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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C15orf57-CBX3 (FusionGDB2 ID:10971)

Fusion Gene Summary for C15orf57-CBX3

Fusion gene summary

Fusion gene information	Fusion gene name: C15orf57-CBX3
	Fusion gene ID: 10971
		Hgene	Tgene
	Gene symbol	C15orf57	CBX3
	Gene ID	90416	11335
	Gene name	coiled-coil domain containing 32	chromobox 3
	Synonyms	C15orf57	HECH\|HP1-GAMMA\|HP1Hs-gamma
	Cytomap	15q15.1	7p15.2
	Type of gene	protein-coding	protein-coding
	Description	coiled-coil domain-containing protein 32uncharacterized protein C15orf57	chromobox protein homolog 3HP1 gamma homologchromobox homolog 3 (HP1 gamma homolog, Drosophila)heterochromatin protein 1 homolog gammaheterochromatin protein HP1 gammaheterochromatin-like protein 1modifier 2 protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q13185
	Ensembl transtripts involved in fusion gene	ENST00000358005, ENST00000416810, ENST00000558113, ENST00000558750, ENST00000558871, ENST00000559911, ENST00000560109, ENST00000560305, ENST00000561011,	ENST00000396386, ENST00000409747, ENST00000337620, ENST00000497498,
Fusion gene scores	* DoF score	4 X 5 X 3=60	9 X 10 X 5=450
	# samples	7	12
	** MAII score	log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C15orf57 [Title/Abstract] AND CBX3 [Title/Abstract] AND fusion [Title/Abstract] Identification of a novel gene fusion (BMX-ARHGAP) in gastric cardia adenocarcinoma (pmid: 25499959)
Most frequent breakpoint	C15orf57(40854180)-CBX3(26241365), # samples:25 CBX3(26241365)-C15orf57(40854180), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CBX3	GO:0045892	negative regulation of transcription, DNA-templated	9636147

Fusion gene breakpoints across C15orf57 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CBX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-44-2665-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-B0-5701-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-B2-5636-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-B2-5636-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-BH-A0DP-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A0DQ-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A0H5-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A1ET-11B	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A1FB-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A1FN-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BH-A1FN-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-BJ-A28X-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BJ-A2N7-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-BJ-A2N9-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-BJ-A2N9-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-CZ-5453-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-CZ-5458-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-CZ-5465-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-CZ-5469-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-CZ-5989-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3GZ-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3N3-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3N3-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-EL-A3TA-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZH-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZH-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZM-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZP-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZQ-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZQ-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
ChimerDB4	Non-Cancer	TCGA-EL-A3ZR-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-HU-A4GC-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-HU-A4GP-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-KL-8336-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-KN-8423-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChimerDB4	Non-Cancer	TCGA-KN-8432-11A	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
ChimerDB4	Non-Cancer	TCGA-KN-8437-11A	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChiTaRS5.0	N/A	BF692738	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
ChiTaRS5.0	N/A	BP423123	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+

Top

Fusion Gene ORF analysis for C15orf57-CBX3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000358005	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000358005	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000358005	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000358005	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000416810	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000416810	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000416810	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000416810	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558113	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558113	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558113	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558113	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558750	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558750	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558750	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558750	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558871	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558871	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000558871	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000558871	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000559911	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000559911	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000559911	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000559911	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000560109	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
5CDS-5UTR	ENST00000560305	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000560305	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000560305	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000560305	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000561011	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000561011	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-5UTR	ENST00000561011	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-5UTR	ENST00000561011	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000358005	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000358005	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000358005	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000358005	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000416810	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000416810	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000416810	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000416810	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558113	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558113	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558113	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558113	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558750	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558750	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558750	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558750	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558871	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558871	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000558871	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000558871	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000559911	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000559911	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000559911	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000559911	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000560109	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
5CDS-intron	ENST00000560109	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
5CDS-intron	ENST00000560109	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
5CDS-intron	ENST00000560305	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000560305	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000560305	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000560305	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000561011	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000561011	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5CDS-intron	ENST00000561011	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5CDS-intron	ENST00000561011	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5UTR-5UTR	ENST00000560109	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5UTR-5UTR	ENST00000560109	ENST00000396386	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5UTR-5UTR	ENST00000560109	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5UTR-5UTR	ENST00000560109	ENST00000409747	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5UTR-intron	ENST00000560109	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5UTR-intron	ENST00000560109	ENST00000337620	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
5UTR-intron	ENST00000560109	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241389	+
5UTR-intron	ENST00000560109	ENST00000497498	C15orf57	chr15	40854971	-	CBX3	chr7	26241383	+
intron-5UTR	ENST00000358005	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000416810	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000558113	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000558750	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000558871	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000559911	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000560305	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-5UTR	ENST00000561011	ENST00000396386	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000358005	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000358005	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000358005	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000416810	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000416810	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000416810	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558113	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558113	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558113	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558750	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558750	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558750	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558871	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558871	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000558871	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000559911	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000559911	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000559911	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000560305	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000560305	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000560305	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000561011	ENST00000337620	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000561011	ENST00000409747	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+
intron-intron	ENST00000561011	ENST00000497498	C15orf57	chr15	40854180	-	CBX3	chr7	26241365	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for C15orf57-CBX3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C15orf57	chr15	40854970	-	CBX3	chr7	26241384	+	0.9999956	4.46E-06
C15orf57	chr15	40854970	-	CBX3	chr7	26241384	+	0.9999956	4.46E-06

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C15orf57-CBX3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40854180/:26241365)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CBX3 Q13185
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250\|UniProtKB:P23198, ECO:0000269\|PubMed:28167679}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for C15orf57-CBX3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C15orf57-CBX3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C15orf57-CBX3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C15orf57-CBX3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source