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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C16orf70-CRTC3 (FusionGDB2 ID:11020)

Fusion Gene Summary for C16orf70-CRTC3

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf70-CRTC3
Fusion gene ID: 11020
HgeneTgene
Gene symbol

C16orf70

CRTC3

Gene ID

80262

64784

Gene namechromosome 16 open reading frame 70CREB regulated transcription coactivator 3
SynonymsC16orf6|LIN10|lin-10TORC-3|TORC3
Cytomap

16q22.1

15q26.1

Type of geneprotein-codingprotein-coding
DescriptionUPF0183 protein C16orf70lin-10 homologCREB-regulated transcription coactivator 3transducer of regulated CREB protein 3transducer of regulated cAMP response element-binding protein (CREB) 3
Modification date2020031320200313
UniProtAcc

Q9BSU1

Q6UUV7

Ensembl transtripts involved in fusion geneENST00000569683, ENST00000219139, 
ENST00000569600, 		ENST00000420329, 
ENST00000558619, ENST00000268184, 
ENST00000560098, 
Fusion gene scores* DoF score10 X 8 X 8=6408 X 11 X 5=440
# samples 1210
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/440*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C16orf70 [Title/Abstract] AND CRTC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC16orf70(67166814)-CRTC3(91136868), # samples:2
Anticipated loss of major functional domain due to fusion event.C16orf70-CRTC3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C16orf70-CRTC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C16orf70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRTC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-AB1X-01AC16orf70chr16

67166814

-CRTC3chr15

91136868

+
ChimerDB4STADTCGA-IN-AB1X-01AC16orf70chr16

67166814

+CRTC3chr15

91136868

+
ChimerDB4STADTCGA-IN-AB1XC16orf70chr16

67166428

+CRTC3chr15

91136867

+
ChimerDB4STADTCGA-IN-AB1XC16orf70chr16

67166814

+CRTC3chr15

91136867

+


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Fusion Gene ORF analysis for C16orf70-CRTC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000569683ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136868

+
3UTR-3CDSENST00000569683ENST00000420329C16orf70chr16

67166428

+CRTC3chr15

91136867

+
3UTR-3CDSENST00000569683ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136867

+
3UTR-3UTRENST00000569683ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136868

+
3UTR-3UTRENST00000569683ENST00000558619C16orf70chr16

67166428

+CRTC3chr15

91136867

+
3UTR-3UTRENST00000569683ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136867

+
3UTR-intronENST00000569683ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136868

+
3UTR-intronENST00000569683ENST00000268184C16orf70chr16

67166428

+CRTC3chr15

91136867

+
3UTR-intronENST00000569683ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136867

+
3UTR-intronENST00000569683ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136868

+
3UTR-intronENST00000569683ENST00000560098C16orf70chr16

67166428

+CRTC3chr15

91136867

+
3UTR-intronENST00000569683ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-3UTRENST00000219139ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-3UTRENST00000219139ENST00000558619C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-3UTRENST00000219139ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-3UTRENST00000569600ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-3UTRENST00000569600ENST00000558619C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-3UTRENST00000569600ENST00000558619C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-intronENST00000219139ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-intronENST00000219139ENST00000268184C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-intronENST00000219139ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-intronENST00000219139ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-intronENST00000219139ENST00000560098C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-intronENST00000219139ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-intronENST00000569600ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-intronENST00000569600ENST00000268184C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-intronENST00000569600ENST00000268184C16orf70chr16

67166814

+CRTC3chr15

91136867

+
5CDS-intronENST00000569600ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136868

+
5CDS-intronENST00000569600ENST00000560098C16orf70chr16

67166428

+CRTC3chr15

91136867

+
5CDS-intronENST00000569600ENST00000560098C16orf70chr16

67166814

+CRTC3chr15

91136867

+
Frame-shiftENST00000219139ENST00000420329C16orf70chr16

67166428

+CRTC3chr15

91136867

+
Frame-shiftENST00000569600ENST00000420329C16orf70chr16

67166428

+CRTC3chr15

91136867

+
In-frameENST00000219139ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136868

+
In-frameENST00000219139ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136867

+
In-frameENST00000569600ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136868

+
In-frameENST00000569600ENST00000420329C16orf70chr16

67166814

+CRTC3chr15

91136867

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569600C16orf70chr1667166814+ENST00000420329CRTC3chr1591136868+536553402159719
ENST00000219139C16orf70chr1667166814+ENST00000420329CRTC3chr1591136868+54696381432263706
ENST00000569600C16orf70chr1667166814+ENST00000420329CRTC3chr1591136867+536553402159719
ENST00000219139C16orf70chr1667166814+ENST00000420329CRTC3chr1591136867+54696381432263706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569600ENST00000420329C16orf70chr1667166814+CRTC3chr1591136868+0.0136196820.9863803
ENST00000219139ENST00000420329C16orf70chr1667166814+CRTC3chr1591136868+0.0120642040.9879358
ENST00000569600ENST00000420329C16orf70chr1667166814+CRTC3chr1591136867+0.0136196820.9863803
ENST00000219139ENST00000420329C16orf70chr1667166814+CRTC3chr1591136867+0.0120642040.9879358

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Fusion Genomic Features for C16orf70-CRTC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C16orf70chr1667166814+CRTC3chr1591136867+1.06E-081
C16orf70chr1667166428+CRTC3chr1591136867+1.98E-091
C16orf70chr1667166814+CRTC3chr1591136867+1.06E-081
C16orf70chr1667166814+CRTC3chr1591136867+1.06E-081
C16orf70chr1667166428+CRTC3chr1591136867+1.98E-091
C16orf70chr1667166814+CRTC3chr1591136867+1.06E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C16orf70-CRTC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67166814/chr15:91136868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf70

Q9BSU1

CRTC3

Q6UUV7

FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCRTC3chr16:67166814chr15:91136867ENST00000268184115180_18377620.0Compositional biasNote=Poly-Gly
TgeneCRTC3chr16:67166814chr15:91136867ENST00000268184115444_45177620.0Compositional biasNote=Poly-Pro
TgeneCRTC3chr16:67166814chr15:91136867ENST00000420329115180_18377619.0Compositional biasNote=Poly-Gly
TgeneCRTC3chr16:67166814chr15:91136867ENST00000420329115444_45177619.0Compositional biasNote=Poly-Pro
TgeneCRTC3chr16:67166814chr15:91136868ENST00000268184115180_18377620.0Compositional biasNote=Poly-Gly
TgeneCRTC3chr16:67166814chr15:91136868ENST00000268184115444_45177620.0Compositional biasNote=Poly-Pro
TgeneCRTC3chr16:67166814chr15:91136868ENST00000420329115180_18377619.0Compositional biasNote=Poly-Gly
TgeneCRTC3chr16:67166814chr15:91136868ENST00000420329115444_45177619.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C16orf70-CRTC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11020_11020_1_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000219139_CRTC3_chr15_91136867_ENST00000420329_length(transcript)=5469nt_BP=638nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGG
CAGTAGCCATTCTTCAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTC
TTAACCTGACTCAGGACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGTGATCGAAGTATGTGATTTGACTAAAGTAA
AGTTAAAATATTGTGGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTTGGCGCAACCCATCCTG
GAGTGTACAACTCCGCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCATGGACTGAGGCTCCAA
AGTATGAGCCGTCATTTCACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAACCGCTTCCACC
CCCTCCACCGAAGGTCTGGGGACAAGCCAGGGCGACAATTTGATGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGA
GTTGGCCAAGGCAGCAGCCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACCAATTCTGATTCTG
CTCTTCACACGAGTGCTCTGAGTACCAAGCCCCAGGACCCCTATGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCT
GTGATGGTGAGAATAATGGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCGAAGCCACTGC
CAAAACAACTGTGGGAGACCAAGGAGATTCAGTCCCTGTCAGGACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATA
ATGGTCAAAACCTAGGCCTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTCCACTACTCGACAC
CCCTGCCAGCCTCCCTGGACACCACCGACCACCACTTTGGCAGTATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCC
ACCTGGGTATAAGAAGCTCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTGCTTTCCTCTT
CCTTAAATAACCACCCACAGACATCTGTTCCCAACGCATCTGCTCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTT
CCACCACAAACCTGAGCGGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCACATCAAGGTT
TCAGCAGACAGCTGTCTTCAACCAGCCCACTGGCCCCATATCCTACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGC
CCACAGAAGCTCAAGCCCAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAGCCCCGCGCCC
CTGAGGCCCCTGCCCAGCAGCCCCAGGCAGCCTCCTCACTGCCACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCA
ACTTCTTCCCAGATGTGGGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGTGCCTCTGGTGCAACAAGGTTCCC
GAGAACTGCAGGACTCTTTTCATTTGAGACCAAGCCCGTATTCCAACTGCGGGAGTCTCCCGAACACCATCCTGCCAGACTCCAGCACCA
GCCTGTTCAAAGACCTCAACAGTGCGCTGGCAGGCCTGCCTGAGGTCAGCCTGAACGTGGACACTCCATTTCCACTGGAAGAGGAGCTGC
AGATTGAACCCCTGAGCCTGGACGGACTCAACATGTTAAGTGACTCCAGCATGGGCCTGCTGGACCCCTCTGTTGAAGAGACGTTTCGAG
CTGACAGACTGTGAACAGAAGGCAGTGGAACAGAAGAATGTTTTTCTGCAACAGCCAAAATAGAATGGAATAGAATGAAGCCAGCTGATA
CCACGGGCTTTCGTTATCTTGACATAGAAGGAAGCAATGCCACGGCTCCAGGGTTTCAGATGAGATCCCATCTCAGACACTGTGGCTTCC
TCCAGATCACACAGCTTTGTACTGCCTCTCCCGCCTGTGGCCAAAGTCGTGTTGCAGCAGGCAGGCTGCTTGGAGCTTCCCATGAACTGG
AAAGCTCACCTCCACTGCATCTTTTTACTGGCCATCCAGTCAGCCGATGTGTAAGAGTAGGAAATACTGTGTCACTGGAGGCCTCCGTAG
CATTGTGTAGTGTGCTCAGAACCACTGATCTCCGTCCGCACCGAAGGCGGGCCCGGAGTGGGAGGCTCGGCCTGGGGCGGCGGCACCGGA
GAGGGCACCTCGATGCCTGCTCTGACCTGACCCAGAGGGCGAGGCCCTCCAGCGGGGGACATTCCCAGGCTGAGTGGACCCCACGGCTCT
CTCCCACGCCTGGATTACGACATGAAGTTTTTACCACAAGCCCGAGGGCAGGCTTGAGTTAGGCAGACTGAAGGCTAATTTTCATTTTCT
CCCAGCTGGTTTCTGCTGCTTCAGAAAAGTACACCTTTTCCTTATGGACCAGAGGAAGAGGAAGACCATTTTATCAGTCACTGAAAAGAG
TCCCCTGGCACTGATGAGCCTGAAGAGAACTGTGCTCCTCCTCGGGGGCTGGGGAAGGAAGACAGGGACTGCAGGTGTCTCATACTCAGT
GGCCTCCAGACAAACTCCAGACAAGCACAGACCTCCCCACTAAGAGCAGCCAGAGGGAGCTGGTGAGGCCCTAACCCCACCCACCGAGCA
ACTGAGCTTCCCCATCCCTCCCCAGAGCTGTGTCTCTGTGGGCTGGGAGTCTAATGTCACCCCCCTAGACCGTAAGCTCCTTGAGGGCAG
GGACAGTGCCTTATCATTGTTGAACCCGTAGCACCTAACACGTGCGTGGCAGCACAGTCGTGTGCTGGAGTGAGTGCTGCAGAACCGTGC
GTGCAGCGCATGATGAATGAGTGCGTCCGCCATGCCGTAAGGCAGGCTCACCTGTAGCTATCCCCTTCCCTGCCAGATCTTCTCAGAGCT
TTAGCTTTTCTAGCACTCGTGCCTATGGTGAAGCATGCACTTTAATATGCTTTTAACACTAGGTGACCAAATCACAGTGAAGCCGGGCAC
TGCATTCTCCTTGGGCTGTGCTCCACGCGGGTGGGTGGGAGCTGTCTTCTGAGTACATCCGGAAGGGCTGAGCAGGTGAGTGCCCTGAGC
ATCCTGGCTGGGCCCCACCCAGGAAGATCTTCCTTCTCAGATCCACGTTTGGCTCTAAATTGCTTCAAGTAGAGATTCATTCTTTGAGGT
TGAAAAAATAGTTTATAGTAAAACGAAGGCCTAATTCATGGAAGCATCATTAGTCATCAATACCTTCTCATAAAATAGATGGGCCAGATT
TCCACCACCGCCTGCCTCCTCTAACTTGGGTGATGCCAGTAGGTTTGAAGGGGGCAGAGCACTGCAGGGGGAGGGGGGGGTCTAGGCTGT
GAGAGGACAGGGTGGAGAGGAGGAGAACCCTGAAGGAGAGACGGAAGATGCCAGGACCTTTGCTTGGACAGCCATTGCCCTTCCAGGAGA
CCCTGGAGTGTACTGAGGGTTGCTGGACTGTTCCACCCAGAGGAGCAAGGCTGTACAATGAGGGTCTGAATCTGGCACACCTGTCCCTTA
TGTAAAAGGAGTCGTGGTCACAAGACCCTGGGCTGGTTAGCCTCTCCCGACCTCATTCCATTTCTATCTTCTGACCTTGCCTCTCATCTT
TAAAATAACCCTCATGGGGTGCCCCTCCACCTTCCTCTGGAATCCAAGTATTCCTGTTTCACATTTGCCCCAAATCTTTGCTGTGGAATT
GGGAAATCAAACCAGAGTCCTCCTCGCCTGATTTCCAGCTCAGGAAGGGCCTGCTGGCCTGCCCTGTTCCCAGTTACACTTTCAGATCCC
TTTGTGCTCAAGATCTCAGAGGGGGTGGCTTTTTGTTAAAGAGCCTTCAGTCGCAATGCTACCCAGCACCCCATGTGCCAAAAGAAACCA
GCTCCTGTGTCAAAGGGCTTCCAAACCTGATCTCACTCTCAACAGGCGATGGTGCTGATGTTTCAAGAATTGTGTTTTTATAAAACAGAG
GTCTCAGCATAGTCACTCTTCACATAGTGCCTTACCCATGGGTATCGTCATATCCGGGTCCCAGTTCAGTTTGTCTGCACAGCAGCCACC
CTGCCTGGCAACAGAGACCCCAAGACCTACACAGTGAACCCTACTGCCCCAAAGGCGTTCTCCAGGTGACTTGTGAAAACAGACCTCCGG
GGAAGTGATTTATTGGGGGTGTACACTGGGGGCAATATGGTTTAGCACTGAATTCAATTTGTCCTTAGGTCTATGAGTGAGTCCGATCTT
TTCTTGTGAAAGGTTTTGGGCATCGTACAACCCACTCTGCCTAGAAGGTGTGGAGGACTCACCACGGGCAGGGTCGCCCTGGCCCACAGC
ACGTGAGCCTGCACTCACTGCGGCCTTTGTAACAAAACCAGTTGTGGTCCTCAGCATTTGAAGCAGCTGCATACTTCAGAGTAAACTATT
TTTCATTATTTAGTTTTGTCACAAGAAATCGACCATTGTACTACTCTCACTTACAGCAGTTAAACAGCATAGAACTAAAAACCTGTCTGC
ATTTCCATTTTTTCTTTCTGTATGGTTGTGGGTTTTAGGACATAGGGGGTTAGGAGAAGGGGTTTCTTGATCATGTCATGAATTCTCCTT
TGTCCTGTTTCTCCTGTTTCATTTCTCCTCCGCCTGCTGTATATTACCTGAGCTGGTGTTGTATCTTCAAGTCCATATGCGTATTTGCAG
ACCTTTCCTGTTCCCACTCTTGTTGGCTCTTCTGATTTATGCACAGATGGTTCCCAGCATGTGTCCAGTGCTTCATGGATGGGACCATCC
CAGCAACTAATCAGACTTCCTGCCAGTGTCCTAACCCCCAGGGCACCCTGTTCAACCATATTTAAAAATTGGAATTTGTATAAAGTTGCT

>11020_11020_1_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000219139_CRTC3_chr15_91136867_ENST00000420329_length(amino acids)=706AA_BP=165
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQR
LKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPSFHQADNVRGTRHH
GLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGG
GQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGG
SLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASALHP
SLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQ
ELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCG

--------------------------------------------------------------
>11020_11020_2_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000219139_CRTC3_chr15_91136868_ENST00000420329_length(transcript)=5469nt_BP=638nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGG
CAGTAGCCATTCTTCAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTC
TTAACCTGACTCAGGACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGTGATCGAAGTATGTGATTTGACTAAAGTAA
AGTTAAAATATTGTGGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTTGGCGCAACCCATCCTG
GAGTGTACAACTCCGCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCATGGACTGAGGCTCCAA
AGTATGAGCCGTCATTTCACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAACCGCTTCCACC
CCCTCCACCGAAGGTCTGGGGACAAGCCAGGGCGACAATTTGATGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGA
GTTGGCCAAGGCAGCAGCCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACCAATTCTGATTCTG
CTCTTCACACGAGTGCTCTGAGTACCAAGCCCCAGGACCCCTATGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCT
GTGATGGTGAGAATAATGGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCGAAGCCACTGC
CAAAACAACTGTGGGAGACCAAGGAGATTCAGTCCCTGTCAGGACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATA
ATGGTCAAAACCTAGGCCTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTCCACTACTCGACAC
CCCTGCCAGCCTCCCTGGACACCACCGACCACCACTTTGGCAGTATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCC
ACCTGGGTATAAGAAGCTCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTGCTTTCCTCTT
CCTTAAATAACCACCCACAGACATCTGTTCCCAACGCATCTGCTCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTT
CCACCACAAACCTGAGCGGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCACATCAAGGTT
TCAGCAGACAGCTGTCTTCAACCAGCCCACTGGCCCCATATCCTACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGC
CCACAGAAGCTCAAGCCCAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAGCCCCGCGCCC
CTGAGGCCCCTGCCCAGCAGCCCCAGGCAGCCTCCTCACTGCCACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCA
ACTTCTTCCCAGATGTGGGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGTGCCTCTGGTGCAACAAGGTTCCC
GAGAACTGCAGGACTCTTTTCATTTGAGACCAAGCCCGTATTCCAACTGCGGGAGTCTCCCGAACACCATCCTGCCAGACTCCAGCACCA
GCCTGTTCAAAGACCTCAACAGTGCGCTGGCAGGCCTGCCTGAGGTCAGCCTGAACGTGGACACTCCATTTCCACTGGAAGAGGAGCTGC
AGATTGAACCCCTGAGCCTGGACGGACTCAACATGTTAAGTGACTCCAGCATGGGCCTGCTGGACCCCTCTGTTGAAGAGACGTTTCGAG
CTGACAGACTGTGAACAGAAGGCAGTGGAACAGAAGAATGTTTTTCTGCAACAGCCAAAATAGAATGGAATAGAATGAAGCCAGCTGATA
CCACGGGCTTTCGTTATCTTGACATAGAAGGAAGCAATGCCACGGCTCCAGGGTTTCAGATGAGATCCCATCTCAGACACTGTGGCTTCC
TCCAGATCACACAGCTTTGTACTGCCTCTCCCGCCTGTGGCCAAAGTCGTGTTGCAGCAGGCAGGCTGCTTGGAGCTTCCCATGAACTGG
AAAGCTCACCTCCACTGCATCTTTTTACTGGCCATCCAGTCAGCCGATGTGTAAGAGTAGGAAATACTGTGTCACTGGAGGCCTCCGTAG
CATTGTGTAGTGTGCTCAGAACCACTGATCTCCGTCCGCACCGAAGGCGGGCCCGGAGTGGGAGGCTCGGCCTGGGGCGGCGGCACCGGA
GAGGGCACCTCGATGCCTGCTCTGACCTGACCCAGAGGGCGAGGCCCTCCAGCGGGGGACATTCCCAGGCTGAGTGGACCCCACGGCTCT
CTCCCACGCCTGGATTACGACATGAAGTTTTTACCACAAGCCCGAGGGCAGGCTTGAGTTAGGCAGACTGAAGGCTAATTTTCATTTTCT
CCCAGCTGGTTTCTGCTGCTTCAGAAAAGTACACCTTTTCCTTATGGACCAGAGGAAGAGGAAGACCATTTTATCAGTCACTGAAAAGAG
TCCCCTGGCACTGATGAGCCTGAAGAGAACTGTGCTCCTCCTCGGGGGCTGGGGAAGGAAGACAGGGACTGCAGGTGTCTCATACTCAGT
GGCCTCCAGACAAACTCCAGACAAGCACAGACCTCCCCACTAAGAGCAGCCAGAGGGAGCTGGTGAGGCCCTAACCCCACCCACCGAGCA
ACTGAGCTTCCCCATCCCTCCCCAGAGCTGTGTCTCTGTGGGCTGGGAGTCTAATGTCACCCCCCTAGACCGTAAGCTCCTTGAGGGCAG
GGACAGTGCCTTATCATTGTTGAACCCGTAGCACCTAACACGTGCGTGGCAGCACAGTCGTGTGCTGGAGTGAGTGCTGCAGAACCGTGC
GTGCAGCGCATGATGAATGAGTGCGTCCGCCATGCCGTAAGGCAGGCTCACCTGTAGCTATCCCCTTCCCTGCCAGATCTTCTCAGAGCT
TTAGCTTTTCTAGCACTCGTGCCTATGGTGAAGCATGCACTTTAATATGCTTTTAACACTAGGTGACCAAATCACAGTGAAGCCGGGCAC
TGCATTCTCCTTGGGCTGTGCTCCACGCGGGTGGGTGGGAGCTGTCTTCTGAGTACATCCGGAAGGGCTGAGCAGGTGAGTGCCCTGAGC
ATCCTGGCTGGGCCCCACCCAGGAAGATCTTCCTTCTCAGATCCACGTTTGGCTCTAAATTGCTTCAAGTAGAGATTCATTCTTTGAGGT
TGAAAAAATAGTTTATAGTAAAACGAAGGCCTAATTCATGGAAGCATCATTAGTCATCAATACCTTCTCATAAAATAGATGGGCCAGATT
TCCACCACCGCCTGCCTCCTCTAACTTGGGTGATGCCAGTAGGTTTGAAGGGGGCAGAGCACTGCAGGGGGAGGGGGGGGTCTAGGCTGT
GAGAGGACAGGGTGGAGAGGAGGAGAACCCTGAAGGAGAGACGGAAGATGCCAGGACCTTTGCTTGGACAGCCATTGCCCTTCCAGGAGA
CCCTGGAGTGTACTGAGGGTTGCTGGACTGTTCCACCCAGAGGAGCAAGGCTGTACAATGAGGGTCTGAATCTGGCACACCTGTCCCTTA
TGTAAAAGGAGTCGTGGTCACAAGACCCTGGGCTGGTTAGCCTCTCCCGACCTCATTCCATTTCTATCTTCTGACCTTGCCTCTCATCTT
TAAAATAACCCTCATGGGGTGCCCCTCCACCTTCCTCTGGAATCCAAGTATTCCTGTTTCACATTTGCCCCAAATCTTTGCTGTGGAATT
GGGAAATCAAACCAGAGTCCTCCTCGCCTGATTTCCAGCTCAGGAAGGGCCTGCTGGCCTGCCCTGTTCCCAGTTACACTTTCAGATCCC
TTTGTGCTCAAGATCTCAGAGGGGGTGGCTTTTTGTTAAAGAGCCTTCAGTCGCAATGCTACCCAGCACCCCATGTGCCAAAAGAAACCA
GCTCCTGTGTCAAAGGGCTTCCAAACCTGATCTCACTCTCAACAGGCGATGGTGCTGATGTTTCAAGAATTGTGTTTTTATAAAACAGAG
GTCTCAGCATAGTCACTCTTCACATAGTGCCTTACCCATGGGTATCGTCATATCCGGGTCCCAGTTCAGTTTGTCTGCACAGCAGCCACC
CTGCCTGGCAACAGAGACCCCAAGACCTACACAGTGAACCCTACTGCCCCAAAGGCGTTCTCCAGGTGACTTGTGAAAACAGACCTCCGG
GGAAGTGATTTATTGGGGGTGTACACTGGGGGCAATATGGTTTAGCACTGAATTCAATTTGTCCTTAGGTCTATGAGTGAGTCCGATCTT
TTCTTGTGAAAGGTTTTGGGCATCGTACAACCCACTCTGCCTAGAAGGTGTGGAGGACTCACCACGGGCAGGGTCGCCCTGGCCCACAGC
ACGTGAGCCTGCACTCACTGCGGCCTTTGTAACAAAACCAGTTGTGGTCCTCAGCATTTGAAGCAGCTGCATACTTCAGAGTAAACTATT
TTTCATTATTTAGTTTTGTCACAAGAAATCGACCATTGTACTACTCTCACTTACAGCAGTTAAACAGCATAGAACTAAAAACCTGTCTGC
ATTTCCATTTTTTCTTTCTGTATGGTTGTGGGTTTTAGGACATAGGGGGTTAGGAGAAGGGGTTTCTTGATCATGTCATGAATTCTCCTT
TGTCCTGTTTCTCCTGTTTCATTTCTCCTCCGCCTGCTGTATATTACCTGAGCTGGTGTTGTATCTTCAAGTCCATATGCGTATTTGCAG
ACCTTTCCTGTTCCCACTCTTGTTGGCTCTTCTGATTTATGCACAGATGGTTCCCAGCATGTGTCCAGTGCTTCATGGATGGGACCATCC
CAGCAACTAATCAGACTTCCTGCCAGTGTCCTAACCCCCAGGGCACCCTGTTCAACCATATTTAAAAATTGGAATTTGTATAAAGTTGCT

>11020_11020_2_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000219139_CRTC3_chr15_91136868_ENST00000420329_length(amino acids)=706AA_BP=165
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQR
LKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPSFHQADNVRGTRHH
GLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGG
GQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGG
SLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASALHP
SLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQ
ELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCG

--------------------------------------------------------------
>11020_11020_3_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000569600_CRTC3_chr15_91136867_ENST00000420329_length(transcript)=5365nt_BP=534nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGGCAGTAGCCATTCTT
CAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTCTTAACCTGACTCAG
GACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGTGATCGAAGTATGTGATTTGACTAAAGTAAAGTTAAAATATTGT
GGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTTGGCGCAACCCATCCTGGAGTGTACAACTCC
GCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCATGGACTGAGGCTCCAAAGTATGAGCCGTCA
TTTCACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAACCGCTTCCACCCCCTCCACCGAAGG
TCTGGGGACAAGCCAGGGCGACAATTTGATGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGAGTTGGCCAAGGCAG
CAGCCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACCAATTCTGATTCTGCTCTTCACACGAGT
GCTCTGAGTACCAAGCCCCAGGACCCCTATGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCTGTGATGGTGAGAAT
AATGGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCGAAGCCACTGCCAAAACAACTGTGG
GAGACCAAGGAGATTCAGTCCCTGTCAGGACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATAATGGTCAAAACCTA
GGCCTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTCCACTACTCGACACCCCTGCCAGCCTCC
CTGGACACCACCGACCACCACTTTGGCAGTATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCCACCTGGGTATAAGA
AGCTCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTGCTTTCCTCTTCCTTAAATAACCAC
CCACAGACATCTGTTCCCAACGCATCTGCTCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTTCCACCACAAACCTG
AGCGGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCACATCAAGGTTTCAGCAGACAGCTG
TCTTCAACCAGCCCACTGGCCCCATATCCTACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGCCCACAGAAGCTCAA
GCCCAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAGCCCCGCGCCCCTGAGGCCCCTGCC
CAGCAGCCCCAGGCAGCCTCCTCACTGCCACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCAACTTCTTCCCAGAT
GTGGGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGTGCCTCTGGTGCAACAAGGTTCCCGAGAACTGCAGGAC
TCTTTTCATTTGAGACCAAGCCCGTATTCCAACTGCGGGAGTCTCCCGAACACCATCCTGCCAGACTCCAGCACCAGCCTGTTCAAAGAC
CTCAACAGTGCGCTGGCAGGCCTGCCTGAGGTCAGCCTGAACGTGGACACTCCATTTCCACTGGAAGAGGAGCTGCAGATTGAACCCCTG
AGCCTGGACGGACTCAACATGTTAAGTGACTCCAGCATGGGCCTGCTGGACCCCTCTGTTGAAGAGACGTTTCGAGCTGACAGACTGTGA
ACAGAAGGCAGTGGAACAGAAGAATGTTTTTCTGCAACAGCCAAAATAGAATGGAATAGAATGAAGCCAGCTGATACCACGGGCTTTCGT
TATCTTGACATAGAAGGAAGCAATGCCACGGCTCCAGGGTTTCAGATGAGATCCCATCTCAGACACTGTGGCTTCCTCCAGATCACACAG
CTTTGTACTGCCTCTCCCGCCTGTGGCCAAAGTCGTGTTGCAGCAGGCAGGCTGCTTGGAGCTTCCCATGAACTGGAAAGCTCACCTCCA
CTGCATCTTTTTACTGGCCATCCAGTCAGCCGATGTGTAAGAGTAGGAAATACTGTGTCACTGGAGGCCTCCGTAGCATTGTGTAGTGTG
CTCAGAACCACTGATCTCCGTCCGCACCGAAGGCGGGCCCGGAGTGGGAGGCTCGGCCTGGGGCGGCGGCACCGGAGAGGGCACCTCGAT
GCCTGCTCTGACCTGACCCAGAGGGCGAGGCCCTCCAGCGGGGGACATTCCCAGGCTGAGTGGACCCCACGGCTCTCTCCCACGCCTGGA
TTACGACATGAAGTTTTTACCACAAGCCCGAGGGCAGGCTTGAGTTAGGCAGACTGAAGGCTAATTTTCATTTTCTCCCAGCTGGTTTCT
GCTGCTTCAGAAAAGTACACCTTTTCCTTATGGACCAGAGGAAGAGGAAGACCATTTTATCAGTCACTGAAAAGAGTCCCCTGGCACTGA
TGAGCCTGAAGAGAACTGTGCTCCTCCTCGGGGGCTGGGGAAGGAAGACAGGGACTGCAGGTGTCTCATACTCAGTGGCCTCCAGACAAA
CTCCAGACAAGCACAGACCTCCCCACTAAGAGCAGCCAGAGGGAGCTGGTGAGGCCCTAACCCCACCCACCGAGCAACTGAGCTTCCCCA
TCCCTCCCCAGAGCTGTGTCTCTGTGGGCTGGGAGTCTAATGTCACCCCCCTAGACCGTAAGCTCCTTGAGGGCAGGGACAGTGCCTTAT
CATTGTTGAACCCGTAGCACCTAACACGTGCGTGGCAGCACAGTCGTGTGCTGGAGTGAGTGCTGCAGAACCGTGCGTGCAGCGCATGAT
GAATGAGTGCGTCCGCCATGCCGTAAGGCAGGCTCACCTGTAGCTATCCCCTTCCCTGCCAGATCTTCTCAGAGCTTTAGCTTTTCTAGC
ACTCGTGCCTATGGTGAAGCATGCACTTTAATATGCTTTTAACACTAGGTGACCAAATCACAGTGAAGCCGGGCACTGCATTCTCCTTGG
GCTGTGCTCCACGCGGGTGGGTGGGAGCTGTCTTCTGAGTACATCCGGAAGGGCTGAGCAGGTGAGTGCCCTGAGCATCCTGGCTGGGCC
CCACCCAGGAAGATCTTCCTTCTCAGATCCACGTTTGGCTCTAAATTGCTTCAAGTAGAGATTCATTCTTTGAGGTTGAAAAAATAGTTT
ATAGTAAAACGAAGGCCTAATTCATGGAAGCATCATTAGTCATCAATACCTTCTCATAAAATAGATGGGCCAGATTTCCACCACCGCCTG
CCTCCTCTAACTTGGGTGATGCCAGTAGGTTTGAAGGGGGCAGAGCACTGCAGGGGGAGGGGGGGGTCTAGGCTGTGAGAGGACAGGGTG
GAGAGGAGGAGAACCCTGAAGGAGAGACGGAAGATGCCAGGACCTTTGCTTGGACAGCCATTGCCCTTCCAGGAGACCCTGGAGTGTACT
GAGGGTTGCTGGACTGTTCCACCCAGAGGAGCAAGGCTGTACAATGAGGGTCTGAATCTGGCACACCTGTCCCTTATGTAAAAGGAGTCG
TGGTCACAAGACCCTGGGCTGGTTAGCCTCTCCCGACCTCATTCCATTTCTATCTTCTGACCTTGCCTCTCATCTTTAAAATAACCCTCA
TGGGGTGCCCCTCCACCTTCCTCTGGAATCCAAGTATTCCTGTTTCACATTTGCCCCAAATCTTTGCTGTGGAATTGGGAAATCAAACCA
GAGTCCTCCTCGCCTGATTTCCAGCTCAGGAAGGGCCTGCTGGCCTGCCCTGTTCCCAGTTACACTTTCAGATCCCTTTGTGCTCAAGAT
CTCAGAGGGGGTGGCTTTTTGTTAAAGAGCCTTCAGTCGCAATGCTACCCAGCACCCCATGTGCCAAAAGAAACCAGCTCCTGTGTCAAA
GGGCTTCCAAACCTGATCTCACTCTCAACAGGCGATGGTGCTGATGTTTCAAGAATTGTGTTTTTATAAAACAGAGGTCTCAGCATAGTC
ACTCTTCACATAGTGCCTTACCCATGGGTATCGTCATATCCGGGTCCCAGTTCAGTTTGTCTGCACAGCAGCCACCCTGCCTGGCAACAG
AGACCCCAAGACCTACACAGTGAACCCTACTGCCCCAAAGGCGTTCTCCAGGTGACTTGTGAAAACAGACCTCCGGGGAAGTGATTTATT
GGGGGTGTACACTGGGGGCAATATGGTTTAGCACTGAATTCAATTTGTCCTTAGGTCTATGAGTGAGTCCGATCTTTTCTTGTGAAAGGT
TTTGGGCATCGTACAACCCACTCTGCCTAGAAGGTGTGGAGGACTCACCACGGGCAGGGTCGCCCTGGCCCACAGCACGTGAGCCTGCAC
TCACTGCGGCCTTTGTAACAAAACCAGTTGTGGTCCTCAGCATTTGAAGCAGCTGCATACTTCAGAGTAAACTATTTTTCATTATTTAGT
TTTGTCACAAGAAATCGACCATTGTACTACTCTCACTTACAGCAGTTAAACAGCATAGAACTAAAAACCTGTCTGCATTTCCATTTTTTC
TTTCTGTATGGTTGTGGGTTTTAGGACATAGGGGGTTAGGAGAAGGGGTTTCTTGATCATGTCATGAATTCTCCTTTGTCCTGTTTCTCC
TGTTTCATTTCTCCTCCGCCTGCTGTATATTACCTGAGCTGGTGTTGTATCTTCAAGTCCATATGCGTATTTGCAGACCTTTCCTGTTCC
CACTCTTGTTGGCTCTTCTGATTTATGCACAGATGGTTCCCAGCATGTGTCCAGTGCTTCATGGATGGGACCATCCCAGCAACTAATCAG
ACTTCCTGCCAGTGTCCTAACCCCCAGGGCACCCTGTTCAACCATATTTAAAAATTGGAATTTGTATAAAGTTGCTTCCAAGTTTTATAA

>11020_11020_3_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000569600_CRTC3_chr15_91136867_ENST00000420329_length(amino acids)=719AA_BP=178
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQ
DGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPS
FHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTS
ALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNL
GLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNH
PQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQ
AQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQD

--------------------------------------------------------------
>11020_11020_4_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000569600_CRTC3_chr15_91136868_ENST00000420329_length(transcript)=5365nt_BP=534nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGGCAGTAGCCATTCTT
CAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTCTTAACCTGACTCAG
GACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGTGATCGAAGTATGTGATTTGACTAAAGTAAAGTTAAAATATTGT
GGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTTGGCGCAACCCATCCTGGAGTGTACAACTCC
GCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCATGGACTGAGGCTCCAAAGTATGAGCCGTCA
TTTCACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAACCGCTTCCACCCCCTCCACCGAAGG
TCTGGGGACAAGCCAGGGCGACAATTTGATGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGAGTTGGCCAAGGCAG
CAGCCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACCAATTCTGATTCTGCTCTTCACACGAGT
GCTCTGAGTACCAAGCCCCAGGACCCCTATGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCTGTGATGGTGAGAAT
AATGGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCGAAGCCACTGCCAAAACAACTGTGG
GAGACCAAGGAGATTCAGTCCCTGTCAGGACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATAATGGTCAAAACCTA
GGCCTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTCCACTACTCGACACCCCTGCCAGCCTCC
CTGGACACCACCGACCACCACTTTGGCAGTATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCCACCTGGGTATAAGA
AGCTCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTGCTTTCCTCTTCCTTAAATAACCAC
CCACAGACATCTGTTCCCAACGCATCTGCTCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTTCCACCACAAACCTG
AGCGGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCACATCAAGGTTTCAGCAGACAGCTG
TCTTCAACCAGCCCACTGGCCCCATATCCTACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGCCCACAGAAGCTCAA
GCCCAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAGCCCCGCGCCCCTGAGGCCCCTGCC
CAGCAGCCCCAGGCAGCCTCCTCACTGCCACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCAACTTCTTCCCAGAT
GTGGGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGTGCCTCTGGTGCAACAAGGTTCCCGAGAACTGCAGGAC
TCTTTTCATTTGAGACCAAGCCCGTATTCCAACTGCGGGAGTCTCCCGAACACCATCCTGCCAGACTCCAGCACCAGCCTGTTCAAAGAC
CTCAACAGTGCGCTGGCAGGCCTGCCTGAGGTCAGCCTGAACGTGGACACTCCATTTCCACTGGAAGAGGAGCTGCAGATTGAACCCCTG
AGCCTGGACGGACTCAACATGTTAAGTGACTCCAGCATGGGCCTGCTGGACCCCTCTGTTGAAGAGACGTTTCGAGCTGACAGACTGTGA
ACAGAAGGCAGTGGAACAGAAGAATGTTTTTCTGCAACAGCCAAAATAGAATGGAATAGAATGAAGCCAGCTGATACCACGGGCTTTCGT
TATCTTGACATAGAAGGAAGCAATGCCACGGCTCCAGGGTTTCAGATGAGATCCCATCTCAGACACTGTGGCTTCCTCCAGATCACACAG
CTTTGTACTGCCTCTCCCGCCTGTGGCCAAAGTCGTGTTGCAGCAGGCAGGCTGCTTGGAGCTTCCCATGAACTGGAAAGCTCACCTCCA
CTGCATCTTTTTACTGGCCATCCAGTCAGCCGATGTGTAAGAGTAGGAAATACTGTGTCACTGGAGGCCTCCGTAGCATTGTGTAGTGTG
CTCAGAACCACTGATCTCCGTCCGCACCGAAGGCGGGCCCGGAGTGGGAGGCTCGGCCTGGGGCGGCGGCACCGGAGAGGGCACCTCGAT
GCCTGCTCTGACCTGACCCAGAGGGCGAGGCCCTCCAGCGGGGGACATTCCCAGGCTGAGTGGACCCCACGGCTCTCTCCCACGCCTGGA
TTACGACATGAAGTTTTTACCACAAGCCCGAGGGCAGGCTTGAGTTAGGCAGACTGAAGGCTAATTTTCATTTTCTCCCAGCTGGTTTCT
GCTGCTTCAGAAAAGTACACCTTTTCCTTATGGACCAGAGGAAGAGGAAGACCATTTTATCAGTCACTGAAAAGAGTCCCCTGGCACTGA
TGAGCCTGAAGAGAACTGTGCTCCTCCTCGGGGGCTGGGGAAGGAAGACAGGGACTGCAGGTGTCTCATACTCAGTGGCCTCCAGACAAA
CTCCAGACAAGCACAGACCTCCCCACTAAGAGCAGCCAGAGGGAGCTGGTGAGGCCCTAACCCCACCCACCGAGCAACTGAGCTTCCCCA
TCCCTCCCCAGAGCTGTGTCTCTGTGGGCTGGGAGTCTAATGTCACCCCCCTAGACCGTAAGCTCCTTGAGGGCAGGGACAGTGCCTTAT
CATTGTTGAACCCGTAGCACCTAACACGTGCGTGGCAGCACAGTCGTGTGCTGGAGTGAGTGCTGCAGAACCGTGCGTGCAGCGCATGAT
GAATGAGTGCGTCCGCCATGCCGTAAGGCAGGCTCACCTGTAGCTATCCCCTTCCCTGCCAGATCTTCTCAGAGCTTTAGCTTTTCTAGC
ACTCGTGCCTATGGTGAAGCATGCACTTTAATATGCTTTTAACACTAGGTGACCAAATCACAGTGAAGCCGGGCACTGCATTCTCCTTGG
GCTGTGCTCCACGCGGGTGGGTGGGAGCTGTCTTCTGAGTACATCCGGAAGGGCTGAGCAGGTGAGTGCCCTGAGCATCCTGGCTGGGCC
CCACCCAGGAAGATCTTCCTTCTCAGATCCACGTTTGGCTCTAAATTGCTTCAAGTAGAGATTCATTCTTTGAGGTTGAAAAAATAGTTT
ATAGTAAAACGAAGGCCTAATTCATGGAAGCATCATTAGTCATCAATACCTTCTCATAAAATAGATGGGCCAGATTTCCACCACCGCCTG
CCTCCTCTAACTTGGGTGATGCCAGTAGGTTTGAAGGGGGCAGAGCACTGCAGGGGGAGGGGGGGGTCTAGGCTGTGAGAGGACAGGGTG
GAGAGGAGGAGAACCCTGAAGGAGAGACGGAAGATGCCAGGACCTTTGCTTGGACAGCCATTGCCCTTCCAGGAGACCCTGGAGTGTACT
GAGGGTTGCTGGACTGTTCCACCCAGAGGAGCAAGGCTGTACAATGAGGGTCTGAATCTGGCACACCTGTCCCTTATGTAAAAGGAGTCG
TGGTCACAAGACCCTGGGCTGGTTAGCCTCTCCCGACCTCATTCCATTTCTATCTTCTGACCTTGCCTCTCATCTTTAAAATAACCCTCA
TGGGGTGCCCCTCCACCTTCCTCTGGAATCCAAGTATTCCTGTTTCACATTTGCCCCAAATCTTTGCTGTGGAATTGGGAAATCAAACCA
GAGTCCTCCTCGCCTGATTTCCAGCTCAGGAAGGGCCTGCTGGCCTGCCCTGTTCCCAGTTACACTTTCAGATCCCTTTGTGCTCAAGAT
CTCAGAGGGGGTGGCTTTTTGTTAAAGAGCCTTCAGTCGCAATGCTACCCAGCACCCCATGTGCCAAAAGAAACCAGCTCCTGTGTCAAA
GGGCTTCCAAACCTGATCTCACTCTCAACAGGCGATGGTGCTGATGTTTCAAGAATTGTGTTTTTATAAAACAGAGGTCTCAGCATAGTC
ACTCTTCACATAGTGCCTTACCCATGGGTATCGTCATATCCGGGTCCCAGTTCAGTTTGTCTGCACAGCAGCCACCCTGCCTGGCAACAG
AGACCCCAAGACCTACACAGTGAACCCTACTGCCCCAAAGGCGTTCTCCAGGTGACTTGTGAAAACAGACCTCCGGGGAAGTGATTTATT
GGGGGTGTACACTGGGGGCAATATGGTTTAGCACTGAATTCAATTTGTCCTTAGGTCTATGAGTGAGTCCGATCTTTTCTTGTGAAAGGT
TTTGGGCATCGTACAACCCACTCTGCCTAGAAGGTGTGGAGGACTCACCACGGGCAGGGTCGCCCTGGCCCACAGCACGTGAGCCTGCAC
TCACTGCGGCCTTTGTAACAAAACCAGTTGTGGTCCTCAGCATTTGAAGCAGCTGCATACTTCAGAGTAAACTATTTTTCATTATTTAGT
TTTGTCACAAGAAATCGACCATTGTACTACTCTCACTTACAGCAGTTAAACAGCATAGAACTAAAAACCTGTCTGCATTTCCATTTTTTC
TTTCTGTATGGTTGTGGGTTTTAGGACATAGGGGGTTAGGAGAAGGGGTTTCTTGATCATGTCATGAATTCTCCTTTGTCCTGTTTCTCC
TGTTTCATTTCTCCTCCGCCTGCTGTATATTACCTGAGCTGGTGTTGTATCTTCAAGTCCATATGCGTATTTGCAGACCTTTCCTGTTCC
CACTCTTGTTGGCTCTTCTGATTTATGCACAGATGGTTCCCAGCATGTGTCCAGTGCTTCATGGATGGGACCATCCCAGCAACTAATCAG
ACTTCCTGCCAGTGTCCTAACCCCCAGGGCACCCTGTTCAACCATATTTAAAAATTGGAATTTGTATAAAGTTGCTTCCAAGTTTTATAA

>11020_11020_4_C16orf70-CRTC3_C16orf70_chr16_67166814_ENST00000569600_CRTC3_chr15_91136868_ENST00000420329_length(amino acids)=719AA_BP=178
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQ
DGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPS
FHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTS
ALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNL
GLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNH
PQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQ
AQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQD

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Fusion Gene PPI Analysis for C16orf70-CRTC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C16orf70-CRTC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C16orf70-CRTC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource