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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTBD1-BBOX1 (FusionGDB2 ID:10439)

Fusion Gene Summary for BTBD1-BBOX1

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD1-BBOX1
Fusion gene ID: 10439
HgeneTgene
Gene symbol

BTBD1

BBOX1

Gene ID

53339

8424

Gene nameBTB domain containing 1gamma-butyrobetaine hydroxylase 1
SynonymsC15orf1|NS5ATP8BBH|BBOX|G-BBH|gamma-BBH
Cytomap

15q25.2

11p14.2

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 1BTB (POZ) domain containing 1HCV NS5A-transactivated protein 8hepatitis C virus NS5A-transactivated protein 8gamma-butyrobetaine dioxygenasebutyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1gamma-butyrobetaine,2-oxoglutarate dioxygenase 1
Modification date2020032720200313
UniProtAcc

Q9H0C5

O75936

Ensembl transtripts involved in fusion geneENST00000261721, ENST00000379403, 
ENST00000560015, 		ENST00000527505, 
ENST00000263182, ENST00000525090, 
ENST00000528583, ENST00000529202, 
Fusion gene scores* DoF score11 X 9 X 9=8914 X 5 X 3=60
# samples 135
** MAII scorelog2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD1 [Title/Abstract] AND BBOX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTBD1(83710480)-BBOX1(27114715), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBBOX1

GO:0045329

carnitine biosynthetic process

9753662|20599753


check buttonFusion gene breakpoints across BTBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BBOX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A9UO-01ABTBD1chr15

83710480

-BBOX1chr11

27114715

+
ChimerDB4CESCTCGA-VS-A9UOBTBD1chr15

83710480

-BBOX1chr11

27114715

+


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Fusion Gene ORF analysis for BTBD1-BBOX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261721ENST00000527505BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5CDS-intronENST00000379403ENST00000527505BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5UTR-3CDSENST00000560015ENST00000263182BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5UTR-3CDSENST00000560015ENST00000525090BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5UTR-3CDSENST00000560015ENST00000528583BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5UTR-3CDSENST00000560015ENST00000529202BTBD1chr15

83710480

-BBOX1chr11

27114715

+
5UTR-intronENST00000560015ENST00000527505BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000261721ENST00000263182BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000261721ENST00000525090BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000261721ENST00000528583BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000261721ENST00000529202BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000379403ENST00000263182BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000379403ENST00000525090BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000379403ENST00000528583BTBD1chr15

83710480

-BBOX1chr11

27114715

+
In-frameENST00000379403ENST00000529202BTBD1chr15

83710480

-BBOX1chr11

27114715

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261721BTBD1chr1583710480-ENST00000529202BBOX1chr1127114715+211710652031894563
ENST00000261721BTBD1chr1583710480-ENST00000263182BBOX1chr1127114715+224910652031894563
ENST00000261721BTBD1chr1583710480-ENST00000528583BBOX1chr1127114715+225110652031894563
ENST00000261721BTBD1chr1583710480-ENST00000525090BBOX1chr1127114715+211310652031894563
ENST00000379403BTBD1chr1583710480-ENST00000529202BBOX1chr1127114715+191486201691563
ENST00000379403BTBD1chr1583710480-ENST00000263182BBOX1chr1127114715+204686201691563
ENST00000379403BTBD1chr1583710480-ENST00000528583BBOX1chr1127114715+204886201691563
ENST00000379403BTBD1chr1583710480-ENST00000525090BBOX1chr1127114715+191086201691563

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261721ENST00000529202BTBD1chr1583710480-BBOX1chr1127114715+0.0010933570.9989066
ENST00000261721ENST00000263182BTBD1chr1583710480-BBOX1chr1127114715+0.0009786860.9990213
ENST00000261721ENST00000528583BTBD1chr1583710480-BBOX1chr1127114715+0.0009811570.9990188
ENST00000261721ENST00000525090BTBD1chr1583710480-BBOX1chr1127114715+0.0011188510.99888116
ENST00000379403ENST00000529202BTBD1chr1583710480-BBOX1chr1127114715+0.0010740460.998926
ENST00000379403ENST00000263182BTBD1chr1583710480-BBOX1chr1127114715+0.0009509060.9990491
ENST00000379403ENST00000528583BTBD1chr1583710480-BBOX1chr1127114715+0.0009557780.99904424
ENST00000379403ENST00000525090BTBD1chr1583710480-BBOX1chr1127114715+0.0011055650.9988945

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Fusion Genomic Features for BTBD1-BBOX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BTBD1chr1583710479-BBOX1chr1127114714+0.0014480260.9985519
BTBD1chr1583710479-BBOX1chr1127114714+0.0014480260.9985519
BTBD1chr1583710479-BBOX1chr1127114714+0.0014480260.9985519
BTBD1chr1583710479-BBOX1chr1127114714+0.0014480260.9985519

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BTBD1-BBOX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:83710480/chr11:27114715)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTBD1

Q9H0C5

BBOX1

O75936

FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}.FUNCTION: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD1chr15:83710480chr11:27114715ENST00000261721-4825_31287483.0Compositional biasPoly-Pro
HgeneBTBD1chr15:83710480chr11:27114715ENST00000379403-4725_31287337.3333333333333Compositional biasPoly-Pro
HgeneBTBD1chr15:83710480chr11:27114715ENST00000261721-48184_284287483.0DomainBACK
HgeneBTBD1chr15:83710480chr11:27114715ENST00000261721-4869_145287483.0DomainBTB
HgeneBTBD1chr15:83710480chr11:27114715ENST00000379403-47184_284287337.3333333333333DomainBACK
HgeneBTBD1chr15:83710480chr11:27114715ENST00000379403-4769_145287337.3333333333333DomainBTB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BTBD1-BBOX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10439_10439_1_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000263182_length(transcript)=2249nt_BP=1065nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAA
TAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACAC
TCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGA
ATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGG
GCTCAGAGCTCCAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAG
TAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTT
ATGGACATACTTGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAG
CCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATG
TGTGCCAAAAACTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACT
GTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGG
ACACAATATTTGATGTGCCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCA
AGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTG
AGATATCCCGCCATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAA
ACTGAAGTCACCTGTAGATAATTTTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTG
ATTTACATATAATTTCCTTAACAATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTA
GATGTTTCACCACTCTTTTGCAAATAAAGCATCCTTTCTGCTCTGTTGCATGCCTGCTCTAATTTCTTTTGCCCATATATGAGTATCTCC

>10439_10439_1_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000263182_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_2_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000525090_length(transcript)=2113nt_BP=1065nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAA
TAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACAC
TCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGA
ATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGG
GCTCAGAGCTCCAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAG
TAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTT
ATGGACATACTTGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAG
CCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATG
TGTGCCAAAAACTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACT
GTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGG
ACACAATATTTGATGTGCCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCA
AGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTG
AGATATCCCGCCATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAA
ACTGAAGTCACCTGTAGATAATTTTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTG
ATTTACATATAATTTCCTTAACAATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTA

>10439_10439_2_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000525090_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_3_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000528583_length(transcript)=2251nt_BP=1065nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAA
TAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACAC
TCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGA
ATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGG
GCTCAGAGCTCCAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAG
TAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTT
ATGGACATACTTGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAG
CCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATG
TGTGCCAAAAACTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACT
GTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGG
ACACAATATTTGATGTGCCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCA
AGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTG
AGATATCCCGCCATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAA
ACTGAAGTCACCTGTAGATAATTTTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTG
ATTTACATATAATTTCCTTAACAATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTA
GATGTTTCACCACTCTTTTGCAAATAAAGCATCCTTTCTGCTCTGTTGCATGCCTGCTCTAATTTCTTTTGCCCATATATGAGTATCTCC
AGAATGTCTACAAATAGTTTTTGTAGCAAATGAAAATTTCTTCAAATAAGCCTTTTGTTTCAAATAAAACTTGTCTCAAAACATGCTTCT

>10439_10439_3_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000528583_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_4_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000529202_length(transcript)=2117nt_BP=1065nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAA
TAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACAC
TCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGA
ATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGG
GCTCAGAGCTCCAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAG
TAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTT
ATGGACATACTTGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAG
CCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATG
TGTGCCAAAAACTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACT
GTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGG
ACACAATATTTGATGTGCCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCA
AGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTG
AGATATCCCGCCATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAA
ACTGAAGTCACCTGTAGATAATTTTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTG
ATTTACATATAATTTCCTTAACAATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTA

>10439_10439_4_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000261721_BBOX1_chr11_27114715_ENST00000529202_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_5_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000263182_length(transcript)=2046nt_BP=862nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCA
ATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTT
TTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAA
GCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGGGCTCAGAGCTCCAGCTACCCACT
TTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGA
GCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACTTGGCAAGTGCAA
GACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTT
CAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAACTAAAGAAAAAT
AATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAA
CATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTTGATGTGCCTGTT
GAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCA
GGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGCCATCTAGAAGGA
GCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAAACTGAAGTCACCTGTAGATAATT
TTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTGATTTACATATAATTTCCTTAACA
ATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTAGATGTTTCACCACTCTTTTGCAA
ATAAAGCATCCTTTCTGCTCTGTTGCATGCCTGCTCTAATTTCTTTTGCCCATATATGAGTATCTCCAGAATGTCTACAAATAGTTTTTG

>10439_10439_5_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000263182_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_6_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000525090_length(transcript)=1910nt_BP=862nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCA
ATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTT
TTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAA
GCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGGGCTCAGAGCTCCAGCTACCCACT
TTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGA
GCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACTTGGCAAGTGCAA
GACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTT
CAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAACTAAAGAAAAAT
AATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAA
CATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTTGATGTGCCTGTT
GAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCA
GGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGCCATCTAGAAGGA
GCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAAACTGAAGTCACCTGTAGATAATT
TTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTGATTTACATATAATTTCCTTAACA
ATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTAGATGTTTCACCACTCTTTTGCAA

>10439_10439_6_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000525090_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_7_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000528583_length(transcript)=2048nt_BP=862nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCA
ATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTT
TTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAA
GCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGGGCTCAGAGCTCCAGCTACCCACT
TTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGA
GCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACTTGGCAAGTGCAA
GACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTT
CAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAACTAAAGAAAAAT
AATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAA
CATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTTGATGTGCCTGTT
GAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCA
GGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGCCATCTAGAAGGA
GCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAAACTGAAGTCACCTGTAGATAATT
TTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTGATTTACATATAATTTCCTTAACA
ATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTAGATGTTTCACCACTCTTTTGCAA
ATAAAGCATCCTTTCTGCTCTGTTGCATGCCTGCTCTAATTTCTTTTGCCCATATATGAGTATCTCCAGAATGTCTACAAATAGTTTTTG

>10439_10439_7_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000528583_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------
>10439_10439_8_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000529202_length(transcript)=1914nt_BP=862nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCA
ATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTT
TTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAA
GCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGAATGCCAATACTGGGGCTCAGAGCTCCAGCTACCCACT
TTGGATTTTGAAGATGTTTTAAGATATGATGAACACGCATACAAGTGGCTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGA
GCATCTGACAAACCAGGAGAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACTTGGCAAGTGCAA
GACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGCTTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTT
CAGCTTCTTCACTGCATAAAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAACTAAAGAAAAAT
AATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACAGACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAA
CATAAAATTATAGAGTTAGATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTTGATGTGCCTGTT
GAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTCATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCA
GGTGATGTGATTACTTTTGATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGCCATCTAGAAGGA
GCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGGCAGAGGGTGGAGAATGGAAACTGAAGTCACCTGTAGATAATT
TTAATAAGATTCCAATGACCATATTTTGTGAGATATGGCACATTATTCACAGACCATGATCTTTGTGATTTACATATAATTTCCTTAACA
ATGAACATGTAACTTCTCTCACAAGAGTACTCTTTACTTTGTAATCATATACAATGTCAACTTTTTAGATGTTTCACCACTCTTTTGCAA

>10439_10439_8_BTBD1-BBOX1_BTBD1_chr15_83710480_ENST00000379403_BBOX1_chr11_27114715_ENST00000529202_length(amino acids)=563AA_BP=287
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGK
ALSLIRFPLMTIEEFAAECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQ
DKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSK
HKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTBD1-BBOX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTBD1-BBOX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTBD1-BBOX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource