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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:C15orf41-LRRC28 (FusionGDB2 ID:10951)

Fusion Gene Summary for C15orf41-LRRC28

Fusion gene summary

Fusion gene information	Fusion gene name: C15orf41-LRRC28
	Fusion gene ID: 10951
		Hgene	Tgene
	Gene symbol	C15orf41	LRRC28
	Gene ID	84529	123355
	Gene name	chromosome 15 open reading frame 41	leucine rich repeat containing 28
	Synonyms	HH114	-
	Cytomap	15q14	15q26.3
	Type of gene	protein-coding	protein-coding
	Description	protein C15orf41uncharacterized protein C15orf41	leucine-rich repeat-containing protein 28
	Modification date	20200313	20200313
	UniProtAcc	.	Q86X40
	Ensembl transtripts involved in fusion gene	ENST00000437989, ENST00000566621, ENST00000569302, ENST00000338183, ENST00000562489, ENST00000562877, ENST00000563167, ENST00000565792, ENST00000567389,	ENST00000331450, ENST00000442993, ENST00000447360, ENST00000559399, ENST00000422500, ENST00000558879, ENST00000301981,
Fusion gene scores	* DoF score	13 X 6 X 8=624	15 X 11 X 9=1485
	# samples	13	19
	** MAII score	log2(13/624*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1485*10)=-2.96639160735718 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C15orf41 [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C15orf41(36872162)-LRRC28(99926235), # samples:1
Anticipated loss of major functional domain due to fusion event.	C15orf41-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across C15orf41 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-8576-01A	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+

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Fusion Gene ORF analysis for C15orf41-LRRC28

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000437989	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000437989	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000437989	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000437989	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000566621	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000566621	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000566621	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000566621	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000569302	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000569302	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000569302	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
5CDS-intron	ENST00000569302	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000437989	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000437989	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000566621	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000566621	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000569302	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
Frame-shift	ENST00000569302	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
In-frame	ENST00000437989	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
In-frame	ENST00000566621	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
In-frame	ENST00000569302	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000338183	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000338183	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000338183	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562489	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562489	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562489	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562877	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562877	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000562877	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000563167	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000563167	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000563167	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000565792	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000565792	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000565792	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000567389	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000567389	ENST00000422500	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-3CDS	ENST00000567389	ENST00000558879	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000338183	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000338183	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000338183	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000338183	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562489	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562489	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562489	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562489	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562877	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562877	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562877	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000562877	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000563167	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000563167	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000563167	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000563167	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000565792	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000565792	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000565792	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000565792	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000567389	ENST00000331450	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000567389	ENST00000442993	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000567389	ENST00000447360	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+
intron-intron	ENST00000567389	ENST00000559399	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000566621

C15orf41

chr15

36872162

ENST00000301981

LRRC28

chr15

99926235

5051

351

118

423

101

ENST00000437989

C15orf41

chr15

36872162

ENST00000301981

LRRC28

chr15

99926235

4818

118

4081

4380

ENST00000569302

C15orf41

chr15

36872162

ENST00000301981

LRRC28

chr15

99926235

4814

114

4077

4376

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000566621	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+	0.80979156	0.19020845
ENST00000437989	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+	0.7982997	0.20170029
ENST00000569302	ENST00000301981	C15orf41	chr15	36872162	+	LRRC28	chr15	99926235	+	0.7965208	0.20347917

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Fusion Genomic Features for C15orf41-LRRC28

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C15orf41	chr15	36872162	+	LRRC28	chr15	99926234	+	1.22E-06	0.9999988
C15orf41	chr15	36872162	+	LRRC28	chr15	99926234	+	1.22E-06	0.9999988

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C15orf41-LRRC28

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:36872162/chr15:99926235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LRRC28 Q86X40
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

112_133

343

368.0

Repeat

Note=LRR 5

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

135_156

343

368.0

Repeat

Note=LRR 6

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

158_180

343

368.0

Repeat

Note=LRR 7

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

16_36

343

368.0

Repeat

Note=LRR 1

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

181_202

343

368.0

Repeat

Note=LRR 8

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

204_226

343

368.0

Repeat

Note=LRR 9

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

42_63

343

368.0

Repeat

Note=LRR 2

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

66_87

343

368.0

Repeat

Note=LRR 3

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000301981

89_110

343

368.0

Repeat

Note=LRR 4

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

112_133

290

313.0

Repeat

Note=LRR 5

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

135_156

290

313.0

Repeat

Note=LRR 6

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

158_180

290

313.0

Repeat

Note=LRR 7

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

16_36

290

313.0

Repeat

Note=LRR 1

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

181_202

290

313.0

Repeat

Note=LRR 8

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

204_226

290

313.0

Repeat

Note=LRR 9

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

42_63

290

313.0

Repeat

Note=LRR 2

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

66_87

290

313.0

Repeat

Note=LRR 3

Tgene

LRRC28

chr15:36872162

chr15:99926235

ENST00000447360

89_110

290

313.0

Repeat

Note=LRR 4

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Fusion Gene Sequence for C15orf41-LRRC28

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10951_10951_1_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000437989_LRRC28_chr15_99926235_ENST00000301981_length(transcript)=4818nt_BP=118nt
CTGGTCCCTGGCCCAACATGATACTGACCAAAGCTCAGTACGACGAGATAGCCCAGTGCCTAGTGTCTGTGCCGCCTACCAGGCAGAGCC
TGAGGAAGCTGAAGCAGAGGTTTCCCAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACC
TGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGT
CCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGG
AATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTG
ATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGACTTGATCATCTAGCCAGATTCCCTTTTGAACACAC
ATACCTTCAGTGATGCTTCCTCTCCTCTCCCCTCCCTTGCTTTCCCCAGAGAGTTATTTCCCTGAGACCATGTTCTCCACAGTGTCTCCA
GTGGAAACTTGTCAGTTTTTGAGGAGTTTCAGCAAACCCCGTGGCCTCAATGGTCTTGAGTAGCAGGGTGGGGCGCCTGAGTTGGCAGCA
AAGTGAGGCTCCCATGGAGGCTCAGTGAGGGTCCCAGAGCACACACCCTCTGGAAAGTTCCAGCCTTGTTTATACGTTCTACAGTGTAGC
AACAGACTTTTGTGAGGGATTTTAAAAACAAAAATGTAGATTGTAATGAAATACACTTCCTGTTTTTTAAAAGTGTTTGCAGAAAAATGA
TTTTTGAAGTTTTTAAATTTCCTGATAAGATTTTTTTTATATGAGAAGAATTTGAGGAATATTTGAAGCTTTACAAGATCTGATTTTTTT
CTTTCTCAATATAAAGTTTCCATACAATGAGAAAGGGGGAGAAAACACACATTGAAATAAGACCTCCGTGTTCTTTTTTGATGGGTTTAT
GATTCAGTTTATACTGACTTTGAAATATTTTTGTCACATGTGAAAGGCTTCAGCTACTTCCACTACTGGTTTTTTTTTGTTGTTGTTGAG
ACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCC
TGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACC
GTGTTAGCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGC
GCCCGGCCCACTACTGGTTTTTAACAGGATGATTCAAAGTACAGCCCGTGCACATTTACTTCGTCACCTGGTGCACCACACTGTCTTCAT
GTTGGCCCTCGTTTCTTGTATACTTAGCTTACTGCCCAGATGCAACTGAGAAAATACAGGAAAAGCAGGTCCAAATTCAGCCTTCGACTT
CTGCAAAAGTCCATAAACAGAAAGTCTGTGAGCCTCCACCCTGCCAGAAAGAACTCTTCATGAAGAAGTCACGTATTTGCTCTTCCTTTC
AAAGGATGGCATTTTAATGTTGCTTTGCTGCCAGATGTTCATCTGCTTGCTGTGAAGTGATTCTTTTTTTAAAATGTTTTTTAATGATGT
AAGTTTTCTAAAAGGCAGGGCTGAATGGAGAACCAAGAATTTGCTTGGTAGAAAAATTATTTTTTTTTAATTTCAGACTTATCAAAAATT
TGGTTGAGGGAATTTTTATTAGCTGCCCTGACTTTATAATGCTACGCTCTTAACAGTGCCAAAAATCCTACATAGTTACTGACAAATGTG
TGATCTTTTTACAGTCACAACACCTGCTGCCCGGAAAGCACACCGTCCACGTAGAATGGAGAAGGCAGAAAGTTACCGTGTGTTCCCACT
GTATCTGCACTGTTCTTACTTCCTCTTGTCCCTTTTCATATCTTGGTCTATTCAGCCTTAACATTTCAAAGGCTTATAGTAAAATAGGAA
CTGAAGATCTGTATCAAAATGTAACACTTTCATCCTTTGGAATAATTGAAGTTTAACATAACCTCTACATGTATATAAGTTAGCTGGTGA
AAATGTGGCATGAAACTTCACAATTGTGCTTCAGGCCTAAGTGACTGCTACCTATGATTTAAGTGACAGTAAATGTCTTGCTACATTTTT
CTATTTCATCCTCTACAATCATATGTCATGGAATGGAGCTATGAAATGTGCTAACTTGGTATTCAGGATTCTCATTGTGATAAGGTGATA
CATTAGTTTTACCTTGTTTGAAATTTTACAAAAATGCTTACAATCCAGGCATTCTTTCTCTACCTATTATGAACTACGGTGTGTTAAACA
ACAGCAGTGGGCTGGGCAGACAACCTTTGGGCAGTCTCAACCTTAATCCTTGGGTACAGCACCTGAACTTAATTGATGAGAAGTGGAACT
TAAGTGGTTTCCCTGGTGCTGTTCATTATGGAAATTTTATGCTGGATTTATCGATGTCATTCTTAATCTTTTGATACTATAAAGGAGTCT
TACCAACTGGAGAAAATTTGCCTACATGCTATATATTTGAATTGTGTCCAAAGCTTTGCAGAAAAGCAAATCTGAAGTTATTATATATGT
TGTTTTCTTGAGCAACAGTTACACTAGGTAGAAAAGTATTCACACAATAATAGTAATGCAAAAAAAGTGAGCTACTTGGAAAGTATCATC
TCTGTTCAGGTAAGTTTACTTCAGTGAACTCTTGTGTGGTTAGCGATAAGTTTTAAAGTCCAGGATAGCCTCATGAGCATAGGCCTTCCT
ATGAAGTAGTGCAAAGGGGGCCGATTTTAGTGGATTACCCTATCAGTGTTCTTCAGTATGTCCAATTGTTATCATACCAAAAACCTTAAT
TACATAACATTGTGTGGATGAAATGCTGCATCTTCAGTTAATACATGTTTTGAGCACATTCTTAAAATACATAATAATTAAATGATCCCT
ATTCAAAAGAACCCTGGCTTGGGTGGAGGATCCACTCTGGCTAACGGATAAGAGTGATGAACTTCTTTGTTACCTGACCCTTCTCTTCTG
GAAAAGTGAGGTGTACATTAAACATCTTTTGGTCACCGTGCCTCACTAAGACCTTTCACATTCCAGCTTGTCCGACTAGTGTAATGTACC
TCTCACTTCTGTTTTACGTTGAGCATTACGAATTAAAATCTTTACAGTCTAGGGGGAAAAAAAGGCTTCAATACCAGTTGGCTTATGAGG
CTCTGCATATAATTTTCTCTAAAATATGTAACTATTTTGTAGTCTGTGGGGACTTTCAAAGCCAATTTTTAAAATTAGTAGTAGTAAAGG
TTTTTCCCTTTCCTGAATGAAAAATCAGAAATTCTAATCTTTGCTATAAAGTACTTAAACACAATACATTGCCTCAGCATAAATAAAAAC
ATTTTTATTAAGATGATTTATGAACATGGATTTCTAACTGGACCAACACTAATGTTGCAACCTGATAAAATTTGAGATGTAAATTCATTT
CACAGACTCATAAACACACTCTCTTTAAGACTCTTCTTTAAATGGATCCTTACATTACCCTGCCTGTTTTATTATGCCTTCATTTTTGTG
GTTTTCATTCACTCCTGCTTGCTTCTATTGAGGTTCTCCTACATTTCCCAGAAACTCAGTGAATATCTTGCCTTTTCTTCAAACAAAGGG
GGTTTTTATAAAGTTTGTATTTTTGAAACTAGCTCTATGTCTATCTAAAAATCAAGTCTCGGCAGTGGCTCATGCCTATAATCCCAGCAC
TTTGGGAGGCCGAGGAGGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAATA
CAAAAAATTAGCCAGGCGTGGTGGCGCGCACCTGCAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGCAGGAAG
AGGTTGCATTGAGCTGAGATCACGCCATTACACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAATCATTCAAGTTTCAC
TGTGCCTACAGTGAGGAGCTACCTCCTTGTGTCATCAGCTAATAGATCTGAAAGTGATGCCGGTGTCTCTAGGAAAGGAATTGATCATAG
CCAAGTGACTGACATTCTCTCGGTCAGGAAAAGAGCTTGCTTCACAGCCTTTGAAGTATGACTGTATGTGTGGTCCCCTTGTACTTTGGA
GACAGAAGGTACTGGCAGCGAGTGTGGTGGATGGGCAGAAGGTGTAGCATTCGGAGATTATTTCTGTATGTAATTAAGAGACTTTCAAGG
GTTAGCCAGACTTTTTTCCACTCAAGTGTGGATTATCTTTGCTACCTGTGTTAAAGAATATCAGGTTTTGTTTCTTATTGTGATTTTTGA
GTCTAAATGATCCAAGATTTTTAAAATAGATACATAATGAAATCCAGGCCTCTGAAAAATTATGGCAACATTCATTTGGAGTGTGGCTAA
AAACTCATACTTTATCCAATTTGGTTGCCTCTCTCAGTTACTGCAGTTTATAGAATAATTGAGCTTGAACCATGTGAATGCTCAGAATGT

>10951_10951_1_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000437989_LRRC28_chr15_99926235_ENST00000301981_length(amino acids)=99AA_BP=
MQSQLLGRLRQENCLNPAGRGCIELRSRHYTPAWATERDSVSKKNHSSFTVPTVRSYLLVSSANRSESDAGVSRKGIDHSQVTDILSVRK

--------------------------------------------------------------
>10951_10951_2_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000566621_LRRC28_chr15_99926235_ENST00000301981_length(transcript)=5051nt_BP=351nt
AAGCCAAGCTAGGGCACTCTGGTGTACAGCCAGTCCCCGCCGCGGAGGTGCCGGTGGAGCCTGGGACCGGGCGAGTCTCCGCCCCGCTTT
TGCAGCTAGGGGTGTGTTTCAGGGGGGATTGGGGCAAGCCAAGCAGGCGAGGACCCGGGCCTGTGCCGCTTTGCCTACCCCTCATCCCTC
GGCACCAAGGCTACTTGAGCCCCAGGGTGTTTTTTCCTTGTTCCCGCCACCTCCTGGTCCCTGGCCCAACATGATACTGACCAAAGCTCA
GTACGACGAGATAGCCCAGTGCCTAGTGTCTGTGCCGCCTACCAGGCAGAGCCTGAGGAAGCTGAAGCAGAGGTTTCCCAGGAAGACAAC
TGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGC
TGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAA
ATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTT
CTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCG
GTCCTTGGAGAACAGTGACTTGATCATCTAGCCAGATTCCCTTTTGAACACACATACCTTCAGTGATGCTTCCTCTCCTCTCCCCTCCCT
TGCTTTCCCCAGAGAGTTATTTCCCTGAGACCATGTTCTCCACAGTGTCTCCAGTGGAAACTTGTCAGTTTTTGAGGAGTTTCAGCAAAC
CCCGTGGCCTCAATGGTCTTGAGTAGCAGGGTGGGGCGCCTGAGTTGGCAGCAAAGTGAGGCTCCCATGGAGGCTCAGTGAGGGTCCCAG
AGCACACACCCTCTGGAAAGTTCCAGCCTTGTTTATACGTTCTACAGTGTAGCAACAGACTTTTGTGAGGGATTTTAAAAACAAAAATGT
AGATTGTAATGAAATACACTTCCTGTTTTTTAAAAGTGTTTGCAGAAAAATGATTTTTGAAGTTTTTAAATTTCCTGATAAGATTTTTTT
TATATGAGAAGAATTTGAGGAATATTTGAAGCTTTACAAGATCTGATTTTTTTCTTTCTCAATATAAAGTTTCCATACAATGAGAAAGGG
GGAGAAAACACACATTGAAATAAGACCTCCGTGTTCTTTTTTGATGGGTTTATGATTCAGTTTATACTGACTTTGAAATATTTTTGTCAC
ATGTGAAAGGCTTCAGCTACTTCCACTACTGGTTTTTTTTTGTTGTTGTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGT
GGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGCGCC
CGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCGGGATGGTCTCGATCTCCTGACCTCGTG
ATCCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCACTACTGGTTTTTAACAGGATGATTCAA
AGTACAGCCCGTGCACATTTACTTCGTCACCTGGTGCACCACACTGTCTTCATGTTGGCCCTCGTTTCTTGTATACTTAGCTTACTGCCC
AGATGCAACTGAGAAAATACAGGAAAAGCAGGTCCAAATTCAGCCTTCGACTTCTGCAAAAGTCCATAAACAGAAAGTCTGTGAGCCTCC
ACCCTGCCAGAAAGAACTCTTCATGAAGAAGTCACGTATTTGCTCTTCCTTTCAAAGGATGGCATTTTAATGTTGCTTTGCTGCCAGATG
TTCATCTGCTTGCTGTGAAGTGATTCTTTTTTTAAAATGTTTTTTAATGATGTAAGTTTTCTAAAAGGCAGGGCTGAATGGAGAACCAAG
AATTTGCTTGGTAGAAAAATTATTTTTTTTTAATTTCAGACTTATCAAAAATTTGGTTGAGGGAATTTTTATTAGCTGCCCTGACTTTAT
AATGCTACGCTCTTAACAGTGCCAAAAATCCTACATAGTTACTGACAAATGTGTGATCTTTTTACAGTCACAACACCTGCTGCCCGGAAA
GCACACCGTCCACGTAGAATGGAGAAGGCAGAAAGTTACCGTGTGTTCCCACTGTATCTGCACTGTTCTTACTTCCTCTTGTCCCTTTTC
ATATCTTGGTCTATTCAGCCTTAACATTTCAAAGGCTTATAGTAAAATAGGAACTGAAGATCTGTATCAAAATGTAACACTTTCATCCTT
TGGAATAATTGAAGTTTAACATAACCTCTACATGTATATAAGTTAGCTGGTGAAAATGTGGCATGAAACTTCACAATTGTGCTTCAGGCC
TAAGTGACTGCTACCTATGATTTAAGTGACAGTAAATGTCTTGCTACATTTTTCTATTTCATCCTCTACAATCATATGTCATGGAATGGA
GCTATGAAATGTGCTAACTTGGTATTCAGGATTCTCATTGTGATAAGGTGATACATTAGTTTTACCTTGTTTGAAATTTTACAAAAATGC
TTACAATCCAGGCATTCTTTCTCTACCTATTATGAACTACGGTGTGTTAAACAACAGCAGTGGGCTGGGCAGACAACCTTTGGGCAGTCT
CAACCTTAATCCTTGGGTACAGCACCTGAACTTAATTGATGAGAAGTGGAACTTAAGTGGTTTCCCTGGTGCTGTTCATTATGGAAATTT
TATGCTGGATTTATCGATGTCATTCTTAATCTTTTGATACTATAAAGGAGTCTTACCAACTGGAGAAAATTTGCCTACATGCTATATATT
TGAATTGTGTCCAAAGCTTTGCAGAAAAGCAAATCTGAAGTTATTATATATGTTGTTTTCTTGAGCAACAGTTACACTAGGTAGAAAAGT
ATTCACACAATAATAGTAATGCAAAAAAAGTGAGCTACTTGGAAAGTATCATCTCTGTTCAGGTAAGTTTACTTCAGTGAACTCTTGTGT
GGTTAGCGATAAGTTTTAAAGTCCAGGATAGCCTCATGAGCATAGGCCTTCCTATGAAGTAGTGCAAAGGGGGCCGATTTTAGTGGATTA
CCCTATCAGTGTTCTTCAGTATGTCCAATTGTTATCATACCAAAAACCTTAATTACATAACATTGTGTGGATGAAATGCTGCATCTTCAG
TTAATACATGTTTTGAGCACATTCTTAAAATACATAATAATTAAATGATCCCTATTCAAAAGAACCCTGGCTTGGGTGGAGGATCCACTC
TGGCTAACGGATAAGAGTGATGAACTTCTTTGTTACCTGACCCTTCTCTTCTGGAAAAGTGAGGTGTACATTAAACATCTTTTGGTCACC
GTGCCTCACTAAGACCTTTCACATTCCAGCTTGTCCGACTAGTGTAATGTACCTCTCACTTCTGTTTTACGTTGAGCATTACGAATTAAA
ATCTTTACAGTCTAGGGGGAAAAAAAGGCTTCAATACCAGTTGGCTTATGAGGCTCTGCATATAATTTTCTCTAAAATATGTAACTATTT
TGTAGTCTGTGGGGACTTTCAAAGCCAATTTTTAAAATTAGTAGTAGTAAAGGTTTTTCCCTTTCCTGAATGAAAAATCAGAAATTCTAA
TCTTTGCTATAAAGTACTTAAACACAATACATTGCCTCAGCATAAATAAAAACATTTTTATTAAGATGATTTATGAACATGGATTTCTAA
CTGGACCAACACTAATGTTGCAACCTGATAAAATTTGAGATGTAAATTCATTTCACAGACTCATAAACACACTCTCTTTAAGACTCTTCT
TTAAATGGATCCTTACATTACCCTGCCTGTTTTATTATGCCTTCATTTTTGTGGTTTTCATTCACTCCTGCTTGCTTCTATTGAGGTTCT
CCTACATTTCCCAGAAACTCAGTGAATATCTTGCCTTTTCTTCAAACAAAGGGGGTTTTTATAAAGTTTGTATTTTTGAAACTAGCTCTA
TGTCTATCTAAAAATCAAGTCTCGGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGAGGGCAGATCATCTGAGGTCAG
GAGTTTGAGACCAGCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCGCGCACCTGCAG
TCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGCAGGAAGAGGTTGCATTGAGCTGAGATCACGCCATTACACTCCA
GCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAATCATTCAAGTTTCACTGTGCCTACAGTGAGGAGCTACCTCCTTGTGTCATCA
GCTAATAGATCTGAAAGTGATGCCGGTGTCTCTAGGAAAGGAATTGATCATAGCCAAGTGACTGACATTCTCTCGGTCAGGAAAAGAGCT
TGCTTCACAGCCTTTGAAGTATGACTGTATGTGTGGTCCCCTTGTACTTTGGAGACAGAAGGTACTGGCAGCGAGTGTGGTGGATGGGCA
GAAGGTGTAGCATTCGGAGATTATTTCTGTATGTAATTAAGAGACTTTCAAGGGTTAGCCAGACTTTTTTCCACTCAAGTGTGGATTATC
TTTGCTACCTGTGTTAAAGAATATCAGGTTTTGTTTCTTATTGTGATTTTTGAGTCTAAATGATCCAAGATTTTTAAAATAGATACATAA
TGAAATCCAGGCCTCTGAAAAATTATGGCAACATTCATTTGGAGTGTGGCTAAAAACTCATACTTTATCCAATTTGGTTGCCTCTCTCAG
TTACTGCAGTTTATAGAATAATTGAGCTTGAACCATGTGAATGCTCAGAATGTCAATGGTGGAGTATTTATTCAAGAGAAATGGCTGAAT

>10951_10951_2_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000566621_LRRC28_chr15_99926235_ENST00000301981_length(amino acids)=101AA_BP=77
MGQAKQARTRACAALPTPHPSAPRLLEPQGVFSLFPPPPGPWPNMILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPRKTTVSFVAYCCS

--------------------------------------------------------------
>10951_10951_3_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000569302_LRRC28_chr15_99926235_ENST00000301981_length(transcript)=4814nt_BP=114nt
TCCCTGGCCCAACATGATACTGACCAAAGCTCAGTACGACGAGATAGCCCAGTGCCTAGTGTCTGTGCCGCCTACCAGGCAGAGCCTGAG
GAAGCTGAAGCAGAGGTTTCCCAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCT
GAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTG
TCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATA
TATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGG
GCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGACTTGATCATCTAGCCAGATTCCCTTTTGAACACACATAC
CTTCAGTGATGCTTCCTCTCCTCTCCCCTCCCTTGCTTTCCCCAGAGAGTTATTTCCCTGAGACCATGTTCTCCACAGTGTCTCCAGTGG
AAACTTGTCAGTTTTTGAGGAGTTTCAGCAAACCCCGTGGCCTCAATGGTCTTGAGTAGCAGGGTGGGGCGCCTGAGTTGGCAGCAAAGT
GAGGCTCCCATGGAGGCTCAGTGAGGGTCCCAGAGCACACACCCTCTGGAAAGTTCCAGCCTTGTTTATACGTTCTACAGTGTAGCAACA
GACTTTTGTGAGGGATTTTAAAAACAAAAATGTAGATTGTAATGAAATACACTTCCTGTTTTTTAAAAGTGTTTGCAGAAAAATGATTTT
TGAAGTTTTTAAATTTCCTGATAAGATTTTTTTTATATGAGAAGAATTTGAGGAATATTTGAAGCTTTACAAGATCTGATTTTTTTCTTT
CTCAATATAAAGTTTCCATACAATGAGAAAGGGGGAGAAAACACACATTGAAATAAGACCTCCGTGTTCTTTTTTGATGGGTTTATGATT
CAGTTTATACTGACTTTGAAATATTTTTGTCACATGTGAAAGGCTTCAGCTACTTCCACTACTGGTTTTTTTTTGTTGTTGTTGAGACGG
AGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCC
TCAGCCTCCCAAGTAGCTGGGACCACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGT
TAGCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCC
GGCCCACTACTGGTTTTTAACAGGATGATTCAAAGTACAGCCCGTGCACATTTACTTCGTCACCTGGTGCACCACACTGTCTTCATGTTG
GCCCTCGTTTCTTGTATACTTAGCTTACTGCCCAGATGCAACTGAGAAAATACAGGAAAAGCAGGTCCAAATTCAGCCTTCGACTTCTGC
AAAAGTCCATAAACAGAAAGTCTGTGAGCCTCCACCCTGCCAGAAAGAACTCTTCATGAAGAAGTCACGTATTTGCTCTTCCTTTCAAAG
GATGGCATTTTAATGTTGCTTTGCTGCCAGATGTTCATCTGCTTGCTGTGAAGTGATTCTTTTTTTAAAATGTTTTTTAATGATGTAAGT
TTTCTAAAAGGCAGGGCTGAATGGAGAACCAAGAATTTGCTTGGTAGAAAAATTATTTTTTTTTAATTTCAGACTTATCAAAAATTTGGT
TGAGGGAATTTTTATTAGCTGCCCTGACTTTATAATGCTACGCTCTTAACAGTGCCAAAAATCCTACATAGTTACTGACAAATGTGTGAT
CTTTTTACAGTCACAACACCTGCTGCCCGGAAAGCACACCGTCCACGTAGAATGGAGAAGGCAGAAAGTTACCGTGTGTTCCCACTGTAT
CTGCACTGTTCTTACTTCCTCTTGTCCCTTTTCATATCTTGGTCTATTCAGCCTTAACATTTCAAAGGCTTATAGTAAAATAGGAACTGA
AGATCTGTATCAAAATGTAACACTTTCATCCTTTGGAATAATTGAAGTTTAACATAACCTCTACATGTATATAAGTTAGCTGGTGAAAAT
GTGGCATGAAACTTCACAATTGTGCTTCAGGCCTAAGTGACTGCTACCTATGATTTAAGTGACAGTAAATGTCTTGCTACATTTTTCTAT
TTCATCCTCTACAATCATATGTCATGGAATGGAGCTATGAAATGTGCTAACTTGGTATTCAGGATTCTCATTGTGATAAGGTGATACATT
AGTTTTACCTTGTTTGAAATTTTACAAAAATGCTTACAATCCAGGCATTCTTTCTCTACCTATTATGAACTACGGTGTGTTAAACAACAG
CAGTGGGCTGGGCAGACAACCTTTGGGCAGTCTCAACCTTAATCCTTGGGTACAGCACCTGAACTTAATTGATGAGAAGTGGAACTTAAG
TGGTTTCCCTGGTGCTGTTCATTATGGAAATTTTATGCTGGATTTATCGATGTCATTCTTAATCTTTTGATACTATAAAGGAGTCTTACC
AACTGGAGAAAATTTGCCTACATGCTATATATTTGAATTGTGTCCAAAGCTTTGCAGAAAAGCAAATCTGAAGTTATTATATATGTTGTT
TTCTTGAGCAACAGTTACACTAGGTAGAAAAGTATTCACACAATAATAGTAATGCAAAAAAAGTGAGCTACTTGGAAAGTATCATCTCTG
TTCAGGTAAGTTTACTTCAGTGAACTCTTGTGTGGTTAGCGATAAGTTTTAAAGTCCAGGATAGCCTCATGAGCATAGGCCTTCCTATGA
AGTAGTGCAAAGGGGGCCGATTTTAGTGGATTACCCTATCAGTGTTCTTCAGTATGTCCAATTGTTATCATACCAAAAACCTTAATTACA
TAACATTGTGTGGATGAAATGCTGCATCTTCAGTTAATACATGTTTTGAGCACATTCTTAAAATACATAATAATTAAATGATCCCTATTC
AAAAGAACCCTGGCTTGGGTGGAGGATCCACTCTGGCTAACGGATAAGAGTGATGAACTTCTTTGTTACCTGACCCTTCTCTTCTGGAAA
AGTGAGGTGTACATTAAACATCTTTTGGTCACCGTGCCTCACTAAGACCTTTCACATTCCAGCTTGTCCGACTAGTGTAATGTACCTCTC
ACTTCTGTTTTACGTTGAGCATTACGAATTAAAATCTTTACAGTCTAGGGGGAAAAAAAGGCTTCAATACCAGTTGGCTTATGAGGCTCT
GCATATAATTTTCTCTAAAATATGTAACTATTTTGTAGTCTGTGGGGACTTTCAAAGCCAATTTTTAAAATTAGTAGTAGTAAAGGTTTT
TCCCTTTCCTGAATGAAAAATCAGAAATTCTAATCTTTGCTATAAAGTACTTAAACACAATACATTGCCTCAGCATAAATAAAAACATTT
TTATTAAGATGATTTATGAACATGGATTTCTAACTGGACCAACACTAATGTTGCAACCTGATAAAATTTGAGATGTAAATTCATTTCACA
GACTCATAAACACACTCTCTTTAAGACTCTTCTTTAAATGGATCCTTACATTACCCTGCCTGTTTTATTATGCCTTCATTTTTGTGGTTT
TCATTCACTCCTGCTTGCTTCTATTGAGGTTCTCCTACATTTCCCAGAAACTCAGTGAATATCTTGCCTTTTCTTCAAACAAAGGGGGTT
TTTATAAAGTTTGTATTTTTGAAACTAGCTCTATGTCTATCTAAAAATCAAGTCTCGGCAGTGGCTCATGCCTATAATCCCAGCACTTTG
GGAGGCCGAGGAGGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAATACAAA
AAATTAGCCAGGCGTGGTGGCGCGCACCTGCAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGCAGGAAGAGGT
TGCATTGAGCTGAGATCACGCCATTACACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAATCATTCAAGTTTCACTGTG
CCTACAGTGAGGAGCTACCTCCTTGTGTCATCAGCTAATAGATCTGAAAGTGATGCCGGTGTCTCTAGGAAAGGAATTGATCATAGCCAA
GTGACTGACATTCTCTCGGTCAGGAAAAGAGCTTGCTTCACAGCCTTTGAAGTATGACTGTATGTGTGGTCCCCTTGTACTTTGGAGACA
GAAGGTACTGGCAGCGAGTGTGGTGGATGGGCAGAAGGTGTAGCATTCGGAGATTATTTCTGTATGTAATTAAGAGACTTTCAAGGGTTA
GCCAGACTTTTTTCCACTCAAGTGTGGATTATCTTTGCTACCTGTGTTAAAGAATATCAGGTTTTGTTTCTTATTGTGATTTTTGAGTCT
AAATGATCCAAGATTTTTAAAATAGATACATAATGAAATCCAGGCCTCTGAAAAATTATGGCAACATTCATTTGGAGTGTGGCTAAAAAC
TCATACTTTATCCAATTTGGTTGCCTCTCTCAGTTACTGCAGTTTATAGAATAATTGAGCTTGAACCATGTGAATGCTCAGAATGTCAAT

>10951_10951_3_C15orf41-LRRC28_C15orf41_chr15_36872162_ENST00000569302_LRRC28_chr15_99926235_ENST00000301981_length(amino acids)=99AA_BP=
MQSQLLGRLRQENCLNPAGRGCIELRSRHYTPAWATERDSVSKKNHSSFTVPTVRSYLLVSSANRSESDAGVSRKGIDHSQVTDILSVRK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for C15orf41-LRRC28

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for C15orf41-LRRC28

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C15orf41-LRRC28

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source