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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:BTN2A1-SPINT2 (FusionGDB2 ID:10546)

Fusion Gene Summary for BTN2A1-SPINT2

Fusion gene summary

Fusion gene information	Fusion gene name: BTN2A1-SPINT2
	Fusion gene ID: 10546
		Hgene	Tgene
	Gene symbol	BTN2A1	SPINT2
	Gene ID	11120	10653
	Gene name	butyrophilin subfamily 2 member A1	serine peptidase inhibitor, Kunitz type 2
	Synonyms	BK14H9.1\|BT2.1\|BTF1\|BTN2.1\|DJ3E1.1	DIAR3\|HAI-2\|HAI2\|Kop\|PB
	Cytomap	6p22.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	butyrophilin subfamily 2 member A1	kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183
	Modification date	20200313	20200315
	UniProtAcc	Q7KYR7	.
	Ensembl transtripts involved in fusion gene	ENST00000312541, ENST00000429381, ENST00000469185, ENST00000541522,	ENST00000301244, ENST00000454580, ENST00000587090,
Fusion gene scores	* DoF score	4 X 4 X 4=64	11 X 6 X 8=528
	# samples	4	13
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/528*10)=-2.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTN2A1 [Title/Abstract] AND SPINT2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BTN2A1(26460056)-SPINT2(38778515), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPINT2	GO:0022408	negative regulation of cell-cell adhesion	19592578
Tgene	SPINT2	GO:2000146	negative regulation of cell motility	19592578

Fusion gene breakpoints across BTN2A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPINT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-30-1857	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+

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Fusion Gene ORF analysis for BTN2A1-SPINT2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000312541	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000312541	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000312541	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000429381	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000429381	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000429381	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000469185	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000469185	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000469185	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000541522	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000541522	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+
In-frame	ENST00000541522	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1725	635	190	1116	308
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1562	635	190	1116	308
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1579	635	190	1116	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1768	678	233	1159	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1605	678	233	1159	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1622	678	233	1159	308
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1631	541	84	1022	312
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1468	541	84	1022	312
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1485	541	84	1022	312
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1732	642	197	1123	308
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1569	642	197	1123	308
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1586	642	197	1123	308

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000469185	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000540556	0.99945945
ENST00000469185	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000585601	0.99941444
ENST00000469185	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000589951	0.99941003
ENST00000312541	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000501685	0.99949825
ENST00000312541	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000554883	0.99944514
ENST00000312541	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000555186	0.9994448
ENST00000541522	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001414619	0.99858546
ENST00000541522	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001513991	0.998486
ENST00000541522	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001564492	0.99843556
ENST00000429381	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000553491	0.99944645
ENST00000429381	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000604645	0.9993954
ENST00000429381	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000611339	0.9993887

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Fusion Genomic Features for BTN2A1-SPINT2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	2.51E-06	0.9999975
BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	2.51E-06	0.9999975

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BTN2A1-SPINT2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:26460056/chr19:38778515)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTN2A1 Q7KYR7	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

29_141

143

528.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

29_141

143

335.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

29_141

143

331.0

Domain

Note=Ig-like V-type

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

219_252

253.0

Topological domain

Cytoplasmic

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

219_252

196.0

Topological domain

Cytoplasmic

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

198_218

253.0

Transmembrane

Helical

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

198_218

196.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

310_506

143

528.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

310_506

143

335.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

310_506

143

331.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

29_141

467.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

310_506

467.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

270_527

143

528.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

29_248

143

528.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

270_527

143

335.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

29_248

143

335.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

270_527

143

331.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

29_248

143

331.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

270_527

467.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

29_248

467.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

249_269

143

528.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

249_269

143

335.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

249_269

143

331.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

249_269

467.0

Transmembrane

Helical

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

28_197

253.0

Topological domain

Extracellular

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

28_197

196.0

Topological domain

Extracellular

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Fusion Gene Sequence for BTN2A1-SPINT2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10546_10546_1_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000301244_length(transcript)=1768nt_BP=678nt
ACTCTTGGGACTGTGGAAGCCCAGGAGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTT
TCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAAC
CAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGC
ACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATC
CCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCC
GGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCT
TTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCC
AAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGG
ATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACG
CAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCC
GGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAA
AGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGA
ACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTC
GCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTG
AGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGC
ATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATT
CCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTT
TTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAAAAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTT
TCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACACTATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATA

>10546_10546_1_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_2_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000454580_length(transcript)=1622nt_BP=678nt
ACTCTTGGGACTGTGGAAGCCCAGGAGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTT
TCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAAC
CAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGC
ACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATC
CCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCC
GGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCT
TTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCC
AAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGG
ATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACG
CAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCC
GGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAA
AGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGA
ACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTC
GCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTG
AGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGC
ATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATT
CCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTT
TTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAAAAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTT

>10546_10546_2_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_3_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000587090_length(transcript)=1605nt_BP=678nt
ACTCTTGGGACTGTGGAAGCCCAGGAGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTT
TCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAAC
CAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGC
ACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATC
CCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCC
GGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCT
TTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCC
AAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGG
ATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACG
CAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCC
GGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAA
AGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGA
ACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTC
GCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTG
AGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGC
ATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATT
CCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTT

>10546_10546_3_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_4_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000301244_length(transcript)=1732nt_BP=642nt
CGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCC
TGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGA
AGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCC
TCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTAC
GCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAG
GTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCC
TGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACC
TCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATT
CTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCT
GGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCT
GCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGT
TGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCG
GAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTG
TGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCC
TGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTC
CTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGG
AATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGT
ACAAGTTTAATAAAAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAAT
GATCACAAGACACTATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGAT

>10546_10546_4_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_5_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000454580_length(transcript)=1586nt_BP=642nt
CGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCC
TGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGA
AGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCC
TCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTAC
GCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAG
GTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCC
TGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACC
TCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATT
CTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCT
GGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCT
GCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGT
TGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCG
GAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTG
TGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCC
TGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTC
CTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGG
AATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGT

>10546_10546_5_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_6_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000587090_length(transcript)=1569nt_BP=642nt
CGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCC
TGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGA
AGGCCTCCTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCC
TCAGCCTGTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTAC
GCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAG
GTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCC
TGGTCATACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACC
TCGTAGTGGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATT
CTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCT
GGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCT
GCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGT
TGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCG
GAGATGACAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTG
TGAGCTTTTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCC
TGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTC
CTCGCTGATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGG
AATCGTTTCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGT

>10546_10546_6_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_7_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000301244_length(transcript)=1725nt_BP=635nt
TGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCC
CTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTC
CTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCT
GTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCA
TCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAG
AGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCAT
ACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGT
GGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGA
CCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTT
TGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCT
CCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCT
CTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGA
CAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTT
TTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTG
GCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTG
ATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTT
TCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTT
TAATAAAAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACA
AGACACTATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAA

>10546_10546_7_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_8_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000454580_length(transcript)=1579nt_BP=635nt
TGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCC
CTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTC
CTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCT
GTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCA
TCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAG
AGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCAT
ACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGT
GGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGA
CCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTT
TGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCT
CCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCT
CTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGA
CAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTT
TTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTG
GCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTG
ATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTT
TCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTT

>10546_10546_8_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_9_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000587090_length(transcript)=1562nt_BP=635nt
TGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGTCTAGTAGTGCCTGTGCCC
CTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTC
CTGTCCCTGCCTGCTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGCCTCCCTCCTCCTCCTCCTCCTCAGCCT
GTGTGCACTGGTCTCAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCA
TCTGTCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAG
AGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCAT
ACACAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGT
GGCAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGA
CCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTT
TGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCT
CCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCT
CTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGA
CAAGGAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTT
TTTTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTG
GCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTG
ATCGATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTT
TCTTTTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTT

>10546_10546_9_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------
>10546_10546_10_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000301244_length(transcript)=1631nt_BP=541nt
AGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGT
CTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGT
TTAATTCTAGAAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTG
TCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAG
AGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACAC
AACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCA
GAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCAC
TCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGAC
GTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGC
TGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTC
CTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAG
GAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTT
TAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAG
GGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCG
ATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTT
TTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAAT
AAAAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGAC
ACTATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGT

>10546_10546_10_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------
>10546_10546_11_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000454580_length(transcript)=1485nt_BP=541nt
AGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGT
CTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGT
TTAATTCTAGAAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTG
TCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAG
AGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACAC
AACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCA
GAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCAC
TCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGAC
GTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGC
TGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTC
CTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAG
GAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTT
TAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAG
GGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCG
ATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTT
TTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAAT

>10546_10546_11_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------
>10546_10546_12_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000587090_length(transcript)=1468nt_BP=541nt
AGACCAGATTTCGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAGGGGAAGAACAATTTTTTCTCCTCTTTTGGGAAGGTTTGTGT
CTAGTAGTGCCTGTGCCCCTGGGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGGAGAAAAGAAAAAGCAACGT
TTAATTCTAGAAGCCCAGTTTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAACACTACGTTACGCTGCCATCTG
TCACCCGAGAAAAATGCTGAGGACATGGAGGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAGGTGGCAGAGAG
AGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACCACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACAC
AACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAGGCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCA
GAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCAC
TCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGAC
GTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGC
TGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTC
CTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAG
GAGCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTT
TAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAG
GGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCG
ATTTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTT
TTGTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAAT

>10546_10546_12_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BTN2A1-SPINT2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BTN2A1-SPINT2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BTN2A1-SPINT2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source