Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BTBD1-ETFA (FusionGDB2 ID:10441)

Fusion Gene Summary for BTBD1-ETFA

Fusion gene summary

Fusion gene information	Fusion gene name: BTBD1-ETFA
	Fusion gene ID: 10441
		Hgene	Tgene
	Gene symbol	BTBD1	ETFA
	Gene ID	53339	2108
	Gene name	BTB domain containing 1	electron transfer flavoprotein subunit alpha
	Synonyms	C15orf1\|NS5ATP8	EMA\|GA2\|MADD
	Cytomap	15q25.2	15q24.2-q24.3
	Type of gene	protein-coding	protein-coding
	Description	BTB/POZ domain-containing protein 1BTB (POZ) domain containing 1HCV NS5A-transactivated protein 8hepatitis C virus NS5A-transactivated protein 8	electron transfer flavoprotein subunit alpha, mitochondrialalpha-ETFelectron transfer flavoprotein alpha subunitelectron transfer flavoprotein, alpha polypeptideepididymis secretory sperm binding proteinglutaric aciduria II
	Modification date	20200327	20200313
	UniProtAcc	Q9H0C5	P13804
	Ensembl transtripts involved in fusion gene	ENST00000261721, ENST00000379403, ENST00000560015,	ENST00000433983, ENST00000559602, ENST00000560726, ENST00000560816, ENST00000557943,
Fusion gene scores	* DoF score	11 X 9 X 9=891	8 X 7 X 6=336
	# samples	13	8
	** MAII score	log2(13/891*10)=-2.77691380849347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTBD1 [Title/Abstract] AND ETFA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BTBD1(83725140)-ETFA(76588078), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ETFA	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	25416781

Fusion gene breakpoints across BTBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ETFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	2397N	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-

Top

Fusion Gene ORF analysis for BTBD1-ETFA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000261721	ENST00000433983	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000261721	ENST00000559602	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000261721	ENST00000560726	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000261721	ENST00000560816	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000379403	ENST00000433983	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000379403	ENST00000559602	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000379403	ENST00000560726	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000379403	ENST00000560816	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
In-frame	ENST00000261721	ENST00000557943	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
In-frame	ENST00000379403	ENST00000557943	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
intron-3CDS	ENST00000560015	ENST00000557943	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
intron-intron	ENST00000560015	ENST00000433983	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
intron-intron	ENST00000560015	ENST00000559602	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
intron-intron	ENST00000560015	ENST00000560726	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-
intron-intron	ENST00000560015	ENST00000560816	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261721	BTBD1	chr15	83725140	-	ENST00000557943	ETFA	chr15	76588078	-	2928	761	203	1723	506
ENST00000379403	BTBD1	chr15	83725140	-	ENST00000557943	ETFA	chr15	76588078	-	2725	558	0	1520	506

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261721	ENST00000557943	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-	0.001177459	0.9988225
ENST00000379403	ENST00000557943	BTBD1	chr15	83725140	-	ETFA	chr15	76588078	-	0.001185361	0.9988147

Top

Fusion Genomic Features for BTBD1-ETFA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for BTBD1-ETFA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:83725140/chr15:76588078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTBD1 Q9H0C5	ETFA P13804
FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250\|UniProtKB:P58544, ECO:0000269\|PubMed:14528312}.	FUNCTION: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). {ECO:0000269\|PubMed:10356313, ECO:0000269\|PubMed:12815589, ECO:0000269\|PubMed:1430199, ECO:0000269\|PubMed:15159392, ECO:0000269\|PubMed:15975918, ECO:0000269\|PubMed:27499296, ECO:0000269\|PubMed:9334218, ECO:0000303\|PubMed:17941859, ECO:0000305\|PubMed:1882842}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000261721

25_31

186

483.0

Compositional bias

Poly-Pro

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000379403

25_31

186

337.3333333333333

Compositional bias

Poly-Pro

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000261721

69_145

186

483.0

Domain

BTB

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000379403

69_145

186

337.3333333333333

Domain

BTB

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000433983

263_266

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000433983

281_286

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000433983

318_319

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000557943

263_266

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000557943

281_286

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000557943

318_319

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000433983

205_333

285.0

Region

Domain II

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000433983

20_204

285.0

Region

Domain I

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000557943

205_333

334.0

Region

Domain II

Tgene

ETFA

chr15:83725140

chr15:76588078

ENST00000557943

20_204

334.0

Region

Domain I

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000261721

184_284

186

483.0

Domain

BACK

Hgene

BTBD1

chr15:83725140

chr15:76588078

ENST00000379403

184_284

186

337.3333333333333

Domain

BACK

Top

Fusion Gene Sequence for BTBD1-ETFA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10441_10441_1_BTBD1-ETFA_BTBD1_chr15_83725140_ENST00000261721_ETFA_chr15_76588078_ENST00000557943_length(transcript)=2928nt_BP=761nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCCTCATTGCTACGATTTCAGAGTACCCTGGTAATAGCTGAGCATGCAA
ATGATTCCCTAGCACCCATTACTTTAAATACCATTACTGCAGCCACACGCCTTGGAGGTGAAGTGTCCTGCTTAGTAGCTGGAACCAAAT
GTGACAAGGTGGCACAAGATCTCTGTAAAGTAGCAGGCATAGCAAAAGTTCTGGTGGCTCAGCATGATGTGTACAAAGGCCTACTTCCAG
AGGAACTGACACCATTGATTTTGGCAACTCAGAAGCAGTTCAATTACACACACATCTGTGCTGGAGCATCTGCCTTCGGAAAGAACCTTT
TGCCCAGAGTAGCAGCCAAACTTGAGGTTGCCCCGATTTCTGACATCATTGCAATCAAGTCACCTGACACATTTGTGAGAACTATTTATG
CAGGAAATGCTCTATGTACAGTGAAGTGTGATGAGAAAGTGAAAGTGTTTTCTGTCCGTGGAACATCCTTTGATGCTGCAGCAACAAGTG
GCGGTAGTGCCAGTTCAGAAAAGGCATCAAGTACTTCACCAGTGGAAATATCAGAGTGGCTTGACCAGAAATTAACAAAAAGTGATCGAC
CAGAGCTAACAGGTGCCAAAGTGGTGGTATCTGGTGGTCGAGGCTTGAAGAGTGGAGAGAACTTTAAGTTGTTATATGACTTGGCAGATC
AACTACATGCTGCAGTTGGTGCTTCCCGTGCTGCTGTTGATGCTGGCTTTGTTCCCAATGACATGCAAGTTGGACAGACGGGAAAAATAG
TAGCACCAGAACTTTATATTGCTGTTGGAATATCTGGAGCCATCCAACATTTAGCTGGGATGAAAGACAGCAAGACAATTGTGGCAATTA
ATAAAGACCCAGAAGCTCCAATTTTCCAAGTGGCAGATTATGGAATAGTTGCAGATTTATTTAAGGTAGTTCCTGAAATGACTGAGATAT
TGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCACTGAAATCACAGATATTTGTGGGTATTATAA
CAATCATTGGAAAGCATGGAGAGCTACATTTCATAATTTGAGGGAAAATTTCTAACAGATGCCAGAATGCTTGTTTATGGGATTGCTGTG
TTTCCTTTTAATTATTTGTGGTTCCAAACAATTATTGTTTGAACTTTTTAAATTCTGTACTAAAATCTATAATAAAGCTTTTCCACAGCT
TTAAAACTATCAGAAATATGCCTAGCCTCTAGAGAAAATTGAAGAAAAGGAGTAAAAATTTTGTTTATTTATTTATTTTTTTGCCTTTCT
TGTTCATGGAGAGCTCTATGTTTTAGGAAGATTGTAAACATGATTGTCTCCACCAGCCTAATCAACCTACTAATCTCATTGTTGAAGGGC
AAACTTCATAGGAGAAGGTAACTGAATTGGCAAGTGCAGAGTTAAAAAAGCACGGCTATAAAGCATGAATATTATCTTAAACATACTCCA
GTCTTCAGAAGACCATAGCTAATGTGACAAAAGCAGACCTGACTTAAACCTGACCCAGCTCCATGTATTTAGTTGGCTTAAGGTAAATTT
CATTTTCCGTTTAATTTTAAGGTTTTGTCAGTTTATAGGACTTTTGTCTGTAAAGGAGGGAGAGTGGAGGAGGGGCTGCTTTGAGACAGC
ATGGCCTCTGATGCAAGCAGATAGTTTGATGTTATTATAAACATTCAAAATCCTGTGCAGAGAATGCTCTAGCCTTTCTTTTGCCTTCTG
TTGGCTTCTTTTGGGCTCTCTTAGGAAGCACCCAGGCCTGTGTAGTCACCTCTGGCACTCTCATTCTGCTGCCCAGGGCACAGCTGAGGT
CCAAGAGTGTCACCAGGGCTGCAGCTGGTGTGGATGCAGGCCCAAGAGCAGAGGCTGGTGAGGCTTTGAACAGGCCTGCAGGAAGGCGTG
GGTAGGTAGGTGAGTAGAACAAAGAGGGCTGCCCTCCTGAATCAGATCTGCAGAAGTAGGAGTAGTGACCTGGATCAAGCAGACAGTAGG
GAAGAGAAGGGAAGTGATAAGTGATGGAGGTGGCTAGAGTGCCTTTGTGTGACCAGCCTGGGGCCCTTCCCCAGCTGACTAGTGAACCCT

>10441_10441_1_BTBD1-ETFA_BTBD1_chr15_83725140_ENST00000261721_ETFA_chr15_76588078_ENST00000557943_length(amino acids)=506AA_BP=186
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGIAKVLVAQHDVYKGLLPEELTPLIL
ATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEK
ASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIA

--------------------------------------------------------------
>10441_10441_2_BTBD1-ETFA_BTBD1_chr15_83725140_ENST00000379403_ETFA_chr15_76588078_ENST00000557943_length(transcript)=2725nt_BP=558nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCCTCATTGCTACGATTTCAGAGTACCCTGGTAATAGCTGAGCATGCAAATGATTCCCTAGCACCCATTACT
TTAAATACCATTACTGCAGCCACACGCCTTGGAGGTGAAGTGTCCTGCTTAGTAGCTGGAACCAAATGTGACAAGGTGGCACAAGATCTC
TGTAAAGTAGCAGGCATAGCAAAAGTTCTGGTGGCTCAGCATGATGTGTACAAAGGCCTACTTCCAGAGGAACTGACACCATTGATTTTG
GCAACTCAGAAGCAGTTCAATTACACACACATCTGTGCTGGAGCATCTGCCTTCGGAAAGAACCTTTTGCCCAGAGTAGCAGCCAAACTT
GAGGTTGCCCCGATTTCTGACATCATTGCAATCAAGTCACCTGACACATTTGTGAGAACTATTTATGCAGGAAATGCTCTATGTACAGTG
AAGTGTGATGAGAAAGTGAAAGTGTTTTCTGTCCGTGGAACATCCTTTGATGCTGCAGCAACAAGTGGCGGTAGTGCCAGTTCAGAAAAG
GCATCAAGTACTTCACCAGTGGAAATATCAGAGTGGCTTGACCAGAAATTAACAAAAAGTGATCGACCAGAGCTAACAGGTGCCAAAGTG
GTGGTATCTGGTGGTCGAGGCTTGAAGAGTGGAGAGAACTTTAAGTTGTTATATGACTTGGCAGATCAACTACATGCTGCAGTTGGTGCT
TCCCGTGCTGCTGTTGATGCTGGCTTTGTTCCCAATGACATGCAAGTTGGACAGACGGGAAAAATAGTAGCACCAGAACTTTATATTGCT
GTTGGAATATCTGGAGCCATCCAACATTTAGCTGGGATGAAAGACAGCAAGACAATTGTGGCAATTAATAAAGACCCAGAAGCTCCAATT
TTCCAAGTGGCAGATTATGGAATAGTTGCAGATTTATTTAAGGTAGTTCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATC
ATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCACTGAAATCACAGATATTTGTGGGTATTATAACAATCATTGGAAAGCATGGAGAG
CTACATTTCATAATTTGAGGGAAAATTTCTAACAGATGCCAGAATGCTTGTTTATGGGATTGCTGTGTTTCCTTTTAATTATTTGTGGTT
CCAAACAATTATTGTTTGAACTTTTTAAATTCTGTACTAAAATCTATAATAAAGCTTTTCCACAGCTTTAAAACTATCAGAAATATGCCT
AGCCTCTAGAGAAAATTGAAGAAAAGGAGTAAAAATTTTGTTTATTTATTTATTTTTTTGCCTTTCTTGTTCATGGAGAGCTCTATGTTT
TAGGAAGATTGTAAACATGATTGTCTCCACCAGCCTAATCAACCTACTAATCTCATTGTTGAAGGGCAAACTTCATAGGAGAAGGTAACT
GAATTGGCAAGTGCAGAGTTAAAAAAGCACGGCTATAAAGCATGAATATTATCTTAAACATACTCCAGTCTTCAGAAGACCATAGCTAAT
GTGACAAAAGCAGACCTGACTTAAACCTGACCCAGCTCCATGTATTTAGTTGGCTTAAGGTAAATTTCATTTTCCGTTTAATTTTAAGGT
TTTGTCAGTTTATAGGACTTTTGTCTGTAAAGGAGGGAGAGTGGAGGAGGGGCTGCTTTGAGACAGCATGGCCTCTGATGCAAGCAGATA
GTTTGATGTTATTATAAACATTCAAAATCCTGTGCAGAGAATGCTCTAGCCTTTCTTTTGCCTTCTGTTGGCTTCTTTTGGGCTCTCTTA
GGAAGCACCCAGGCCTGTGTAGTCACCTCTGGCACTCTCATTCTGCTGCCCAGGGCACAGCTGAGGTCCAAGAGTGTCACCAGGGCTGCA
GCTGGTGTGGATGCAGGCCCAAGAGCAGAGGCTGGTGAGGCTTTGAACAGGCCTGCAGGAAGGCGTGGGTAGGTAGGTGAGTAGAACAAA
GAGGGCTGCCCTCCTGAATCAGATCTGCAGAAGTAGGAGTAGTGACCTGGATCAAGCAGACAGTAGGGAAGAGAAGGGAAGTGATAAGTG
ATGGAGGTGGCTAGAGTGCCTTTGTGTGACCAGCCTGGGGCCCTTCCCCAGCTGACTAGTGAACCCTTTCTGATTTGTGTCACAATCAGT

>10441_10441_2_BTBD1-ETFA_BTBD1_chr15_83725140_ENST00000379403_ETFA_chr15_76588078_ENST00000557943_length(amino acids)=506AA_BP=186
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGIAKVLVAQHDVYKGLLPEELTPLIL
ATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEK
ASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BTBD1-ETFA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BTBD1-ETFA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BTBD1-ETFA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source