|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BSN-ARL8B (FusionGDB2 ID:10406) |
Fusion Gene Summary for BSN-ARL8B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BSN-ARL8B | Fusion gene ID: 10406 | Hgene | Tgene | Gene symbol | BSN | ARL8B | Gene ID | 8927 | 55207 |
| Gene name | bassoon presynaptic cytomatrix protein | ADP ribosylation factor like GTPase 8B | |
| Synonyms | ZNF231 | ARL10C|Gie1 | |
| Cytomap | 3p21.31 | 3p26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein bassoonneuronal double zinc finger proteinzinc finger protein 231 | ADP-ribosylation factor-like protein 8BADP-ribosylation factor-like 10CADP-ribosylation factor-like 8BADP-ribosylation factor-like protein 10Cnovel small G protein indispensable for equal chromosome segregation 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9UPA5 | Q9NVJ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000296452, | ENST00000468010, ENST00000256496, ENST00000419534, | |
| Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 5 X 5 X 3=75 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/60*10)=0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BSN [Title/Abstract] AND ARL8B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BSN(49680585)-ARL8B(5212188), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across BSN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ARL8B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LGG | TCGA-DU-6396-01A | BSN | chr3 | 49680585 | - | ARL8B | chr3 | 5212188 | + |
| ChimerDB4 | LGG | TCGA-DU-6396-01A | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + |
| ChimerDB4 | LGG | TCGA-DU-6396 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + |
| ChimerDB4 | LGG | TCGA-DU-6396 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + |
Top |
Fusion Gene ORF analysis for BSN-ARL8B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000296452 | ENST00000468010 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + |
| 5CDS-intron | ENST00000296452 | ENST00000468010 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + |
| In-frame | ENST00000296452 | ENST00000256496 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + |
| In-frame | ENST00000296452 | ENST00000256496 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + |
| In-frame | ENST00000296452 | ENST00000419534 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + |
| In-frame | ENST00000296452 | ENST00000419534 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000296452 | BSN | chr3 | 49680585 | + | ENST00000256496 | ARL8B | chr3 | 5212188 | + | 4268 | 1632 | 105 | 2069 | 654 |
| ENST00000296452 | BSN | chr3 | 49680585 | + | ENST00000419534 | ARL8B | chr3 | 5212188 | + | 3023 | 1632 | 105 | 2000 | 631 |
| ENST00000296452 | BSN | chr3 | 49688512 | + | ENST00000256496 | ARL8B | chr3 | 5212188 | + | 4736 | 2100 | 105 | 2537 | 810 |
| ENST00000296452 | BSN | chr3 | 49688512 | + | ENST00000419534 | ARL8B | chr3 | 5212188 | + | 3491 | 2100 | 105 | 2468 | 787 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000296452 | ENST00000256496 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + | 0.008408714 | 0.9915912 |
| ENST00000296452 | ENST00000419534 | BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212188 | + | 0.031115916 | 0.96888405 |
| ENST00000296452 | ENST00000256496 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + | 0.00460885 | 0.99539113 |
| ENST00000296452 | ENST00000419534 | BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212188 | + | 0.015036936 | 0.984963 |
Top |
Fusion Genomic Features for BSN-ARL8B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212187 | + | 0.002957863 | 0.9970421 |
| BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212187 | + | 5.05E-08 | 1 |
| BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212187 | + | 5.05E-08 | 1 |
| BSN | chr3 | 49688512 | + | ARL8B | chr3 | 5212187 | + | 0.002957863 | 0.9970421 |
| BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212187 | + | 5.05E-08 | 1 |
| BSN | chr3 | 49680585 | + | ARL8B | chr3 | 5212187 | + | 5.05E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for BSN-ARL8B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:49680585/chr3:5212188) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BSN | ARL8B |
| FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). {ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. | FUNCTION: Plays a role in lysosome motility (PubMed:16537643, PubMed:25898167). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:25898167}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 23_32 | 506 | 5026.666666666667 | Region | Note=5 X 2 AA tandem repeats of P-G |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 61_74 | 506 | 5026.666666666667 | Region | Note=7 X 2 AA tandem repeats of P-G |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 23_32 | 662 | 5026.666666666667 | Region | Note=5 X 2 AA tandem repeats of P-G |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 571_591 | 662 | 5026.666666666667 | Region | Note=3 X 7 AA tandem repeats of K-A-S-P-[LQ]-[APS]-[KST] |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 61_74 | 662 | 5026.666666666667 | Region | Note=7 X 2 AA tandem repeats of P-G |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 571_577 | 662 | 5026.666666666667 | Repeat | Note=1 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 578_584 | 662 | 5026.666666666667 | Repeat | Note=2 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 585_591 | 662 | 5026.666666666667 | Repeat | Note=3 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 170_193 | 506 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 198_220 | 506 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 465_488 | 506 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 170_193 | 662 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 198_220 | 662 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 465_488 | 662 | 5026.666666666667 | Zinc finger | C4-type |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 493_515 | 662 | 5026.666666666667 | Zinc finger | C4-type |
| Tgene | ARL8B | chr3:49680585 | chr3:5212188 | ENST00000256496 | 0 | 7 | 130_133 | 41 | 187.0 | Nucleotide binding | Note=GTP | |
| Tgene | ARL8B | chr3:49680585 | chr3:5212188 | ENST00000256496 | 0 | 7 | 71_75 | 41 | 187.0 | Nucleotide binding | GTP | |
| Tgene | ARL8B | chr3:49688512 | chr3:5212188 | ENST00000256496 | 0 | 7 | 130_133 | 41 | 187.0 | Nucleotide binding | Note=GTP | |
| Tgene | ARL8B | chr3:49688512 | chr3:5212188 | ENST00000256496 | 0 | 7 | 71_75 | 41 | 187.0 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 1037_1092 | 506 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 1181_1208 | 506 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 1276_1294 | 506 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 2351_2476 | 506 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 2939_2981 | 506 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 1037_1092 | 662 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 1181_1208 | 662 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 1276_1294 | 662 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 2351_2476 | 662 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 2939_2981 | 662 | 5026.666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 2600_2606 | 506 | 5026.666666666667 | Compositional bias | Note=Poly-Arg |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 2627_2632 | 506 | 5026.666666666667 | Compositional bias | Note=Poly-Arg |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 3775_3783 | 506 | 5026.666666666667 | Compositional bias | Note=Poly-Gln |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 2600_2606 | 662 | 5026.666666666667 | Compositional bias | Note=Poly-Arg |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 2627_2632 | 662 | 5026.666666666667 | Compositional bias | Note=Poly-Arg |
| Hgene | BSN | chr3:49688512 | chr3:5212188 | ENST00000296452 | + | 4 | 12 | 3775_3783 | 662 | 5026.666666666667 | Compositional bias | Note=Poly-Gln |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 571_591 | 506 | 5026.666666666667 | Region | Note=3 X 7 AA tandem repeats of K-A-S-P-[LQ]-[APS]-[KST] |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 571_577 | 506 | 5026.666666666667 | Repeat | Note=1 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 578_584 | 506 | 5026.666666666667 | Repeat | Note=2 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 585_591 | 506 | 5026.666666666667 | Repeat | Note=3 |
| Hgene | BSN | chr3:49680585 | chr3:5212188 | ENST00000296452 | + | 3 | 12 | 493_515 | 506 | 5026.666666666667 | Zinc finger | C4-type |
| Tgene | ARL8B | chr3:49680585 | chr3:5212188 | ENST00000256496 | 0 | 7 | 1_19 | 41 | 187.0 | Intramembrane | Note=Note%3DMediates targeting to membranes | |
| Tgene | ARL8B | chr3:49688512 | chr3:5212188 | ENST00000256496 | 0 | 7 | 1_19 | 41 | 187.0 | Intramembrane | Note=Note%3DMediates targeting to membranes | |
| Tgene | ARL8B | chr3:49680585 | chr3:5212188 | ENST00000256496 | 0 | 7 | 29_35 | 41 | 187.0 | Nucleotide binding | Note=GTP | |
| Tgene | ARL8B | chr3:49688512 | chr3:5212188 | ENST00000256496 | 0 | 7 | 29_35 | 41 | 187.0 | Nucleotide binding | Note=GTP |
Top |
Fusion Gene Sequence for BSN-ARL8B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >10406_10406_1_BSN-ARL8B_BSN_chr3_49680585_ENST00000296452_ARL8B_chr3_5212188_ENST00000256496_length(transcript)=4268nt_BP=1632nt GAGCCGAGCTGGGAGATGGCGGCGGCAGCGGCGGCGCCGAGAGTGTGAGCACCGCCCGGGAGCCGCCGGCCCGGGCGCAGCGCGACCCCG ACCCCGCCCGCCCGCCTGCCCGCCATGGGCAACGAGGTCAGCCTGGAGGGCGGCGCTGGCGACGGGCCGCTGCCGCCCGGCGGCGCCGGC CCCGGCCCGGGCCCCGGCCCCGGCCCCGGCGCAGGAAAGCCGCCTTCAGCACCGGCCGGTGGCGGACAGCTCCCCGCGGCGGGAGCAGCG CGGTCGACCGCGGTACCACCGGTCCCTGGCCCCGGCCCCGGCCCCGGTCCCGGCCCTGGCCCGGGCAGCACTTCCCGGAGACTGGACCCC AAGGAACCCCTGGGTAACCAGAGAGCAGCTTCCCCAACTCCGAAGCAGGCTTCTGCTACCACTCCTGGCCATGAGAGCCCCCGAGAGACA AGGGCACAGGGACCAGCAGGCCAGGAGGCTGATGGTCCCCGCAGGACGCTGCAGGTAGACAGCAGGACACAGAGATCAGGGCGGTCCCCC TCAGTGTCACCGGACAGAGGCAGCACCCCCACATCACCCTACTCCGTCCCTCAGATCGCCCCCCTTCCCAGCAGCACGCTGTGTCCCATA TGCAAGACTTCGGACCTCACGTCGACCCCCAGCCAGCCAAACTTCAACACCTGCACCCAGTGTCACAACAAGGTCTGCAACCAGTGTGGG TTCAACCCCAACCCTCATCTCACCCAGGTGAAGGAGTGGCTCTGTCTGAACTGTCAGATGCAGAGGGCTCTGGGAATGGACATGACCACT GCACCTCGCTCCAAGAGCCAGCAGCAGCTGCACTCCCCAGCCCTGTCTCCTGCCCACTCCCCGGCCAAACAGCCCCTGGGGAAGCCAGAC CAAGAGAGATCTCGGGGCCCAGGAGGACCACAGCCTGGGTCCCGCCAGGCTGAGACAGCCAGGGCCACCTCAGTGCCGGGGCCTGCCCAA GCAGCTGCCCCTCCAGAGGTGGGGAGGGTGTCTCCTCAGCCCCCTCAACCCACCAAGCCTTCCACAGCTGAGCCCAGGCCACCTGCAGGA GAGGCCCCGGCCAAAAGTGCCACCGCAGTGCCCGCTGGGCTTGGTGCCACTGAGCAGACCCAGGAGGGCCTCACTGGTAAGCTCTTCGGC CTTGGCGCGTCACTGCTAACCCAGGCGAGCACCCTCATGTCTGTGCAGCCCGAGGCTGACACCCAGGGCCAGCCTGCCCCCAGCAAGGGG ACACCTAAGATCGTCTTCAATGATGCCAGCAAGGAGGCTGGCCCAAAACCCTTGGGCTCAGGGCCCGGGCCTGGGCCAGCACCTGGAGCC AAAACTGAGCCTGGGGCTAGAATGGGTCCTGGATCTGGACCTGGAGCCCTGCCGAAAACTGGGGGAACAACCAGTCCAAAGCATGGCAGA GCAGAACATCAGGCAGCATCGAAGGCTGCTGCCAAGCCAAAGACCATGCCGAAGGAAAGGGCCATCTGCCCACTGTGCCAAGCCGAGCTC AACGTGGGCAGCAAGAGCCCAGCCAACTATAACACATGCACCACCTGCAGGCTCCAGGTGTGCAACCTGTGTGGCTTCAACCCAACACCC CACCTGGTGGAGTCAGGTCAATTCAGTGAAGATATGATACCCACAGTGGGCTTCAACATGAGGAAGGTAACTAAAGGTAACGTCACAATA AAGATCTGGGACATAGGAGGACAACCCCGATTTCGAAGCATGTGGGAGCGGTATTGCAGAGGAGTCAATGCTATTGTTTACATGATAGAT GCTGCAGATCGTGAAAAGATAGAAGCTTCCCGAAATGAGCTACATAATCTTCTAGATAAACCACAGTTACAAGGAATTCCAGTGCTAGTG CTTGGAAACAAGAGAGATCTTCCTAATGCCTTGGATGAGAAACAGCTAATTGAAAAAATGAATCTGTCTGCTATTCAGGATAGAGAAATT TGCTGCTATTCAATTTCTTGCAAAGAAAAGGATAATATAGATATCACACTTCAGTGGCTTATTCAGCATTCAAAATCTAGAAGAAGCTGA AGCATCTCCTGAAGTCTTCCAGTCCTTCTTGGCTATAATCCTAGAATTATTGTCCGTTCCTCTGAAGTAATTCCCAGAATACGGTCCTTC CTAAACCCCAGAAATTGCCTTTTTCAGAGTTTATTTCTCATGTGCACTGCTGAAGATGAATATCCCTAATCCTTCATAAAGAATCAGCTA GAGTTGTCATGATAAAGTCAGCACACACAAAAAGGCTTCTTACACATACCTGTCTTAAACCATGTGTAGAGCTTTAAAAACAGAAAAAAA ACCCCATATACTTATGACCATCTTAAATCAAGAAAATTGCATATTTCCATTCTGGTCTTTCTGGGCCAGATTTTTATATTGGTTTTCAGT AAATGTCTATCTATAATATTTCATTATAGAGTCCAGTAGCTTAATACTGACACTGACTTGATACAGCATGAAGTTTCTAGTGCCACACAC AGTATTTAGAAAACCTTTAGGCGTGAATGACTCATGTGGGATATATGTAAACATAATGTTTATTTTATCTCACAAATGCATGTGAAATGT ATAATTACATCTTAGGAATCCAAAATGGTCTGCAGAGAGTGAGCGGAGGCACCAGATCAATGTTGGTTCTTTGCACTGGTGAGATTCTGC CTGATGAATATTAAAGATATCCTGCTTTCTGAGAACTCTATCACCAGATGGCAGTTGGGATATGGGAGGAACTAAAGCATCCTGTTTTGT ATCTGTCCAGATCATTATTTCTGTCTCTTGTTTTTTCTTCCTGGTTCAGGATACTTTTTTAAGGGGTTGAGAATTGAAGATTTTCCAAAA GCGTTCATGAATTTAGAGCATTCCACCCAATATAATAAAACCTGTTAAGAATGTCAGTCTTTGTTCAAACATCTGTTTGTTCTATCTCCA GTCATTAAATCAGTGCTGCTGCATGACACTCTTAACTCCTGACTTTTTATATCCAGTCATAAAGTTGACTTTCAGCACAAAAGATACTTA TAAACAAATAAAAAATTTTTATTTTTCTCTCTTACTGATGTAAGCTTTGGCACTCTTTTGACTGGTGCCATTAGACATCTTGATTATTGT GACAACTCTAGACCTGCCTGCTTTATCTAATGTAATCATGCTCAATGTCTACAGGTTGTTTAATAATCAGTCACACAGAGAACTGAGGAA CTGATGCTGTTTGTTTGCTTCTATGATACAGAGATGTCTAAAAACTTCAAATGGACATGTTTTGTAGTTTAGCGACTTCCGTATACATAA AGGGACATATTAATACTGGTTCATTTGTAAATTATTATTCATATAGACCACTGTAGTAGATAAAACTCTATGGTACACCTGCTTATGTGT TGCCTCACACTGTGTGTGATTTTGTTTCTTTTGTTAAGCAGCACTTATGTAGACTGCATTTCCAAATGTGTTGAGCACTCAGAGTGTAGT CAACAGTAAGTTCTTTTAATGAATATCAGTTTTAATTTATAGACTGCCATGGCCTTAAAAATATTCTGTACAATATACTGCACTGTGTTG CACAGACACTACTTGCTTTTCTCCATTCATATTTTTATGAGTAGAATCTGGGCTTTTAAATTTCTCTTCTTATTCTTTGAAGCATGTTGC ATACTACCCTGGTGGGATGGATGGTTCTGTAAATGAAGGGATATTTAAACTTGCTACTGTTGTTCAACACCATTAATGGTCAGTGTGAAC CATTACAAAGAATGTGGCAACTTGCTTGTGCCTAAAAGGAGGAATTGGAACTAGAATGTGTGACTCTGTGGGGACTGCATAGGTTTGTTA ATTGACCTATAGCTAAACCTTAATGTGTTTGTGTGTCTATACATTGCTTTCCGCATTTCAAGACATCCAGACGCTATTACCAACATTTTC CTGTGCATTAACCTCTGCATGTGAAAACTTTTAACAGTTACTGAACTATGTAAATATGTGAATTTTTTTATTTAGGTGGATGCATTTTTT GTCTGTTTACTGCTCTTCTCAGCTTTATTCAATAAACTTGCATTTTAAGGGTTGTATTGGCAATTTTAACTTAAAATGTGCATCATGATG GAAGGTGCAGACTTTTTTGGAAGTTTCCGAGAGGAGGGTCTATAGACCATTTGTCAGAAATCAGATCAGCCCTCAAAGAATGGGGTCTGT >10406_10406_1_BSN-ARL8B_BSN_chr3_49680585_ENST00000296452_ARL8B_chr3_5212188_ENST00000256496_length(amino acids)=654AA_BP=507 MPAMGNEVSLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKEPLG NQRAASPTPKQASATTPGHESPRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSD LTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSR GPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTAEPRPPAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASL LTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSGPGPGPAPGAKTEPGARMGPGSGPGALPKTGGTTSPKHGRAEHQA ASKAAAKPKTMPKERAICPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVESGQFSEDMIPTVGFNMRKVTKGNVTIKIWDI GGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSI -------------------------------------------------------------- >10406_10406_2_BSN-ARL8B_BSN_chr3_49680585_ENST00000296452_ARL8B_chr3_5212188_ENST00000419534_length(transcript)=3023nt_BP=1632nt GAGCCGAGCTGGGAGATGGCGGCGGCAGCGGCGGCGCCGAGAGTGTGAGCACCGCCCGGGAGCCGCCGGCCCGGGCGCAGCGCGACCCCG ACCCCGCCCGCCCGCCTGCCCGCCATGGGCAACGAGGTCAGCCTGGAGGGCGGCGCTGGCGACGGGCCGCTGCCGCCCGGCGGCGCCGGC CCCGGCCCGGGCCCCGGCCCCGGCCCCGGCGCAGGAAAGCCGCCTTCAGCACCGGCCGGTGGCGGACAGCTCCCCGCGGCGGGAGCAGCG CGGTCGACCGCGGTACCACCGGTCCCTGGCCCCGGCCCCGGCCCCGGTCCCGGCCCTGGCCCGGGCAGCACTTCCCGGAGACTGGACCCC AAGGAACCCCTGGGTAACCAGAGAGCAGCTTCCCCAACTCCGAAGCAGGCTTCTGCTACCACTCCTGGCCATGAGAGCCCCCGAGAGACA AGGGCACAGGGACCAGCAGGCCAGGAGGCTGATGGTCCCCGCAGGACGCTGCAGGTAGACAGCAGGACACAGAGATCAGGGCGGTCCCCC TCAGTGTCACCGGACAGAGGCAGCACCCCCACATCACCCTACTCCGTCCCTCAGATCGCCCCCCTTCCCAGCAGCACGCTGTGTCCCATA TGCAAGACTTCGGACCTCACGTCGACCCCCAGCCAGCCAAACTTCAACACCTGCACCCAGTGTCACAACAAGGTCTGCAACCAGTGTGGG TTCAACCCCAACCCTCATCTCACCCAGGTGAAGGAGTGGCTCTGTCTGAACTGTCAGATGCAGAGGGCTCTGGGAATGGACATGACCACT GCACCTCGCTCCAAGAGCCAGCAGCAGCTGCACTCCCCAGCCCTGTCTCCTGCCCACTCCCCGGCCAAACAGCCCCTGGGGAAGCCAGAC CAAGAGAGATCTCGGGGCCCAGGAGGACCACAGCCTGGGTCCCGCCAGGCTGAGACAGCCAGGGCCACCTCAGTGCCGGGGCCTGCCCAA GCAGCTGCCCCTCCAGAGGTGGGGAGGGTGTCTCCTCAGCCCCCTCAACCCACCAAGCCTTCCACAGCTGAGCCCAGGCCACCTGCAGGA GAGGCCCCGGCCAAAAGTGCCACCGCAGTGCCCGCTGGGCTTGGTGCCACTGAGCAGACCCAGGAGGGCCTCACTGGTAAGCTCTTCGGC CTTGGCGCGTCACTGCTAACCCAGGCGAGCACCCTCATGTCTGTGCAGCCCGAGGCTGACACCCAGGGCCAGCCTGCCCCCAGCAAGGGG ACACCTAAGATCGTCTTCAATGATGCCAGCAAGGAGGCTGGCCCAAAACCCTTGGGCTCAGGGCCCGGGCCTGGGCCAGCACCTGGAGCC AAAACTGAGCCTGGGGCTAGAATGGGTCCTGGATCTGGACCTGGAGCCCTGCCGAAAACTGGGGGAACAACCAGTCCAAAGCATGGCAGA GCAGAACATCAGGCAGCATCGAAGGCTGCTGCCAAGCCAAAGACCATGCCGAAGGAAAGGGCCATCTGCCCACTGTGCCAAGCCGAGCTC AACGTGGGCAGCAAGAGCCCAGCCAACTATAACACATGCACCACCTGCAGGCTCCAGGTGTGCAACCTGTGTGGCTTCAACCCAACACCC CACCTGGTGGAGTCAGGTCAATTCAGTGAAGATATGATACCCACAGTGGGCTTCAACATGAGGAAGGTAACTAAAGGTAACGTCACAATA AAGATCTGGGACATAGGAGGACAACCCCGATTTCGAAGCATGTGGGAGCGGTATTGCAGAGGAGTCAATGCTATTGTTTACATGATAGAT GCTGCAGATCGTGAAAAGATAGAAGCTTCCCGAAATGAGCTACATAATCTTCTAGATAAACCACAGTTACAAGGAATTCCAATATCACAC TTCAGTGGCTTATTCAGCATTCAAAATCTAGAAGAAGCTGAAGCATCTCCTGAAGTCTTCCAGTCCTTCTTGGCTATAATCCTAGAATTA TTGTCCGTTCCTCTGAAGTAATTCCCAGAATACGGTCCTTCCTAAACCCCAGAAATTGCCTTTTTCAGAGTTTATTTCTCATGTGCACTG CTGAAGATGAATATCCCTAATCCTTCATAAAGAATCAGCTAGAGTTGTCATGATAAAGTCAGCACACACAAAAAGGCTTCTTACACATAC CTGTCTTAAACCATGTGTAGAGCTTTAAAAACAGAAAAAAAACCCCATATACTTATGACCATCTTAAATCAAGAAAATTGCATATTTCCA TTCTGGTCTTTCTGGGCCAGATTTTTATATTGGTTTTCAGTAAATGTCTATCTATAATATTTCATTATAGAGTCCAGTAGCTTAATACTG ACACTGACTTGATACAGCATGAAGTTTCTAGTGCCACACACAGTATTTAGAAAACCTTTAGGCGTGAATGACTCATGTGGGATATATGTA AACATAATGTTTATTTTATCTCACAAATGCATGTGAAATGTATAATTACATCTTAGGAATCCAAAATGGTCTGCAGAGAGTGAGCGGAGG CACCAGATCAATGTTGGTTCTTTGCACTGGTGAGATTCTGCCTGATGAATATTAAAGATATCCTGCTTTCTGAGAACTCTATCACCAGAT GGCAGTTGGGATATGGGAGGAACTAAAGCATCCTGTTTTGTATCTGTCCAGATCATTATTTCTGTCTCTTGTTTTTTCTTCCTGGTTCAG GATACTTTTTTAAGGGGTTGAGAATTGAAGATTTTCCAAAAGCGTTCATGAATTTAGAGCATTCCACCCAATATAATAAAACCTGTTAAG AATGTCAGTCTTTGTTCAAACATCTGTTTGTTCTATCTCCAGTCATTAAATCAGTGCTGCTGCATGACACTCTTAACTCCTGACTTTTTA TATCCAGTCATAAAGTTGACTTTCAGCACAAAAGATACTTATAAACAAATAAAAAATTTTTATTTTTCTCTCTTACTGATGTAAGCTTTG >10406_10406_2_BSN-ARL8B_BSN_chr3_49680585_ENST00000296452_ARL8B_chr3_5212188_ENST00000419534_length(amino acids)=631AA_BP=507 MPAMGNEVSLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKEPLG NQRAASPTPKQASATTPGHESPRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSD LTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSR GPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTAEPRPPAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASL LTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSGPGPGPAPGAKTEPGARMGPGSGPGALPKTGGTTSPKHGRAEHQA ASKAAAKPKTMPKERAICPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVESGQFSEDMIPTVGFNMRKVTKGNVTIKIWDI GGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPISHFSGLFSIQNLEEAEASPEVFQSFLAIILELLSVPL -------------------------------------------------------------- >10406_10406_3_BSN-ARL8B_BSN_chr3_49688512_ENST00000296452_ARL8B_chr3_5212188_ENST00000256496_length(transcript)=4736nt_BP=2100nt GAGCCGAGCTGGGAGATGGCGGCGGCAGCGGCGGCGCCGAGAGTGTGAGCACCGCCCGGGAGCCGCCGGCCCGGGCGCAGCGCGACCCCG ACCCCGCCCGCCCGCCTGCCCGCCATGGGCAACGAGGTCAGCCTGGAGGGCGGCGCTGGCGACGGGCCGCTGCCGCCCGGCGGCGCCGGC CCCGGCCCGGGCCCCGGCCCCGGCCCCGGCGCAGGAAAGCCGCCTTCAGCACCGGCCGGTGGCGGACAGCTCCCCGCGGCGGGAGCAGCG CGGTCGACCGCGGTACCACCGGTCCCTGGCCCCGGCCCCGGCCCCGGTCCCGGCCCTGGCCCGGGCAGCACTTCCCGGAGACTGGACCCC AAGGAACCCCTGGGTAACCAGAGAGCAGCTTCCCCAACTCCGAAGCAGGCTTCTGCTACCACTCCTGGCCATGAGAGCCCCCGAGAGACA AGGGCACAGGGACCAGCAGGCCAGGAGGCTGATGGTCCCCGCAGGACGCTGCAGGTAGACAGCAGGACACAGAGATCAGGGCGGTCCCCC TCAGTGTCACCGGACAGAGGCAGCACCCCCACATCACCCTACTCCGTCCCTCAGATCGCCCCCCTTCCCAGCAGCACGCTGTGTCCCATA TGCAAGACTTCGGACCTCACGTCGACCCCCAGCCAGCCAAACTTCAACACCTGCACCCAGTGTCACAACAAGGTCTGCAACCAGTGTGGG TTCAACCCCAACCCTCATCTCACCCAGGTGAAGGAGTGGCTCTGTCTGAACTGTCAGATGCAGAGGGCTCTGGGAATGGACATGACCACT GCACCTCGCTCCAAGAGCCAGCAGCAGCTGCACTCCCCAGCCCTGTCTCCTGCCCACTCCCCGGCCAAACAGCCCCTGGGGAAGCCAGAC CAAGAGAGATCTCGGGGCCCAGGAGGACCACAGCCTGGGTCCCGCCAGGCTGAGACAGCCAGGGCCACCTCAGTGCCGGGGCCTGCCCAA GCAGCTGCCCCTCCAGAGGTGGGGAGGGTGTCTCCTCAGCCCCCTCAACCCACCAAGCCTTCCACAGCTGAGCCCAGGCCACCTGCAGGA GAGGCCCCGGCCAAAAGTGCCACCGCAGTGCCCGCTGGGCTTGGTGCCACTGAGCAGACCCAGGAGGGCCTCACTGGTAAGCTCTTCGGC CTTGGCGCGTCACTGCTAACCCAGGCGAGCACCCTCATGTCTGTGCAGCCCGAGGCTGACACCCAGGGCCAGCCTGCCCCCAGCAAGGGG ACACCTAAGATCGTCTTCAATGATGCCAGCAAGGAGGCTGGCCCAAAACCCTTGGGCTCAGGGCCCGGGCCTGGGCCAGCACCTGGAGCC AAAACTGAGCCTGGGGCTAGAATGGGTCCTGGATCTGGACCTGGAGCCCTGCCGAAAACTGGGGGAACAACCAGTCCAAAGCATGGCAGA GCAGAACATCAGGCAGCATCGAAGGCTGCTGCCAAGCCAAAGACCATGCCGAAGGAAAGGGCCATCTGCCCACTGTGCCAAGCCGAGCTC AACGTGGGCAGCAAGAGCCCAGCCAACTATAACACATGCACCACCTGCAGGCTCCAGGTGTGCAACCTGTGTGGCTTCAACCCAACACCC CACCTGGTGGAGAAAACAGAGTGGCTCTGTCTGAACTGCCAAACCAAGCGGCTACTGGAGGGCAGCCTAGGAGAGCCGACCCCCCTGCCG CCGCCCACCTCACAGCAGCCCCCTGTAGGGGCCCCTCACCGTGCATCTGGAACATCCCCTCTGAAGCAGAAAGGGCCACAGGGGCTGGGC CAGCCTTCAGGCCCCCTGCCTGCCAAGGCCAGCCCTCTATCCACCAAGGCCAGCCCTCTGCCCAGCAAGGCCAGCCCCCAGGCCAAGCCC CTCAGGGCTTCTGAACCCAGCAAGACCCCAAGCAGTGTCCAGGAAAAGAAGACCCGAGTCCCCACTAAAGCTGAGCCCATGCCGAAGCCA CCTCCAGAGACTACCCCAACCCCTGCGACTCCTAAAGTAAAGAGTGGGGTGAGGAGGGCTGAACCTGCCACCCCTGTCGTCAAGGCTGTT CCAGAAGCCCCCAAGGGTGGGGAGGCGGAGTCAGGTCAATTCAGTGAAGATATGATACCCACAGTGGGCTTCAACATGAGGAAGGTAACT AAAGGTAACGTCACAATAAAGATCTGGGACATAGGAGGACAACCCCGATTTCGAAGCATGTGGGAGCGGTATTGCAGAGGAGTCAATGCT ATTGTTTACATGATAGATGCTGCAGATCGTGAAAAGATAGAAGCTTCCCGAAATGAGCTACATAATCTTCTAGATAAACCACAGTTACAA GGAATTCCAGTGCTAGTGCTTGGAAACAAGAGAGATCTTCCTAATGCCTTGGATGAGAAACAGCTAATTGAAAAAATGAATCTGTCTGCT ATTCAGGATAGAGAAATTTGCTGCTATTCAATTTCTTGCAAAGAAAAGGATAATATAGATATCACACTTCAGTGGCTTATTCAGCATTCA AAATCTAGAAGAAGCTGAAGCATCTCCTGAAGTCTTCCAGTCCTTCTTGGCTATAATCCTAGAATTATTGTCCGTTCCTCTGAAGTAATT CCCAGAATACGGTCCTTCCTAAACCCCAGAAATTGCCTTTTTCAGAGTTTATTTCTCATGTGCACTGCTGAAGATGAATATCCCTAATCC TTCATAAAGAATCAGCTAGAGTTGTCATGATAAAGTCAGCACACACAAAAAGGCTTCTTACACATACCTGTCTTAAACCATGTGTAGAGC TTTAAAAACAGAAAAAAAACCCCATATACTTATGACCATCTTAAATCAAGAAAATTGCATATTTCCATTCTGGTCTTTCTGGGCCAGATT TTTATATTGGTTTTCAGTAAATGTCTATCTATAATATTTCATTATAGAGTCCAGTAGCTTAATACTGACACTGACTTGATACAGCATGAA GTTTCTAGTGCCACACACAGTATTTAGAAAACCTTTAGGCGTGAATGACTCATGTGGGATATATGTAAACATAATGTTTATTTTATCTCA CAAATGCATGTGAAATGTATAATTACATCTTAGGAATCCAAAATGGTCTGCAGAGAGTGAGCGGAGGCACCAGATCAATGTTGGTTCTTT GCACTGGTGAGATTCTGCCTGATGAATATTAAAGATATCCTGCTTTCTGAGAACTCTATCACCAGATGGCAGTTGGGATATGGGAGGAAC TAAAGCATCCTGTTTTGTATCTGTCCAGATCATTATTTCTGTCTCTTGTTTTTTCTTCCTGGTTCAGGATACTTTTTTAAGGGGTTGAGA ATTGAAGATTTTCCAAAAGCGTTCATGAATTTAGAGCATTCCACCCAATATAATAAAACCTGTTAAGAATGTCAGTCTTTGTTCAAACAT CTGTTTGTTCTATCTCCAGTCATTAAATCAGTGCTGCTGCATGACACTCTTAACTCCTGACTTTTTATATCCAGTCATAAAGTTGACTTT CAGCACAAAAGATACTTATAAACAAATAAAAAATTTTTATTTTTCTCTCTTACTGATGTAAGCTTTGGCACTCTTTTGACTGGTGCCATT AGACATCTTGATTATTGTGACAACTCTAGACCTGCCTGCTTTATCTAATGTAATCATGCTCAATGTCTACAGGTTGTTTAATAATCAGTC ACACAGAGAACTGAGGAACTGATGCTGTTTGTTTGCTTCTATGATACAGAGATGTCTAAAAACTTCAAATGGACATGTTTTGTAGTTTAG CGACTTCCGTATACATAAAGGGACATATTAATACTGGTTCATTTGTAAATTATTATTCATATAGACCACTGTAGTAGATAAAACTCTATG GTACACCTGCTTATGTGTTGCCTCACACTGTGTGTGATTTTGTTTCTTTTGTTAAGCAGCACTTATGTAGACTGCATTTCCAAATGTGTT GAGCACTCAGAGTGTAGTCAACAGTAAGTTCTTTTAATGAATATCAGTTTTAATTTATAGACTGCCATGGCCTTAAAAATATTCTGTACA ATATACTGCACTGTGTTGCACAGACACTACTTGCTTTTCTCCATTCATATTTTTATGAGTAGAATCTGGGCTTTTAAATTTCTCTTCTTA TTCTTTGAAGCATGTTGCATACTACCCTGGTGGGATGGATGGTTCTGTAAATGAAGGGATATTTAAACTTGCTACTGTTGTTCAACACCA TTAATGGTCAGTGTGAACCATTACAAAGAATGTGGCAACTTGCTTGTGCCTAAAAGGAGGAATTGGAACTAGAATGTGTGACTCTGTGGG GACTGCATAGGTTTGTTAATTGACCTATAGCTAAACCTTAATGTGTTTGTGTGTCTATACATTGCTTTCCGCATTTCAAGACATCCAGAC GCTATTACCAACATTTTCCTGTGCATTAACCTCTGCATGTGAAAACTTTTAACAGTTACTGAACTATGTAAATATGTGAATTTTTTTATT TAGGTGGATGCATTTTTTGTCTGTTTACTGCTCTTCTCAGCTTTATTCAATAAACTTGCATTTTAAGGGTTGTATTGGCAATTTTAACTT AAAATGTGCATCATGATGGAAGGTGCAGACTTTTTTGGAAGTTTCCGAGAGGAGGGTCTATAGACCATTTGTCAGAAATCAGATCAGCCC >10406_10406_3_BSN-ARL8B_BSN_chr3_49688512_ENST00000296452_ARL8B_chr3_5212188_ENST00000256496_length(amino acids)=810AA_BP=665 MPAMGNEVSLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKEPLG NQRAASPTPKQASATTPGHESPRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSD LTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSR GPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTAEPRPPAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASL LTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSGPGPGPAPGAKTEPGARMGPGSGPGALPKTGGTTSPKHGRAEHQA ASKAAAKPKTMPKERAICPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLGEPTPLPPPTSQ QPPVGAPHRASGTSPLKQKGPQGLGQPSGPLPAKASPLSTKASPLPSKASPQAKPLRASEPSKTPSSVQEKKTRVPTKAEPMPKPPPETT PTPATPKVKSGVRRAEPATPVVKAVPEAPKGGEAESGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMI DAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS -------------------------------------------------------------- >10406_10406_4_BSN-ARL8B_BSN_chr3_49688512_ENST00000296452_ARL8B_chr3_5212188_ENST00000419534_length(transcript)=3491nt_BP=2100nt GAGCCGAGCTGGGAGATGGCGGCGGCAGCGGCGGCGCCGAGAGTGTGAGCACCGCCCGGGAGCCGCCGGCCCGGGCGCAGCGCGACCCCG ACCCCGCCCGCCCGCCTGCCCGCCATGGGCAACGAGGTCAGCCTGGAGGGCGGCGCTGGCGACGGGCCGCTGCCGCCCGGCGGCGCCGGC CCCGGCCCGGGCCCCGGCCCCGGCCCCGGCGCAGGAAAGCCGCCTTCAGCACCGGCCGGTGGCGGACAGCTCCCCGCGGCGGGAGCAGCG CGGTCGACCGCGGTACCACCGGTCCCTGGCCCCGGCCCCGGCCCCGGTCCCGGCCCTGGCCCGGGCAGCACTTCCCGGAGACTGGACCCC AAGGAACCCCTGGGTAACCAGAGAGCAGCTTCCCCAACTCCGAAGCAGGCTTCTGCTACCACTCCTGGCCATGAGAGCCCCCGAGAGACA AGGGCACAGGGACCAGCAGGCCAGGAGGCTGATGGTCCCCGCAGGACGCTGCAGGTAGACAGCAGGACACAGAGATCAGGGCGGTCCCCC TCAGTGTCACCGGACAGAGGCAGCACCCCCACATCACCCTACTCCGTCCCTCAGATCGCCCCCCTTCCCAGCAGCACGCTGTGTCCCATA TGCAAGACTTCGGACCTCACGTCGACCCCCAGCCAGCCAAACTTCAACACCTGCACCCAGTGTCACAACAAGGTCTGCAACCAGTGTGGG TTCAACCCCAACCCTCATCTCACCCAGGTGAAGGAGTGGCTCTGTCTGAACTGTCAGATGCAGAGGGCTCTGGGAATGGACATGACCACT GCACCTCGCTCCAAGAGCCAGCAGCAGCTGCACTCCCCAGCCCTGTCTCCTGCCCACTCCCCGGCCAAACAGCCCCTGGGGAAGCCAGAC CAAGAGAGATCTCGGGGCCCAGGAGGACCACAGCCTGGGTCCCGCCAGGCTGAGACAGCCAGGGCCACCTCAGTGCCGGGGCCTGCCCAA GCAGCTGCCCCTCCAGAGGTGGGGAGGGTGTCTCCTCAGCCCCCTCAACCCACCAAGCCTTCCACAGCTGAGCCCAGGCCACCTGCAGGA GAGGCCCCGGCCAAAAGTGCCACCGCAGTGCCCGCTGGGCTTGGTGCCACTGAGCAGACCCAGGAGGGCCTCACTGGTAAGCTCTTCGGC CTTGGCGCGTCACTGCTAACCCAGGCGAGCACCCTCATGTCTGTGCAGCCCGAGGCTGACACCCAGGGCCAGCCTGCCCCCAGCAAGGGG ACACCTAAGATCGTCTTCAATGATGCCAGCAAGGAGGCTGGCCCAAAACCCTTGGGCTCAGGGCCCGGGCCTGGGCCAGCACCTGGAGCC AAAACTGAGCCTGGGGCTAGAATGGGTCCTGGATCTGGACCTGGAGCCCTGCCGAAAACTGGGGGAACAACCAGTCCAAAGCATGGCAGA GCAGAACATCAGGCAGCATCGAAGGCTGCTGCCAAGCCAAAGACCATGCCGAAGGAAAGGGCCATCTGCCCACTGTGCCAAGCCGAGCTC AACGTGGGCAGCAAGAGCCCAGCCAACTATAACACATGCACCACCTGCAGGCTCCAGGTGTGCAACCTGTGTGGCTTCAACCCAACACCC CACCTGGTGGAGAAAACAGAGTGGCTCTGTCTGAACTGCCAAACCAAGCGGCTACTGGAGGGCAGCCTAGGAGAGCCGACCCCCCTGCCG CCGCCCACCTCACAGCAGCCCCCTGTAGGGGCCCCTCACCGTGCATCTGGAACATCCCCTCTGAAGCAGAAAGGGCCACAGGGGCTGGGC CAGCCTTCAGGCCCCCTGCCTGCCAAGGCCAGCCCTCTATCCACCAAGGCCAGCCCTCTGCCCAGCAAGGCCAGCCCCCAGGCCAAGCCC CTCAGGGCTTCTGAACCCAGCAAGACCCCAAGCAGTGTCCAGGAAAAGAAGACCCGAGTCCCCACTAAAGCTGAGCCCATGCCGAAGCCA CCTCCAGAGACTACCCCAACCCCTGCGACTCCTAAAGTAAAGAGTGGGGTGAGGAGGGCTGAACCTGCCACCCCTGTCGTCAAGGCTGTT CCAGAAGCCCCCAAGGGTGGGGAGGCGGAGTCAGGTCAATTCAGTGAAGATATGATACCCACAGTGGGCTTCAACATGAGGAAGGTAACT AAAGGTAACGTCACAATAAAGATCTGGGACATAGGAGGACAACCCCGATTTCGAAGCATGTGGGAGCGGTATTGCAGAGGAGTCAATGCT ATTGTTTACATGATAGATGCTGCAGATCGTGAAAAGATAGAAGCTTCCCGAAATGAGCTACATAATCTTCTAGATAAACCACAGTTACAA GGAATTCCAATATCACACTTCAGTGGCTTATTCAGCATTCAAAATCTAGAAGAAGCTGAAGCATCTCCTGAAGTCTTCCAGTCCTTCTTG GCTATAATCCTAGAATTATTGTCCGTTCCTCTGAAGTAATTCCCAGAATACGGTCCTTCCTAAACCCCAGAAATTGCCTTTTTCAGAGTT TATTTCTCATGTGCACTGCTGAAGATGAATATCCCTAATCCTTCATAAAGAATCAGCTAGAGTTGTCATGATAAAGTCAGCACACACAAA AAGGCTTCTTACACATACCTGTCTTAAACCATGTGTAGAGCTTTAAAAACAGAAAAAAAACCCCATATACTTATGACCATCTTAAATCAA GAAAATTGCATATTTCCATTCTGGTCTTTCTGGGCCAGATTTTTATATTGGTTTTCAGTAAATGTCTATCTATAATATTTCATTATAGAG TCCAGTAGCTTAATACTGACACTGACTTGATACAGCATGAAGTTTCTAGTGCCACACACAGTATTTAGAAAACCTTTAGGCGTGAATGAC TCATGTGGGATATATGTAAACATAATGTTTATTTTATCTCACAAATGCATGTGAAATGTATAATTACATCTTAGGAATCCAAAATGGTCT GCAGAGAGTGAGCGGAGGCACCAGATCAATGTTGGTTCTTTGCACTGGTGAGATTCTGCCTGATGAATATTAAAGATATCCTGCTTTCTG AGAACTCTATCACCAGATGGCAGTTGGGATATGGGAGGAACTAAAGCATCCTGTTTTGTATCTGTCCAGATCATTATTTCTGTCTCTTGT TTTTTCTTCCTGGTTCAGGATACTTTTTTAAGGGGTTGAGAATTGAAGATTTTCCAAAAGCGTTCATGAATTTAGAGCATTCCACCCAAT ATAATAAAACCTGTTAAGAATGTCAGTCTTTGTTCAAACATCTGTTTGTTCTATCTCCAGTCATTAAATCAGTGCTGCTGCATGACACTC TTAACTCCTGACTTTTTATATCCAGTCATAAAGTTGACTTTCAGCACAAAAGATACTTATAAACAAATAAAAAATTTTTATTTTTCTCTC >10406_10406_4_BSN-ARL8B_BSN_chr3_49688512_ENST00000296452_ARL8B_chr3_5212188_ENST00000419534_length(amino acids)=787AA_BP=665 MPAMGNEVSLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKEPLG NQRAASPTPKQASATTPGHESPRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSD LTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSR GPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTAEPRPPAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASL LTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSGPGPGPAPGAKTEPGARMGPGSGPGALPKTGGTTSPKHGRAEHQA ASKAAAKPKTMPKERAICPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLGEPTPLPPPTSQ QPPVGAPHRASGTSPLKQKGPQGLGQPSGPLPAKASPLSTKASPLPSKASPQAKPLRASEPSKTPSSVQEKKTRVPTKAEPMPKPPPETT PTPATPKVKSGVRRAEPATPVVKAVPEAPKGGEAESGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMI -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for BSN-ARL8B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for BSN-ARL8B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for BSN-ARL8B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies