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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BZW2-GAP43 (FusionGDB2 ID:10599)

Fusion Gene Summary for BZW2-GAP43

check button Fusion gene summary
Fusion gene informationFusion gene name: BZW2-GAP43
Fusion gene ID: 10599
HgeneTgene
Gene symbol

BZW2

GAP43

Gene ID

28969

2596

Gene namebasic leucine zipper and W2 domains 2growth associated protein 43
SynonymsHSPC028|MST017|MSTP017B-50|GAP-43|PP46
Cytomap

7p21.1

3q13.31

Type of geneprotein-codingprotein-coding
Descriptionbasic leucine zipper and W2 domain-containing protein 2neuromodulinaxonal membrane protein GAP-43calmodulin-binding protein P-57nerve growth-related peptide GAP43neural phosphoprotein B-50neuron growth-associated protein 43protein F1
Modification date2020031320200313
UniProtAcc

Q9Y6E2

P17677

Ensembl transtripts involved in fusion geneENST00000432311, ENST00000258761, 
ENST00000405202, ENST00000433922, 
ENST00000452975, ENST00000407633, 
ENST00000305124, ENST00000393780, 
Fusion gene scores* DoF score10 X 7 X 7=4908 X 7 X 5=280
# samples 139
** MAII scorelog2(13/490*10)=-1.91427012597412
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BZW2 [Title/Abstract] AND GAP43 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBZW2(16685913)-GAP43(115439641), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAP43

GO:0051489

regulation of filopodium assembly

14978216


check buttonFusion gene breakpoints across BZW2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GAP43 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-RD-A7C1-01ABZW2chr7

16685913

-GAP43chr3

115439641

+
ChimerDB4STADTCGA-RD-A7C1-01ABZW2chr7

16685913

+GAP43chr3

115439641

+
ChimerDB4STADTCGA-RD-A7C1-01ABZW2chr7

16685929

+GAP43chr3

115439641

+
ChimerDB4STADTCGA-RD-A7C1BZW2chr7

16685913

+GAP43chr3

115439640

+


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Fusion Gene ORF analysis for BZW2-GAP43

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000432311ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
3UTR-3CDSENST00000432311ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000258761ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000258761ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000258761ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000258761ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000405202ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000405202ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000405202ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000405202ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000433922ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000433922ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000452975ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000452975ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
5UTR-3CDSENST00000452975ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000452975ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
intron-3CDSENST00000258761ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000258761ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000405202ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000405202ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439640

+
intron-3CDSENST00000407633ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439640

+
intron-3CDSENST00000452975ENST00000305124BZW2chr7

16685929

+GAP43chr3

115439641

+
intron-3CDSENST00000452975ENST00000393780BZW2chr7

16685929

+GAP43chr3

115439641

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BZW2-GAP43


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BZW2chr716685929+GAP43chr3115439640+1.27E-060.9999987
BZW2chr716685913+GAP43chr3115439640+1.86E-070.99999976
BZW2chr716685913+GAP43chr3115439640+1.86E-070.99999976
BZW2chr716685929+GAP43chr3115439640+1.27E-060.9999987
BZW2chr716685913+GAP43chr3115439640+1.86E-070.99999976
BZW2chr716685913+GAP43chr3115439640+1.86E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BZW2-GAP43


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:16685913/:115439641)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BZW2

Q9Y6E2

GAP43

P17677

FUNCTION: May be involved in neuronal differentiation. {ECO:0000250}.FUNCTION: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BZW2-GAP43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BZW2-GAP43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BZW2-GAP43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BZW2-GAP43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource