCCCCATTTTTGTATTACTTAAGATAGATTATCAGAAAGACAGTTACTTTGTCAAAGAGTA
TGGGCACTTGATACATAATGCCAAATTATTCTTCATAAGAGCTGTTGCCAAATCAGTGATAATGTTCATTTAATTGTATTCTTGCCAGCC
ATGTTTACTGGGGTGATAGTTGTTATTGTGGTTGTTATTGTTCTTTAGGGGTAGGTTCCCAATATGTGGTCTTTAAATAATTATCTAATG
GTGTTTAAAAAGATGTTTATTCTGTTTGTCAGGTACAAAGATATTTATGATACATGTATGACTTGTCTAAGTTATTAACATTTTCTCTAG
CCTTAGGTAATGCATGAAAGCACATGTTTCAGTGCCACTCACATAAGAAGTGCCCGGTAAGTGTTAGCTATTATTGTCTACTTGAGTTAC
TACTTTCTAAAAGTATGTTGAAGTCTTTTTCTGTAATTGCAGATTTGTTGATTTTGCATTTGAGTATTTTCTATATTTTGAAGCTGTTAG
ATGCGTAGTCATGATTTTTGGTGGAATGTTTTATCAATTTTTGAAAATTGCCTTTGTCTCATATAATGCTTTTCATATTGAACTATATTT

>103179_103179_6_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409936_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_7_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409957_length(transcript)=3899nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG
CTATCTGAATAAAGTTATAAGCTCCTATAAGCCATAATTTACTTTTAAACATTTTATTTTTTTCAAAACATTTGAGAACCTTTCTTAAAG
CAGTTACATTCAAGCTACAGAAATATCGAAGAATTAATGATTGTTCACCAAGCAGCATGCTGTACATGAAGCTATTACAAATGCTTACAA
TCCCACTGAAATGCCAGTGTCTTCATCTCTTCATAAAGGTGCCTAACACGAGGTATACAGTATGTTCAGTACACTGGAATAGCATGCTCG
ATTGGAAACAAAGCATCTATCTCTGAAAGCTGTTTGGCGATGAAGGAGATTCTTCGTGTTGTGTTCAAAGATGAGTCCCTCTCCCTTGTC
CAGAAAAATGCCACTTGTATCAACTTTACTGCCTTTGTCGGCAGAATTGGTACTTAACCTTATTCTCATTTTAGCGGGAAGGCCCGAAAT
CATATTATGTAGATTTAACAGTGTTGATTCTCCAAAATTCAGAACCACGATAAAGATTCTGTCGATGCCATCCAGCTCTCTTGTGTACAC
AACATAGTGGCTGTCATTCCTCAAATGGCAAAACCAGCCCCTGTTGAGGAGTAGCTCATTGGCATGAAGTAGACTTAAATCTTGATATAA
CTTCAAAGCCGATCTGGGCTGAGTCTTTTGGACCTATTTTTTTAAAAAAGTATTTACGTAAGTGTTTGATTCTAAGAATTGTTTGTAAGT
ATTTTTAATATATTGTAAGGAGTTATTTACCCAAAACACTTGCTCCAATTTTGCCCCTTATAATTGCCAAATTGTAAGCATCAATAAGTA
GGTAAGAACAATTTATATAAAAACTGATAGAAATGACAAATTCGGGGTTTCGGCTTGTCTGGGAGTCAATAAGTACGCACAGTGCTCTGC
TACATTGTAGAGTTTCTGTAGAGATCAAATTTGACTCCACTTTAGGAGTCCCAAAGCAAATGTCCATGTCTAAGATGAATATTTAACTTG
CATAGTCATTCTGTGCTATATTGTAACTGCCAGATGGCCAGAAAGAAGGCAACAGTGGACTCAGACTTCTGAGGAATTTGGGTTTGTTCC
CCTTTGTAGACTAATGTGTAGGTTGCTGTTGTGCGAAGATCGTGTAACTTTAGCAGACATGTATTTCTTGCACAGCTAATAGAAGACAAA
GTTGAAAAAAAGGATGCAAAATAAAAAGCTGCCTAAGGTGAAAGTTAGAAATTGTAGACTTTTTTTTACCATAATAGTATGTGTTCATTA
AAGATGATTTGGGTTTATTTTACAGCTATATAAAACATAATTTGATGATGTACTTCTAACCTTTCAAGCATTTTCTGTTATTGACTATAT
AATATAGCCTCCATAAATGTTTTTAATGACAATATTCTGTTGAACGGTTGTACCATACTCAGCCATGCCCTTTCATTTTGACGATAGTGT
TTCTAATATTTTGTATTTTTATTCCCCTCCCCCCATTTTTGTATTACTTAAGATAGATTATCAGAAAGACAGTTACTTTGTCAAAGAGTA
TGGGCACTTGATACATAATGCCAAATTATTCTTCATAAGAGCTGTTGCCAAATCAGTGATAATGTTCATTTAATTGTATTCTTGCCAGCC
ATGTTTACTGGGGTGATAGTTGTTATTGTGGTTGTTATTGTTCTTTAGGGGTAGGTTCCCAATATGTGGTCTTTAAATAATTATCTAATG
GTGTTTAAAAAGATGTTTATTCTGTTTGTCAGGTACAAAGATATTTATGATACATGTATGACTTGTCTAAGTTATTAACATTTTCTCTAG
CCTTAGGTAATGCATGAAAGCACATGTTTCAGTGCCACTCACATAAGAAGTGCCCGGTAAGTGTTAGCTATTATTGTCTACTTGAGTTAC
TACTTTCTAAAAGTATGTTGAAGTCTTTTTCTGTAATTGCAGATTTGTTGATTTTGCATTTGAGTATTTTCTATATTTTGAAGCTGTTAG
ATGCGTAGTCATGATTTTTGGTGGAATGTTTTATCAATTTTTGAAAATTGCCTTTGTCTCATATAATGCTTTTCATATTGAACTATATTT

>103179_103179_7_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000409957_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_8_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000410081_length(transcript)=1740nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA

>103179_103179_8_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000410081_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------
>103179_103179_9_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000541738_length(transcript)=5051nt_BP=475nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGATGGAAAATTAGTGCCAATGACTGTTTTCCACAAAACTGACTCTGAGGACTTGCAGAAGAAACC
TCTCTTGGTACATGTATATGGAGCTTATGGAATGGATTTGAAAATGAATTTCAGGCCTGAGAGGCGGGTCCTGGTGGATGATGGATGGAT
ATTAGCATACTGCCATGTTCGAGGTGGTGGTGAGTTAGGCCTCCAGTGGCACGCTGATGGCCGCCTAACTAAAAAACTCAATGGCCTTGC
TGATTTAGAGGCTTGCATTAAGACGCTTCATGGCCAAGGCTTTTCTCAGCCAAGTCTAACAACCCTGACTGCTTTCAGTGCTGGAGGGGT
GCTTGCAGGAGCATTGTGTAATTCTAATCCAGAGCTGGTGAGAGCGGTGACTTTGGAGGCACCTTTCTTGGATGTTCTCAACACCATGAT
GGACACTACACTTCCTCTGACATTAGAAGAATTAGAAGAATGGGGGAATCCTTCATCTGATGAAAAACACAAGAACTACATAAAACGTTA
CTGTCCCTATCAAAATATTAAACCTCAGCATTATCCTTCAATTCACATAACGGCATATGAAAACGATGAACGGGTACCTCTGAAAGGAAT
TGTAAGTTATACTGAGAAACTCAAGGAAGCCATCGCGGAGCATGCTAAGGACACAGGTGAAGGCTATCAGACCCCTAATATTATTCTAGA
TATTCAGCCTGGAGGCAATCATGTAATTGAGGATTCTCACAAAAAGATTACAGCCCAAATTAAATTCCTGTACGAGGAACTTGGACTTGA
CAGCACCAGTGTTTTCGAGGATCTTAAGAAATACCTGAAATTCTGAAACACTGCATTCAACTGGGAATTGGAAACACACTGAAATATTTC
ATAGTCTTACTTCCAATTGAGTTAGCAAAAAAAAAATTAATAACTTGAGACTTTTAAGTTATTAATTTTTTAAAATGTGCTTCTCCATCT
AAATTTTGCTTAGTCTACATCTCACTTGCTTATACTATTCTCTCCATTGATGCACATGCCCATTAACCTAGGAAAGTAATTTTCAAATCA
TGCTCCTTAGAAGGATGTGGAGTAGAGGGAAGGGAAGGATTGGTGATAGCAGAGCTCCAGGCCTCCCTTCCAGTCAGAACAGTTGAGCAG
TTTACAAATTAGTGTCCTGCCTCTTTGCTAGCAAATGCTTTTAGACACTGTGGCAGTGAGTCATCCTCTAATTTCTATGACTGCATTTTA
AGGGAAAAGATAAAATTCTTCCCCTTAAAATTCGTTAAAGTTTTTGAATAATCTGGGGTCCTAATGTGTTCTGGTCATCCCTGATTGATG
CTATCTGAATAAAGTTATAAGCTCCTATAAGCCATAATTTACTTTTAAACATTTTATTTTTTTCAAAACATTTGAGAACCTTTCTTAAAG
CAGTTACATTCAAGCTACAGAAATATCGAAGAATTAATGATTGTTCACCAAGCAGCATGCTGTACATGAAGCTATTACAAATGCTTACAA
TCCCACTGAAATGCCAGTGTCTTCATCTCTTCATAAAGGTGCCTAACACGAGGTATACAGTATGTTCAGTACACTGGAATAGCATGCTCG
ATTGGAAACAAAGCATCTATCTCTGAAAGCTGTTTGGCGATGAAGGAGATTCTTCGTGTTGTGTTCAAAGATGAGTCCCTCTCCCTTGTC
CAGAAAAATGCCACTTGTATCAACTTTACTGCCTTTGTCGGCAGAATTGGTACTTAACCTTATTCTCATTTTAGCGGGAAGGCCCGAAAT
CATATTATGTAGATTTAACAGTGTTGATTCTCCAAAATTCAGAACCACGATAAAGATTCTGTCGATGCCATCCAGCTCTCTTGTGTACAC
AACATAGTGGCTGTCATTCCTCAAATGGCAAAACCAGCCCCTGTTGAGGAGTAGCTCATTGGCATGAAGTAGACTTAAATCTTGATATAA
CTTCAAAGCCGATCTGGGCTGAGTCTTTTGGACCTATTTTTTTAAAAAAGTATTTACGTAAGTGTTTGATTCTAAGAATTGTTTGTAAGT
ATTTTTAATATATTGTAAGGAGTTATTTACCCAAAACACTTGCTCCAATTTTGCCCCTTATAATTGCCAAATTGTAAGCATCAATAAGTA
GGTAAGAACAATTTATATAAAAACTGATAGAAATGACAAATTCGGGGTTTCGGCTTGTCTGGGAGTCAATAAGTACGCACAGTGCTCTGC
TACATTGTAGAGTTTCTGTAGAGATCAAATTTGACTCCACTTTAGGAGTCCCAAAGCAAATGTCCATGTCTAAGATGAATATTTAACTTG
CATAGTCATTCTGTGCTATATTGTAACTGCCAGATGGCCAGAAAGAAGGCAACAGTGGACTCAGACTTCTGAGGAATTTGGGTTTGTTCC
CCTTTGTAGACTAATGTGTAGGTTGCTGTTGTGCGAAGATCGTGTAACTTTAGCAGACATGTATTTCTTGCACAGCTAATAGAAGACAAA
GTTGAAAAAAAGGATGCAAAATAAAAAGCTGCCTAAGGTGAAAGTTAGAAATTGTAGACTTTTTTTTACCATAATAGTATGTGTTCATTA
AAGATGATTTGGGTTTATTTTACAGCTATATAAAACATAATTTGATGATGTACTTCTAACCTTTCAAGCATTTTCTGTTATTGACTATAT
AATATAGCCTCCATAAATGTTTTTAATGACAATATTCTGTTGAACGGTTGTACCATACTCAGCCATGCCCTTTCATTTTGACGATAGTGT
TTCTAATATTTTGTATTTTTATTCCCCTCCCCCCATTTTTGTATTACTTAAGATAGATTATCAGAAAGACAGTTACTTTGTCAAAGAGTA
TGGGCACTTGATACATAATGCCAAATTATTCTTCATAAGAGCTGTTGCCAAATCAGTGATAATGTTCATTTAATTGTATTCTTGCCAGCC
ATGTTTACTGGGGTGATAGTTGTTATTGTGGTTGTTATTGTTCTTTAGGGGTAGGTTCCCAATATGTGGTCTTTAAATAATTATCTAATG
GTGTTTAAAAAGATGTTTATTCTGTTTGTCAGGTACAAAGATATTTATGATACATGTATGACTTGTCTAAGTTATTAACATTTTCTCTAG
CCTTAGGTAATGCATGAAAGCACATGTTTCAGTGCCACTCACATAAGAAGTGCCCGGTAAGTGTTAGCTATTATTGTCTACTTGAGTTAC
TACTTTCTAAAAGTATGTTGAAGTCTTTTTCTGTAATTGCAGATTTGTTGATTTTGCATTTGAGTATTTTCTATATTTTGAAGCTGTTAG
ATGCGTAGTCATGATTTTTGGTGGAATGTTTTATCAATTTTTGAAAATTGCCTTTGTCTCATATAATGCTTTTCATATTGAACTATATTT
TGTCTGCTATTAAATACTTCCAAGCCTGATTTTTGTAATTTTATTTTTTATTCAATTACAAGAATACATACTATAAAAAGGTTTTCTTCA
ACACCTTTCCATAGCTTCACAGTTCCCCTCAGAGACAGGCACTATATGTTCTTTTGTTTTTAATGTATCATATGTTTGCATAGGCACAGA
ATGTATCATTTCATATGTTTATATATTTTTCTTTACACAGTTGGTGATATGTTACCATTCTATACTTTATTGAATACCTGTTTGAAATGG
TCTCATATCAATGTATATAGAACTGTCATTTTTAAAAGCTGCATACTGGGCCCATAGTTGATAGAACTGGTTTTCTGTTGATAAAATATT
TAAATCATTTCTTGTGTCTTCTATTAAAAACAAATTTTGCAGGCCAGGCAAGGTGGCTCAGGCCCGTAATCCTAGCACTTTGGGAGGCAA
GGCAGACAGATCACCAGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACACCATCTCTACTAAAAAATACAGAAATTACCC
GGGCATAATGACGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGCAGCAGGAGAATCACTTGAACCCAGGAAGCAGAGGCTGCAGTGTG
CCGAGATCACGCCACTGCACTCGAGCATGGGTGACGGAGCAAGACTGTCTCAAAAAAAAAAAAAAACAGTGTTGAGATCCTTTAAGTATT
ATTGTGCACATGTGCAAATATTTCTAAGTATTAGGAATGGAATTATTAGGTCAAAAGATAACTTCATTTTTTGTGTTTATAGCTATAGCT
GGGTTGCAAGCTTTCTATTATTTGCTTGCTATATCTTCATTTTAATTCTTTGTGTTTTATGTTAGTGTTTCTTATGTCTGTTTTTGTTAT
CTGAGTGGTTTTATCTTTTAATAGGCTAATTTAACCCATTCATATTTGTAATTATTGTATTATTTAGACATAATTCGGAAGCCCTATTTT
ATTTGTAGTTATACTATTGTTTAGGGTTTTTTTCTATTAAGCTTTTTGTTGGATTGACTGTATAATTTTTTTCTTCTAGTATTCTTTGAA
AATTTGAAAATTGTTATATTTTATGTCTAGTGTTCTTTGAAAATAATTCTTTGAAAATTATTTTTATGTCCTAATTTTACCATTAAAATT

>103179_103179_9_ZNRF3-PREPL_ZNRF3_chr22_29280054_ENST00000544604_PREPL_chr2_44556251_ENST00000541738_length(amino acids)=376AA_BP=100
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNG
LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIK
RYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNRF3-PREPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNRF3-PREPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNRF3-PREPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource