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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTBD2-OAS2 (FusionGDB2 ID:10461)

Fusion Gene Summary for BTBD2-OAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD2-OAS2
Fusion gene ID: 10461
HgeneTgene
Gene symbol

BTBD2

OAS2

Gene ID

55643

4939

Gene nameBTB domain containing 22'-5'-oligoadenylate synthetase 2
Synonyms--
Cytomap

19p13.3

12q24.13

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 2BTB (POZ) domain containing 22'-5'-oligoadenylate synthase 2(2'-5')oligo(A) synthetase 22'-5'-oligoadenylate synthetase 2, 69/71kDa2-5A synthase 2p69 OAS / p71 OAS
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000255608, ENST00000590646, 
ENST00000449768, ENST00000342315, 
ENST00000392583, 
Fusion gene scores* DoF score13 X 11 X 11=15734 X 4 X 4=64
# samples 185
** MAII scorelog2(18/1573*10)=-3.12744985908601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD2 [Title/Abstract] AND OAS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTBD2(1993019)-OAS2(113424843), # samples:3
Anticipated loss of major functional domain due to fusion event.BTBD2-OAS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BTBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OAS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-A4MU-01BBTBD2chr19

1993018

-OAS2chr12

113424842

+
ChimerDB4LGGTCGA-FG-A4MU-01BBTBD2chr19

1993019

-OAS2chr12

113424843

+
ChimerDB4LGGTCGA-FG-A4MUBTBD2chr19

1993018

-OAS2chr12

113424842

+
ChimerDB4LGGTCGA-FG-A4MUBTBD2chr19

1993019

-OAS2chr12

113424843

+


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Fusion Gene ORF analysis for BTBD2-OAS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000255608ENST00000449768BTBD2chr19

1993019

-OAS2chr12

113424843

+
Frame-shiftENST00000255608ENST00000449768BTBD2chr19

1993018

-OAS2chr12

113424842

+
In-frameENST00000255608ENST00000342315BTBD2chr19

1993019

-OAS2chr12

113424843

+
In-frameENST00000255608ENST00000342315BTBD2chr19

1993018

-OAS2chr12

113424842

+
In-frameENST00000255608ENST00000392583BTBD2chr19

1993019

-OAS2chr12

113424843

+
In-frameENST00000255608ENST00000392583BTBD2chr19

1993018

-OAS2chr12

113424842

+
intron-3CDSENST00000590646ENST00000342315BTBD2chr19

1993019

-OAS2chr12

113424843

+
intron-3CDSENST00000590646ENST00000342315BTBD2chr19

1993018

-OAS2chr12

113424842

+
intron-3CDSENST00000590646ENST00000392583BTBD2chr19

1993019

-OAS2chr12

113424843

+
intron-3CDSENST00000590646ENST00000392583BTBD2chr19

1993018

-OAS2chr12

113424842

+
intron-3CDSENST00000590646ENST00000449768BTBD2chr19

1993019

-OAS2chr12

113424843

+
intron-3CDSENST00000590646ENST00000449768BTBD2chr19

1993018

-OAS2chr12

113424842

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255608BTBD2chr191993019-ENST00000342315OAS2chr12113424843+3923701172683888
ENST00000255608BTBD2chr191993019-ENST00000392583OAS2chr12113424843+5051701172587856
ENST00000255608BTBD2chr191993018-ENST00000342315OAS2chr12113424842+3923701172683888
ENST00000255608BTBD2chr191993018-ENST00000392583OAS2chr12113424842+5051701172587856

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255608ENST00000342315BTBD2chr191993019-OAS2chr12113424843+0.0014815970.9985184
ENST00000255608ENST00000392583BTBD2chr191993019-OAS2chr12113424843+0.0010926160.9989073
ENST00000255608ENST00000342315BTBD2chr191993018-OAS2chr12113424842+0.0014815970.9985184
ENST00000255608ENST00000392583BTBD2chr191993018-OAS2chr12113424842+0.0010926160.9989073

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Fusion Genomic Features for BTBD2-OAS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BTBD2chr191993018-OAS2chr12113424842+6.61E-121
BTBD2chr191993018-OAS2chr12113424842+6.61E-121
BTBD2chr191993018-OAS2chr12113424842+6.61E-121
BTBD2chr191993018-OAS2chr12113424842+6.61E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BTBD2-OAS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1993019/chr12:113424843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD2chr19:1993018chr12:113424842ENST00000255608-3941_54228526.0Compositional biasNote=Poly-Ala
HgeneBTBD2chr19:1993019chr12:113424843ENST00000255608-3941_54228526.0Compositional biasNote=Poly-Ala
HgeneBTBD2chr19:1993018chr12:113424842ENST00000255608-39117_187228526.0DomainBTB
HgeneBTBD2chr19:1993019chr12:113424843ENST00000255608-39117_187228526.0DomainBTB
TgeneOAS2chr19:1993018chr12:113424842ENST00000342315011326_34659720.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993018chr12:113424842ENST00000392583010326_34659688.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993018chr12:113424842ENST0000044976802326_34659173.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993019chr12:113424843ENST00000342315011326_34659720.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993019chr12:113424843ENST00000392583010326_34659688.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993019chr12:113424843ENST0000044976802326_34659173.0Compositional biasNote=Pro-rich (linker)
TgeneOAS2chr19:1993018chr12:113424842ENST00000342315011343_68359720.0RegionNote=OAS domain 2
TgeneOAS2chr19:1993018chr12:113424842ENST00000392583010343_68359688.0RegionNote=OAS domain 2
TgeneOAS2chr19:1993018chr12:113424842ENST0000044976802343_68359173.0RegionNote=OAS domain 2
TgeneOAS2chr19:1993019chr12:113424843ENST00000342315011343_68359720.0RegionNote=OAS domain 2
TgeneOAS2chr19:1993019chr12:113424843ENST00000392583010343_68359688.0RegionNote=OAS domain 2
TgeneOAS2chr19:1993019chr12:113424843ENST0000044976802343_68359173.0RegionNote=OAS domain 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOAS2chr19:1993018chr12:113424842ENST0000034231501111_33559720.0RegionNote=OAS domain 1
TgeneOAS2chr19:1993018chr12:113424842ENST0000039258301011_33559688.0RegionNote=OAS domain 1
TgeneOAS2chr19:1993018chr12:113424842ENST000004497680211_33559173.0RegionNote=OAS domain 1
TgeneOAS2chr19:1993019chr12:113424843ENST0000034231501111_33559720.0RegionNote=OAS domain 1
TgeneOAS2chr19:1993019chr12:113424843ENST0000039258301011_33559688.0RegionNote=OAS domain 1
TgeneOAS2chr19:1993019chr12:113424843ENST000004497680211_33559173.0RegionNote=OAS domain 1


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Fusion Gene Sequence for BTBD2-OAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10461_10461_1_BTBD2-OAS2_BTBD2_chr19_1993018_ENST00000255608_OAS2_chr12_113424842_ENST00000342315_length(transcript)=3923nt_BP=701nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGTTCGTGCTGGCCGTGGGCAGCGCCG
TCTTTGATGCCATGTTCAACGGGGGAATGGCCACAACATCCACGGAGATTGAGCTGCCCGACGTGGAACCCGCTGCCTTCCTCGCACTGC
TCAAGTTTCTCTACTCGGACGAGGTGCAGATTGGCCCGGAGACGGTGATGACCACGCTATACACCGCCAAGAAGTACGCGGTGCCAGCGC
TCGAGGCCCATTGCGTGGAGTTCCTGAAGAAGAACCTGCGAGCCGACAACGCCTTCATGCTGCTCACGCAGGGTGGCTCCTATGGACGGA
AAACAGTCTTAAGAGGCAACTCCGATGGTACCCTTGTCCTCTTCTTCAGTGACTTAAAACAATTCCAGGATCAGAAGAGAAGCCAACGTG
ACATCCTCGATAAAACTGGGGATAAGCTGAAGTTCTGTCTGTTCACGAAGTGGTTGAAAAACAATTTCGAGATCCAGAAGTCCCTTGATG
GGTTCACCATCCAGGTGTTCACAAAAAATCAGAGAATCTCTTTCGAGGTGCTGGCCGCCTTCAACGCTCTGAGCTTAAATGATAATCCCA
GCCCCTGGATCTATCGAGAGCTCAAAAGATCCTTGGATAAGACAAATGCCAGTCCTGGTGAGTTTGCAGTCTGCTTCACTGAACTCCAGC
AGAAGTTTTTTGACAACCGTCCTGGAAAACTAAAGGATTTGATCCTCTTGATAAAGCACTGGCATCAACAGTGCCAGAAAAAAATCAAGG
ATTTACCCTCGCTGTCTCCGTATGCCCTGGAGCTGCTTACGGTGTATGCCTGGGAACAGGGGTGCAGAAAAGACAACTTTGACATTGCTG
AAGGCGTCAGAACCGTACTGGAGCTGATCAAATGCCAGGAGAAGCTGTGTATCTATTGGATGGTCAACTACAACTTTGAAGATGAGACCA
TCAGGAACATCCTGCTGCACCAGCTCCAATCAGCGAGGCCAGTAATCTTGGATCCAGTTGACCCAACCAATAATGTGAGTGGAGATAAAA
TATGCTGGCAATGGCTGAAAAAAGAAGCTCAAACCTGGTTGACTTCTCCCAACCTGGATAATGAGTTACCTGCACCATCTTGGAATGTTC
TGCCTGCACCACTCTTCACGACCCCAGGCCACCTTCTGGATAAGTTCATCAAGGAGTTTCTCCAGCCCAACAAATGCTTCCTAGAGCAGA
TTGACAGTGCTGTTAACATCATCCGTACATTCCTTAAAGAAAACTGCTTCCGACAATCAACAGCCAAGATCCAGATTGTCCGGGGAGGAT
CAACCGCCAAAGGCACAGCTCTGAAGACTGGCTCTGATGCCGATCTCGTCGTGTTCCATAACTCACTTAAAAGCTACACCTCCCAAAAAA
ACGAGCGGCACAAAATCGTCAAGGAAATCCATGAACAGCTGAAAGCCTTTTGGAGGGAGAAGGAGGAGGAGCTTGAAGTCAGCTTTGAGC
CTCCCAAGTGGAAGGCTCCCAGGGTGCTGAGCTTCTCTCTGAAATCCAAAGTCCTCAACGAAAGTGTCAGCTTTGATGTGCTTCCTGCCT
TTAATGCACTGGGTCAGCTGAGTTCTGGCTCCACACCCAGCCCCGAGGTTTATGCAGGGCTCATTGATCTGTATAAATCCTCGGACCTCC
CGGGAGGAGAGTTTTCTACCTGTTTCACAGTCCTGCAGCGAAACTTCATTCGCTCCCGGCCCACCAAACTAAAGGATTTAATTCGCCTGG
TGAAGCACTGGTACAAAGAGTGTGAAAGGAAACTGAAGCCAAAGGGGTCTTTGCCCCCAAAGTATGCCTTGGAGCTGCTCACCATCTATG
CCTGGGAGCAGGGGAGTGGAGTGCCGGATTTTGACACTGCAGAAGGTTTCCGGACAGTCCTGGAGCTGGTCACACAATATCAGCAGCTCT
GCATCTTCTGGAAGGTCAATTACAACTTTGAAGATGAGACCGTGAGGAAGTTTCTACTGAGCCAGTTGCAGAAAACCAGGCCTGTGATCT
TGGACCCAGCCGAACCCACAGGTGACGTGGGTGGAGGGGACCGTTGGTGTTGGCATCTTCTGGCAAAAGAAGCAAAGGAATGGTTATCCT
CTCCCTGCTTCAAGGATGGGACTGGAAACCCAATACCACCTTGGAAAGTGCCGACAATGCAGACACCAGGAAGTTGTGGAGCTAGGATCC
ATCCTATTGTCAATGAGATGTTCTCATCCAGAAGCCATAGAATCCTGAATAATAATTCTAAAAGAAACTTCTAGAGATCATCTGGCAATC
GCTTTTAAAGACTCGGCTCACCGTGAGAAAGAGTCACTCACATCCATTCTTCCCTTGATGGTCCCTATTCCTCCTTCCCTTGCTTCTTGG
ACTTCTTGAAATCAATCAAGACTGCAAACCCTTTCATAAAGTCTTGCCTTGCTGAACTCCCTCTCTGCAGGCAGCCTGCCTTTAAAAATA
GTTGCTGTCATCCACTTTATGTGCATCTTATTTCTGTCAACTTGTATTTTTTTTCTTGTATTTTTCCAATTAGCTCCTCCTTTTTCCTTC
CAGTCTAAAAAAGGAATCCTCTGTGTCTTCAAAGCAAAGCTCTTTACTTTCCCCTTGGTTCTCATAACTCTGTGATCTTGCTCTCGGTGC
TTCCAACTCATCCACGTCCTGTCTGTTTCCTCTGTATACAAAACCCTTTCTGCCCCTGCTGACACAGACATCCTCTATGCCAGCAGCCAG
CCAACCCTTTCATTAGAACTTCAAGCTCTCCAAAGGCTCAGATTATAACTGTTGTCATATTTATATGAGGCTGTTGTCTTTTCCTTCTGA
GCCTGCCTTTCTCCCCCCCACCCAGGAGTATCCTCTTGCCAAATCAAAAGACTTTTTCCTTGGGCTTTAGCCTTAAAGATACTTGAAGGT
CTAGGTGCTTTAACCTCACATACCCTCACTTAAACTTTTATCACTGTTGCATATACCAGTTGTGATACAATAAAGAATGTATCTGGATTT
TGTGCCTAGTTCCTAGCACACAGCTTCAAAAATTCTAGAGTTTCCTGATAGGAGTGTCTTTTGTATTCATAACAAGCCCTTTTCACCCAT
GCCTGGGTTTATGCTAACAAGGTTACCCATGGTGGGCCCTTAGTTTCAAGGAAGGAGTTGGCCAAGCCAGAAAGACCAAGCATGTGGTTA
AAGCATTGGAATTTTCAGCCCCATCCCACCCCCAATCTCCAAGGAGGTGATGGGGCTGGAAATTGAGTTCAATTTTAACATGGCCAGTGA
TTTAAGCAATGCTGCCTATGTAAAGAAACCCCAATAAAAACTCTGGACAGTGAGGCTTGGGGAGCTTCCTGATTGGCAGACATTCCAATG
TACTAGGAAGGTAGCGCATCTTGATTCCACAGGGACAAAGGCTCCTGAGCTCTGGGCCCTTCCAGTGCTTGCCACCCTACATACTCTTTG

>10461_10461_1_BTBD2-OAS2_BTBD2_chr19_1993018_ENST00000255608_OAS2_chr12_113424842_ENST00000342315_length(amino acids)=888AA_BP=562
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQR
EAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKT
GDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDN
RPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILL
HQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVN
IIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKA
PRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYK
ECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEP

--------------------------------------------------------------
>10461_10461_2_BTBD2-OAS2_BTBD2_chr19_1993018_ENST00000255608_OAS2_chr12_113424842_ENST00000392583_length(transcript)=5051nt_BP=701nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGTTCGTGCTGGCCGTGGGCAGCGCCG
TCTTTGATGCCATGTTCAACGGGGGAATGGCCACAACATCCACGGAGATTGAGCTGCCCGACGTGGAACCCGCTGCCTTCCTCGCACTGC
TCAAGTTTCTCTACTCGGACGAGGTGCAGATTGGCCCGGAGACGGTGATGACCACGCTATACACCGCCAAGAAGTACGCGGTGCCAGCGC
TCGAGGCCCATTGCGTGGAGTTCCTGAAGAAGAACCTGCGAGCCGACAACGCCTTCATGCTGCTCACGCAGGGTGGCTCCTATGGACGGA
AAACAGTCTTAAGAGGCAACTCCGATGGTACCCTTGTCCTCTTCTTCAGTGACTTAAAACAATTCCAGGATCAGAAGAGAAGCCAACGTG
ACATCCTCGATAAAACTGGGGATAAGCTGAAGTTCTGTCTGTTCACGAAGTGGTTGAAAAACAATTTCGAGATCCAGAAGTCCCTTGATG
GGTTCACCATCCAGGTGTTCACAAAAAATCAGAGAATCTCTTTCGAGGTGCTGGCCGCCTTCAACGCTCTGAGCTTAAATGATAATCCCA
GCCCCTGGATCTATCGAGAGCTCAAAAGATCCTTGGATAAGACAAATGCCAGTCCTGGTGAGTTTGCAGTCTGCTTCACTGAACTCCAGC
AGAAGTTTTTTGACAACCGTCCTGGAAAACTAAAGGATTTGATCCTCTTGATAAAGCACTGGCATCAACAGTGCCAGAAAAAAATCAAGG
ATTTACCCTCGCTGTCTCCGTATGCCCTGGAGCTGCTTACGGTGTATGCCTGGGAACAGGGGTGCAGAAAAGACAACTTTGACATTGCTG
AAGGCGTCAGAACCGTACTGGAGCTGATCAAATGCCAGGAGAAGCTGTGTATCTATTGGATGGTCAACTACAACTTTGAAGATGAGACCA
TCAGGAACATCCTGCTGCACCAGCTCCAATCAGCGAGGCCAGTAATCTTGGATCCAGTTGACCCAACCAATAATGTGAGTGGAGATAAAA
TATGCTGGCAATGGCTGAAAAAAGAAGCTCAAACCTGGTTGACTTCTCCCAACCTGGATAATGAGTTACCTGCACCATCTTGGAATGTTC
TGCCTGCACCACTCTTCACGACCCCAGGCCACCTTCTGGATAAGTTCATCAAGGAGTTTCTCCAGCCCAACAAATGCTTCCTAGAGCAGA
TTGACAGTGCTGTTAACATCATCCGTACATTCCTTAAAGAAAACTGCTTCCGACAATCAACAGCCAAGATCCAGATTGTCCGGGGAGGAT
CAACCGCCAAAGGCACAGCTCTGAAGACTGGCTCTGATGCCGATCTCGTCGTGTTCCATAACTCACTTAAAAGCTACACCTCCCAAAAAA
ACGAGCGGCACAAAATCGTCAAGGAAATCCATGAACAGCTGAAAGCCTTTTGGAGGGAGAAGGAGGAGGAGCTTGAAGTCAGCTTTGAGC
CTCCCAAGTGGAAGGCTCCCAGGGTGCTGAGCTTCTCTCTGAAATCCAAAGTCCTCAACGAAAGTGTCAGCTTTGATGTGCTTCCTGCCT
TTAATGCACTGGGTCAGCTGAGTTCTGGCTCCACACCCAGCCCCGAGGTTTATGCAGGGCTCATTGATCTGTATAAATCCTCGGACCTCC
CGGGAGGAGAGTTTTCTACCTGTTTCACAGTCCTGCAGCGAAACTTCATTCGCTCCCGGCCCACCAAACTAAAGGATTTAATTCGCCTGG
TGAAGCACTGGTACAAAGAGTGTGAAAGGAAACTGAAGCCAAAGGGGTCTTTGCCCCCAAAGTATGCCTTGGAGCTGCTCACCATCTATG
CCTGGGAGCAGGGGAGTGGAGTGCCGGATTTTGACACTGCAGAAGGTTTCCGGACAGTCCTGGAGCTGGTCACACAATATCAGCAGCTCT
GCATCTTCTGGAAGGTCAATTACAACTTTGAAGATGAGACCGTGAGGAAGTTTCTACTGAGCCAGTTGCAGAAAACCAGGCCTGTGATCT
TGGACCCAGCCGAACCCACAGGTGACGTGGGTGGAGGGGACCGTTGGTGTTGGCATCTTCTGGCAAAAGAAGCAAAGGAATGGTTATCCT
CTCCCTGCTTCAAGGATGGGACTGGAAACCCAATACCACCTTGGAAAGTGCCGGTAAAAGTCATCTAAAGGAGGCGTTGTCTGGAAATAG
CCCTGTAACAGGCTTGAATCAAAGAACTTCTCCTACTGTAGCAACCTGAAATTAACTCAGACACAAATAAAGGAAACCCAGCTCACAGGA
GCTTAAACAGCTGGTCAGCCCCCTAAGCCCCCACTACAAGTGATCCTCAGGCAGGTAACCCCAGATTCATGCACTGTAGGGTGCTGCGCA
GCATCCCTAGTCTCTACCCAGTAGATGCCACTAGCCCTCCTCTCCCAGTGACAACCAAAAGTCTTCAGACATTGTCAAACGTTCCCCTGG
GTTCACAGATCTTTCTGCCTTTGGCTTTTGGCTCCACCCTCTTTAGCTGTTAATTTGAGTACTTATGGCCCTGAAAGCGGCCACGGTGCC
TCCAGATGGCAGGTTTGCAATCCAAGCAGGAAGAAGGAAAAGATACCCAAAGGTCAAGAACACAGTGATTTTATTAGAAGTTTCATCCGC
AAATTTTCTTCCATTTCATTGCTCAGAAATGTCATGTGGCTACCTGTAACTTGAAGGTGGCTACAAAGATGACTGTGGACGTGGGTTGCA
CTGGCCACCCAAGGATGTCTGCCACACCTCTCCAAAGCCCTCCCTACCTACCAAGATATACCTGATATATTCCACCAGGATATCCTCCCT
CCAGATATACTTGGTTCTCTCCACCAGGTTCTTTCTTTAAAGCAGGATTTCTCAACTTTGATACTTACTCACATTTGGGGCTAGACAGTT
CTTTGTTTGGAGGCTCTCTTGTGCATTGTAGGATGTTGAGCAGCATCTCTGGCCTGTACCCAGTAGATGCCACCCAGTTGTGACAATTAA
AAGTGTCTTGAGACTTTATCATGTGTCTTCTGCCCTAGGTGAGAACCCTTGCACTAGAGGAACCCTACACCCCAACCCTGGGGGGAATGT
AGGGAAGAGGTGGCCAAGCCAACCGTGGGGTTAGCTCTAATTATTAAGATATGCATTATAAATAAATACCAAAAAATTGTCTCTGGCAAT
AGTTACCTTCCCAGATACAGGTCCCCCCTTTTTTCCCCTAACTCTTTTAAGCAATGATTGTAACTATTAGGAGACATTGCTCTCCCACGT
ATGTTTTTCTTTTTAGACAATGCAGACACCAGGAAGTTGTGGAGCTAGGATCCATCCTATTGTCAATGAGATGTTCTCATCCAGAAGCCA
TAGAATCCTGAATAATAATTCTAAAAGAAACTTCTAGAGATCATCTGGCAATCGCTTTTAAAGACTCGGCTCACCGTGAGAAAGAGTCAC
TCACATCCATTCTTCCCTTGATGGTCCCTATTCCTCCTTCCCTTGCTTCTTGGACTTCTTGAAATCAATCAAGACTGCAAACCCTTTCAT
AAAGTCTTGCCTTGCTGAACTCCCTCTCTGCAGGCAGCCTGCCTTTAAAAATAGTTGCTGTCATCCACTTTATGTGCATCTTATTTCTGT
CAACTTGTATTTTTTTTCTTGTATTTTTCCAATTAGCTCCTCCTTTTTCCTTCCAGTCTAAAAAAGGAATCCTCTGTGTCTTCAAAGCAA
AGCTCTTTACTTTCCCCTTGGTTCTCATAACTCTGTGATCTTGCTCTCGGTGCTTCCAACTCATCCACGTCCTGTCTGTTTCCTCTGTAT
ACAAAACCCTTTCTGCCCCTGCTGACACAGACATCCTCTATGCCAGCAGCCAGCCAACCCTTTCATTAGAACTTCAAGCTCTCCAAAGGC
TCAGATTATAACTGTTGTCATATTTATATGAGGCTGTTGTCTTTTCCTTCTGAGCCTGCCTTTCTCCCCCCCACCCAGGAGTATCCTCTT
GCCAAATCAAAAGACTTTTTCCTTGGGCTTTAGCCTTAAAGATACTTGAAGGTCTAGGTGCTTTAACCTCACATACCCTCACTTAAACTT
TTATCACTGTTGCATATACCAGTTGTGATACAATAAAGAATGTATCTGGATTTTGTGCCTAGTTCCTAGCACACAGCTTCAAAAATTCTA
GAGTTTCCTGATAGGAGTGTCTTTTGTATTCATAACAAGCCCTTTTCACCCATGCCTGGGTTTATGCTAACAAGGTTACCCATGGTGGGC
CCTTAGTTTCAAGGAAGGAGTTGGCCAAGCCAGAAAGACCAAGCATGTGGTTAAAGCATTGGAATTTTCAGCCCCATCCCACCCCCAATC
TCCAAGGAGGTGATGGGGCTGGAAATTGAGTTCAATTTTAACATGGCCAGTGATTTAAGCAATGCTGCCTATGTAAAGAAACCCCAATAA
AAACTCTGGACAGTGAGGCTTGGGGAGCTTCCTGATTGGCAGACATTCCAATGTACTAGGAAGGTAGCGCATCTTGATTCCACAGGGACA
AAGGCTCCTGAGCTCTGGGCCCTTCCAGTGCTTGCCACCCTACATACTCTTTGTCTGGCTCTTCATTTGTATTCTTTATAATAAAATGGT

>10461_10461_2_BTBD2-OAS2_BTBD2_chr19_1993018_ENST00000255608_OAS2_chr12_113424842_ENST00000392583_length(amino acids)=856AA_BP=562
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQR
EAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKT
GDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDN
RPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILL
HQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVN
IIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKA
PRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYK
ECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEP

--------------------------------------------------------------
>10461_10461_3_BTBD2-OAS2_BTBD2_chr19_1993019_ENST00000255608_OAS2_chr12_113424843_ENST00000342315_length(transcript)=3923nt_BP=701nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGTTCGTGCTGGCCGTGGGCAGCGCCG
TCTTTGATGCCATGTTCAACGGGGGAATGGCCACAACATCCACGGAGATTGAGCTGCCCGACGTGGAACCCGCTGCCTTCCTCGCACTGC
TCAAGTTTCTCTACTCGGACGAGGTGCAGATTGGCCCGGAGACGGTGATGACCACGCTATACACCGCCAAGAAGTACGCGGTGCCAGCGC
TCGAGGCCCATTGCGTGGAGTTCCTGAAGAAGAACCTGCGAGCCGACAACGCCTTCATGCTGCTCACGCAGGGTGGCTCCTATGGACGGA
AAACAGTCTTAAGAGGCAACTCCGATGGTACCCTTGTCCTCTTCTTCAGTGACTTAAAACAATTCCAGGATCAGAAGAGAAGCCAACGTG
ACATCCTCGATAAAACTGGGGATAAGCTGAAGTTCTGTCTGTTCACGAAGTGGTTGAAAAACAATTTCGAGATCCAGAAGTCCCTTGATG
GGTTCACCATCCAGGTGTTCACAAAAAATCAGAGAATCTCTTTCGAGGTGCTGGCCGCCTTCAACGCTCTGAGCTTAAATGATAATCCCA
GCCCCTGGATCTATCGAGAGCTCAAAAGATCCTTGGATAAGACAAATGCCAGTCCTGGTGAGTTTGCAGTCTGCTTCACTGAACTCCAGC
AGAAGTTTTTTGACAACCGTCCTGGAAAACTAAAGGATTTGATCCTCTTGATAAAGCACTGGCATCAACAGTGCCAGAAAAAAATCAAGG
ATTTACCCTCGCTGTCTCCGTATGCCCTGGAGCTGCTTACGGTGTATGCCTGGGAACAGGGGTGCAGAAAAGACAACTTTGACATTGCTG
AAGGCGTCAGAACCGTACTGGAGCTGATCAAATGCCAGGAGAAGCTGTGTATCTATTGGATGGTCAACTACAACTTTGAAGATGAGACCA
TCAGGAACATCCTGCTGCACCAGCTCCAATCAGCGAGGCCAGTAATCTTGGATCCAGTTGACCCAACCAATAATGTGAGTGGAGATAAAA
TATGCTGGCAATGGCTGAAAAAAGAAGCTCAAACCTGGTTGACTTCTCCCAACCTGGATAATGAGTTACCTGCACCATCTTGGAATGTTC
TGCCTGCACCACTCTTCACGACCCCAGGCCACCTTCTGGATAAGTTCATCAAGGAGTTTCTCCAGCCCAACAAATGCTTCCTAGAGCAGA
TTGACAGTGCTGTTAACATCATCCGTACATTCCTTAAAGAAAACTGCTTCCGACAATCAACAGCCAAGATCCAGATTGTCCGGGGAGGAT
CAACCGCCAAAGGCACAGCTCTGAAGACTGGCTCTGATGCCGATCTCGTCGTGTTCCATAACTCACTTAAAAGCTACACCTCCCAAAAAA
ACGAGCGGCACAAAATCGTCAAGGAAATCCATGAACAGCTGAAAGCCTTTTGGAGGGAGAAGGAGGAGGAGCTTGAAGTCAGCTTTGAGC
CTCCCAAGTGGAAGGCTCCCAGGGTGCTGAGCTTCTCTCTGAAATCCAAAGTCCTCAACGAAAGTGTCAGCTTTGATGTGCTTCCTGCCT
TTAATGCACTGGGTCAGCTGAGTTCTGGCTCCACACCCAGCCCCGAGGTTTATGCAGGGCTCATTGATCTGTATAAATCCTCGGACCTCC
CGGGAGGAGAGTTTTCTACCTGTTTCACAGTCCTGCAGCGAAACTTCATTCGCTCCCGGCCCACCAAACTAAAGGATTTAATTCGCCTGG
TGAAGCACTGGTACAAAGAGTGTGAAAGGAAACTGAAGCCAAAGGGGTCTTTGCCCCCAAAGTATGCCTTGGAGCTGCTCACCATCTATG
CCTGGGAGCAGGGGAGTGGAGTGCCGGATTTTGACACTGCAGAAGGTTTCCGGACAGTCCTGGAGCTGGTCACACAATATCAGCAGCTCT
GCATCTTCTGGAAGGTCAATTACAACTTTGAAGATGAGACCGTGAGGAAGTTTCTACTGAGCCAGTTGCAGAAAACCAGGCCTGTGATCT
TGGACCCAGCCGAACCCACAGGTGACGTGGGTGGAGGGGACCGTTGGTGTTGGCATCTTCTGGCAAAAGAAGCAAAGGAATGGTTATCCT
CTCCCTGCTTCAAGGATGGGACTGGAAACCCAATACCACCTTGGAAAGTGCCGACAATGCAGACACCAGGAAGTTGTGGAGCTAGGATCC
ATCCTATTGTCAATGAGATGTTCTCATCCAGAAGCCATAGAATCCTGAATAATAATTCTAAAAGAAACTTCTAGAGATCATCTGGCAATC
GCTTTTAAAGACTCGGCTCACCGTGAGAAAGAGTCACTCACATCCATTCTTCCCTTGATGGTCCCTATTCCTCCTTCCCTTGCTTCTTGG
ACTTCTTGAAATCAATCAAGACTGCAAACCCTTTCATAAAGTCTTGCCTTGCTGAACTCCCTCTCTGCAGGCAGCCTGCCTTTAAAAATA
GTTGCTGTCATCCACTTTATGTGCATCTTATTTCTGTCAACTTGTATTTTTTTTCTTGTATTTTTCCAATTAGCTCCTCCTTTTTCCTTC
CAGTCTAAAAAAGGAATCCTCTGTGTCTTCAAAGCAAAGCTCTTTACTTTCCCCTTGGTTCTCATAACTCTGTGATCTTGCTCTCGGTGC
TTCCAACTCATCCACGTCCTGTCTGTTTCCTCTGTATACAAAACCCTTTCTGCCCCTGCTGACACAGACATCCTCTATGCCAGCAGCCAG
CCAACCCTTTCATTAGAACTTCAAGCTCTCCAAAGGCTCAGATTATAACTGTTGTCATATTTATATGAGGCTGTTGTCTTTTCCTTCTGA
GCCTGCCTTTCTCCCCCCCACCCAGGAGTATCCTCTTGCCAAATCAAAAGACTTTTTCCTTGGGCTTTAGCCTTAAAGATACTTGAAGGT
CTAGGTGCTTTAACCTCACATACCCTCACTTAAACTTTTATCACTGTTGCATATACCAGTTGTGATACAATAAAGAATGTATCTGGATTT
TGTGCCTAGTTCCTAGCACACAGCTTCAAAAATTCTAGAGTTTCCTGATAGGAGTGTCTTTTGTATTCATAACAAGCCCTTTTCACCCAT
GCCTGGGTTTATGCTAACAAGGTTACCCATGGTGGGCCCTTAGTTTCAAGGAAGGAGTTGGCCAAGCCAGAAAGACCAAGCATGTGGTTA
AAGCATTGGAATTTTCAGCCCCATCCCACCCCCAATCTCCAAGGAGGTGATGGGGCTGGAAATTGAGTTCAATTTTAACATGGCCAGTGA
TTTAAGCAATGCTGCCTATGTAAAGAAACCCCAATAAAAACTCTGGACAGTGAGGCTTGGGGAGCTTCCTGATTGGCAGACATTCCAATG
TACTAGGAAGGTAGCGCATCTTGATTCCACAGGGACAAAGGCTCCTGAGCTCTGGGCCCTTCCAGTGCTTGCCACCCTACATACTCTTTG

>10461_10461_3_BTBD2-OAS2_BTBD2_chr19_1993019_ENST00000255608_OAS2_chr12_113424843_ENST00000342315_length(amino acids)=888AA_BP=562
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQR
EAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKT
GDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDN
RPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILL
HQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVN
IIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKA
PRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYK
ECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEP

--------------------------------------------------------------
>10461_10461_4_BTBD2-OAS2_BTBD2_chr19_1993019_ENST00000255608_OAS2_chr12_113424843_ENST00000392583_length(transcript)=5051nt_BP=701nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGTTCGTGCTGGCCGTGGGCAGCGCCG
TCTTTGATGCCATGTTCAACGGGGGAATGGCCACAACATCCACGGAGATTGAGCTGCCCGACGTGGAACCCGCTGCCTTCCTCGCACTGC
TCAAGTTTCTCTACTCGGACGAGGTGCAGATTGGCCCGGAGACGGTGATGACCACGCTATACACCGCCAAGAAGTACGCGGTGCCAGCGC
TCGAGGCCCATTGCGTGGAGTTCCTGAAGAAGAACCTGCGAGCCGACAACGCCTTCATGCTGCTCACGCAGGGTGGCTCCTATGGACGGA
AAACAGTCTTAAGAGGCAACTCCGATGGTACCCTTGTCCTCTTCTTCAGTGACTTAAAACAATTCCAGGATCAGAAGAGAAGCCAACGTG
ACATCCTCGATAAAACTGGGGATAAGCTGAAGTTCTGTCTGTTCACGAAGTGGTTGAAAAACAATTTCGAGATCCAGAAGTCCCTTGATG
GGTTCACCATCCAGGTGTTCACAAAAAATCAGAGAATCTCTTTCGAGGTGCTGGCCGCCTTCAACGCTCTGAGCTTAAATGATAATCCCA
GCCCCTGGATCTATCGAGAGCTCAAAAGATCCTTGGATAAGACAAATGCCAGTCCTGGTGAGTTTGCAGTCTGCTTCACTGAACTCCAGC
AGAAGTTTTTTGACAACCGTCCTGGAAAACTAAAGGATTTGATCCTCTTGATAAAGCACTGGCATCAACAGTGCCAGAAAAAAATCAAGG
ATTTACCCTCGCTGTCTCCGTATGCCCTGGAGCTGCTTACGGTGTATGCCTGGGAACAGGGGTGCAGAAAAGACAACTTTGACATTGCTG
AAGGCGTCAGAACCGTACTGGAGCTGATCAAATGCCAGGAGAAGCTGTGTATCTATTGGATGGTCAACTACAACTTTGAAGATGAGACCA
TCAGGAACATCCTGCTGCACCAGCTCCAATCAGCGAGGCCAGTAATCTTGGATCCAGTTGACCCAACCAATAATGTGAGTGGAGATAAAA
TATGCTGGCAATGGCTGAAAAAAGAAGCTCAAACCTGGTTGACTTCTCCCAACCTGGATAATGAGTTACCTGCACCATCTTGGAATGTTC
TGCCTGCACCACTCTTCACGACCCCAGGCCACCTTCTGGATAAGTTCATCAAGGAGTTTCTCCAGCCCAACAAATGCTTCCTAGAGCAGA
TTGACAGTGCTGTTAACATCATCCGTACATTCCTTAAAGAAAACTGCTTCCGACAATCAACAGCCAAGATCCAGATTGTCCGGGGAGGAT
CAACCGCCAAAGGCACAGCTCTGAAGACTGGCTCTGATGCCGATCTCGTCGTGTTCCATAACTCACTTAAAAGCTACACCTCCCAAAAAA
ACGAGCGGCACAAAATCGTCAAGGAAATCCATGAACAGCTGAAAGCCTTTTGGAGGGAGAAGGAGGAGGAGCTTGAAGTCAGCTTTGAGC
CTCCCAAGTGGAAGGCTCCCAGGGTGCTGAGCTTCTCTCTGAAATCCAAAGTCCTCAACGAAAGTGTCAGCTTTGATGTGCTTCCTGCCT
TTAATGCACTGGGTCAGCTGAGTTCTGGCTCCACACCCAGCCCCGAGGTTTATGCAGGGCTCATTGATCTGTATAAATCCTCGGACCTCC
CGGGAGGAGAGTTTTCTACCTGTTTCACAGTCCTGCAGCGAAACTTCATTCGCTCCCGGCCCACCAAACTAAAGGATTTAATTCGCCTGG
TGAAGCACTGGTACAAAGAGTGTGAAAGGAAACTGAAGCCAAAGGGGTCTTTGCCCCCAAAGTATGCCTTGGAGCTGCTCACCATCTATG
CCTGGGAGCAGGGGAGTGGAGTGCCGGATTTTGACACTGCAGAAGGTTTCCGGACAGTCCTGGAGCTGGTCACACAATATCAGCAGCTCT
GCATCTTCTGGAAGGTCAATTACAACTTTGAAGATGAGACCGTGAGGAAGTTTCTACTGAGCCAGTTGCAGAAAACCAGGCCTGTGATCT
TGGACCCAGCCGAACCCACAGGTGACGTGGGTGGAGGGGACCGTTGGTGTTGGCATCTTCTGGCAAAAGAAGCAAAGGAATGGTTATCCT
CTCCCTGCTTCAAGGATGGGACTGGAAACCCAATACCACCTTGGAAAGTGCCGGTAAAAGTCATCTAAAGGAGGCGTTGTCTGGAAATAG
CCCTGTAACAGGCTTGAATCAAAGAACTTCTCCTACTGTAGCAACCTGAAATTAACTCAGACACAAATAAAGGAAACCCAGCTCACAGGA
GCTTAAACAGCTGGTCAGCCCCCTAAGCCCCCACTACAAGTGATCCTCAGGCAGGTAACCCCAGATTCATGCACTGTAGGGTGCTGCGCA
GCATCCCTAGTCTCTACCCAGTAGATGCCACTAGCCCTCCTCTCCCAGTGACAACCAAAAGTCTTCAGACATTGTCAAACGTTCCCCTGG
GTTCACAGATCTTTCTGCCTTTGGCTTTTGGCTCCACCCTCTTTAGCTGTTAATTTGAGTACTTATGGCCCTGAAAGCGGCCACGGTGCC
TCCAGATGGCAGGTTTGCAATCCAAGCAGGAAGAAGGAAAAGATACCCAAAGGTCAAGAACACAGTGATTTTATTAGAAGTTTCATCCGC
AAATTTTCTTCCATTTCATTGCTCAGAAATGTCATGTGGCTACCTGTAACTTGAAGGTGGCTACAAAGATGACTGTGGACGTGGGTTGCA
CTGGCCACCCAAGGATGTCTGCCACACCTCTCCAAAGCCCTCCCTACCTACCAAGATATACCTGATATATTCCACCAGGATATCCTCCCT
CCAGATATACTTGGTTCTCTCCACCAGGTTCTTTCTTTAAAGCAGGATTTCTCAACTTTGATACTTACTCACATTTGGGGCTAGACAGTT
CTTTGTTTGGAGGCTCTCTTGTGCATTGTAGGATGTTGAGCAGCATCTCTGGCCTGTACCCAGTAGATGCCACCCAGTTGTGACAATTAA
AAGTGTCTTGAGACTTTATCATGTGTCTTCTGCCCTAGGTGAGAACCCTTGCACTAGAGGAACCCTACACCCCAACCCTGGGGGGAATGT
AGGGAAGAGGTGGCCAAGCCAACCGTGGGGTTAGCTCTAATTATTAAGATATGCATTATAAATAAATACCAAAAAATTGTCTCTGGCAAT
AGTTACCTTCCCAGATACAGGTCCCCCCTTTTTTCCCCTAACTCTTTTAAGCAATGATTGTAACTATTAGGAGACATTGCTCTCCCACGT
ATGTTTTTCTTTTTAGACAATGCAGACACCAGGAAGTTGTGGAGCTAGGATCCATCCTATTGTCAATGAGATGTTCTCATCCAGAAGCCA
TAGAATCCTGAATAATAATTCTAAAAGAAACTTCTAGAGATCATCTGGCAATCGCTTTTAAAGACTCGGCTCACCGTGAGAAAGAGTCAC
TCACATCCATTCTTCCCTTGATGGTCCCTATTCCTCCTTCCCTTGCTTCTTGGACTTCTTGAAATCAATCAAGACTGCAAACCCTTTCAT
AAAGTCTTGCCTTGCTGAACTCCCTCTCTGCAGGCAGCCTGCCTTTAAAAATAGTTGCTGTCATCCACTTTATGTGCATCTTATTTCTGT
CAACTTGTATTTTTTTTCTTGTATTTTTCCAATTAGCTCCTCCTTTTTCCTTCCAGTCTAAAAAAGGAATCCTCTGTGTCTTCAAAGCAA
AGCTCTTTACTTTCCCCTTGGTTCTCATAACTCTGTGATCTTGCTCTCGGTGCTTCCAACTCATCCACGTCCTGTCTGTTTCCTCTGTAT
ACAAAACCCTTTCTGCCCCTGCTGACACAGACATCCTCTATGCCAGCAGCCAGCCAACCCTTTCATTAGAACTTCAAGCTCTCCAAAGGC
TCAGATTATAACTGTTGTCATATTTATATGAGGCTGTTGTCTTTTCCTTCTGAGCCTGCCTTTCTCCCCCCCACCCAGGAGTATCCTCTT
GCCAAATCAAAAGACTTTTTCCTTGGGCTTTAGCCTTAAAGATACTTGAAGGTCTAGGTGCTTTAACCTCACATACCCTCACTTAAACTT
TTATCACTGTTGCATATACCAGTTGTGATACAATAAAGAATGTATCTGGATTTTGTGCCTAGTTCCTAGCACACAGCTTCAAAAATTCTA
GAGTTTCCTGATAGGAGTGTCTTTTGTATTCATAACAAGCCCTTTTCACCCATGCCTGGGTTTATGCTAACAAGGTTACCCATGGTGGGC
CCTTAGTTTCAAGGAAGGAGTTGGCCAAGCCAGAAAGACCAAGCATGTGGTTAAAGCATTGGAATTTTCAGCCCCATCCCACCCCCAATC
TCCAAGGAGGTGATGGGGCTGGAAATTGAGTTCAATTTTAACATGGCCAGTGATTTAAGCAATGCTGCCTATGTAAAGAAACCCCAATAA
AAACTCTGGACAGTGAGGCTTGGGGAGCTTCCTGATTGGCAGACATTCCAATGTACTAGGAAGGTAGCGCATCTTGATTCCACAGGGACA
AAGGCTCCTGAGCTCTGGGCCCTTCCAGTGCTTGCCACCCTACATACTCTTTGTCTGGCTCTTCATTTGTATTCTTTATAATAAAATGGT

>10461_10461_4_BTBD2-OAS2_BTBD2_chr19_1993019_ENST00000255608_OAS2_chr12_113424843_ENST00000392583_length(amino acids)=856AA_BP=562
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQR
EAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKT
GDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDN
RPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILL
HQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVN
IIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKA
PRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYK
ECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTBD2-OAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTBD2-OAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTBD2-OAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource