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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRSK1-HSPBP1 (FusionGDB2 ID:10333)

Fusion Gene Summary for BRSK1-HSPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRSK1-HSPBP1
Fusion gene ID: 10333
HgeneTgene
Gene symbol

BRSK1

HSPBP1

Gene ID

84446

23640

Gene nameBR serine/threonine kinase 1HSPA (Hsp70) binding protein 1
SynonymshSAD1FES1
Cytomap

19q13.42

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase BRSK1BR serine/threonine-protein kinase 1SAD1 homologSAD1 kinaseSadB kinase short isoformbrain-selective kinase 1brain-specific serine/threonine-protein kinase 1protein kinase SAD1Aserine/threonine-protein kinase SAhsp70-binding protein 1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1heat shock protein-binding protein 1hsp70 interacting protein
Modification date2020031320200313
UniProtAcc

Q8TDC3

Q9NZL4

Ensembl transtripts involved in fusion geneENST00000309383, ENST00000585418, 
ENST00000590333, ENST00000326848, 
ENST00000588584, 		ENST00000376343, 
ENST00000587922, ENST00000255631, 
ENST00000433386, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 3=48
# samples 44
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRSK1 [Title/Abstract] AND HSPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRSK1(55795946)-HSPBP1(55777654), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRSK1

GO:0000086

G2/M transition of mitotic cell cycle

15150265

HgeneBRSK1

GO:0006468

protein phosphorylation

15150265

HgeneBRSK1

GO:0006974

cellular response to DNA damage stimulus

15150265

HgeneBRSK1

GO:0007095

mitotic G2 DNA damage checkpoint

15150265

HgeneBRSK1

GO:0009411

response to UV

15150265

HgeneBRSK1

GO:0010212

response to ionizing radiation

15150265

HgeneBRSK1

GO:0018105

peptidyl-serine phosphorylation

15150265

TgeneHSPBP1

GO:0031398

positive regulation of protein ubiquitination

16831871

TgeneHSPBP1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

16831871


check buttonFusion gene breakpoints across BRSK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSPBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03V-01ABRSK1chr19

55795946

+HSPBP1chr19

55777654

-
ChimerDB4BRCATCGA-AO-A03VBRSK1chr19

55795946

+HSPBP1chr19

55777654

-


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Fusion Gene ORF analysis for BRSK1-HSPBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309383ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000309383ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000585418ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000585418ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000590333ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000590333ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000309383ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000309383ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000585418ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000585418ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000590333ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000590333ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000326848ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000326848ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000588584ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000588584ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000326848ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000326848ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000588584ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000588584ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BRSK1-HSPBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRSK1-HSPBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:55795946/chr19:55777654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRSK1

Q8TDC3

HSPBP1

Q9NZL4

FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.FUNCTION: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857, ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:21247889, ECO:0000269|PubMed:9830037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+11940_4845779.0Nucleotide bindingATP
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+11040_4845344.0Nucleotide bindingATP
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+32140_4861795.0Nucleotide bindingATP
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000025563149220_259213360.0RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000025563149262_301213360.0RepeatNote=ARM 4
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000043338638220_259213360.0RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000043338638262_301213360.0RepeatNote=ARM 4
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000058792227220_259213360.0RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000058792227262_301213360.0RepeatNote=ARM 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+119492_54045779.0Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+110492_54045344.0Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+321492_54061795.0Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+119314_35645779.0DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+11934_28545779.0DomainProtein kinase
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+110314_35645344.0DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+11034_28545344.0DomainProtein kinase
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+321314_35661795.0DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+32134_28561795.0DomainProtein kinase
TgeneHSPBP1chr19:55795946chr19:55777654ENST000002556314921_37213360.0Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST000004333863821_37213360.0Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST000005879222721_37213360.0Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000025563149132_174213360.0RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000025563149177_217213360.0RepeatNote=ARM 2
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000043338638132_174213360.0RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000043338638177_217213360.0RepeatNote=ARM 2
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000058792227132_174213360.0RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST0000058792227177_217213360.0RepeatNote=ARM 2


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Fusion Gene Sequence for BRSK1-HSPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BRSK1-HSPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRSK1-HSPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRSK1-HSPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource