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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BTNL8-SPG7 (FusionGDB2 ID:10556)

Fusion Gene Summary for BTNL8-SPG7

Fusion gene summary

Fusion gene information	Fusion gene name: BTNL8-SPG7
	Fusion gene ID: 10556
		Hgene	Tgene
	Gene symbol	BTNL8	SPG7
	Gene ID	79908	6687
	Gene name	butyrophilin like 8	SPG7 matrix AAA peptidase subunit, paraplegin
	Synonyms	BTN9.2	CAR\|CMAR\|PGN\|SPG5C
	Cytomap	5q35.3	16q24.3
	Type of gene	protein-coding	protein-coding
	Description	butyrophilin-like protein 8B7-H5 costimulatory molecule	parapleginSPG7, paraplegin matrix AAA peptidase subunitcell matrix adhesion regulatorspastic paraplegia 7 (pure and complicated autosomal recessive)spastic paraplegia 7 protein
	Modification date	20200313	20200320
	UniProtAcc	Q6UX41	.
	Ensembl transtripts involved in fusion gene	ENST00000231229, ENST00000340184, ENST00000508408, ENST00000511704, ENST00000400707, ENST00000505126, ENST00000533815,	ENST00000341316, ENST00000565891, ENST00000268704,
Fusion gene scores	* DoF score	1 X 1 X 1=1	11 X 8 X 7=616
	# samples	1	11
	** MAII score	log2(1/1*10)=3.32192809488736	log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTNL8 [Title/Abstract] AND SPG7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BTNL8(180326359)-SPG7(89611056), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across BTNL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPG7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315409	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+

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Fusion Gene ORF analysis for BTNL8-SPG7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000231229	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000231229	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000340184	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000340184	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000508408	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000508408	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000511704	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5CDS-intron	ENST00000511704	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5UTR-3CDS	ENST00000400707	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5UTR-intron	ENST00000400707	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
5UTR-intron	ENST00000400707	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
In-frame	ENST00000231229	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
In-frame	ENST00000340184	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
In-frame	ENST00000508408	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
In-frame	ENST00000511704	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-3CDS	ENST00000505126	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-3CDS	ENST00000533815	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-intron	ENST00000505126	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-intron	ENST00000505126	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-intron	ENST00000533815	ENST00000341316	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+
intron-intron	ENST00000533815	ENST00000565891	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000231229

BTNL8

chr5

180326359

ENST00000268704

SPG7

chr16

89611056

2020

283

1421

279

380

ENST00000340184

BTNL8

chr5

180326359

ENST00000268704

SPG7

chr16

89611056

1992

255

1393

251

380

ENST00000508408

BTNL8

chr5

180326359

ENST00000268704

SPG7

chr16

89611056

1823

1224

380

ENST00000511704

BTNL8

chr5

180326359

ENST00000268704

SPG7

chr16

89611056

1823

1224

380

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000231229	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+	0.002838747	0.99716127
ENST00000340184	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+	0.003082347	0.9969176
ENST00000508408	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+	0.002961083	0.99703896
ENST00000511704	ENST00000268704	BTNL8	chr5	180326359	+	SPG7	chr16	89611056	+	0.002961083	0.99703896

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Fusion Genomic Features for BTNL8-SPG7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BTNL8	chr5	180326359	+	SPG7	chr16	89611055	+	0.000156979	0.999843
BTNL8	chr5	180326359	+	SPG7	chr16	89611055	+	0.000156979	0.999843

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BTNL8-SPG7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:180326359/chr16:89611056)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTNL8 Q6UX41	.
FUNCTION: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production. {ECO:0000269\|PubMed:24036152}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

349_357

490.0

Nucleotide binding

ATP

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

106_144

490.0

Topological domain

Mitochondrial matrix

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

166_248

490.0

Topological domain

Mitochondrial intermembrane

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

270_795

490.0

Topological domain

Mitochondrial matrix

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

145_165

490.0

Transmembrane

Helical

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000341316

249_269

490.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

133_222

348.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

19_132

348.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

270_466

348.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

133_222

501.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

19_132

501.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

270_466

501.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

133_222

376.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

19_132

376.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

270_466

376.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

133_222

341.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

19_132

341.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

270_466

341.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

133_222

385.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

19_132

385.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

270_466

385.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

133_222

317.0

Domain

Note=Ig-like V-type 2

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

19_132

317.0

Domain

Note=Ig-like V-type 1

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

270_466

317.0

Domain

B30.2/SPRY

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

18_238

348.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

260_500

348.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

18_238

501.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

260_500

501.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

18_238

376.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

260_500

376.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

18_238

341.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

260_500

341.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

18_238

385.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

260_500

385.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

18_238

317.0

Topological domain

Extracellular

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

260_500

317.0

Topological domain

Cytoplasmic

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000231229

239_259

348.0

Transmembrane

Helical

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000340184

239_259

501.0

Transmembrane

Helical

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000400707

239_259

376.0

Transmembrane

Helical

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000508408

239_259

341.0

Transmembrane

Helical

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000511704

239_259

385.0

Transmembrane

Helical

Hgene

BTNL8

chr5:180326359

chr16:89611056

ENST00000533815

239_259

317.0

Transmembrane

Helical

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

349_357

441

796.0

Nucleotide binding

ATP

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

106_144

441

796.0

Topological domain

Mitochondrial matrix

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

166_248

441

796.0

Topological domain

Mitochondrial intermembrane

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

270_795

441

796.0

Topological domain

Mitochondrial matrix

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

145_165

441

796.0

Transmembrane

Helical

Tgene

SPG7

chr5:180326359

chr16:89611056

ENST00000268704

249_269

441

796.0

Transmembrane

Helical

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Fusion Gene Sequence for BTNL8-SPG7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10556_10556_1_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000231229_SPG7_chr16_89611056_ENST00000268704_length(transcript)=2020nt_BP=283nt
TAGACATTTATGCAGTGGTTCAAAGTCTAGAGTCCCTACACTTCTGGTACATGACAGCTGTGTCTCGATGGAGTAGACTCTCAGAACAGC
GCAGTTTGCCCTCCGCTCACGCAGAGCCTCTCCGTGGCTTCCGCACCTTGAGCATTAGGCCAGTTCTCCTCTTCTCTCTAATCCATCCGT
CACCTCTCCTGTCATCCGTTTCCATGCCGTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTC
AAGCTGGGATCAGGAATGGGTACCACAGACCATGTCATCGTCCTGGCGTCCACGAACCGAGCTGACATTTTGGACGGTGCTCTGATGAGG
CCAGGCCGACTGGACCGGCACGTCTTCATTGATCTCCCCACGCTGCAGGAGAGGCGGGAGATTTTTGAGCAGCACCTGAAGAGCCTGAAG
CTGACCCAGTCCAGCACCTTTTACTCCCAGCGTCTGGCAGAGCTGACACCAGGATTCAGTGGGGCTGACATCGCCAACATCTGCAATGAG
GCTGCGCTGCACGCGGCGCGGGAGGGACACACTTCCGTGCACACTCTCAACTTCGAGTACGCCGTGGAGCGCGTCCTCGCAGGGACTGCC
AAAAAGAGCAAGATCCTGTCCAAGGAAGAACAGAAAGTGGTTGCGTTTCATGAGTCGGGCCACGCCTTGGTGGGCTGGATGCTGGAGCAC
ACGGAGGCCGTGATGAAGGTCTCCATAACCCCTCGGACAAACGCCGCCCTGGGCTTTGCTCAGATGCTCCCCAGAGACCAGCACCTCTTC
ACCAAGGAGCAGCTGTTTGAGCGGATGTGCATGGCCCTGGGAGGACGGGCCTCGGAAGCACTGTCCTTCAACGAGGTCACTTCTGGGGCA
CAGGACGACCTGAGGAAGGTCACCCGCATCGCCTACTCCATGGTGAAGCAGTTTGGGATGGCACCTGGCATCGGGCCCATCTCCTTCCCT
GAGGCGCAGGAGGGCCTCATGGGCATCGGGCGGCGCCCCTTCAGCCAAGGCCTGCAGCAGATGATGGACCATGAAGCAAGACTGCTGGTG
GCCAAGGCCTACAGACACACCGAGAAGGTGCTGCAGGACAACCTGGACAAGTTGCAGGCGCTGGCAAACGCCCTTCTGGAAAAGGAAGTG
ATAAACTATGAGGACATTGAGGCTCTCATTGGCCCGCCGCCCCATGGGCCGAAGAAAATGATCGCACCGCAGAGGTGGATCGACGCCCAG
AGGGAGAAACAGGACTTGGGCGAGGAGGAGACCGAAGAGACCCAGCAGCCTCCACTTGGAGGCGAAGAGCCGACTTGGCCCAAGTAGTTG
GGAGGTGTTGGCTGCACGTGCGGGTGGTCCGGGAAGTGAGGGCTCACTCAGCCACCCTGAGTTGCTTTTCAGCTGAGGTTTGCACTTCCT
CTCGCGGCCCTCAGTAGTCCCTGCACAGTGACTTCTGAGATCTGTTGATTGATGACCCTTTTCATGATTTTAAGTTTCTCTGCAGAAACT
ACTGACGGAGTCCTGTGTTTGTGAGTCGTTTCCCCTATGGGGAAGGTTATCAGTGCTTCCCGAGTGAGCATGGAACACTTCGAGTTCCCA
GGGTTATAGACAGTCGTTCCCAGTGTGGCTGAGGCCACCCAGAGGCAGCAGAGCATTCAGACTCCAAACAGACCCCTGTTCATGCCGACG
CTTGCACGACCGCCCCAGTTCCTGTGGCTCCCTCGGAATGCTAAGGGGATCGGACATGAAAGGACCCTGTGAGCCGATTGTCCTATCTCC
AGCGGCCCTGTCATCCAGCTCACTCATCAATGGGGCCAGTCAGGCCCAGGCACTGGGCTCCGGAGGACTCACCACTGCCCCCTGCTGCCA
TGTGGACTGGTGCAAGTTGAGGACTTCTTGCTGGTCTAGTCACGCATGCAGTGTTGGGGATGCCTTGGTTTTTACTGCTCTGAGAATTGT

>10556_10556_1_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000231229_SPG7_chr16_89611056_ENST00000268704_length(amino acids)=380AA_BP=1
MKSNSGWLSEPSLPGPPARAANTSQLLGPSRLFASKWRLLGLFGLLLAQVLFLPLGVDPPLRCDHFLRPMGRRANESLNVLIVYHFLFQK
GVCQRLQLVQVVLQHLLGVSVGLGHQQSCFMVHHLLQALAEGAPPDAHEALLRLREGDGPDARCHPKLLHHGVGDAGDLPQVVLCPRSDL
VEGQCFRGPSSQGHAHPLKQLLLGEEVLVSGEHLSKAQGGVCPRGYGDLHHGLRVLQHPAHQGVARLMKRNHFLFFLGQDLALFGSPCED
ALHGVLEVESVHGSVSLPRRVQRSLIADVGDVSPTESWCQLCQTLGVKGAGLGQLQALQVLLKNLPPLLQRGEINEDVPVQSAWPHQSTV

--------------------------------------------------------------
>10556_10556_2_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000340184_SPG7_chr16_89611056_ENST00000268704_length(transcript)=1992nt_BP=255nt
AGAGTCCCTACACTTCTGGTACATGACAGCTGTGTCTCGATGGAGTAGACTCTCAGAACAGCGCAGTTTGCCCTCCGCTCACGCAGAGCC
TCTCCGTGGCTTCCGCACCTTGAGCATTAGGCCAGTTCTCCTCTTCTCTCTAATCCATCCGTCACCTCTCCTGTCATCCGTTTCCATGCC
GTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTGGGATCAGGAATGGGTACCACAG
ACCATGTCATCGTCCTGGCGTCCACGAACCGAGCTGACATTTTGGACGGTGCTCTGATGAGGCCAGGCCGACTGGACCGGCACGTCTTCA
TTGATCTCCCCACGCTGCAGGAGAGGCGGGAGATTTTTGAGCAGCACCTGAAGAGCCTGAAGCTGACCCAGTCCAGCACCTTTTACTCCC
AGCGTCTGGCAGAGCTGACACCAGGATTCAGTGGGGCTGACATCGCCAACATCTGCAATGAGGCTGCGCTGCACGCGGCGCGGGAGGGAC
ACACTTCCGTGCACACTCTCAACTTCGAGTACGCCGTGGAGCGCGTCCTCGCAGGGACTGCCAAAAAGAGCAAGATCCTGTCCAAGGAAG
AACAGAAAGTGGTTGCGTTTCATGAGTCGGGCCACGCCTTGGTGGGCTGGATGCTGGAGCACACGGAGGCCGTGATGAAGGTCTCCATAA
CCCCTCGGACAAACGCCGCCCTGGGCTTTGCTCAGATGCTCCCCAGAGACCAGCACCTCTTCACCAAGGAGCAGCTGTTTGAGCGGATGT
GCATGGCCCTGGGAGGACGGGCCTCGGAAGCACTGTCCTTCAACGAGGTCACTTCTGGGGCACAGGACGACCTGAGGAAGGTCACCCGCA
TCGCCTACTCCATGGTGAAGCAGTTTGGGATGGCACCTGGCATCGGGCCCATCTCCTTCCCTGAGGCGCAGGAGGGCCTCATGGGCATCG
GGCGGCGCCCCTTCAGCCAAGGCCTGCAGCAGATGATGGACCATGAAGCAAGACTGCTGGTGGCCAAGGCCTACAGACACACCGAGAAGG
TGCTGCAGGACAACCTGGACAAGTTGCAGGCGCTGGCAAACGCCCTTCTGGAAAAGGAAGTGATAAACTATGAGGACATTGAGGCTCTCA
TTGGCCCGCCGCCCCATGGGCCGAAGAAAATGATCGCACCGCAGAGGTGGATCGACGCCCAGAGGGAGAAACAGGACTTGGGCGAGGAGG
AGACCGAAGAGACCCAGCAGCCTCCACTTGGAGGCGAAGAGCCGACTTGGCCCAAGTAGTTGGGAGGTGTTGGCTGCACGTGCGGGTGGT
CCGGGAAGTGAGGGCTCACTCAGCCACCCTGAGTTGCTTTTCAGCTGAGGTTTGCACTTCCTCTCGCGGCCCTCAGTAGTCCCTGCACAG
TGACTTCTGAGATCTGTTGATTGATGACCCTTTTCATGATTTTAAGTTTCTCTGCAGAAACTACTGACGGAGTCCTGTGTTTGTGAGTCG
TTTCCCCTATGGGGAAGGTTATCAGTGCTTCCCGAGTGAGCATGGAACACTTCGAGTTCCCAGGGTTATAGACAGTCGTTCCCAGTGTGG
CTGAGGCCACCCAGAGGCAGCAGAGCATTCAGACTCCAAACAGACCCCTGTTCATGCCGACGCTTGCACGACCGCCCCAGTTCCTGTGGC
TCCCTCGGAATGCTAAGGGGATCGGACATGAAAGGACCCTGTGAGCCGATTGTCCTATCTCCAGCGGCCCTGTCATCCAGCTCACTCATC
AATGGGGCCAGTCAGGCCCAGGCACTGGGCTCCGGAGGACTCACCACTGCCCCCTGCTGCCATGTGGACTGGTGCAAGTTGAGGACTTCT
TGCTGGTCTAGTCACGCATGCAGTGTTGGGGATGCCTTGGTTTTTACTGCTCTGAGAATTGTTGAGATACTTTACTAATAAACTGTGTAG

>10556_10556_2_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000340184_SPG7_chr16_89611056_ENST00000268704_length(amino acids)=380AA_BP=1
MKSNSGWLSEPSLPGPPARAANTSQLLGPSRLFASKWRLLGLFGLLLAQVLFLPLGVDPPLRCDHFLRPMGRRANESLNVLIVYHFLFQK
GVCQRLQLVQVVLQHLLGVSVGLGHQQSCFMVHHLLQALAEGAPPDAHEALLRLREGDGPDARCHPKLLHHGVGDAGDLPQVVLCPRSDL
VEGQCFRGPSSQGHAHPLKQLLLGEEVLVSGEHLSKAQGGVCPRGYGDLHHGLRVLQHPAHQGVARLMKRNHFLFFLGQDLALFGSPCED
ALHGVLEVESVHGSVSLPRRVQRSLIADVGDVSPTESWCQLCQTLGVKGAGLGQLQALQVLLKNLPPLLQRGEINEDVPVQSAWPHQSTV

--------------------------------------------------------------
>10556_10556_3_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000508408_SPG7_chr16_89611056_ENST00000268704_length(transcript)=1823nt_BP=86nt
GTTTCCATGCCGTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTGGGATCAGGAAT
GGGTACCACAGACCATGTCATCGTCCTGGCGTCCACGAACCGAGCTGACATTTTGGACGGTGCTCTGATGAGGCCAGGCCGACTGGACCG
GCACGTCTTCATTGATCTCCCCACGCTGCAGGAGAGGCGGGAGATTTTTGAGCAGCACCTGAAGAGCCTGAAGCTGACCCAGTCCAGCAC
CTTTTACTCCCAGCGTCTGGCAGAGCTGACACCAGGATTCAGTGGGGCTGACATCGCCAACATCTGCAATGAGGCTGCGCTGCACGCGGC
GCGGGAGGGACACACTTCCGTGCACACTCTCAACTTCGAGTACGCCGTGGAGCGCGTCCTCGCAGGGACTGCCAAAAAGAGCAAGATCCT
GTCCAAGGAAGAACAGAAAGTGGTTGCGTTTCATGAGTCGGGCCACGCCTTGGTGGGCTGGATGCTGGAGCACACGGAGGCCGTGATGAA
GGTCTCCATAACCCCTCGGACAAACGCCGCCCTGGGCTTTGCTCAGATGCTCCCCAGAGACCAGCACCTCTTCACCAAGGAGCAGCTGTT
TGAGCGGATGTGCATGGCCCTGGGAGGACGGGCCTCGGAAGCACTGTCCTTCAACGAGGTCACTTCTGGGGCACAGGACGACCTGAGGAA
GGTCACCCGCATCGCCTACTCCATGGTGAAGCAGTTTGGGATGGCACCTGGCATCGGGCCCATCTCCTTCCCTGAGGCGCAGGAGGGCCT
CATGGGCATCGGGCGGCGCCCCTTCAGCCAAGGCCTGCAGCAGATGATGGACCATGAAGCAAGACTGCTGGTGGCCAAGGCCTACAGACA
CACCGAGAAGGTGCTGCAGGACAACCTGGACAAGTTGCAGGCGCTGGCAAACGCCCTTCTGGAAAAGGAAGTGATAAACTATGAGGACAT
TGAGGCTCTCATTGGCCCGCCGCCCCATGGGCCGAAGAAAATGATCGCACCGCAGAGGTGGATCGACGCCCAGAGGGAGAAACAGGACTT
GGGCGAGGAGGAGACCGAAGAGACCCAGCAGCCTCCACTTGGAGGCGAAGAGCCGACTTGGCCCAAGTAGTTGGGAGGTGTTGGCTGCAC
GTGCGGGTGGTCCGGGAAGTGAGGGCTCACTCAGCCACCCTGAGTTGCTTTTCAGCTGAGGTTTGCACTTCCTCTCGCGGCCCTCAGTAG
TCCCTGCACAGTGACTTCTGAGATCTGTTGATTGATGACCCTTTTCATGATTTTAAGTTTCTCTGCAGAAACTACTGACGGAGTCCTGTG
TTTGTGAGTCGTTTCCCCTATGGGGAAGGTTATCAGTGCTTCCCGAGTGAGCATGGAACACTTCGAGTTCCCAGGGTTATAGACAGTCGT
TCCCAGTGTGGCTGAGGCCACCCAGAGGCAGCAGAGCATTCAGACTCCAAACAGACCCCTGTTCATGCCGACGCTTGCACGACCGCCCCA
GTTCCTGTGGCTCCCTCGGAATGCTAAGGGGATCGGACATGAAAGGACCCTGTGAGCCGATTGTCCTATCTCCAGCGGCCCTGTCATCCA
GCTCACTCATCAATGGGGCCAGTCAGGCCCAGGCACTGGGCTCCGGAGGACTCACCACTGCCCCCTGCTGCCATGTGGACTGGTGCAAGT
TGAGGACTTCTTGCTGGTCTAGTCACGCATGCAGTGTTGGGGATGCCTTGGTTTTTACTGCTCTGAGAATTGTTGAGATACTTTACTAAT

>10556_10556_3_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000508408_SPG7_chr16_89611056_ENST00000268704_length(amino acids)=380AA_BP=1
MKSNSGWLSEPSLPGPPARAANTSQLLGPSRLFASKWRLLGLFGLLLAQVLFLPLGVDPPLRCDHFLRPMGRRANESLNVLIVYHFLFQK
GVCQRLQLVQVVLQHLLGVSVGLGHQQSCFMVHHLLQALAEGAPPDAHEALLRLREGDGPDARCHPKLLHHGVGDAGDLPQVVLCPRSDL
VEGQCFRGPSSQGHAHPLKQLLLGEEVLVSGEHLSKAQGGVCPRGYGDLHHGLRVLQHPAHQGVARLMKRNHFLFFLGQDLALFGSPCED
ALHGVLEVESVHGSVSLPRRVQRSLIADVGDVSPTESWCQLCQTLGVKGAGLGQLQALQVLLKNLPPLLQRGEINEDVPVQSAWPHQSTV

--------------------------------------------------------------
>10556_10556_4_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000511704_SPG7_chr16_89611056_ENST00000268704_length(transcript)=1823nt_BP=86nt
GTTTCCATGCCGTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTGGGATCAGGAAT
GGGTACCACAGACCATGTCATCGTCCTGGCGTCCACGAACCGAGCTGACATTTTGGACGGTGCTCTGATGAGGCCAGGCCGACTGGACCG
GCACGTCTTCATTGATCTCCCCACGCTGCAGGAGAGGCGGGAGATTTTTGAGCAGCACCTGAAGAGCCTGAAGCTGACCCAGTCCAGCAC
CTTTTACTCCCAGCGTCTGGCAGAGCTGACACCAGGATTCAGTGGGGCTGACATCGCCAACATCTGCAATGAGGCTGCGCTGCACGCGGC
GCGGGAGGGACACACTTCCGTGCACACTCTCAACTTCGAGTACGCCGTGGAGCGCGTCCTCGCAGGGACTGCCAAAAAGAGCAAGATCCT
GTCCAAGGAAGAACAGAAAGTGGTTGCGTTTCATGAGTCGGGCCACGCCTTGGTGGGCTGGATGCTGGAGCACACGGAGGCCGTGATGAA
GGTCTCCATAACCCCTCGGACAAACGCCGCCCTGGGCTTTGCTCAGATGCTCCCCAGAGACCAGCACCTCTTCACCAAGGAGCAGCTGTT
TGAGCGGATGTGCATGGCCCTGGGAGGACGGGCCTCGGAAGCACTGTCCTTCAACGAGGTCACTTCTGGGGCACAGGACGACCTGAGGAA
GGTCACCCGCATCGCCTACTCCATGGTGAAGCAGTTTGGGATGGCACCTGGCATCGGGCCCATCTCCTTCCCTGAGGCGCAGGAGGGCCT
CATGGGCATCGGGCGGCGCCCCTTCAGCCAAGGCCTGCAGCAGATGATGGACCATGAAGCAAGACTGCTGGTGGCCAAGGCCTACAGACA
CACCGAGAAGGTGCTGCAGGACAACCTGGACAAGTTGCAGGCGCTGGCAAACGCCCTTCTGGAAAAGGAAGTGATAAACTATGAGGACAT
TGAGGCTCTCATTGGCCCGCCGCCCCATGGGCCGAAGAAAATGATCGCACCGCAGAGGTGGATCGACGCCCAGAGGGAGAAACAGGACTT
GGGCGAGGAGGAGACCGAAGAGACCCAGCAGCCTCCACTTGGAGGCGAAGAGCCGACTTGGCCCAAGTAGTTGGGAGGTGTTGGCTGCAC
GTGCGGGTGGTCCGGGAAGTGAGGGCTCACTCAGCCACCCTGAGTTGCTTTTCAGCTGAGGTTTGCACTTCCTCTCGCGGCCCTCAGTAG
TCCCTGCACAGTGACTTCTGAGATCTGTTGATTGATGACCCTTTTCATGATTTTAAGTTTCTCTGCAGAAACTACTGACGGAGTCCTGTG
TTTGTGAGTCGTTTCCCCTATGGGGAAGGTTATCAGTGCTTCCCGAGTGAGCATGGAACACTTCGAGTTCCCAGGGTTATAGACAGTCGT
TCCCAGTGTGGCTGAGGCCACCCAGAGGCAGCAGAGCATTCAGACTCCAAACAGACCCCTGTTCATGCCGACGCTTGCACGACCGCCCCA
GTTCCTGTGGCTCCCTCGGAATGCTAAGGGGATCGGACATGAAAGGACCCTGTGAGCCGATTGTCCTATCTCCAGCGGCCCTGTCATCCA
GCTCACTCATCAATGGGGCCAGTCAGGCCCAGGCACTGGGCTCCGGAGGACTCACCACTGCCCCCTGCTGCCATGTGGACTGGTGCAAGT
TGAGGACTTCTTGCTGGTCTAGTCACGCATGCAGTGTTGGGGATGCCTTGGTTTTTACTGCTCTGAGAATTGTTGAGATACTTTACTAAT

>10556_10556_4_BTNL8-SPG7_BTNL8_chr5_180326359_ENST00000511704_SPG7_chr16_89611056_ENST00000268704_length(amino acids)=380AA_BP=1
MKSNSGWLSEPSLPGPPARAANTSQLLGPSRLFASKWRLLGLFGLLLAQVLFLPLGVDPPLRCDHFLRPMGRRANESLNVLIVYHFLFQK
GVCQRLQLVQVVLQHLLGVSVGLGHQQSCFMVHHLLQALAEGAPPDAHEALLRLREGDGPDARCHPKLLHHGVGDAGDLPQVVLCPRSDL
VEGQCFRGPSSQGHAHPLKQLLLGEEVLVSGEHLSKAQGGVCPRGYGDLHHGLRVLQHPAHQGVARLMKRNHFLFFLGQDLALFGSPCED
ALHGVLEVESVHGSVSLPRRVQRSLIADVGDVSPTESWCQLCQTLGVKGAGLGQLQALQVLLKNLPPLLQRGEINEDVPVQSAWPHQSTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTNL8-SPG7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SPG7	chr5:180326359	chr16:89611056	ENST00000268704		8	17	701_795	441.3333333333333	796.0	PPIF
Tgene	SPG7	chr5:180326359	chr16:89611056	ENST00000341316		0	10	701_795	0	490.0	PPIF

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BTNL8-SPG7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BTNL8-SPG7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source