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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTBD2-AMZ2 (FusionGDB2 ID:10450)

Fusion Gene Summary for BTBD2-AMZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD2-AMZ2
Fusion gene ID: 10450
HgeneTgene
Gene symbol

BTBD2

AMZ2

Gene ID

55643

51321

Gene nameBTB domain containing 2archaelysin family metallopeptidase 2
Synonyms--
Cytomap

19p13.3

17q24.2

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 2BTB (POZ) domain containing 2archaemetzincin-2archaemetzincins-2archeobacterial metalloproteinase-like protein 2
Modification date2020032720200313
UniProtAcc.

Q86W34

Ensembl transtripts involved in fusion geneENST00000255608, ENST00000590646, 
ENST00000585050, ENST00000359783, 
ENST00000359904, ENST00000392720, 
ENST00000577866, ENST00000580753, 
ENST00000577273, ENST00000577985, 
Fusion gene scores* DoF score13 X 11 X 11=15738 X 10 X 5=400
# samples 1810
** MAII scorelog2(18/1573*10)=-3.12744985908601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD2 [Title/Abstract] AND AMZ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTBD2(2015296)-AMZ2(66244781), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BTBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AMZ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-ZB-A96L-01ABTBD2chr19

2015296

-AMZ2chr17

66244781

+
ChimerDB4THYMTCGA-ZB-A96LBTBD2chr19

2015296

-AMZ2chr17

66244781

+
ChimerDB4THYMTCGA-ZB-A96LBTBD2chr19

2015296

-AMZ2chr17

66244785

+
ChimerDB4THYMTCGA-ZB-A96LBTBD2chr19

2015296

-AMZ2chr17

66246329

+


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Fusion Gene ORF analysis for BTBD2-AMZ2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000255608ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-3UTRENST00000255608ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-5UTRENST00000255608ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-5UTRENST00000255608ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-5UTRENST00000255608ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-5UTRENST00000255608ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-5UTRENST00000255608ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-5UTRENST00000255608ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-5UTRENST00000255608ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-5UTRENST00000255608ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-5UTRENST00000255608ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-5UTRENST00000255608ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-intronENST00000255608ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-intronENST00000255608ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-intronENST00000255608ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66246329

+
5CDS-intronENST00000255608ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66244781

+
5CDS-intronENST00000255608ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66244785

+
5CDS-intronENST00000255608ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66246329

+
5CDS-intronENST00000255608ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66246329

+
In-frameENST00000255608ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66246329

+
In-frameENST00000255608ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66246329

+
In-frameENST00000255608ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66246329

+
In-frameENST00000255608ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66246329

+
In-frameENST00000255608ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3CDSENST00000590646ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3CDSENST00000590646ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3CDSENST00000590646ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3CDSENST00000590646ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3CDSENST00000590646ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-3UTRENST00000590646ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-3UTRENST00000590646ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-5UTRENST00000590646ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-5UTRENST00000590646ENST00000359783BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-5UTRENST00000590646ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-5UTRENST00000590646ENST00000359904BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-5UTRENST00000590646ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-5UTRENST00000590646ENST00000392720BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-5UTRENST00000590646ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-5UTRENST00000590646ENST00000577866BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-5UTRENST00000590646ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-5UTRENST00000590646ENST00000580753BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-intronENST00000590646ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-intronENST00000590646ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-intronENST00000590646ENST00000577273BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-intronENST00000590646ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66244781

+
intron-intronENST00000590646ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66244785

+
intron-intronENST00000590646ENST00000577985BTBD2chr19

2015296

-AMZ2chr17

66246329

+
intron-intronENST00000590646ENST00000585050BTBD2chr19

2015296

-AMZ2chr17

66246329

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255608BTBD2chr192015296-ENST00000359904AMZ2chr1766246329+16944243011506401
ENST00000255608BTBD2chr192015296-ENST00000580753AMZ2chr1766246329+16774243011506401
ENST00000255608BTBD2chr192015296-ENST00000392720AMZ2chr1766246329+16924243011506401
ENST00000255608BTBD2chr192015296-ENST00000359783AMZ2chr1766246329+14914243011332343
ENST00000255608BTBD2chr192015296-ENST00000577866AMZ2chr1766246329+16284243011506401

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255608ENST00000359904BTBD2chr192015296-AMZ2chr1766246329+0.0084190190.991581
ENST00000255608ENST00000580753BTBD2chr192015296-AMZ2chr1766246329+0.0085145420.9914854
ENST00000255608ENST00000392720BTBD2chr192015296-AMZ2chr1766246329+0.0084652680.99153477
ENST00000255608ENST00000359783BTBD2chr192015296-AMZ2chr1766246329+0.0057865770.9942134
ENST00000255608ENST00000577866BTBD2chr192015296-AMZ2chr1766246329+0.0075910590.9924089

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Fusion Genomic Features for BTBD2-AMZ2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BTBD2chr192015295-AMZ2chr1766244780+5.40E-050.999946
BTBD2chr192015295-AMZ2chr1766244780+5.40E-050.999946
BTBD2chr192015295-AMZ2chr1766246327+2.19E-070.99999976
BTBD2chr192015295-AMZ2chr1766244780+5.40E-050.999946
BTBD2chr192015295-AMZ2chr1766244780+5.40E-050.999946
BTBD2chr192015295-AMZ2chr1766246327+2.19E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BTBD2-AMZ2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:2015296/chr17:66244781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AMZ2

Q86W34

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2. {ECO:0000269|PubMed:15972818}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD2chr19:2015296chr17:66246329ENST00000255608-1941_54135526.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD2chr19:2015296chr17:66246329ENST00000255608-19117_187135526.0DomainBTB


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Fusion Gene Sequence for BTBD2-AMZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10450_10450_1_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000359783_length(transcript)=1491nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGATGCAAATAATACGGCACTCCGAACA
GACACTAAAAACAGCTCTCATCTCAAAGAACCCAGTGCTTGTATCACAGTATGAGAAATTAAATGCTGGGGAACAACGTTTAATGAATGA
AGCCTTCCAGCCAGCCAGTGATCTCTTTGGACCCATTACCTTGCATTCTCCATCAGATTGGATCACCTCCCACCCTGAGGCTCCCCAAGA
CTTTGAACAGTTCTTCAGTGATCCTTACAGAAAGACACCCTCTCCAAACAAACGCAGCATTTATATACAGTCCATTGGGGACATCCTGAA
GTTCTTGAAAAAGAAGAAACCTGAAGATGCCTTCTGTGTTGTGGGAATAACAATGATTGATCTTTACCCAAGAGACTCGTGGAATTTTGT
CTTTGGACAGGCCTCTTTGACAGATGGTGTGGGGATATTCAGCTTTGCCAGGTATGGCAGTGATTTTTATAGCATGCACTATAAAGGCAA
AGTGAAGAAGCTCAAGAAAACATCTTCAAGTGACTATTCAATTTTCGACAACTATTATATTCCAGAAATAACTAGTGTTTTACTACTTCG
ATCCTGTAAGACTTTAACCCATGAGATCGGACACATATTTGGACTGCGACACTGCCAGTGGCTTGCATGCCTCATGCAAGGCTCCAACCA
CTTGGAAGAAGCTGACCGGCGCCCTCTAAACCTTTGCCCTATCTGTTTGCACAAGTTGCAGTGTGCTGTTGGCTTCAGCATTGTAGAAAG
ATACAAAGCACTGGTGAGGTGGATTGATGATGAATCTTCTGACACACCTGGAGCAACTCCAGAACACAGTCACGAGGATAATGGGAATTT
ACCGAAACCCGTGGAAGCCTTTAAGGAATGGAAAGAGTGGATAATAAAATGCCTGGCTGTTCTCCAAAAATGAGGACCTTCAAATAGGAG
TGATTGAAATAAATAACTACTTGCATGTTATGCTTTCATTTGGGTGGAATACTTCATTGGAATAAACTACTGATCTTGTGCTGTGTCAAA

>10450_10450_1_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000359783_length(amino acids)=343AA_BP=41
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQMQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFG
PITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGV
GIFSFARYGSDFYSMHYKGKVKKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLN

--------------------------------------------------------------
>10450_10450_2_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000359904_length(transcript)=1694nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGATGCAAATAATACGGCACTCCGAACA
GACACTAAAAACAGCTCTCATCTCAAAGAACCCAGTGCTTGTATCACAGTATGAGAAATTAAATGCTGGGGAACAACGTTTAATGAATGA
AGCCTTCCAGCCAGCCAGTGATCTCTTTGGACCCATTACCTTGCATTCTCCATCAGATTGGATCACCTCCCACCCTGAGGCTCCCCAAGA
CTTTGAACAGTTCTTCAGTGATCCTTACAGAAAGACACCCTCTCCAAACAAACGCAGCATTTATATACAGTCCATTGGCTCTCTAGGAAA
CACCAGAATTATCAGTGAAGAATATATTAAATGGCTCACGGGCTACTGTAAAGCATATTTCTATGGCTTGAGAGTAAAACTCCTAGAACC
AGTTCCTGTTTCTGTAACAAGATGTTCCTTTAGAGTCAATGAGAACACACACAACCTACAAATTCATGCAGGGGACATCCTGAAGTTCTT
GAAAAAGAAGAAACCTGAAGATGCCTTCTGTGTTGTGGGAATAACAATGATTGATCTTTACCCAAGAGACTCGTGGAATTTTGTCTTTGG
ACAGGCCTCTTTGACAGATGGTGTGGGGATATTCAGCTTTGCCAGGTATGGCAGTGATTTTTATAGCATGCACTATAAAGGCAAAGTGAA
GAAGCTCAAGAAAACATCTTCAAGTGACTATTCAATTTTCGACAACTATTATATTCCAGAAATAACTAGTGTTTTACTACTTCGATCCTG
TAAGACTTTAACCCATGAGATCGGACACATATTTGGACTGCGACACTGCCAGTGGCTTGCATGCCTCATGCAAGGCTCCAACCACTTGGA
AGAAGCTGACCGGCGCCCTCTAAACCTTTGCCCTATCTGTTTGCACAAGTTGCAGTGTGCTGTTGGCTTCAGCATTGTAGAAAGATACAA
AGCACTGGTGAGGTGGATTGATGATGAATCTTCTGACACACCTGGAGCAACTCCAGAACACAGTCACGAGGATAATGGGAATTTACCGAA
ACCCGTGGAAGCCTTTAAGGAATGGAAAGAGTGGATAATAAAATGCCTGGCTGTTCTCCAAAAATGAGGACCTTCAAATAGGAGTGATTG
AAATAAATAACTACTTGCATGTTATGCTTTCATTTGGGTGGAATACTTCATTGGAATAAACTACTGATCTTGTGCTGTGTCAAAGTAACA

>10450_10450_2_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000359904_length(amino acids)=401AA_BP=41
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQMQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFG
PITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSF
RVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDY
SIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDES

--------------------------------------------------------------
>10450_10450_3_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000392720_length(transcript)=1692nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGATGCAAATAATACGGCACTCCGAACA
GACACTAAAAACAGCTCTCATCTCAAAGAACCCAGTGCTTGTATCACAGTATGAGAAATTAAATGCTGGGGAACAACGTTTAATGAATGA
AGCCTTCCAGCCAGCCAGTGATCTCTTTGGACCCATTACCTTGCATTCTCCATCAGATTGGATCACCTCCCACCCTGAGGCTCCCCAAGA
CTTTGAACAGTTCTTCAGTGATCCTTACAGAAAGACACCCTCTCCAAACAAACGCAGCATTTATATACAGTCCATTGGCTCTCTAGGAAA
CACCAGAATTATCAGTGAAGAATATATTAAATGGCTCACGGGCTACTGTAAAGCATATTTCTATGGCTTGAGAGTAAAACTCCTAGAACC
AGTTCCTGTTTCTGTAACAAGATGTTCCTTTAGAGTCAATGAGAACACACACAACCTACAAATTCATGCAGGGGACATCCTGAAGTTCTT
GAAAAAGAAGAAACCTGAAGATGCCTTCTGTGTTGTGGGAATAACAATGATTGATCTTTACCCAAGAGACTCGTGGAATTTTGTCTTTGG
ACAGGCCTCTTTGACAGATGGTGTGGGGATATTCAGCTTTGCCAGGTATGGCAGTGATTTTTATAGCATGCACTATAAAGGCAAAGTGAA
GAAGCTCAAGAAAACATCTTCAAGTGACTATTCAATTTTCGACAACTATTATATTCCAGAAATAACTAGTGTTTTACTACTTCGATCCTG
TAAGACTTTAACCCATGAGATCGGACACATATTTGGACTGCGACACTGCCAGTGGCTTGCATGCCTCATGCAAGGCTCCAACCACTTGGA
AGAAGCTGACCGGCGCCCTCTAAACCTTTGCCCTATCTGTTTGCACAAGTTGCAGTGTGCTGTTGGCTTCAGCATTGTAGAAAGATACAA
AGCACTGGTGAGGTGGATTGATGATGAATCTTCTGACACACCTGGAGCAACTCCAGAACACAGTCACGAGGATAATGGGAATTTACCGAA
ACCCGTGGAAGCCTTTAAGGAATGGAAAGAGTGGATAATAAAATGCCTGGCTGTTCTCCAAAAATGAGGACCTTCAAATAGGAGTGATTG
AAATAAATAACTACTTGCATGTTATGCTTTCATTTGGGTGGAATACTTCATTGGAATAAACTACTGATCTTGTGCTGTGTCAAAGTAACA

>10450_10450_3_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000392720_length(amino acids)=401AA_BP=41
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQMQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFG
PITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSF
RVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDY
SIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDES

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>10450_10450_4_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000577866_length(transcript)=1628nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGATGCAAATAATACGGCACTCCGAACA
GACACTAAAAACAGCTCTCATCTCAAAGAACCCAGTGCTTGTATCACAGTATGAGAAATTAAATGCTGGGGAACAACGTTTAATGAATGA
AGCCTTCCAGCCAGCCAGTGATCTCTTTGGACCCATTACCTTGCATTCTCCATCAGATTGGATCACCTCCCACCCTGAGGCTCCCCAAGA
CTTTGAACAGTTCTTCAGTGATCCTTACAGAAAGACACCCTCTCCAAACAAACGCAGCATTTATATACAGTCCATTGGCTCTCTAGGAAA
CACCAGAATTATCAGTGAAGAATATATTAAATGGCTCACGGGCTACTGTAAAGCATATTTCTATGGCTTGAGAGTAAAACTCCTAGAACC
AGTTCCTGTTTCTGTAACAAGATGTTCCTTTAGAGTCAATGAGAACACACACAACCTACAAATTCATGCAGGGGACATCCTGAAGTTCTT
GAAAAAGAAGAAACCTGAAGATGCCTTCTGTGTTGTGGGAATAACAATGATTGATCTTTACCCAAGAGACTCGTGGAATTTTGTCTTTGG
ACAGGCCTCTTTGACAGATGGTGTGGGGATATTCAGCTTTGCCAGGTATGGCAGTGATTTTTATAGCATGCACTATAAAGGCAAAGTGAA
GAAGCTCAAGAAAACATCTTCAAGTGACTATTCAATTTTCGACAACTATTATATTCCAGAAATAACTAGTGTTTTACTACTTCGATCCTG
TAAGACTTTAACCCATGAGATCGGACACATATTTGGACTGCGACACTGCCAGTGGCTTGCATGCCTCATGCAAGGCTCCAACCACTTGGA
AGAAGCTGACCGGCGCCCTCTAAACCTTTGCCCTATCTGTTTGCACAAGTTGCAGTGTGCTGTTGGCTTCAGCATTGTAGAAAGATACAA
AGCACTGGTGAGGTGGATTGATGATGAATCTTCTGACACACCTGGAGCAACTCCAGAACACAGTCACGAGGATAATGGGAATTTACCGAA
ACCCGTGGAAGCCTTTAAGGAATGGAAAGAGTGGATAATAAAATGCCTGGCTGTTCTCCAAAAATGAGGACCTTCAAATAGGAGTGATTG
AAATAAATAACTACTTGCATGTTATGCTTTCATTTGGGTGGAATACTTCATTGGAATAAACTACTGATCTTGTGCTGTGTCAAAGTAACA

>10450_10450_4_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000577866_length(amino acids)=401AA_BP=41
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQMQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFG
PITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSF
RVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDY
SIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDES

--------------------------------------------------------------
>10450_10450_5_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000580753_length(transcript)=1677nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGATGCAAATAATACGGCACTCCGAACA
GACACTAAAAACAGCTCTCATCTCAAAGAACCCAGTGCTTGTATCACAGTATGAGAAATTAAATGCTGGGGAACAACGTTTAATGAATGA
AGCCTTCCAGCCAGCCAGTGATCTCTTTGGACCCATTACCTTGCATTCTCCATCAGATTGGATCACCTCCCACCCTGAGGCTCCCCAAGA
CTTTGAACAGTTCTTCAGTGATCCTTACAGAAAGACACCCTCTCCAAACAAACGCAGCATTTATATACAGTCCATTGGCTCTCTAGGAAA
CACCAGAATTATCAGTGAAGAATATATTAAATGGCTCACGGGCTACTGTAAAGCATATTTCTATGGCTTGAGAGTAAAACTCCTAGAACC
AGTTCCTGTTTCTGTAACAAGATGTTCCTTTAGAGTCAATGAGAACACACACAACCTACAAATTCATGCAGGGGACATCCTGAAGTTCTT
GAAAAAGAAGAAACCTGAAGATGCCTTCTGTGTTGTGGGAATAACAATGATTGATCTTTACCCAAGAGACTCGTGGAATTTTGTCTTTGG
ACAGGCCTCTTTGACAGATGGTGTGGGGATATTCAGCTTTGCCAGGTATGGCAGTGATTTTTATAGCATGCACTATAAAGGCAAAGTGAA
GAAGCTCAAGAAAACATCTTCAAGTGACTATTCAATTTTCGACAACTATTATATTCCAGAAATAACTAGTGTTTTACTACTTCGATCCTG
TAAGACTTTAACCCATGAGATCGGACACATATTTGGACTGCGACACTGCCAGTGGCTTGCATGCCTCATGCAAGGCTCCAACCACTTGGA
AGAAGCTGACCGGCGCCCTCTAAACCTTTGCCCTATCTGTTTGCACAAGTTGCAGTGTGCTGTTGGCTTCAGCATTGTAGAAAGATACAA
AGCACTGGTGAGGTGGATTGATGATGAATCTTCTGACACACCTGGAGCAACTCCAGAACACAGTCACGAGGATAATGGGAATTTACCGAA
ACCCGTGGAAGCCTTTAAGGAATGGAAAGAGTGGATAATAAAATGCCTGGCTGTTCTCCAAAAATGAGGACCTTCAAATAGGAGTGATTG
AAATAAATAACTACTTGCATGTTATGCTTTCATTTGGGTGGAATACTTCATTGGAATAAACTACTGATCTTGTGCTGTGTCAAAGTAACA

>10450_10450_5_BTBD2-AMZ2_BTBD2_chr19_2015296_ENST00000255608_AMZ2_chr17_66246329_ENST00000580753_length(amino acids)=401AA_BP=41
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQMQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFG
PITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSF
RVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDY
SIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDES

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Fusion Gene PPI Analysis for BTBD2-AMZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTBD2-AMZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTBD2-AMZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource