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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BTBD1-CSTF3 (FusionGDB2 ID:10440)

Fusion Gene Summary for BTBD1-CSTF3

Fusion gene summary

Fusion gene information	Fusion gene name: BTBD1-CSTF3
	Fusion gene ID: 10440
		Hgene	Tgene
	Gene symbol	BTBD1	CSTF3
	Gene ID	53339	1479
	Gene name	BTB domain containing 1	cleavage stimulation factor subunit 3
	Synonyms	C15orf1\|NS5ATP8	CSTF-77
	Cytomap	15q25.2	11p13
	Type of gene	protein-coding	protein-coding
	Description	BTB/POZ domain-containing protein 1BTB (POZ) domain containing 1HCV NS5A-transactivated protein 8hepatitis C virus NS5A-transactivated protein 8	cleavage stimulation factor subunit 3CF-1 77 kDa subunitCSTF 77 kDa subunitcleavage stimulation factor 77 kDa subunitcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
	Modification date	20200327	20200313
	UniProtAcc	Q9H0C5	Q12996
	Ensembl transtripts involved in fusion gene	ENST00000261721, ENST00000379403, ENST00000560015,	ENST00000431742, ENST00000438862, ENST00000526480, ENST00000323959, ENST00000524827,
Fusion gene scores	* DoF score	11 X 9 X 9=891	7 X 4 X 6=168
	# samples	13	8
	** MAII score	log2(13/891*10)=-2.77691380849347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTBD1 [Title/Abstract] AND CSTF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BTBD1(83725140)-CSTF3(33163532), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across BTBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CSTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AX-A3FS	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-

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Fusion Gene ORF analysis for BTBD1-CSTF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000261721	ENST00000431742	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
5CDS-5UTR	ENST00000261721	ENST00000438862	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
5CDS-5UTR	ENST00000261721	ENST00000526480	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
5CDS-5UTR	ENST00000379403	ENST00000431742	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
5CDS-5UTR	ENST00000379403	ENST00000438862	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
5CDS-5UTR	ENST00000379403	ENST00000526480	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
In-frame	ENST00000261721	ENST00000323959	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
In-frame	ENST00000261721	ENST00000524827	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
In-frame	ENST00000379403	ENST00000323959	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
In-frame	ENST00000379403	ENST00000524827	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
intron-3CDS	ENST00000560015	ENST00000323959	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
intron-3CDS	ENST00000560015	ENST00000524827	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
intron-5UTR	ENST00000560015	ENST00000431742	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
intron-5UTR	ENST00000560015	ENST00000438862	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-
intron-5UTR	ENST00000560015	ENST00000526480	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261721	BTBD1	chr15	83725140	-	ENST00000323959	CSTF3	chr11	33163532	-	3391	761	203	2887	894
ENST00000261721	BTBD1	chr15	83725140	-	ENST00000524827	CSTF3	chr11	33163532	-	1196	761	203	1195	331
ENST00000379403	BTBD1	chr15	83725140	-	ENST00000323959	CSTF3	chr11	33163532	-	3188	558	0	2684	894
ENST00000379403	BTBD1	chr15	83725140	-	ENST00000524827	CSTF3	chr11	33163532	-	993	558	0	992	330

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261721	ENST00000323959	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-	0.000718785	0.9992812
ENST00000261721	ENST00000524827	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-	0.001857725	0.99814224
ENST00000379403	ENST00000323959	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-	0.000771522	0.9992285
ENST00000379403	ENST00000524827	BTBD1	chr15	83725140	-	CSTF3	chr11	33163532	-	0.001391931	0.99860805

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Fusion Genomic Features for BTBD1-CSTF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BTBD1-CSTF3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:83725140/chr11:33163532)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTBD1 Q9H0C5	CSTF3 Q12996
FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250\|UniProtKB:P58544, ECO:0000269\|PubMed:14528312}.	FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000261721

25_31

186

483.0

Compositional bias

Poly-Pro

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000379403

25_31

186

337.3333333333333

Compositional bias

Poly-Pro

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000261721

69_145

186

483.0

Domain

BTB

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000379403

69_145

186

337.3333333333333

Domain

BTB

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

559_626

718.0

Compositional bias

Note=Pro-rich

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

559_626

45.0

Compositional bias

Note=Pro-rich

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

559_626

104.0

Compositional bias

Note=Pro-rich

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

117_152

718.0

Repeat

Note=HAT 3

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

163_196

718.0

Repeat

Note=HAT 4

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

221_261

718.0

Repeat

Note=HAT 5

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

271_303

718.0

Repeat

Note=HAT 6

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

319_352

718.0

Repeat

Note=HAT 7

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

354_387

718.0

Repeat

Note=HAT 8

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

458_494

718.0

Repeat

Note=HAT 9

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

45_77

718.0

Repeat

Note=HAT 1

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000323959

79_110

718.0

Repeat

Note=HAT 2

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

117_152

45.0

Repeat

Note=HAT 3

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

163_196

45.0

Repeat

Note=HAT 4

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

221_261

45.0

Repeat

Note=HAT 5

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

271_303

45.0

Repeat

Note=HAT 6

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

319_352

45.0

Repeat

Note=HAT 7

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

354_387

45.0

Repeat

Note=HAT 8

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

458_494

45.0

Repeat

Note=HAT 9

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

45_77

45.0

Repeat

Note=HAT 1

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000431742

79_110

45.0

Repeat

Note=HAT 2

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

117_152

104.0

Repeat

Note=HAT 3

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

163_196

104.0

Repeat

Note=HAT 4

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

221_261

104.0

Repeat

Note=HAT 5

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

271_303

104.0

Repeat

Note=HAT 6

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

319_352

104.0

Repeat

Note=HAT 7

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

354_387

104.0

Repeat

Note=HAT 8

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

458_494

104.0

Repeat

Note=HAT 9

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

45_77

104.0

Repeat

Note=HAT 1

Tgene

CSTF3

chr15:83725140

chr11:33163532

ENST00000438862

79_110

104.0

Repeat

Note=HAT 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000261721

184_284

186

483.0

Domain

BACK

Hgene

BTBD1

chr15:83725140

chr11:33163532

ENST00000379403

184_284

186

337.3333333333333

Domain

BACK

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Fusion Gene Sequence for BTBD1-CSTF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10440_10440_1_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000323959_length(transcript)=3391nt_BP=761nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAG
AAGAGAATCCATATGACCTTGATGCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAAC
GCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAA
AGCTATTTCAGAGATGCCTTATGAAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTAC
CAAGTTACAAAGAAAAAATGGCTCAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATT
ACATCAATTTCCTAAAAGGCGTGGAAGCTGTAGGATCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTT
GTGTTAATCCGATGATCAACATTGAACAGCTCTGGAGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGA
TTGAAGATCGGAGTAGAGATTATATGAATGCTAGACGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCT
CGGTGCCTCCTCAGAATACTCCTCAAGAAGCTCAACAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTA
CAGAGGATCAGACCCTTATAACAAAAAGAGTTATGTTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATG
AAGCTGCCCAGTATCTTGAGCAGTCAAGTAAACTGCTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTA
ATATATATGAAAGAGCCATAAGCACTTTATTGAAGAAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGT
ATGAAAAGGTTCACAGTATATATAACAGACTTCTGGCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCAC
GGAGAGCAGAAGGCATCAAATCTGGAAGAATGATATTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAG
CACTCATGGAATATTACTGTAGTAAGGACAAATCTGTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGT
ATGTCCTGGCCTATATTGACTATCTTTCTCACCTCAATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCC
TTCCTCCTGAGAAGTCTGGAGAAATCTGGGCCCGATTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGA
AAAGACGGTTTACAGCATTCAAAGAAGAGTATGAAGGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTT
GCTCTGCAAGTGAATTAAAAGCACTTGGTTATAAGGATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTT
CTATAGTGCCTGTTCTGAAAGATGAAGTGGATAGAAAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGAC
ATTTAGCACCTCCAGGTTTACACCCTGTACCTGGTGGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTC
CTATCTGTTTCCAGGGTCCTTTTGTACAAGTGGATGAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTG
TGAGGATCATTACTGGTGGGGCCCCAGAGCTAGCTGTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAA
GGCCCAACGAGGATTCAGATGAAGATGAAGAAAAGGGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGA
TTCGGTAGGGTTTTAAACGCCTCTGCAGAAAACTCCTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGT
TACAAGGTTCTTGGAAACAAAGTTGTATTGTCATTGGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTA
GAATACGGAACAGACCTATGCTCTAAGCAAAATTAGGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTC
TTCAAGGGTGTCTTGTATGTGCCGCTTGAAGATTTGTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCA
TTTTATCACATTTTCTGAAAACAATTGTTCTTGGTTTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATG

>10440_10440_1_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000323959_length(amino acids)=894AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM
KVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINI
EQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLIT
KRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIY
NRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDY
LSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKA
LGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPF

--------------------------------------------------------------
>10440_10440_2_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000524827_length(transcript)=1196nt_BP=761nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAG
AAGAGAATCCATATGACCTTGATGCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAAC
GCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAA
AGCTATTTCAGAGATGCCTTATGAAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTAC
CAAGTTACAAAGAAAAAATGGCTCAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATT

>10440_10440_2_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000524827_length(amino acids)=331AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM

--------------------------------------------------------------
>10440_10440_3_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000323959_length(transcript)=3188nt_BP=558nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGAT
GCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGT
TCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATG
AAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCT
CAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTG
GAAGCTGTAGGATCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTTGTGTTAATCCGATGATCAACATT
GAACAGCTCTGGAGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGATTGAAGATCGGAGTAGAGATTAT
ATGAATGCTAGACGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCTCGGTGCCTCCTCAGAATACTCCT
CAAGAAGCTCAACAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTACAGAGGATCAGACCCTTATAACA
AAAAGAGTTATGTTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATGAAGCTGCCCAGTATCTTGAGCAG
TCAAGTAAACTGCTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTAATATATATGAAAGAGCCATAAGC
ACTTTATTGAAGAAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGTATGAAAAGGTTCACAGTATATAT
AACAGACTTCTGGCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCACGGAGAGCAGAAGGCATCAAATCT
GGAAGAATGATATTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAGCACTCATGGAATATTACTGTAGT
AAGGACAAATCTGTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGTATGTCCTGGCCTATATTGACTAT
CTTTCTCACCTCAATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCCTTCCTCCTGAGAAGTCTGGAGAA
ATCTGGGCCCGATTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGAAAAGACGGTTTACAGCATTCAAA
GAAGAGTATGAAGGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTTGCTCTGCAAGTGAATTAAAAGCA
CTTGGTTATAAGGATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTTCTATAGTGCCTGTTCTGAAAGAT
GAAGTGGATAGAAAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGACATTTAGCACCTCCAGGTTTACAC
CCTGTACCTGGTGGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTCCTATCTGTTTCCAGGGTCCTTTT
GTACAAGTGGATGAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTGTGAGGATCATTACTGGTGGGGCC
CCAGAGCTAGCTGTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAAGGCCCAACGAGGATTCAGATGAA
GATGAAGAAAAGGGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGATTCGGTAGGGTTTTAAACGCCTC
TGCAGAAAACTCCTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGTTACAAGGTTCTTGGAAACAAAGT
TGTATTGTCATTGGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTAGAATACGGAACAGACCTATGCTC
TAAGCAAAATTAGGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTCTTCAAGGGTGTCTTGTATGTGCC
GCTTGAAGATTTGTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCATTTTATCACATTTTCTGAAAACA
ATTGTTCTTGGTTTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATGAAATCCGTTTTGTAGTTTCAAAT

>10440_10440_3_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000323959_length(amino acids)=894AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM
KVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINI
EQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLIT
KRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIY
NRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDY
LSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKA
LGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPF

--------------------------------------------------------------
>10440_10440_4_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000524827_length(transcript)=993nt_BP=558nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGAT
GCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGT
TCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATG
AAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCT
CAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTG

>10440_10440_4_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000524827_length(amino acids)=330AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BTBD1-CSTF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BTBD1-CSTF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BTBD1-CSTF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source