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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTAF1-MARCH5 (FusionGDB2 ID:10425)

Fusion Gene Summary for BTAF1-MARCH5

check button Fusion gene summary
Fusion gene informationFusion gene name: BTAF1-MARCH5
Fusion gene ID: 10425
HgeneTgene
Gene symbol

BTAF1

MARCH5

Gene ID

9044

54708

Gene nameB-TFIID TATA-box binding protein associated factor 1membrane associated ring-CH-type finger 5
SynonymsMOT1|TAF(II)170|TAF172|TAFII170MARCH-V|MARCH5|MITOL|RNF153
Cytomap

10q23.32

10q23.32-q23.33

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 172ATP-dependent helicase BTAF1B-TFIID transcription factor-associated 170 kDa subunitBTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)Mot1 homologTBP-associaE3 ubiquitin-protein ligase MARCH5RING-type E3 ubiquitin transferase MARCH5membrane associated ring finger 5membrane-associated RING finger protein 5membrane-associated RING-CH protein Vmembrane-associated ring finger (C3HC4) 5mitochondrial ubiquiti
Modification date2020031320200313
UniProtAcc

O14981

.
Ensembl transtripts involved in fusion geneENST00000265990, ENST00000471217, 
ENST00000544642, 		ENST00000467521, 
ENST00000358935, 
Fusion gene scores* DoF score7 X 4 X 9=2526 X 7 X 4=168
# samples 108
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTAF1 [Title/Abstract] AND MARCH5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTAF1(93683847)-MARCH5(94070892), # samples:2
Anticipated loss of major functional domain due to fusion event.BTAF1-MARCH5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBTAF1

GO:0045892

negative regulation of transcription, DNA-templated

9488487

TgeneMARCH5

GO:0000209

protein polyubiquitination

16936636

TgeneMARCH5

GO:0051865

protein autoubiquitination

16874301


check buttonFusion gene breakpoints across BTAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARCH5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EA-A50E-01ABTAF1chr10

93683847

+MARCH5chr10

94109106

+
ChimerDB4LUSCTCGA-85-8071-01ABTAF1chr10

93683847

+MARCH5chr10

94070892

+
ChimerDB4LUSCTCGA-85-8071BTAF1chr10

93683847

+MARCH5chr10

94070891

+
ChimerDB4LUSCTCGA-85-8071BTAF1chr10

93683847

+MARCH5chr10

94070892

+


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Fusion Gene ORF analysis for BTAF1-MARCH5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265990ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94109106

+
5CDS-3UTRENST00000265990ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070892

+
5CDS-3UTRENST00000265990ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070891

+
Frame-shiftENST00000265990ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94109106

+
In-frameENST00000265990ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070892

+
In-frameENST00000265990ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070891

+
intron-3CDSENST00000471217ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94109106

+
intron-3CDSENST00000471217ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070892

+
intron-3CDSENST00000471217ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070891

+
intron-3CDSENST00000544642ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94109106

+
intron-3CDSENST00000544642ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070892

+
intron-3CDSENST00000544642ENST00000358935BTAF1chr10

93683847

+MARCH5chr10

94070891

+
intron-3UTRENST00000471217ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94109106

+
intron-3UTRENST00000471217ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070892

+
intron-3UTRENST00000471217ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070891

+
intron-3UTRENST00000544642ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94109106

+
intron-3UTRENST00000544642ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070892

+
intron-3UTRENST00000544642ENST00000467521BTAF1chr10

93683847

+MARCH5chr10

94070891

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265990BTAF1chr1093683847+ENST00000358935MARCH5chr1094070892+38813223081123271
ENST00000265990BTAF1chr1093683847+ENST00000358935MARCH5chr1094070891+38813223081123271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265990ENST00000358935BTAF1chr1093683847+MARCH5chr1094070892+0.0004024980.9995975
ENST00000265990ENST00000358935BTAF1chr1093683847+MARCH5chr1094070891+0.0004024980.9995975

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Fusion Genomic Features for BTAF1-MARCH5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BTAF1-MARCH5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93683847/chr10:94070892)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTAF1

O14981

.
FUNCTION: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARCH5chr10:93683847chr10:94070891ENST0000035893506139_15911279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070891ENST0000035893506209_22911279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070891ENST0000035893506238_25811279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070891ENST000003589350699_11911279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070892ENST0000035893506139_15911279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070892ENST0000035893506209_22911279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070892ENST0000035893506238_25811279.0TransmembraneHelical
TgeneMARCH5chr10:93683847chr10:94070892ENST000003589350699_11911279.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381278_145341850.0DomainHelicase ATP-binding
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381636_179041850.0DomainHelicase C-terminal
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381278_145341850.0DomainHelicase ATP-binding
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381636_179041850.0DomainHelicase C-terminal
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381404_140741850.0MotifNote=DEGH box
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138191_20741850.0MotifNuclear localization signal
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381404_140741850.0MotifNote=DEGH box
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138191_20741850.0MotifNuclear localization signal
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381291_129841850.0Nucleotide bindingATP
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381291_129841850.0Nucleotide bindingATP
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381102_113941850.0RepeatNote=HEAT 7
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+1381182_121941850.0RepeatNote=HEAT 8
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138385_42241850.0RepeatNote=HEAT 1
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138426_46341850.0RepeatNote=HEAT 2
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138513_55041850.0RepeatNote=HEAT 3
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138554_59641850.0RepeatNote=HEAT 4
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138818_85541850.0RepeatNote=HEAT 5
HgeneBTAF1chr10:93683847chr10:94070891ENST00000265990+138872_91041850.0RepeatNote=HEAT 6
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381102_113941850.0RepeatNote=HEAT 7
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+1381182_121941850.0RepeatNote=HEAT 8
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138385_42241850.0RepeatNote=HEAT 1
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138426_46341850.0RepeatNote=HEAT 2
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138513_55041850.0RepeatNote=HEAT 3
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138554_59641850.0RepeatNote=HEAT 4
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138818_85541850.0RepeatNote=HEAT 5
HgeneBTAF1chr10:93683847chr10:94070892ENST00000265990+138872_91041850.0RepeatNote=HEAT 6
TgeneMARCH5chr10:93683847chr10:94070891ENST00000358935066_7511279.0Zinc fingerRING-CH-type
TgeneMARCH5chr10:93683847chr10:94070892ENST00000358935066_7511279.0Zinc fingerRING-CH-type


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Fusion Gene Sequence for BTAF1-MARCH5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10425_10425_1_BTAF1-MARCH5_BTAF1_chr10_93683847_ENST00000265990_MARCH5_chr10_94070891_ENST00000358935_length(transcript)=3881nt_BP=322nt
CAGTTGTGCGTGCCGACGCCCGCGTCAGCAAAGAGCGGAGCTGAGGGTACCCGGTTTGAAGTCGTGCGGGTCGGAGGACTGCCGCCTCCG
CTACCGTCTTGGACCCCTGCTTACCGGCCGCCGCGGGGACGAGCTCGGGTAGGCGGCAGGGCAGATGCCCGAGGGCCTGCGCTGGAACGC
CCCACGCCGCACCGGCCGCTCCCCTGTGCTCCGCGGCCTGGGCCTGCGCCGCTCAGCTCTCTGGAAACTAGCGCCTCAGCTGCGCGGCGC
GTAGGTCGCGGGGAGCTCCGAACCGCCGGCGCCCGGCCATGGCGGTCTCCAGAAGTTGCTGGGTTTGTTTTGCTACTGATGAAGATGATA
GAACAGCTGAATGGGTGAGACCATGCAGGTGCAGAGGATCTACAAAATGGGTTCACCAGGCCTGTCTACAACGCTGGGTGGATGAAAAGC
AAAGAGGAAACAGTACAGCCAGAGTGGCATGTCCTCAGTGCAATGCTGAATACCTAATAGTTTTTCCAAAATTGGGTCCAGTGGTTTACG
TCTTGGATCTTGCAGATAGACTGATCTCAAAAGCCTGTCCATTTGCTGCAGCAGGAATAATGGTCGGCTCTATCTATTGGACAGCTGTGA
CTTATGGAGCAGTGACAGTGATGCAGGTTGTAGGTCATAAAGAAGGTCTGGATGTTATGGAGAGAGCTGATCCTTTATTCCTTTTAATTG
GACTTCCTACTATTCCTGTCATGCTGATATTAGGCAAGATGATTCGCTGGGAGGACTATGTGCTTAGACTGTGGCGCAAATACTCGAATA
AACTACAAATTTTAAATAGTATATTTCCAGGGATAGGTTGTCCTGTTCCTCGAATTCCAGCTGAGGCCAATCCTTTAGCAGATCATGTCT
CTGCTACTCGAATCTTGTGTGGAGCCCTTGTCTTTCCTACTATTGCTACAATAGTTGGTAAATTGATGTTCAGTAGTGTTAACTCTAATT
TACAAAGGACAATCTTGGGTGGAATTGCGTTTGTTGCCATAAAAGGAGCATTTAAAGTTTACTTCAAACAGCAGCAATATTTACGACAGG
CACACCGCAAAATTCTGAATTATCCAGAACAAGAAGAAGCATAAAACTGACTTCTGGTTGTTCTGCAGTTCTCTCATCCTTATGAATCTG
TTGTGTTGTTTTGATTCCATCATTAATGCACTTGTGGAGACTTGTGATAAGCTGCTGCTCCTATATTTTTTAAGAAATATAATAAAGCAC
TTAGGGCAGGGGAAATCATCTCGGTAATCATGGAACCTAAGGATGTGATTTGTTTTCATTGTTTGTATGTACTACTTTTATGGCAGTCAT
ATGAACCATTATCTTAGCATGGTAAACCTGGGTTTTGTTCATATTTTCTCCAGACAGAAATGCAAAGATCAAACTGTGCAAATATTAAAA
AAATGCACATGCTGTTTTATTCAAATGCCTCTTTTGTACATGTTCATGTTTAGTGTTTTCTCAGAATCAGCAACTCAAGGTACTATGAGG
ATTTTTCTCACTGACATAATTTGATTACATACTAAATAAGAGGATATGTTAATATGAGGAAATGTAAATTAAATTAGTTATAAATAAATA
ACCAAAAATGTATGTAAACATTCAAATGATTATCTGAACAAATGAGATTTTGTGGTGTTTTCTTTAACCCATGTGATGTCCTCCAAAATG
TGTAGGGTAAAAATTCACAGGGCTTCCAGATCACTTTTTCAATATTAAATTTTATTTACATAATGTTGACATCTCATACTTCATGAAGTA
ATTTTGACTCATGCAGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGTTTCAGTGTTTCATCAGGTCCTTCC
ATCTCTGGGAGTTTTTTCAACCCATATTTCTAGAAATTACAGCTGCCAGTTTATAGTAGTTTGAGCAGAGGATGATTTGCAAAAATAAAA
ATAAAGTTATTTTACTCTCCTCTTGCATTGATTCAGTTATTGAGATATTCGTTGATCACCTCCTATTTCCCAGGCACTGTGCAGAGTGCT
GTAGGACATAGTGGTGAACAAGACAGACTTGGTCCAAGCTCTTACAGAGTTGACAGTCTAGTTTCAGCACATAGAAAACCAGCAGTGAAT
AAACCAAGGTGAGGCCTTGAGCTCTTTGTTTTTATATTAATGAGGAGAAAAGTATGAAAACAAGAAGTCTTAAGTAAATATTGAGGTCAT
TGTTTTTGGCTTAAGTTTATTATAGAAAATCAACACTAATGTTTTTAGATTTTAATTGTCCTATTGATGAGGCTAGCACCTTAATCACTG
TTTAGTTTTGTATTCATTTTTAAAAGCAATTATTGAAGCCATTTTCAATAGATTGGCCATTTTAATGTTCAGCAACCTGAATGGTTATTT
TTGTTAATTAAAATTAAATTTTTAAGAGATATTTTCAAAACCCTATTTATTTTCTTGTTCACAGTAATGCATGTCAATAATAAATGTTTC
CCCTTACTGATAAGCGGCCACTTTAGGAGTGTAGCAAATATAGATTGAGCTATGTTAGTTTGCAATAATATATGTTAACTTTAGTAATTA
AAGACTGGTTTCTATAGTATGAATGTCTTAATTTTGAGTTATATGATGTTTATTTGAATGACTGTTGAACATTCAAATTTGTATTATTTG
GAGATGAAGATTTGACTAACAGTGAGCCTTATTAAGAACACTACTACAGTTCTGAAGGGGAAATATAACATCTATGGTTATATATTTTAA
AAACTTAGATTATAGGCTGTAATTATAAAATATATTGGCTTTTGTTTTCAATGTGAAAGATACATTAAATGGACACATATCTTGCAAAAT
TTTGTTGTATAGAACAGTTTTTAGGCAGCCTTTACTAAAGTTATGCAAACACACAGTTCCCCATTTACTACATTAATGCCCTTGACAGGG
AGTAGCTGCTTGGTTTTATAGGTATTAGGGCTCATGAAGGCCGGGGAACAACTCTAATCCTTTTGGGGCAGGAGGGAGGGTTTTTTTAGG
GTTGCGGGGAGGGAACTGCAAGTGCCTGAGGACCAGAGTGGCCTCTAGCCCCGAATTGAACACTTTTAAACCTAAAGAGCCTTATTATTA
TTAGCTCGAGAAATACCACATGCCAGTCTTCCCAGGAAGGTGACCTGCCTGACCATGAAGCAACAAAAGAGCATAGGCAGACTTAAAGTT
GGATAGACCTGGGTTCAAATCATAGTTCAGCTTTCAATAACTGTATGTATGATTTTGGCTAAAGGATTTGACTTTCTCTCAACTGCAGTT
TTCTTAATCTTTGAAATGCAAATAATGTTTATCTCAGAAGACTATTTCTAGGATTAACTGAGAGATTAAAGGAACAGCAGCACTTAGGCT
CAAAATCGCCCCTACAAAGCAGTAGTTGTTTCTTAATTGCTAAGTAATCTGTTTGCACTCTAGGAAAAGTAAATGGAGAGGTAAAAGAAA
GGCATTGGGGACAAATGAAAGAGATGATGTAGATTTTTCGGATGGGTGGGTATATTTTATTTTCCAGTTTATTTTCATATTTCTTTACTG
TGTTATTTCTGGAAACTTTAATGTTTTAAACCTCTTTTATAAAATTCAATGACGACTACTAGAATTCTTTTCAAAAGTTAACTTATCTCC
AAAGTGGCTGAAAATATTGTTTACCATTACATGATTATGAAATGACTGTGAAGAATATAAAATTAAACTTAGTGACTTAATTAGTCACTG
CCTTGCTAACTTTGCTGTAATTTTTTTAAACGTCTTGTTTTTAATATAGCAAACTATCTCAATACTGGCTGGATTAGGTTAAATAAAGAA

>10425_10425_1_BTAF1-MARCH5_BTAF1_chr10_93683847_ENST00000265990_MARCH5_chr10_94070891_ENST00000358935_length(amino acids)=271AA_BP=4
MAVSRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKAC
PFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIG
CPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEE

--------------------------------------------------------------
>10425_10425_2_BTAF1-MARCH5_BTAF1_chr10_93683847_ENST00000265990_MARCH5_chr10_94070892_ENST00000358935_length(transcript)=3881nt_BP=322nt
CAGTTGTGCGTGCCGACGCCCGCGTCAGCAAAGAGCGGAGCTGAGGGTACCCGGTTTGAAGTCGTGCGGGTCGGAGGACTGCCGCCTCCG
CTACCGTCTTGGACCCCTGCTTACCGGCCGCCGCGGGGACGAGCTCGGGTAGGCGGCAGGGCAGATGCCCGAGGGCCTGCGCTGGAACGC
CCCACGCCGCACCGGCCGCTCCCCTGTGCTCCGCGGCCTGGGCCTGCGCCGCTCAGCTCTCTGGAAACTAGCGCCTCAGCTGCGCGGCGC
GTAGGTCGCGGGGAGCTCCGAACCGCCGGCGCCCGGCCATGGCGGTCTCCAGAAGTTGCTGGGTTTGTTTTGCTACTGATGAAGATGATA
GAACAGCTGAATGGGTGAGACCATGCAGGTGCAGAGGATCTACAAAATGGGTTCACCAGGCCTGTCTACAACGCTGGGTGGATGAAAAGC
AAAGAGGAAACAGTACAGCCAGAGTGGCATGTCCTCAGTGCAATGCTGAATACCTAATAGTTTTTCCAAAATTGGGTCCAGTGGTTTACG
TCTTGGATCTTGCAGATAGACTGATCTCAAAAGCCTGTCCATTTGCTGCAGCAGGAATAATGGTCGGCTCTATCTATTGGACAGCTGTGA
CTTATGGAGCAGTGACAGTGATGCAGGTTGTAGGTCATAAAGAAGGTCTGGATGTTATGGAGAGAGCTGATCCTTTATTCCTTTTAATTG
GACTTCCTACTATTCCTGTCATGCTGATATTAGGCAAGATGATTCGCTGGGAGGACTATGTGCTTAGACTGTGGCGCAAATACTCGAATA
AACTACAAATTTTAAATAGTATATTTCCAGGGATAGGTTGTCCTGTTCCTCGAATTCCAGCTGAGGCCAATCCTTTAGCAGATCATGTCT
CTGCTACTCGAATCTTGTGTGGAGCCCTTGTCTTTCCTACTATTGCTACAATAGTTGGTAAATTGATGTTCAGTAGTGTTAACTCTAATT
TACAAAGGACAATCTTGGGTGGAATTGCGTTTGTTGCCATAAAAGGAGCATTTAAAGTTTACTTCAAACAGCAGCAATATTTACGACAGG
CACACCGCAAAATTCTGAATTATCCAGAACAAGAAGAAGCATAAAACTGACTTCTGGTTGTTCTGCAGTTCTCTCATCCTTATGAATCTG
TTGTGTTGTTTTGATTCCATCATTAATGCACTTGTGGAGACTTGTGATAAGCTGCTGCTCCTATATTTTTTAAGAAATATAATAAAGCAC
TTAGGGCAGGGGAAATCATCTCGGTAATCATGGAACCTAAGGATGTGATTTGTTTTCATTGTTTGTATGTACTACTTTTATGGCAGTCAT
ATGAACCATTATCTTAGCATGGTAAACCTGGGTTTTGTTCATATTTTCTCCAGACAGAAATGCAAAGATCAAACTGTGCAAATATTAAAA
AAATGCACATGCTGTTTTATTCAAATGCCTCTTTTGTACATGTTCATGTTTAGTGTTTTCTCAGAATCAGCAACTCAAGGTACTATGAGG
ATTTTTCTCACTGACATAATTTGATTACATACTAAATAAGAGGATATGTTAATATGAGGAAATGTAAATTAAATTAGTTATAAATAAATA
ACCAAAAATGTATGTAAACATTCAAATGATTATCTGAACAAATGAGATTTTGTGGTGTTTTCTTTAACCCATGTGATGTCCTCCAAAATG
TGTAGGGTAAAAATTCACAGGGCTTCCAGATCACTTTTTCAATATTAAATTTTATTTACATAATGTTGACATCTCATACTTCATGAAGTA
ATTTTGACTCATGCAGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGTTTCAGTGTTTCATCAGGTCCTTCC
ATCTCTGGGAGTTTTTTCAACCCATATTTCTAGAAATTACAGCTGCCAGTTTATAGTAGTTTGAGCAGAGGATGATTTGCAAAAATAAAA
ATAAAGTTATTTTACTCTCCTCTTGCATTGATTCAGTTATTGAGATATTCGTTGATCACCTCCTATTTCCCAGGCACTGTGCAGAGTGCT
GTAGGACATAGTGGTGAACAAGACAGACTTGGTCCAAGCTCTTACAGAGTTGACAGTCTAGTTTCAGCACATAGAAAACCAGCAGTGAAT
AAACCAAGGTGAGGCCTTGAGCTCTTTGTTTTTATATTAATGAGGAGAAAAGTATGAAAACAAGAAGTCTTAAGTAAATATTGAGGTCAT
TGTTTTTGGCTTAAGTTTATTATAGAAAATCAACACTAATGTTTTTAGATTTTAATTGTCCTATTGATGAGGCTAGCACCTTAATCACTG
TTTAGTTTTGTATTCATTTTTAAAAGCAATTATTGAAGCCATTTTCAATAGATTGGCCATTTTAATGTTCAGCAACCTGAATGGTTATTT
TTGTTAATTAAAATTAAATTTTTAAGAGATATTTTCAAAACCCTATTTATTTTCTTGTTCACAGTAATGCATGTCAATAATAAATGTTTC
CCCTTACTGATAAGCGGCCACTTTAGGAGTGTAGCAAATATAGATTGAGCTATGTTAGTTTGCAATAATATATGTTAACTTTAGTAATTA
AAGACTGGTTTCTATAGTATGAATGTCTTAATTTTGAGTTATATGATGTTTATTTGAATGACTGTTGAACATTCAAATTTGTATTATTTG
GAGATGAAGATTTGACTAACAGTGAGCCTTATTAAGAACACTACTACAGTTCTGAAGGGGAAATATAACATCTATGGTTATATATTTTAA
AAACTTAGATTATAGGCTGTAATTATAAAATATATTGGCTTTTGTTTTCAATGTGAAAGATACATTAAATGGACACATATCTTGCAAAAT
TTTGTTGTATAGAACAGTTTTTAGGCAGCCTTTACTAAAGTTATGCAAACACACAGTTCCCCATTTACTACATTAATGCCCTTGACAGGG
AGTAGCTGCTTGGTTTTATAGGTATTAGGGCTCATGAAGGCCGGGGAACAACTCTAATCCTTTTGGGGCAGGAGGGAGGGTTTTTTTAGG
GTTGCGGGGAGGGAACTGCAAGTGCCTGAGGACCAGAGTGGCCTCTAGCCCCGAATTGAACACTTTTAAACCTAAAGAGCCTTATTATTA
TTAGCTCGAGAAATACCACATGCCAGTCTTCCCAGGAAGGTGACCTGCCTGACCATGAAGCAACAAAAGAGCATAGGCAGACTTAAAGTT
GGATAGACCTGGGTTCAAATCATAGTTCAGCTTTCAATAACTGTATGTATGATTTTGGCTAAAGGATTTGACTTTCTCTCAACTGCAGTT
TTCTTAATCTTTGAAATGCAAATAATGTTTATCTCAGAAGACTATTTCTAGGATTAACTGAGAGATTAAAGGAACAGCAGCACTTAGGCT
CAAAATCGCCCCTACAAAGCAGTAGTTGTTTCTTAATTGCTAAGTAATCTGTTTGCACTCTAGGAAAAGTAAATGGAGAGGTAAAAGAAA
GGCATTGGGGACAAATGAAAGAGATGATGTAGATTTTTCGGATGGGTGGGTATATTTTATTTTCCAGTTTATTTTCATATTTCTTTACTG
TGTTATTTCTGGAAACTTTAATGTTTTAAACCTCTTTTATAAAATTCAATGACGACTACTAGAATTCTTTTCAAAAGTTAACTTATCTCC
AAAGTGGCTGAAAATATTGTTTACCATTACATGATTATGAAATGACTGTGAAGAATATAAAATTAAACTTAGTGACTTAATTAGTCACTG
CCTTGCTAACTTTGCTGTAATTTTTTTAAACGTCTTGTTTTTAATATAGCAAACTATCTCAATACTGGCTGGATTAGGTTAAATAAAGAA

>10425_10425_2_BTAF1-MARCH5_BTAF1_chr10_93683847_ENST00000265990_MARCH5_chr10_94070892_ENST00000358935_length(amino acids)=271AA_BP=4
MAVSRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKAC
PFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIG
CPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEE

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Fusion Gene PPI Analysis for BTAF1-MARCH5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTAF1-MARCH5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTAF1-MARCH5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource