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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZSWIM6-NDUFAF2 (FusionGDB2 ID:103291)

Fusion Gene Summary for ZSWIM6-NDUFAF2

Fusion gene summary

Fusion gene information	Fusion gene name: ZSWIM6-NDUFAF2
	Fusion gene ID: 103291
		Hgene	Tgene
	Gene symbol	ZSWIM6	NDUFAF2
	Gene ID	57688	91942
	Gene name	zinc finger SWIM-type containing 6	NADH:ubiquinone oxidoreductase complex assembly factor 2
	Synonyms	AFND\|NEDMAGA	B17.2L\|MC1DN10\|MMTN\|NDUFA12L\|mimitin
	Cytomap	5q12.1	5q12.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger SWIM domain-containing protein 6zinc finger, SWIM domain containing 6	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q8N183
	Ensembl transtripts involved in fusion gene	ENST00000252744,	ENST00000511107, ENST00000512623, ENST00000296597,
Fusion gene scores	* DoF score	7 X 6 X 4=168	13 X 7 X 9=819
	# samples	9	15
	** MAII score	log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/819*10)=-2.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZSWIM6 [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZSWIM6(60628775)-NDUFAF2(60394819), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZSWIM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-94-8491	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+
ChimerDB4	LUSC	TCGA-94-8491	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368952	+
ChimerDB4	SKCM	TCGA-FS-A4FC-06A	ZSWIM6	chr5	60628775	-	NDUFAF2	chr5	60394819	+
ChimerDB4	SKCM	TCGA-FS-A4FC-06A	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394819	+
ChimerDB4	SKCM	TCGA-FS-A4FC-06A	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448531	+

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Fusion Gene ORF analysis for ZSWIM6-NDUFAF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000252744	ENST00000511107	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448531	+
5CDS-3UTR	ENST00000252744	ENST00000512623	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000252744	ENST00000512623	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000252744	ENST00000512623	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394819	+
5CDS-3UTR	ENST00000252744	ENST00000512623	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448531	+
5CDS-intron	ENST00000252744	ENST00000511107	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000252744	ENST00000511107	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368952	+
Frame-shift	ENST00000252744	ENST00000511107	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394819	+
In-frame	ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+
In-frame	ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368952	+
In-frame	ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394819	+
In-frame	ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448531	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000252744

ZSWIM6

chr5

60628775

ENST00000296597

NDUFAF2

chr5

60368951

1130

676

1058

352

ENST00000252744

ZSWIM6

chr5

60628775

ENST00000296597

NDUFAF2

chr5

60368952

1130

676

1058

352

ENST00000252744

ZSWIM6

chr5

60628775

ENST00000296597

NDUFAF2

chr5

60394819

1040

676

968

322

ENST00000252744

ZSWIM6

chr5

60628775

ENST00000296597

NDUFAF2

chr5

60448531

999

676

713

238

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+	0.022850506	0.97714955
ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368952	+	0.022850506	0.97714955
ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394819	+	0.052338134	0.9476619
ENST00000252744	ENST00000296597	ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448531	+	0.08419053	0.9158095

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Fusion Genomic Features for ZSWIM6-NDUFAF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+	8.45E-13	1
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394818	+	6.32E-10	1
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448530	+	1.50E-08	1
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60368951	+	8.45E-13	1
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60394818	+	6.32E-10	1
ZSWIM6	chr5	60628775	+	NDUFAF2	chr5	60448530	+	1.50E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZSWIM6-NDUFAF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:60628775/chr5:60394819)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NDUFAF2 Q8N183
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269\|PubMed:16200211, ECO:0000269\|PubMed:19384974, ECO:0000269\|PubMed:27626371}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZSWIM6

chr5:60628775

chr5:60368951

ENST00000252744

155_158

225

1216.0

Compositional bias

Note=Poly-Ser

Hgene

ZSWIM6

chr5:60628775

chr5:60368951

ENST00000252744

160_197

225

1216.0

Compositional bias

Note=Ala-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60368951

ENST00000252744

19_154

225

1216.0

Compositional bias

Note=Gly-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60368952

ENST00000252744

155_158

225

1216.0

Compositional bias

Note=Poly-Ser

Hgene

ZSWIM6

chr5:60628775

chr5:60368952

ENST00000252744

160_197

225

1216.0

Compositional bias

Note=Ala-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60368952

ENST00000252744

19_154

225

1216.0

Compositional bias

Note=Gly-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60394819

ENST00000252744

155_158

225

1216.0

Compositional bias

Note=Poly-Ser

Hgene

ZSWIM6

chr5:60628775

chr5:60394819

ENST00000252744

160_197

225

1216.0

Compositional bias

Note=Ala-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60394819

ENST00000252744

19_154

225

1216.0

Compositional bias

Note=Gly-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60448531

ENST00000252744

155_158

225

1216.0

Compositional bias

Note=Poly-Ser

Hgene

ZSWIM6

chr5:60628775

chr5:60448531

ENST00000252744

160_197

225

1216.0

Compositional bias

Note=Ala-rich

Hgene

ZSWIM6

chr5:60628775

chr5:60448531

ENST00000252744

19_154

225

1216.0

Compositional bias

Note=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZSWIM6

chr5:60628775

chr5:60368951

ENST00000252744

246_283

225

1216.0

Zinc finger

SWIM-type

Hgene

ZSWIM6

chr5:60628775

chr5:60368952

ENST00000252744

246_283

225

1216.0

Zinc finger

SWIM-type

Hgene

ZSWIM6

chr5:60628775

chr5:60394819

ENST00000252744

246_283

225

1216.0

Zinc finger

SWIM-type

Hgene

ZSWIM6

chr5:60628775

chr5:60448531

ENST00000252744

246_283

225

1216.0

Zinc finger

SWIM-type

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Fusion Gene Sequence for ZSWIM6-NDUFAF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>103291_103291_1_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1130nt_BP=676nt
ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC
GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC
GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG
TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG
ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC
GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC
ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAA
AAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAA
ATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGT
GAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCC
AGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTT

>103291_103291_1_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=352AA_BP=225
MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRPGPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWP
FQRVEERFERIPEPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAA
AAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGCVDNVLQVGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEE

--------------------------------------------------------------
>103291_103291_2_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1130nt_BP=676nt
ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC
GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC
GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG
TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG
ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC
GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC
ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAA
AAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAA
ATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGT
GAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCC
AGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTT

>103291_103291_2_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=352AA_BP=225
MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRPGPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWP
FQRVEERFERIPEPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAA
AAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGCVDNVLQVGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEE

--------------------------------------------------------------
>103291_103291_3_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60394819_ENST00000296597_length(transcript)=1040nt_BP=676nt
ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC
GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC
GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG
TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG
ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC
GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC
ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAA
ATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGT
GAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCC
AGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTT

>103291_103291_3_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60394819_ENST00000296597_length(amino acids)=322AA_BP=225
MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRPGPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWP
FQRVEERFERIPEPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAA
AAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGCVDNVLQVAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETS

--------------------------------------------------------------
>103291_103291_4_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60448531_ENST00000296597_length(transcript)=999nt_BP=676nt
ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC
GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC
GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG
TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG
ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC
GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC
ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAA
AAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGG
CCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCC
ACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAACAAATAAAAGAAGT

>103291_103291_4_ZSWIM6-NDUFAF2_ZSWIM6_chr5_60628775_ENST00000252744_NDUFAF2_chr5_60448531_ENST00000296597_length(amino acids)=238AA_BP=62
MISSLCFSFFSISDLQDVVYAAAFQQRDAPAERQPRLVAAVRRPGSPHRRGPGPRGGGGGGGGGGSGGGGRGCGRRGCGRGRRGAAAAAA
ARAAAATAVVAGAARGAAAGVEGRVHADLPLAAGEGPIDYAALHRLRDALKALLHALERPLLRHPARRDVQQRLGALGLARRQQPQRRAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZSWIM6-NDUFAF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZSWIM6-NDUFAF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZSWIM6-NDUFAF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source