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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRWD1-ABCG1 (FusionGDB2 ID:10337)

Fusion Gene Summary for BRWD1-ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1-ABCG1
Fusion gene ID: 10337
HgeneTgene
Gene symbol

BRWD1

ABCG1

Gene ID

54014

9619

Gene namebromodomain and WD repeat domain containing 1ATP binding cassette subfamily G member 1
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9ABC8|WHITE1
Cytomap

21q22.2

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143ATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2020031320200329
UniProtAcc

Q9NSI6

P45844

Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 		ENST00000343687, 
ENST00000347800, ENST00000361802, 
ENST00000398449, ENST00000462050, 
ENST00000340588, ENST00000398437, 
ENST00000398457, 
Fusion gene scores* DoF score28 X 28 X 10=78409 X 5 X 8=360
# samples 3210
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD1(40665737)-ABCG1(43645781), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612

TgeneABCG1

GO:0050714

positive regulation of protein secretion

17293612

TgeneABCG1

GO:1902004

positive regulation of amyloid-beta formation

17293612


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NF-01ABRWD1chr21

40665737

-ABCG1chr21

43645781

+


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Fusion Gene ORF analysis for BRWD1-ABCG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000333229ENST00000343687BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000333229ENST00000347800BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000333229ENST00000361802BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000333229ENST00000398449BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000333229ENST00000462050BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000342449ENST00000343687BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000342449ENST00000347800BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000342449ENST00000361802BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000342449ENST00000398449BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000342449ENST00000462050BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000380800ENST00000343687BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000380800ENST00000347800BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000380800ENST00000361802BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000380800ENST00000398449BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000380800ENST00000462050BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000333229ENST00000340588BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000333229ENST00000398437BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000342449ENST00000340588BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000342449ENST00000398437BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000380800ENST00000340588BRWD1chr21

40665737

-ABCG1chr21

43645781

+
5CDS-intronENST00000380800ENST00000398437BRWD1chr21

40665737

-ABCG1chr21

43645781

+
In-frameENST00000333229ENST00000398457BRWD1chr21

40665737

-ABCG1chr21

43645781

+
In-frameENST00000342449ENST00000398457BRWD1chr21

40665737

-ABCG1chr21

43645781

+
In-frameENST00000380800ENST00000398457BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3CDSENST00000341322ENST00000398457BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3CDSENST00000470108ENST00000398457BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000341322ENST00000343687BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000341322ENST00000347800BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000341322ENST00000361802BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000341322ENST00000398449BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000341322ENST00000462050BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000470108ENST00000343687BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000470108ENST00000347800BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000470108ENST00000361802BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000470108ENST00000398449BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-3UTRENST00000470108ENST00000462050BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-intronENST00000341322ENST00000340588BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-intronENST00000341322ENST00000398437BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-intronENST00000470108ENST00000340588BRWD1chr21

40665737

-ABCG1chr21

43645781

+
intron-intronENST00000470108ENST00000398437BRWD1chr21

40665737

-ABCG1chr21

43645781

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140665737-ENST00000398457ABCG1chr2143645781+397011592353117960
ENST00000342449BRWD1chr2140665737-ENST00000398457ABCG1chr2143645781+3721910792868929
ENST00000380800BRWD1chr2140665737-ENST00000398457ABCG1chr2143645781+374193062888960

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000398457BRWD1chr2140665737-ABCG1chr2143645781+0.0009936110.99900645
ENST00000342449ENST00000398457BRWD1chr2140665737-ABCG1chr2143645781+0.0010433870.99895656
ENST00000380800ENST00000398457BRWD1chr2140665737-ABCG1chr2143645781+0.0010210670.998979

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Fusion Genomic Features for BRWD1-ABCG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BRWD1chr2140665736-ABCG1chr2143645780+1.37E-081
BRWD1chr2140665736-ABCG1chr2143645780+1.37E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BRWD1-ABCG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40665737/chr21:43645781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD1

Q9NSI6

ABCG1

P45844

FUNCTION: May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842184_2232772321.0RepeatNote=WD 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842226_2652772321.0RepeatNote=WD 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841184_2232772270.0RepeatNote=WD 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841226_2652772270.0RepeatNote=WD 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842184_2232772200.0RepeatNote=WD 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842226_2652772200.0RepeatNote=WD 2
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015415_67325678.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:40665737chr21:43645781ENST0000034368701577_31725678.0DomainABC transporter
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015415_67311664.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:40665737chr21:43645781ENST0000034780001577_31711664.0DomainABC transporter
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015415_67314679.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:40665737chr21:43645781ENST0000036180201577_31714679.0DomainABC transporter
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015415_67314667.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:40665737chr21:43645781ENST0000039844901577_31714667.0DomainABC transporter
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116415_67316669.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:40665737chr21:43645781ENST0000039845711677_31716669.0DomainABC transporter
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015118_12525678.0Nucleotide bindingATP
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015118_12511664.0Nucleotide bindingATP
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015118_12514679.0Nucleotide bindingATP
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015118_12514667.0Nucleotide bindingATP
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116118_12516669.0Nucleotide bindingATP
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015446_45625678.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015478_50625678.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015526_53325678.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015556_56725678.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015587_64925678.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015670_67825678.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015446_45611664.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015478_50611664.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015526_53311664.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015556_56711664.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015587_64911664.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015670_67811664.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015446_45614679.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015478_50614679.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015526_53314679.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015556_56714679.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015587_64914679.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015670_67814679.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015446_45614667.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015478_50614667.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015526_53314667.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015556_56714667.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015587_64914667.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015670_67814667.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116446_45616669.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116478_50616669.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116526_53316669.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116556_56716669.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116587_64916669.0Topological domainExtracellular
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116670_67816669.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015427_44525678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015457_47725678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015507_52525678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015534_55525678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015568_58625678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000343687015650_66925678.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015427_44511664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015457_47711664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015507_52511664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015534_55511664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015568_58611664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000347800015650_66911664.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015427_44514679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015457_47714679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015507_52514679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015534_55514679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015568_58614679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000361802015650_66914679.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015427_44514667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015457_47714667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015507_52514667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015534_55514667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015568_58614667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398449015650_66914667.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116427_44516669.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116457_47716669.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116507_52516669.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116534_55516669.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116568_58616669.0TransmembraneHelical
TgeneABCG1chr21:40665737chr21:43645781ENST00000398457116650_66916669.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-8421539_15482772321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-8421687_16922772321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842661_6682772321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842821_8242772321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-8411539_15482772270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-8411687_16922772270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841661_6682772270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841821_8242772270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-8421539_15482772200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-8421687_16922772200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842661_6682772200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842821_8242772200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-8421177_12472772321.0DomainBromo 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-8421330_14002772321.0DomainBromo 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-8411177_12472772270.0DomainBromo 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-8411330_14002772270.0DomainBromo 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-8421177_12472772200.0DomainBromo 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-8421330_14002772200.0DomainBromo 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842268_3112772321.0RepeatNote=WD 3
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842322_3652772321.0RepeatNote=WD 4
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842366_4052772321.0RepeatNote=WD 5
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842424_4632772321.0RepeatNote=WD 6
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842466_5062772321.0RepeatNote=WD 7
HgeneBRWD1chr21:40665737chr21:43645781ENST00000333229-842514_5532772321.0RepeatNote=WD 8
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40665737chr21:43645781ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841268_3112772270.0RepeatNote=WD 3
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841322_3652772270.0RepeatNote=WD 4
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841366_4052772270.0RepeatNote=WD 5
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841424_4632772270.0RepeatNote=WD 6
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841466_5062772270.0RepeatNote=WD 7
HgeneBRWD1chr21:40665737chr21:43645781ENST00000342449-841514_5532772270.0RepeatNote=WD 8
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842268_3112772200.0RepeatNote=WD 3
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842322_3652772200.0RepeatNote=WD 4
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842366_4052772200.0RepeatNote=WD 5
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842424_4632772200.0RepeatNote=WD 6
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842466_5062772200.0RepeatNote=WD 7
HgeneBRWD1chr21:40665737chr21:43645781ENST00000380800-842514_5532772200.0RepeatNote=WD 8
TgeneABCG1chr21:40665737chr21:43645781ENST000003436870151_42625678.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST000003478000151_42611664.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST000003618020151_42614679.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST000003984490151_42614667.0Topological domainCytoplasmic
TgeneABCG1chr21:40665737chr21:43645781ENST000003984571161_42616669.0Topological domainCytoplasmic


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Fusion Gene Sequence for BRWD1-ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10337_10337_1_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000333229_ABCG1_chr21_43645781_ENST00000398457_length(transcript)=3970nt_BP=1159nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGAATGCCAGCAG
TTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAGACGGACCT
GCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGA
ATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTT
CAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGG
CATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGATGACATGCT
GCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAA
GGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGC
GCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCT
GATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTA
CGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTA
CCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCAT
GTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTC
CATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTC
GGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAA
GGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGA
GATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTGCCCTTTCA
GATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCT
GGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCC
AGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTC
CTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAGACGTGCCA
CTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCAT
CTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAACAGGAAGATTAG
ACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCAACCCCTAGAAC
CGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGA
AGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCTGCAACACAGCT
GGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGAT
GGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTTTCATCTTTCTA
AGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATACCTTTTTAGTAC
TTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCTCATACATAGAC
AGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATTTTTAAAAGCTA
TACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTTTAAGCGAAATATATTGTTTGT

>10337_10337_1_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000333229_ABCG1_chr21_43645781_ENST00000398457_length(amino acids)=960AA_BP=308
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRF
SSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR
KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSG
LDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQ
NSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG
LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQP
SDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDR

--------------------------------------------------------------
>10337_10337_2_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000342449_ABCG1_chr21_43645781_ENST00000398457_length(transcript)=3721nt_BP=910nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACAT
GGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCG
GAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCT
GAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCT
GGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTA
CATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGA
AGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCA
GCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTC
CTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTT
CGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTT
GGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGT
GAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCC
CTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTT
CCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGG
GATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTAC
TGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGAC
CATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCG
CTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCA
GGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCT
ACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTG
TGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCAT
CGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAAT
GCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTC
TTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCC
CCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGA
ATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACT
GCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTT
TTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAA
GAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACC
CAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCA
TGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTT

>10337_10337_2_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000342449_ABCG1_chr21_43645781_ENST00000398457_length(amino acids)=929AA_BP=277
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGY
KTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQ
EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS
AKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL
WHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA
LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAAS
TSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY

--------------------------------------------------------------
>10337_10337_3_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000380800_ABCG1_chr21_43645781_ENST00000398457_length(transcript)=3741nt_BP=930nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGAT
GAGGTGGTGTCCAGCAACATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAG
CGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAG
AAAGGATACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAG
TCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGC
TTCCGGAAGGTGTCCTGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTG
AAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACC
GGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACC
AGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCAC
CAGCCCAGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTT
GTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGT
GATCAGAACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAAC
CCTTTTCTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGC
ATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTC
ATTGGCCTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATG
TTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAG
GCCTACTACCTGGCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCG
CAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGA
GCCGCCTCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTC
GACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTA
GACCGGGAAGATCTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCC
AAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCA
GAGAGGTAAAACACCTGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCC
GACCGACGACACAGAGACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGG
TTGGATCTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTA
AATACCACAACTGGGGCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCG
TGGGTCCTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGAT
TCCATTTTATGACTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCG
ATCAATCGCATTCATTTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCG
AGGGGTTTAACCGAGTCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGG
ACACCATCTCCACTGAGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTT

>10337_10337_3_BRWD1-ABCG1_BRWD1_chr21_40665737_ENST00000380800_ABCG1_chr21_43645781_ENST00000398457_length(amino acids)=960AA_BP=308
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRF
SSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR
KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSG
LDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQ
NSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG
LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQP
SDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDR

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Fusion Gene PPI Analysis for BRWD1-ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRWD1-ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRWD1-ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource