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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C15orf57-TPT1 (FusionGDB2 ID:10974)

Fusion Gene Summary for C15orf57-TPT1

check button Fusion gene summary
Fusion gene informationFusion gene name: C15orf57-TPT1
Fusion gene ID: 10974
HgeneTgene
Gene symbol

C15orf57

TPT1

Gene ID

90416

7178

Gene namecoiled-coil domain containing 32tumor protein, translationally-controlled 1
SynonymsC15orf57HRF|TCTP|p02|p23
Cytomap

15q15.1

13q14.13

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 32uncharacterized protein C15orf57translationally-controlled tumor proteinfortilinhistamine-releasing factor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358005, ENST00000416810, 
ENST00000558113, ENST00000558750, 
ENST00000559911, ENST00000560305, 
ENST00000561011, ENST00000558871, 
ENST00000560109, 		ENST00000379055, 
ENST00000379060, ENST00000529421, 
ENST00000530705, ENST00000309246, 
ENST00000379056, 
Fusion gene scores* DoF score4 X 5 X 3=6026 X 23 X 7=4186
# samples 734
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(34/4186*10)=-3.62196566011801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C15orf57 [Title/Abstract] AND TPT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC15orf57(40849414)-TPT1(45911523), # samples:1
Anticipated loss of major functional domain due to fusion event.C15orf57-TPT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C15orf57 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-A8CXC15orf57chr15

40849414

-TPT1chr13

45911523

-


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Fusion Gene ORF analysis for C15orf57-TPT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358005ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000358005ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000358005ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000358005ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000416810ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000416810ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000416810ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000416810ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558113ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558113ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558113ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558113ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558750ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558750ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558750ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000558750ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000559911ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000559911ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000559911ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000559911ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000560305ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000560305ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000560305ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000560305ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000561011ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000561011ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000561011ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-5UTRENST00000561011ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000358005ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000416810ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000558113ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000558750ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000559911ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000560305ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
5CDS-intronENST00000561011ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
Frame-shiftENST00000358005ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
Frame-shiftENST00000558750ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
Frame-shiftENST00000561011ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
In-frameENST00000416810ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
In-frameENST00000558113ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
In-frameENST00000559911ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
In-frameENST00000560305ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-3CDSENST00000558871ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-3CDSENST00000560109ENST00000379056C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000558871ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000558871ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000558871ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000558871ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000560109ENST00000379055C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000560109ENST00000379060C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000560109ENST00000529421C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-5UTRENST00000560109ENST00000530705C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-intronENST00000558871ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-
intron-intronENST00000560109ENST00000309246C15orf57chr15

40849414

-TPT1chr13

45911523

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000560305C15orf57chr1540849414-ENST00000379056TPT1chr1345911523-96544948611187
ENST00000559911C15orf57chr1540849414-ENST00000379056TPT1chr1345911523-96544948611187
ENST00000558113C15orf57chr1540849414-ENST00000379056TPT1chr1345911523-96544948611187
ENST00000416810C15orf57chr1540849414-ENST00000379056TPT1chr1345911523-101149594657187

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000560305ENST00000379056C15orf57chr1540849414-TPT1chr1345911523-0.0043477310.99565226
ENST00000559911ENST00000379056C15orf57chr1540849414-TPT1chr1345911523-0.0043477310.99565226
ENST00000558113ENST00000379056C15orf57chr1540849414-TPT1chr1345911523-0.0043477310.99565226
ENST00000416810ENST00000379056C15orf57chr1540849414-TPT1chr1345911523-0.0031354590.9968645

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Fusion Genomic Features for C15orf57-TPT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C15orf57-TPT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:40849414/chr13:45911523)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC15orf57chr15:40849414chr13:45911523ENST00000358005-3478_98133186.0Coiled coilOntology_term=ECO:0000255
HgeneC15orf57chr15:40849414chr13:45911523ENST00000416810-3478_98133186.0Coiled coilOntology_term=ECO:0000255
HgeneC15orf57chr15:40849414chr13:45911523ENST00000558750-3478_98142195.0Coiled coilOntology_term=ECO:0000255
HgeneC15orf57chr15:40849414chr13:45911523ENST00000561011-3478_98133135.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC15orf57chr15:40849414chr13:45911523ENST00000558871-1378_980135.0Coiled coilOntology_term=ECO:0000255
TgeneTPT1chr15:40849414chr13:45911523ENST00000530705461_172172173.0DomainTCTP


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Fusion Gene Sequence for C15orf57-TPT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10974_10974_1_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000416810_TPT1_chr13_45911523_ENST00000379056_length(transcript)=1011nt_BP=495nt
ACTAGGGGACTCCGCCCCTCCCGATTTCCTCCGGGCTACAGGCGACAGAGCTGAGCCAAGCGTTTACTGGGCAGCTGTTACGCTCAGATT
CCAAATGAAAATGTTTGAGAGCGCTGACTCTACAGCCACAAGATCTGGCCAGGATCTCTGGGCTGAAATTTGTTCCTGTCTGCCAAATCC
TGAACAAGAAGATGGTGCCAACAATGCATTCTCAGACTCCTTTGTGGATTCTTGCCCTGAAGGTGAAGGCCAGAGGGAGGTGGCTGACTT
TGCTGTCCAGCCAGCTGTAAAGCCTTGGGCTCCCTTGCAGGATTCAGAAGTGTATTTAGCATCTCTAGAGAAGAAGCTAAGAAGAATCAA
AGGTTTAAATCAGGAAGTGACTTCCAAGGACATGCTTCGAACTCTGGCCCAAGCCAAGAAGGAATGCTGGGATCGGTTCCTCCAGGAGAA
GTTAGCTTCAGAGTTCTTTGTGGATGGACTTGATTCTGATGAGAGTAACAAATGTGGCAATTATTTTGGATCTATCACCTGTCATCATAA
CTGGCTTCTGCTTGTCATCCACACAACACCAGGACTTAAGACAAATGGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACTGTGAT
TTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAGGTTGTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATGC
CTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGTAGTGTTCCTGGAGAAGCTAGAGCCTGATTGTAGGCTACTACTCATCAATTA
ACTTCTACAGTGGAGACTACTTCTGGGACTGGAATATAAAAAAGAATCAAAGGTTCTGATTTTGAGTTGCAATAAAGGGAAAGACCATGC
TCATAGCAGTGCCAACATCTGAAGTGTGGAGCCTTACCCATTTCATCACCTACAACGGAAGTAGTTAACTGGAAGAGATTACCAAGAGAA

>10974_10974_1_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000416810_TPT1_chr13_45911523_ENST00000379056_length(amino acids)=187AA_BP=133
MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFVDSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKG
LNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESNKCGNYFGSITCHHNWLLLVIHTTPGLKTNGTDVILSSSFILTVIY

--------------------------------------------------------------
>10974_10974_2_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000558113_TPT1_chr13_45911523_ENST00000379056_length(transcript)=965nt_BP=449nt
AGAGCTGAGCCAAGCGTTTACTGGGCAGCTGTTACGCTCAGATTCCAAATGAAAATGTTTGAGAGCGCTGACTCTACAGCCACAAGATCT
GGCCAGGATCTCTGGGCTGAAATTTGTTCCTGTCTGCCAAATCCTGAACAAGAAGATGGTGCCAACAATGCATTCTCAGACTCCTTTGTG
GATTCTTGCCCTGAAGGTGAAGGCCAGAGGGAGGTGGCTGACTTTGCTGTCCAGCCAGCTGTAAAGCCTTGGGCTCCCTTGCAGGATTCA
GAAGTGTATTTAGCATCTCTAGAGAAGAAGCTAAGAAGAATCAAAGGTTTAAATCAGGAAGTGACTTCCAAGGACATGCTTCGAACTCTG
GCCCAAGCCAAGAAGGAATGCTGGGATCGGTTCCTCCAGGAGAAGTTAGCTTCAGAGTTCTTTGTGGATGGACTTGATTCTGATGAGAGT
AACAAATGTGGCAATTATTTTGGATCTATCACCTGTCATCATAACTGGCTTCTGCTTGTCATCCACACAACACCAGGACTTAAGACAAAT
GGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACTGTGATTTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAG
GTTGTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATGCCTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGTAGTGTTC
CTGGAGAAGCTAGAGCCTGATTGTAGGCTACTACTCATCAATTAACTTCTACAGTGGAGACTACTTCTGGGACTGGAATATAAAAAAGAA
TCAAAGGTTCTGATTTTGAGTTGCAATAAAGGGAAAGACCATGCTCATAGCAGTGCCAACATCTGAAGTGTGGAGCCTTACCCATTTCAT

>10974_10974_2_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000558113_TPT1_chr13_45911523_ENST00000379056_length(amino acids)=187AA_BP=133
MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFVDSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKG
LNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESNKCGNYFGSITCHHNWLLLVIHTTPGLKTNGTDVILSSSFILTVIY

--------------------------------------------------------------
>10974_10974_3_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000559911_TPT1_chr13_45911523_ENST00000379056_length(transcript)=965nt_BP=449nt
AGAGCTGAGCCAAGCGTTTACTGGGCAGCTGTTACGCTCAGATTCCAAATGAAAATGTTTGAGAGCGCTGACTCTACAGCCACAAGATCT
GGCCAGGATCTCTGGGCTGAAATTTGTTCCTGTCTGCCAAATCCTGAACAAGAAGATGGTGCCAACAATGCATTCTCAGACTCCTTTGTG
GATTCTTGCCCTGAAGGTGAAGGCCAGAGGGAGGTGGCTGACTTTGCTGTCCAGCCAGCTGTAAAGCCTTGGGCTCCCTTGCAGGATTCA
GAAGTGTATTTAGCATCTCTAGAGAAGAAGCTAAGAAGAATCAAAGGTTTAAATCAGGAAGTGACTTCCAAGGACATGCTTCGAACTCTG
GCCCAAGCCAAGAAGGAATGCTGGGATCGGTTCCTCCAGGAGAAGTTAGCTTCAGAGTTCTTTGTGGATGGACTTGATTCTGATGAGAGT
AACAAATGTGGCAATTATTTTGGATCTATCACCTGTCATCATAACTGGCTTCTGCTTGTCATCCACACAACACCAGGACTTAAGACAAAT
GGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACTGTGATTTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAG
GTTGTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATGCCTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGTAGTGTTC
CTGGAGAAGCTAGAGCCTGATTGTAGGCTACTACTCATCAATTAACTTCTACAGTGGAGACTACTTCTGGGACTGGAATATAAAAAAGAA
TCAAAGGTTCTGATTTTGAGTTGCAATAAAGGGAAAGACCATGCTCATAGCAGTGCCAACATCTGAAGTGTGGAGCCTTACCCATTTCAT

>10974_10974_3_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000559911_TPT1_chr13_45911523_ENST00000379056_length(amino acids)=187AA_BP=133
MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFVDSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKG
LNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESNKCGNYFGSITCHHNWLLLVIHTTPGLKTNGTDVILSSSFILTVIY

--------------------------------------------------------------
>10974_10974_4_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000560305_TPT1_chr13_45911523_ENST00000379056_length(transcript)=965nt_BP=449nt
AGAGCTGAGCCAAGCGTTTACTGGGCAGCTGTTACGCTCAGATTCCAAATGAAAATGTTTGAGAGCGCTGACTCTACAGCCACAAGATCT
GGCCAGGATCTCTGGGCTGAAATTTGTTCCTGTCTGCCAAATCCTGAACAAGAAGATGGTGCCAACAATGCATTCTCAGACTCCTTTGTG
GATTCTTGCCCTGAAGGTGAAGGCCAGAGGGAGGTGGCTGACTTTGCTGTCCAGCCAGCTGTAAAGCCTTGGGCTCCCTTGCAGGATTCA
GAAGTGTATTTAGCATCTCTAGAGAAGAAGCTAAGAAGAATCAAAGGTTTAAATCAGGAAGTGACTTCCAAGGACATGCTTCGAACTCTG
GCCCAAGCCAAGAAGGAATGCTGGGATCGGTTCCTCCAGGAGAAGTTAGCTTCAGAGTTCTTTGTGGATGGACTTGATTCTGATGAGAGT
AACAAATGTGGCAATTATTTTGGATCTATCACCTGTCATCATAACTGGCTTCTGCTTGTCATCCACACAACACCAGGACTTAAGACAAAT
GGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACTGTGATTTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAG
GTTGTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATGCCTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGTAGTGTTC
CTGGAGAAGCTAGAGCCTGATTGTAGGCTACTACTCATCAATTAACTTCTACAGTGGAGACTACTTCTGGGACTGGAATATAAAAAAGAA
TCAAAGGTTCTGATTTTGAGTTGCAATAAAGGGAAAGACCATGCTCATAGCAGTGCCAACATCTGAAGTGTGGAGCCTTACCCATTTCAT

>10974_10974_4_C15orf57-TPT1_C15orf57_chr15_40849414_ENST00000560305_TPT1_chr13_45911523_ENST00000379056_length(amino acids)=187AA_BP=133
MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFVDSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKG
LNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESNKCGNYFGSITCHHNWLLLVIHTTPGLKTNGTDVILSSSFILTVIY

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Fusion Gene PPI Analysis for C15orf57-TPT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C15orf57-TPT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C15orf57-TPT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource