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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZP3-ST7 (FusionGDB2 ID:103188)

Fusion Gene Summary for ZP3-ST7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZP3-ST7
Fusion gene ID: 103188
HgeneTgene
Gene symbol

ZP3

ST7

Gene ID

7784

93655

Gene namezona pellucida glycoprotein 3ST7 overlapping transcript 3
SynonymsOOMD3|ZP3A|ZP3B|ZPC|Zp-3NCRNA00026|ST7|ST7OT3
Cytomap

7q11.23

7q31.2

Type of geneprotein-codingncRNA
Descriptionzona pellucida sperm-binding protein 3ZP3A/ZP3Bsperm receptorzona pellucida glycoprotein 3Bzona pellucida glycoprotein ZP3zona pellucida protein CST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336517, ENST00000394857, 
ENST00000416245, ENST00000467555, 
ENST00000393443, ENST00000393444, 
ENST00000393447, ENST00000465133, 
ENST00000487459, ENST00000265437, 
ENST00000323984, ENST00000393446, 
ENST00000393449, ENST00000393451, 
ENST00000422922, ENST00000432298, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 10 X 8=1040
# samples 214
** MAII scorelog2(2/8*10)=1.32192809488736log2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZP3 [Title/Abstract] AND ST7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZP3(76058950)-ST7(116849841), # samples:1
Anticipated loss of major functional domain due to fusion event.ZP3-ST7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZP3-ST7 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZP3

GO:0002922

positive regulation of humoral immune response

19004505

HgeneZP3

GO:0007339

binding of sperm to zona pellucida

19246320|19700799

HgeneZP3

GO:2000344

positive regulation of acrosome reaction

11751269|18667750|20394732

HgeneZP3

GO:2000360

negative regulation of binding of sperm to zona pellucida

18667750

HgeneZP3

GO:2000368

positive regulation of acrosomal vesicle exocytosis

19246320


check buttonFusion gene breakpoints across ZP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ST7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4690-01AZP3chr7

76058950

+ST7chr7

116849841

+


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Fusion Gene ORF analysis for ZP3-ST7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336517ENST00000393443ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000336517ENST00000393444ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000336517ENST00000393447ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000336517ENST00000465133ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000336517ENST00000487459ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000394857ENST00000393443ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000394857ENST00000393444ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000394857ENST00000393447ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000394857ENST00000465133ZP3chr7

76058950

+ST7chr7

116849841

+
5CDS-intronENST00000394857ENST00000487459ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000265437ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000323984ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000393446ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000393449ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000393451ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000422922ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-3CDSENST00000416245ENST00000432298ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-intronENST00000416245ENST00000393443ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-intronENST00000416245ENST00000393444ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-intronENST00000416245ENST00000393447ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-intronENST00000416245ENST00000465133ZP3chr7

76058950

+ST7chr7

116849841

+
5UTR-intronENST00000416245ENST00000487459ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000265437ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000323984ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000393446ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000393449ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000393451ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000422922ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000336517ENST00000432298ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000265437ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000323984ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000393446ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000393449ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000393451ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000422922ZP3chr7

76058950

+ST7chr7

116849841

+
Frame-shiftENST00000394857ENST00000432298ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000265437ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000323984ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000393446ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000393449ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000393451ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000422922ZP3chr7

76058950

+ST7chr7

116849841

+
intron-3CDSENST00000467555ENST00000432298ZP3chr7

76058950

+ST7chr7

116849841

+
intron-intronENST00000467555ENST00000393443ZP3chr7

76058950

+ST7chr7

116849841

+
intron-intronENST00000467555ENST00000393444ZP3chr7

76058950

+ST7chr7

116849841

+
intron-intronENST00000467555ENST00000393447ZP3chr7

76058950

+ST7chr7

116849841

+
intron-intronENST00000467555ENST00000465133ZP3chr7

76058950

+ST7chr7

116849841

+
intron-intronENST00000467555ENST00000487459ZP3chr7

76058950

+ST7chr7

116849841

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZP3-ST7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZP3chr776058950+ST7chr7116849840+1.96E-060.9999981
ZP3chr776058950+ST7chr7116849840+1.96E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZP3-ST7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76058950/:116849841)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZP3-ST7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZP3-ST7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZP3-ST7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZP3-ST7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource