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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C16orf70-ARL16 (FusionGDB2 ID:11017)

Fusion Gene Summary for C16orf70-ARL16

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf70-ARL16
Fusion gene ID: 11017
HgeneTgene
Gene symbol

C16orf70

ARL16

Gene ID

80262

339231

Gene namechromosome 16 open reading frame 70ADP ribosylation factor like GTPase 16
SynonymsC16orf6|LIN10|lin-10-
Cytomap

16q22.1

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0183 protein C16orf70lin-10 homologADP-ribosylation factor-like protein 16
Modification date2020031320200320
UniProtAcc

Q9BSU1

Q0P5N6

Ensembl transtripts involved in fusion geneENST00000569683, ENST00000219139, 
ENST00000569600, 		ENST00000397498, 
ENST00000570561, ENST00000576135, 
ENST00000573392, ENST00000574938, 
Fusion gene scores* DoF score10 X 8 X 8=6401 X 1 X 1=1
# samples 121
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: C16orf70 [Title/Abstract] AND ARL16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL16(79650566)-C16orf70(67159862), # samples:2
C16orf70(67154097)-ARL16(79650156), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C16orf70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARL16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-3792-01AC16orf70chr16

67154097

+ARL16chr17

79650156

-


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Fusion Gene ORF analysis for C16orf70-ARL16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000569683ENST00000397498C16orf70chr16

67154097

+ARL16chr17

79650156

-
3UTR-5UTRENST00000569683ENST00000570561C16orf70chr16

67154097

+ARL16chr17

79650156

-
3UTR-5UTRENST00000569683ENST00000576135C16orf70chr16

67154097

+ARL16chr17

79650156

-
3UTR-intronENST00000569683ENST00000573392C16orf70chr16

67154097

+ARL16chr17

79650156

-
3UTR-intronENST00000569683ENST00000574938C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-5UTRENST00000219139ENST00000570561C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-5UTRENST00000219139ENST00000576135C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-5UTRENST00000569600ENST00000570561C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-5UTRENST00000569600ENST00000576135C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-intronENST00000219139ENST00000573392C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-intronENST00000219139ENST00000574938C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-intronENST00000569600ENST00000573392C16orf70chr16

67154097

+ARL16chr17

79650156

-
5CDS-intronENST00000569600ENST00000574938C16orf70chr16

67154097

+ARL16chr17

79650156

-
In-frameENST00000219139ENST00000397498C16orf70chr16

67154097

+ARL16chr17

79650156

-
In-frameENST00000569600ENST00000397498C16orf70chr16

67154097

+ARL16chr17

79650156

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569600C16orf70chr1667154097+ENST00000397498ARL16chr1779650156-11672310632210
ENST00000219139C16orf70chr1667154097+ENST00000397498ARL16chr1779650156-1271335143736197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569600ENST00000397498C16orf70chr1667154097+ARL16chr1779650156-0.0055847570.9944153
ENST00000219139ENST00000397498C16orf70chr1667154097+ARL16chr1779650156-0.0050903290.9949097

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Fusion Genomic Features for C16orf70-ARL16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C16orf70-ARL16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:79650566/chr17:67159862)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf70

Q9BSU1

ARL16

Q0P5N6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARL16chr16:67154097chr17:79650156ENST0000039749815139_14264198.0Nucleotide bindingGTP
TgeneARL16chr16:67154097chr17:79650156ENST000003974981582_8664198.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARL16chr16:67154097chr17:79650156ENST000003974981530_3764198.0Nucleotide bindingGTP


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Fusion Gene Sequence for C16orf70-ARL16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11017_11017_1_C16orf70-ARL16_C16orf70_chr16_67154097_ENST00000219139_ARL16_chr17_79650156_ENST00000397498_length(transcript)=1271nt_BP=335nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGG
CAGTAGCCATTCTTCAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGGTGGGCACCAATCTTACTGACATCG
TGGCACAGAGAAAGATCACCATCCGGGAGCTTGGGGGGTGCATGGGCCCCATCTGGTCCAGTTACTATGGAAACTGCCGTTCTCTCCTGT
TTGTGATGGACGCCTCTGACCCCACCCAGCTCTCTGCATCCTGTGTGCAGCTCTTAGGTCTCCTTTCTGCAGAACAACTTGCAGAAGCAT
CGGTGCTGATACTCTTCAATAAAATCGACCTACCCTGTTACATGTCCACGGAGGAGATGAAGTCATTAATCAGGCTTCCAGACATCATTG
CTTGTGCCAAGCAGAACATCACCACGGCAGAAATCAGCGCCCGTGAAGGCACTGGCTTAGCAGGGGTGCTGGCCTGGCTCCAGGCCACCC
ACAGAGCCAACGATTGACTGCACGGCAGAGGCGCAGCTGGCCTGAGCTGGGGAGAGGTGGCAGAGGGCAGTATGGCTTTGCTGCCAATAG
TTTCTTCTCACAGGGGCAGAATAACCCAAAGTAACCCTACATGATGGGGCTCTGTGCTGAGATGCAATGATGTGTAAACTGAGGCATGTG
GAGATGGAAGTTGACATCTGGCCTCTGAAAAAAGTGTCCCCAGGGGCTAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGG
CCGAGGCGGGTGTATCACCTGAGGTCGGGAGTTCGAGACTAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAG
CTGGGTGTGCTGGTGCATGCCTGTAATCTCAGCTACTTGGGAGGCTGAGACAGGAGAATCCCTTGAACCTGGGAGGTGGAGGTTGCAGTG
AGTCGAGATCATGCCATTGCACTGCACCTGGGCAACAAGAGTGAAACTCCGTCTTAAAAAATATAAGAAATAAAAAAATAAAAACCTGTC

>11017_11017_1_C16orf70-ARL16_C16orf70_chr16_67154097_ENST00000219139_ARL16_chr17_79650156_ENST00000397498_length(amino acids)=197AA_BP=64
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQVGTNLTDIVAQRKITIRELGGCMGPI
WSSYYGNCRSLLFVMDASDPTQLSASCVQLLGLLSAEQLAEASVLILFNKIDLPCYMSTEEMKSLIRLPDIIACAKQNITTAEISAREGT

--------------------------------------------------------------
>11017_11017_2_C16orf70-ARL16_C16orf70_chr16_67154097_ENST00000569600_ARL16_chr17_79650156_ENST00000397498_length(transcript)=1167nt_BP=231nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGGCAGTAGCCATTCTT
CAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGGTGGGCACCAATCTTACTGACATCGTGGCACAGAGAAAG
ATCACCATCCGGGAGCTTGGGGGGTGCATGGGCCCCATCTGGTCCAGTTACTATGGAAACTGCCGTTCTCTCCTGTTTGTGATGGACGCC
TCTGACCCCACCCAGCTCTCTGCATCCTGTGTGCAGCTCTTAGGTCTCCTTTCTGCAGAACAACTTGCAGAAGCATCGGTGCTGATACTC
TTCAATAAAATCGACCTACCCTGTTACATGTCCACGGAGGAGATGAAGTCATTAATCAGGCTTCCAGACATCATTGCTTGTGCCAAGCAG
AACATCACCACGGCAGAAATCAGCGCCCGTGAAGGCACTGGCTTAGCAGGGGTGCTGGCCTGGCTCCAGGCCACCCACAGAGCCAACGAT
TGACTGCACGGCAGAGGCGCAGCTGGCCTGAGCTGGGGAGAGGTGGCAGAGGGCAGTATGGCTTTGCTGCCAATAGTTTCTTCTCACAGG
GGCAGAATAACCCAAAGTAACCCTACATGATGGGGCTCTGTGCTGAGATGCAATGATGTGTAAACTGAGGCATGTGGAGATGGAAGTTGA
CATCTGGCCTCTGAAAAAAGTGTCCCCAGGGGCTAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGCCGAGGCGGGTGTA
TCACCTGAGGTCGGGAGTTCGAGACTAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCTGGGTGTGCTGGT
GCATGCCTGTAATCTCAGCTACTTGGGAGGCTGAGACAGGAGAATCCCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGTCGAGATCATGC

>11017_11017_2_C16orf70-ARL16_C16orf70_chr16_67154097_ENST00000569600_ARL16_chr17_79650156_ENST00000397498_length(amino acids)=210AA_BP=77
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQVGTNLTDIVAQRK
ITIRELGGCMGPIWSSYYGNCRSLLFVMDASDPTQLSASCVQLLGLLSAEQLAEASVLILFNKIDLPCYMSTEEMKSLIRLPDIIACAKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C16orf70-ARL16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C16orf70-ARL16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C16orf70-ARL16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource