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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf24-PALM (FusionGDB2 ID:11167)

Fusion Gene Summary for C19orf24-PALM

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf24-PALM
Fusion gene ID: 11167
HgeneTgene
Gene symbol

C19orf24

PALM

Gene ID

55009

5064

Gene namefamily with sequence similarity 174 member Cparalemmin
SynonymsC19orf24PALM1
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM174Cparalemmin-1
Modification date2020031320200313
UniProtAcc.

ZDHHC9

Ensembl transtripts involved in fusion geneENST00000409293, ENST00000469144, 
ENST00000590269, 		ENST00000593172, 
ENST00000264560, ENST00000338448, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 5 X 7=315
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf24 [Title/Abstract] AND PALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf24(1275829)-PALM(726138), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePALM

GO:0051491

positive regulation of filopodium assembly

14978216

TgenePALM

GO:0060160

negative regulation of dopamine receptor signaling pathway

16386234


check buttonFusion gene breakpoints across C19orf24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-A64U-01AC19orf24chr19

1275829

-PALMchr19

726138

+
ChimerDB4LGGTCGA-DB-A64U-01AC19orf24chr19

1275829

+PALMchr19

726138

+
ChimerDB4LGGTCGA-DB-A64UC19orf24chr19

1275829

+PALMchr19

726138

+


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Fusion Gene ORF analysis for C19orf24-PALM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409293ENST00000593172C19orf24chr19

1275829

+PALMchr19

726138

+
In-frameENST00000409293ENST00000264560C19orf24chr19

1275829

+PALMchr19

726138

+
In-frameENST00000409293ENST00000338448C19orf24chr19

1275829

+PALMchr19

726138

+
intron-3CDSENST00000469144ENST00000264560C19orf24chr19

1275829

+PALMchr19

726138

+
intron-3CDSENST00000469144ENST00000338448C19orf24chr19

1275829

+PALMchr19

726138

+
intron-3CDSENST00000590269ENST00000264560C19orf24chr19

1275829

+PALMchr19

726138

+
intron-3CDSENST00000590269ENST00000338448C19orf24chr19

1275829

+PALMchr19

726138

+
intron-intronENST00000469144ENST00000593172C19orf24chr19

1275829

+PALMchr19

726138

+
intron-intronENST00000590269ENST00000593172C19orf24chr19

1275829

+PALMchr19

726138

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409293C19orf24chr191275829+ENST00000264560PALMchr19726138+33458044751830451
ENST00000409293C19orf24chr191275829+ENST00000338448PALMchr19726138+34788044751962495

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409293ENST00000264560C19orf24chr191275829+PALMchr19726138+0.0051120510.994888
ENST00000409293ENST00000338448C19orf24chr191275829+PALMchr19726138+0.0046042690.9953957

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Fusion Genomic Features for C19orf24-PALM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C19orf24chr191275829+PALMchr19726137+2.00E-070.99999976
C19orf24chr191275829+PALMchr19726137+2.00E-070.99999976
C19orf24chr191275829+PALMchr19726137+2.00E-070.99999976
C19orf24chr191275829+PALMchr19726137+2.00E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C19orf24-PALM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1275829/chr19:726138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PALM

ZDHHC9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.364

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC19orf24chr19:1275829chr19:726138ENST00000409293+1373_9393133.0TransmembraneHelical
TgenePALMchr19:1275829chr19:726138ENST00000264560089_1011344.0Coiled coilOntology_term=ECO:0000255
TgenePALMchr19:1275829chr19:726138ENST00000338448099_1011388.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C19orf24-PALM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11167_11167_1_C19orf24-PALM_C19orf24_chr19_1275829_ENST00000409293_PALM_chr19_726138_ENST00000264560_length(transcript)=3345nt_BP=804nt
CGGCCGCGCAGCCGCTGTCAGGCCCCGTCTTGGGCCGAGTCCCGGGTTCCCTGTAGCAGGCTTGGGAGCGGGGCGCCACCTTCCTGGGCC
CTGGACGTGGCCGACGCGTTCTCAGTGTCCGTGAGGCCGGGGCAGGAGTGGCGGGGGTCGCCCCGAAGTGGGTGGGAATGAGCGGCCCGA
GGTCCTGAAGTCGGGGTCCGCCCCGTCTCCCCGCTGCCAGCCCGATTTCCTCGGAAGCCGCGACCCCCCACGCTGGGCTGGCAGTTCTGG
GCTCTGCCGGCTGCGCCTTGCCGGGACTCCCACGGGCGGGCTCCGGGCCTCCGTCCTGATCCCTTGGAGCGGTTCGACGAAGCAAGTTCC
GCGGCGGGCGCGCGGGGCACTGTGGGTAGCGCCGGGGCTCACCAGGCGGAGGCGGGGCCCGGCGTCAAGCTCCGCCTCCGCGCCCCATTG
GCTGGCATCACCTCCGCGCGCCTGACTGACAGCGCGCATAGGGGCGGGGCGCCGCCACCGCTTCCGCCGGGCCATGGGGCCGCGCGTGCT
GCAGCCGCCGCTGCTGCTGCTCCTGCTGGCGCTGCTGCTGGCGGCGCTGCCGTGCGGTGCCGAAGAGGCCTCGCCGCTGCGCCCCGCGCA
GGTCACGTTGTCGCCGCCGCCGGCCGTGACGAACGGGAGCCAGCCGGGCGCGCCACACAACAGCACGCACACGCGTCCGCCGGGGGCGTC
GGGCTCGGCGCTGACGCGCTCCTTCTACGTGATCCTGGGCTTCTGCGGCCTGACCGCGCTCTACTTCCTGATCCGGGCGTTTAGGGTCCT
GGCGGCAGAGACCACGTCCCAGCAGGAGCGGCTGCAGGCCATCGCAGAGAAGCGGAAGCGGCAGGCGGAGATCGAGAACAAGCGCCGGCA
GCTGGAGGACGAGCGGAGGCAGCTGCAGCACCTGAAGTCCAAGGCACTGCGGGAGCGCTGGCTGCTGGAGGGGACGCCGTCCTCGGCCTC
AGAGGGGGATGAGGACCTGAGGAGGCAGATGCAGGACGACGAGCAGAAGACACGGCTGCTGGAGGACTCGGTGTCCAGGTTGGAGAAGGA
AATTGAGGTGCTGGAGCGTGGAGACTCCGCCCCAGCCACTGCCAAGGAGAACGCGGCGGCCCCGAGCCCAGTCCGGGCCCCAGCCCCGAG
TCCAGCCAAGGAGGAGCGCAAGACAGAGGTGGTGATGAATTCACAGCAGACGCCGGTGGGCACGCCCAAAGACAAGCGAGTCTCCAACAC
GCCCCTGAGGACGGTTGACGGCTCCCCCATGATGAAGGCAGTGGTCCATGCTGTGGACGGCACCGCCGAGAACGGGATCCACCCCCTGAG
CTCCTCCGAGGTGGACGAACTCATCCACAAAGCGGACGAGGTCACGCTGAGCGAGGCAGGGTCCACGGCCGGGGCGGCAGAGACCCGGGG
GGCTGTGGAGGGGGCAGCCCGGACCACGCCCTCCCGGCGGGAGATCACCGGTGTGCAGGCACAGCCAGGCGAGGCCACGTCCGGCCCGCC
GGGGATCCAGCCCGGCCAGGAGCCCCCGGTCACAATGATCTTCATGGGTTACCAGAACGTGGAGGATGAGGCCGAGACCAAGAAGGTGCT
GGGCCTTCAAGATACCATCACGGCGGAGCTGGTGGTCATCGAAGACGCGGCTGAGCCCAAGGAGCCTGCACCACCCAACGGCAGTGCTGC
CGAGCCTCCCACGGAGGCCGCCTCCAGGGAAGAGAATCAGGCGGGGCCCGAGGCCACCACCAGCGACCCCCAGGACCTCGACATGAAGAA
GCACCGTTGTAAATGCTGCTCCATCATGTGAGCCGGCCCCCGAGACCCCGGCCCCCACCCCACACCACAGACACCCACCAGCCCGGCCCC
TCCCGGCGCCTGCCCACCCTCCACCCACAGCCTCACGGGTCCAGGACTTGGCGTGTTGTTACATGTTCCTTCCGAGTTTTCTTTCGCTGG
AAAGAGGGACAGGGGCCCCCACCCGTCACCACGCCCCAACACTCCCCCCGAACCAGAGCCGTGCACTTGTGCCTGGTAGGAGAGAGACAG
GACAGACCCGCTTTTCCCGAGACAAGGACCCCCCATGTCACGGCAGCTTCACAGACGCGGCTCGCGCCCACCGGGGTCCTGGCGGGTGGG
ACCCGCAGCCTCCACGCGGCCCAGGCCAGCCTGCCACCCTCTGGGCCTCCTACCTGTGCCTTTCTCTGAGGGGACACCCCGCCAGAGAGG
GCCCCGGGAGCCGGGGGTGGGTACTGAGGCCTGCTCAGGCCCTGGAAGTGAGGCTCTATGGGGTTCCCTGGCCAAGGCGCTGGCCCCCCA
ATCTCAGGCAGTTGGGGTGAGGCCGTGCCTCTTTGGGGGCTAAAGGTCTTGGGTGGAGGACAGGCCCCTCTGCTGTGCCCCTATGCCCTG
TGTGGGCCCAACCAGTGGACAATGGAGTCTGGGGGAGGGGGAACCCCGGGGACATGCCCCCACCCGGGAGGGGCCGGTAACCCCTGGGCT
ATCTTCTAGACGGGGCGAACCAGGGGTCATTGACCTGCCCCCTGCACAGGGCAGGGACCGAGTGAGCCACTCCTTGTCCCGAGCTCCCGC
CCCCACTGGGCCCTCCTTCCTCCTGGTGCTAATTTGGGGACCCCAGGGGCCGCCCCCGGCCTCTTCTCCATCCTGCTTGGACCAGGGTCC
TGGGTCTTCCCAACCATACCCCGAGATCAGGCCCCACCTGCCAGCTCTACTGGGCTTGGAGCACGTCCGGGCAGTGGAGGGAGGGACACA
GCCTGGGACAGGAAGCCTCTTGGGTTGGAGCAGGAGACCCTCATTTGCCACCCAGACCAATGTGAGCCTGCCCCCAGCCCCCTCTCATTG
GAAGTGGCAAGGGGCTTCCCTCCTGGGGGCAGCTACACTCGTCCCCAGAGGCACATTCGTGCACATTCTCACAGACACCGTCTCACACGT
TGGCTTTGGACAACCAGGCCCCAACTTGGTCCCTGCCCTAGGGACCTCCAGCCTGGTGCCCAGTGCTCAGGCCACCTCCTGGTCCAGTCA
CCACCTGCAGCCTCGGCAGGGCAGGTACAGGGGCCACCTCAGATGGGAGCCTGGGTCCCTGCCTCCGCTCTGCCCCTGGGTGGCTGGGAG
GAGAGGCCCTCTCGGGGGTGACCTGGGCGTCAGCCGTGGAACCCCCTCCTCCTCCCTGGAGTCTGCCTGAGTCCCTCGAGCCGCGAGCCT
TCGCTGAAGTGCCCTTGCTATAACCCCCTCTGCTTCTGGTGTGTGACGAGGCCCCCGATGTTCTTGATTTTCCCAGAGAAGCAAATAAAC

>11167_11167_1_C19orf24-PALM_C19orf24_chr19_1275829_ENST00000409293_PALM_chr19_726138_ENST00000264560_length(amino acids)=451AA_BP=109
MTARIGAGRRHRFRRAMGPRVLQPPLLLLLLALLLAALPCGAEEASPLRPAQVTLSPPPAVTNGSQPGAPHNSTHTRPPGASGSALTRSF
YVILGFCGLTALYFLIRAFRVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDLRR
QMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGS
PMMKAVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEP
PVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSI

--------------------------------------------------------------
>11167_11167_2_C19orf24-PALM_C19orf24_chr19_1275829_ENST00000409293_PALM_chr19_726138_ENST00000338448_length(transcript)=3478nt_BP=804nt
CGGCCGCGCAGCCGCTGTCAGGCCCCGTCTTGGGCCGAGTCCCGGGTTCCCTGTAGCAGGCTTGGGAGCGGGGCGCCACCTTCCTGGGCC
CTGGACGTGGCCGACGCGTTCTCAGTGTCCGTGAGGCCGGGGCAGGAGTGGCGGGGGTCGCCCCGAAGTGGGTGGGAATGAGCGGCCCGA
GGTCCTGAAGTCGGGGTCCGCCCCGTCTCCCCGCTGCCAGCCCGATTTCCTCGGAAGCCGCGACCCCCCACGCTGGGCTGGCAGTTCTGG
GCTCTGCCGGCTGCGCCTTGCCGGGACTCCCACGGGCGGGCTCCGGGCCTCCGTCCTGATCCCTTGGAGCGGTTCGACGAAGCAAGTTCC
GCGGCGGGCGCGCGGGGCACTGTGGGTAGCGCCGGGGCTCACCAGGCGGAGGCGGGGCCCGGCGTCAAGCTCCGCCTCCGCGCCCCATTG
GCTGGCATCACCTCCGCGCGCCTGACTGACAGCGCGCATAGGGGCGGGGCGCCGCCACCGCTTCCGCCGGGCCATGGGGCCGCGCGTGCT
GCAGCCGCCGCTGCTGCTGCTCCTGCTGGCGCTGCTGCTGGCGGCGCTGCCGTGCGGTGCCGAAGAGGCCTCGCCGCTGCGCCCCGCGCA
GGTCACGTTGTCGCCGCCGCCGGCCGTGACGAACGGGAGCCAGCCGGGCGCGCCACACAACAGCACGCACACGCGTCCGCCGGGGGCGTC
GGGCTCGGCGCTGACGCGCTCCTTCTACGTGATCCTGGGCTTCTGCGGCCTGACCGCGCTCTACTTCCTGATCCGGGCGTTTAGGGTCCT
GGCGGCAGAGACCACGTCCCAGCAGGAGCGGCTGCAGGCCATCGCAGAGAAGCGGAAGCGGCAGGCGGAGATCGAGAACAAGCGCCGGCA
GCTGGAGGACGAGCGGAGGCAGCTGCAGCACCTGAAGTCCAAGGCACTGCGGGAGCGCTGGCTGCTGGAGGGGACGCCGTCCTCGGCCTC
AGAGGGGGATGAGGACCTGAGGAGGCAGATGCAGGACGACGAGCAGAAGACACGGCTGCTGGAGGACTCGGTGTCCAGGTTGGAGAAGGA
AATTGAGGTGCTGGAGCGTGGAGACTCCGCCCCAGCCACTGCCAAGGAGAACGCGGCGGCCCCGAGCCCAGTCCGGGCCCCAGCCCCGAG
TCCAGCCAAGGAGGAGCGCAAGACAGAGGTGGTGATGAATTCACAGCAGACGCCGGTGGGCACGCCCAAAGACAAGCGAGTCTCCAACAC
GCCCCTGAGGACGGTTGACGGCTCCCCCATGATGAAGGCAGCCATGTACTCGGTTGAGATCACTGTGGAGAAGGACAAGGTGACAGGGGA
GACCAGGGTGCTGTCCAGCACCACGCTGCTCCCTCGGCAGCCGCTCCCTCTGGGCATCAAAGTCTACGAGGACGAGACCAAAGTGGTCCA
TGCTGTGGACGGCACCGCCGAGAACGGGATCCACCCCCTGAGCTCCTCCGAGGTGGACGAACTCATCCACAAAGCGGACGAGGTCACGCT
GAGCGAGGCAGGGTCCACGGCCGGGGCGGCAGAGACCCGGGGGGCTGTGGAGGGGGCAGCCCGGACCACGCCCTCCCGGCGGGAGATCAC
CGGTGTGCAGGCACAGCCAGGCGAGGCCACGTCCGGCCCGCCGGGGATCCAGCCCGGCCAGGAGCCCCCGGTCACAATGATCTTCATGGG
TTACCAGAACGTGGAGGATGAGGCCGAGACCAAGAAGGTGCTGGGCCTTCAAGATACCATCACGGCGGAGCTGGTGGTCATCGAAGACGC
GGCTGAGCCCAAGGAGCCTGCACCACCCAACGGCAGTGCTGCCGAGCCTCCCACGGAGGCCGCCTCCAGGGAAGAGAATCAGGCGGGGCC
CGAGGCCACCACCAGCGACCCCCAGGACCTCGACATGAAGAAGCACCGTTGTAAATGCTGCTCCATCATGTGAGCCGGCCCCCGAGACCC
CGGCCCCCACCCCACACCACAGACACCCACCAGCCCGGCCCCTCCCGGCGCCTGCCCACCCTCCACCCACAGCCTCACGGGTCCAGGACT
TGGCGTGTTGTTACATGTTCCTTCCGAGTTTTCTTTCGCTGGAAAGAGGGACAGGGGCCCCCACCCGTCACCACGCCCCAACACTCCCCC
CGAACCAGAGCCGTGCACTTGTGCCTGGTAGGAGAGAGACAGGACAGACCCGCTTTTCCCGAGACAAGGACCCCCCATGTCACGGCAGCT
TCACAGACGCGGCTCGCGCCCACCGGGGTCCTGGCGGGTGGGACCCGCAGCCTCCACGCGGCCCAGGCCAGCCTGCCACCCTCTGGGCCT
CCTACCTGTGCCTTTCTCTGAGGGGACACCCCGCCAGAGAGGGCCCCGGGAGCCGGGGGTGGGTACTGAGGCCTGCTCAGGCCCTGGAAG
TGAGGCTCTATGGGGTTCCCTGGCCAAGGCGCTGGCCCCCCAATCTCAGGCAGTTGGGGTGAGGCCGTGCCTCTTTGGGGGCTAAAGGTC
TTGGGTGGAGGACAGGCCCCTCTGCTGTGCCCCTATGCCCTGTGTGGGCCCAACCAGTGGACAATGGAGTCTGGGGGAGGGGGAACCCCG
GGGACATGCCCCCACCCGGGAGGGGCCGGTAACCCCTGGGCTATCTTCTAGACGGGGCGAACCAGGGGTCATTGACCTGCCCCCTGCACA
GGGCAGGGACCGAGTGAGCCACTCCTTGTCCCGAGCTCCCGCCCCCACTGGGCCCTCCTTCCTCCTGGTGCTAATTTGGGGACCCCAGGG
GCCGCCCCCGGCCTCTTCTCCATCCTGCTTGGACCAGGGTCCTGGGTCTTCCCAACCATACCCCGAGATCAGGCCCCACCTGCCAGCTCT
ACTGGGCTTGGAGCACGTCCGGGCAGTGGAGGGAGGGACACAGCCTGGGACAGGAAGCCTCTTGGGTTGGAGCAGGAGACCCTCATTTGC
CACCCAGACCAATGTGAGCCTGCCCCCAGCCCCCTCTCATTGGAAGTGGCAAGGGGCTTCCCTCCTGGGGGCAGCTACACTCGTCCCCAG
AGGCACATTCGTGCACATTCTCACAGACACCGTCTCACACGTTGGCTTTGGACAACCAGGCCCCAACTTGGTCCCTGCCCTAGGGACCTC
CAGCCTGGTGCCCAGTGCTCAGGCCACCTCCTGGTCCAGTCACCACCTGCAGCCTCGGCAGGGCAGGTACAGGGGCCACCTCAGATGGGA
GCCTGGGTCCCTGCCTCCGCTCTGCCCCTGGGTGGCTGGGAGGAGAGGCCCTCTCGGGGGTGACCTGGGCGTCAGCCGTGGAACCCCCTC
CTCCTCCCTGGAGTCTGCCTGAGTCCCTCGAGCCGCGAGCCTTCGCTGAAGTGCCCTTGCTATAACCCCCTCTGCTTCTGGTGTGTGACG

>11167_11167_2_C19orf24-PALM_C19orf24_chr19_1275829_ENST00000409293_PALM_chr19_726138_ENST00000338448_length(amino acids)=495AA_BP=109
MTARIGAGRRHRFRRAMGPRVLQPPLLLLLLALLLAALPCGAEEASPLRPAQVTLSPPPAVTNGSQPGAPHNSTHTRPPGASGSALTRSF
YVILGFCGLTALYFLIRAFRVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDLRR
QMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGS
PMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAG
AAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C19orf24-PALM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf24-PALM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf24-PALM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource