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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf25-MED1 (FusionGDB2 ID:11172)

Fusion Gene Summary for C19orf25-MED1

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf25-MED1
Fusion gene ID: 11172
HgeneTgene
Gene symbol

C19orf25

MED1

Gene ID

148223

8930

Gene namechromosome 19 open reading frame 25methyl-CpG binding domain 4, DNA glycosylase
Synonyms-MED1
Cytomap

19p13.3

3q21.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0449 protein C19orf25methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth
Modification date2020031320200313
UniProtAcc.

A0JLT2

Ensembl transtripts involved in fusion geneENST00000591027, ENST00000436106, 
ENST00000586564, ENST00000588427, 
ENST00000588849, ENST00000588871, 
ENST00000592872, ENST00000585675, 
ENST00000427685, 		ENST00000300651, 
ENST00000394287, 
Fusion gene scores* DoF score10 X 4 X 9=3609 X 8 X 5=360
# samples 1210
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf25 [Title/Abstract] AND MED1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf25(1478773)-MED1(37604157), # samples:3
Anticipated loss of major functional domain due to fusion event.C19orf25-MED1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C19orf25-MED1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
C19orf25-MED1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C19orf25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0EY-01AC19orf25chr19

1478773

-MED1chr17

37604157

-
ChimerDB4BRCATCGA-A2-A0EYC19orf25chr19

1478772

-MED1chr17

37604157

-


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Fusion Gene ORF analysis for C19orf25-MED1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000591027ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
5UTR-3CDSENST00000591027ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
5UTR-3CDSENST00000591027ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
5UTR-3CDSENST00000591027ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000436106ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000436106ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000436106ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000436106ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000586564ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000586564ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000586564ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000586564ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588427ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588427ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588427ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588427ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588849ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588849ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588849ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588849ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588871ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588871ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000588871ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000588871ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000592872ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000592872ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
Frame-shiftENST00000592872ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
Frame-shiftENST00000592872ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
In-frameENST00000585675ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
In-frameENST00000585675ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
In-frameENST00000585675ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
In-frameENST00000585675ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-
intron-3CDSENST00000427685ENST00000300651C19orf25chr19

1478773

-MED1chr17

37604157

-
intron-3CDSENST00000427685ENST00000300651C19orf25chr19

1478772

-MED1chr17

37604157

-
intron-3CDSENST00000427685ENST00000394287C19orf25chr19

1478773

-MED1chr17

37604157

-
intron-3CDSENST00000427685ENST00000394287C19orf25chr19

1478772

-MED1chr17

37604157

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585675C19orf25chr191478773-ENST00000394287MED1chr1737604157-2813174441819591
ENST00000585675C19orf25chr191478773-ENST00000300651MED1chr1737604157-57691744448941616
ENST00000585675C19orf25chr191478772-ENST00000394287MED1chr1737604157-2813174441819591
ENST00000585675C19orf25chr191478772-ENST00000300651MED1chr1737604157-57691744448941616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585675ENST00000394287C19orf25chr191478773-MED1chr1737604157-0.0009684690.99903154
ENST00000585675ENST00000300651C19orf25chr191478773-MED1chr1737604157-0.0007338240.9992662
ENST00000585675ENST00000394287C19orf25chr191478772-MED1chr1737604157-0.0009684690.99903154
ENST00000585675ENST00000300651C19orf25chr191478772-MED1chr1737604157-0.0007338240.9992662

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Fusion Genomic Features for C19orf25-MED1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C19orf25-MED1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1478773/chr17:37604157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MED1

A0JLT2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMED1chr19:1478772chr17:37604157ENST000003006510171078_148281582.0Compositional biasNote=Ser-rich
TgeneMED1chr19:1478772chr17:37604157ENST000003006510171496_152981582.0Compositional biasNote=Lys-rich
TgeneMED1chr19:1478772chr17:37604157ENST000003942870181078_14828557.0Compositional biasNote=Ser-rich
TgeneMED1chr19:1478772chr17:37604157ENST000003942870181496_15298557.0Compositional biasNote=Lys-rich
TgeneMED1chr19:1478773chr17:37604157ENST000003006510171078_148281582.0Compositional biasNote=Ser-rich
TgeneMED1chr19:1478773chr17:37604157ENST000003006510171496_152981582.0Compositional biasNote=Lys-rich
TgeneMED1chr19:1478773chr17:37604157ENST000003942870181078_14828557.0Compositional biasNote=Ser-rich
TgeneMED1chr19:1478773chr17:37604157ENST000003942870181496_15298557.0Compositional biasNote=Lys-rich
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017604_60881582.0MotifNote=LXXLL motif 1
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017645_64981582.0MotifNote=LXXLL motif 2
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017875_90281582.0MotifIntegrase domain-binding motif (IBM)
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018604_6088557.0MotifNote=LXXLL motif 1
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018645_6498557.0MotifNote=LXXLL motif 2
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018875_9028557.0MotifIntegrase domain-binding motif (IBM)
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017604_60881582.0MotifNote=LXXLL motif 1
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017645_64981582.0MotifNote=LXXLL motif 2
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017875_90281582.0MotifIntegrase domain-binding motif (IBM)
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018604_6088557.0MotifNote=LXXLL motif 1
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018645_6498557.0MotifNote=LXXLL motif 2
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018875_9028557.0MotifIntegrase domain-binding motif (IBM)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC19orf25chr19:1478772chr17:37604157ENST00000436106-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478772chr17:37604157ENST00000585675-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478772chr17:37604157ENST00000586564-1281_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478772chr17:37604157ENST00000592872-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr17:37604157ENST00000436106-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr17:37604157ENST00000585675-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr17:37604157ENST00000586564-1281_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr17:37604157ENST00000592872-2381_10943119.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for C19orf25-MED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11172_11172_1_C19orf25-MED1_C19orf25_chr19_1478772_ENST00000585675_MED1_chr17_37604157_ENST00000300651_length(transcript)=5769nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGAGTCAG
AAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGC
GTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAG
TAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAAT
GTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGA
ATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGT
ATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGT
ACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGA
ACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTT
TGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTG
ACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAA
TCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATG
AACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGC
AGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACC
CTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGA
AAGAAGATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGGTATGGCATGA
CCACAGGCAACAACCCAATGAGTGGTACCACTACACCAACCAACACCTTTCCGGGGGGTCCCATTACCACCTTGTTTAATATGAGCATGA
GCATCAAAGATCGGCATGAGTCGGTGGGCCATGGGGAGGACTTCAGCAAGGTGTCTCAGAACCCAATTCTTACCAGTTTGTTGCAAATCA
CAGGGAACGGGGGGTCTACCATTGGCTCGAGTCCGACCCCTCCTCATCACACGCCGCCACCTGTCTCTTCGATGGCCGGCAACACCAAGA
ACCACCCGATGCTCATGAACCTTCTTAAAGATAATCCTGCCCAGGATTTCTCAACCCTTTATGGAAGCAGCCCTTTAGAAAGGCAGAACT
CCTCTTCCGGCTCACCCCGCATGGAAATATGCTCGGGGAGCAACAAGACCAAGAAAAAGAAGTCATCAAGATTACCACCTGAGAAACCAA
AGCACCAGACTGAAGATGACTTTCAGAGGGAGCTATTTTCAATGGATGTTGACTCACAGAACCCTATCTTTGATGTCAACATGACAGCTG
ACACGCTGGATACGCCACACATCACTCCAGCTCCAAGCCAGTGTAGCACTCCCCCAACAACTTACCCACAACCAGTACCTCACCCCCAAC
CCAGTATTCAAAGGATGGTCCGACTATCCAGTTCAGACAGCATTGGCCCAGATGTAACTGACATCCTTTCAGACATTGCAGAAGAAGCTT
CTAAACTTCCCAGCACTAGTGATGATTGCCCAGCCATTGGCACCCCTCTTCGAGATTCTTCAAGCTCTGGGCATTCTCAGAGTACCCTGT
TTGACTCTGATGTCTTTCAAACTAACAATAATGAAAATCCATACACTGATCCAGCTGATCTTATTGCAGATGCTGCTGGAAGCCCCAGTA
GTGACTCTCCTACCAATCATTTTTTTCATGATGGAGTAGATTTCAATCCTGATTTATTGAACAGCCAGAGCCAAAGTGGTTTTGGAGAAG
AATATTTTGATGAAAGCAGCCAAAGTGGGGATAATGATGATTTCAAAGGATTTGCATCTCAGGCACTAAATACTTTGGGGGTGCCAATGC
TTGGAGGTGATAATGGGGAGACCAAGTTTAAGGGCAATAACCAAGCCGACACAGTTGATTTCAGTATTATTTCAGTAGCCGGCAAAGCTT
TAGCTCCTGCAGATCTTATGGAGCATCACAGTGGTAGTCAGGGTCCTTTACTGACCACTGGGGACTTAGGGAAAGAAAAGACTCAAAAGA
GGGTAAAGGAAGGCAATGGCACCAGTAATAGTACTCTCTCGGGGCCCGGATTAGACAGCAAACCAGGGAAGCGCAGTCGGACCCCTTCTA
ATGATGGGAAAAGCAAAGATAAGCCTCCAAAGCGGAAGAAGGCAGACACTGAGGGAAAGTCTCCATCTCATAGTTCTTCTAACAGACCTT
TTACCCCACCTACCAGTACAGGTGGATCTAAATCGCCAGGCAGTGCAGGAAGATCTCAGACTCCCCCAGGTGTTGCCACACCACCCATTC
CCAAAATCACTATTCAGATTCCTAAGGGAACAGTGATGGTGGGCAAGCCTTCCTCTCACAGTCAGTATACCAGCAGTGGTTCTGTGTCTT
CCTCAGGCAGCAAAAGCCACCATAGCCATTCTTCCTCCTCTTCCTCATCTGCTTCCACCTCAGGGAAGATGAAAAGCAGTAAATCAGAAG
GTTCATCAAGTTCCAAGTTAAGTAGCAGTATGTATTCTAGCCAGGGGTCTTCTGGATCTAGCCAGTCCAAAAATTCATCCCAGTCTGGGG
GGAAGCCAGGCTCCTCTCCCATAACCAAGCATGGACTGAGCAGTGGCTCTAGCAGCACCAAGATGAAACCTCAAGGAAAGCCATCATCAC
TTATGAATCCTTCTTTAAGTAAACCAAACATATCCCCTTCTCATTCAAGGCCACCTGGAGGCTCTGACAAGCTTGCCTCTCCAATGAAGC
CTGTTCCTGGAACTCCTCCATCCTCTAAAGCCAAGTCCCCTATCAGTTCAGGTTCTGGTGGTTCTCATATGTCTGGAACTAGTTCAAGCT
CTGGCATGAAGTCATCTTCAGGGTTAGGATCCTCAGGCTCGTTGTCCCAGAAAACTCCCCCATCATCTAATTCCTGTACGGCATCTTCCT
CCTCCTTTTCCTCAAGTGGCTCTTCCATGTCATCCTCTCAGAACCAGCATGGGAGTTCTAAAGGAAAATCTCCCAGCAGAAACAAGAAGC
CGTCCTTGACAGCTGTCATAGATAAACTGAAGCATGGGGTTGTCACCAGTGGCCCTGGGGGTGAAGACCCACTGGACGGCCAGATGGGGG
TGAGCACAAATTCTTCCAGCCATCCTATGTCCTCCAAACATAACATGTCAGGAGGAGAGTTTCAGGGCAAGCGTGAGAAAAGTGATAAAG
ACAAATCAAAGGTTTCCACCTCCGGGAGTTCAGTGGATTCTTCTAAGAAGACCTCAGAGTCAAAAAATGTGGGGAGCACAGGTGTGGCAA
AAATTATCATCAGTAAGCATGATGGAGGCTCCCCTAGCATTAAAGCCAAAGTGACTTTGCAGAAACCTGGGGAAAGTAGTGGAGAAGGGC
TTAGGCCTCAAATGGCTTCTTCTAAAAACTATGGCTCTCCACTCATCAGTGGTTCCACTCCAAAGCATGAGCGTGGCTCTCCCAGCCATA
GTAAGTCACCAGCATATACCCCCCAGAATCTGGACAGTGAAAGTGAGTCAGGCTCCTCCATAGCAGAGAAATCTTATCAGAATAGTCCCA
GCTCAGACGATGGTATCCGACCACTTCCAGAATACAGCACAGAGAAACATAAGAAGCACAAAAAGGAAAAGAAGAAAGTAAAAGACAAAG
ATAGGGACCGAGACCGGGACAAAGACCGAGACAAGAAAAAATCTCATAGCATCAAGCCAGAGAGTTGGTCCAAATCACCCATCTCTTCAG
ACCAGTCCTTGTCTATGACAAGTAACACAATCTTATCTGCAGACAGACCCTCAAGGCTCAGCCCAGACTTTATGATTGGGGAGGAAGATG
ATGATCTTATGGATGTGGCCCTGATTGGGAATTAGGAACCTTATTTCCTAAAAGAAACAGGGCCAGAGGAAAAAAAACTATTGATAAGTT
TATAGGCAAACCACCATAAGGGGTGAGTCAGACAGGTCTGATTTGGTTAAGAATCCTAAATGGCATGGCTTTGACATCAAGCTGGGTGAA
TTAGAAAGGCATATCCAGACCCTATTAAAGAAACCACAGGGTTTGATTCTGGTTACCAGGAAGTCTTCTTTGTTCCTGTGCCAGAAAGAA
AGTTAAAATACTTGCTTAAGAAAGGGAGGGGGGTGGGAGGGGTGTAGGGAGAGGGAAGGGAGGGAAACAGTTTTGTGGGAAATATTCATA
TATATTTTCTTCTCCCTTTTTCCATTTTTAGGCCATGTTTTAAACTCATTTTAGTGCATGTATATGAAGGGCTGGGCAGAAAATGAAAAA
GCAATACATTCCTTGATGCATTTGCATGAAGGTTGTTCAACTTTGTTTGAGGTAGTTGTCCGTTTGAGTCATGGGCAAATGAAGGACTTT
GGTCATTTTGGACACTTAAGTAATGTTTGGTGTCTGTTTCTTAGGAGTGACTGGGGGAGGGAAGATTATTTTAGCTATTTATTTGTAATA
TTTTAACCCTTTATCTGTTTGTTTTTATACAGTGTTTCGTTCTAAATCTATGAGGTTTAGGGTTCAAAATGATGGAAGGCCGAAGAGCAA
GGCTTATATGGTGGTAGGGAGCTTATAGCTTGTGCTAATACTGTAGCATCAAGCCCAAGCAAATTAGTCAGAGCCCGCCTTTAGAGTTAA
ATATAATAGAAAAACCAAAATGATATTTTTATTTTAGGAGGGTTTAAATAGGGTTCAGAGATCATAGGAATATTAGGAGTTACCTCTCTG

>11172_11172_1_C19orf25-MED1_C19orf25_chr19_1478772_ENST00000585675_MED1_chr17_37604157_ENST00000300651_length(amino acids)=1616AA_BP=43
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGH
QHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREK
NFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDK
TASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCT
GIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQV
AYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIP
VTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDF
SKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSN
KTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSI
GPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDF
NPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQG
PLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGS
AGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQ
GSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPI
SSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVV
TSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIK
AKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTE

--------------------------------------------------------------
>11172_11172_2_C19orf25-MED1_C19orf25_chr19_1478772_ENST00000585675_MED1_chr17_37604157_ENST00000394287_length(transcript)=2813nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGAGTCAG
AAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGC
GTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAG
TAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAAT
GTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGA
ATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGT
ATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGT
ACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGA
ACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTT
TGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTG
ACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAA
TCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATG
AACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGC
AGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACC
CTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGA
AAGAAGATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGATCAAAGAATC
CCGAGTTAGGATCTGGATGAAGGATAAGCCCCTGAATTGTCGATGGGCTCACCCCCACACTGACCCAGCATCTGAACTTGCTTAACAGGG
AGCCGGGGCTAAACTGCTTCACCCTGCCTGAGAACCAGGGAGCACTGCATTTCTCCACAGGGTGGAGGAGAAGAGGCAGAATAAACCAAG
CCTGGGACACCTCCCTCCTGTCTAGGTGTACTCATTCTTCTGTTTCAAAAGAAGGCAAGGACATGAAGTCAACTTCTACCTATCTTCTGC
TGCTGGTGTCTTATGTATTCTCAGTTTGACCTGATTCCTCTTCTGTCTTTTGACTTAACATTAGGGGTTCTTGGTCATAACCTGCTCTGA
TGTACATAAAGATTTCAGGTTCAATATCAATGTGTCTTAAAACAGAAGTATTTTAGCGGGTGGGGGGTGGGGTGGTGGGGACAAACAACG
CAGGATATAATTGCCAAAACCAGGCTTGAGGTTGGTGACTCTTGAAAGATTTTCTTTCTTCAGGCCTAGATCAGAAAATTAAGTGCAGCA
ATATCATGAATTCTCAGAAGCCCTTTCAGGGAGCCAGTGAGTCATACAGTATCCACAGTTGAGTCACTTAAAGATGTCAGTATACGAAAC
ATTATTCACAATCCTTGGGCAATCTCATTTTTTTTTCCTTCTCCCCTCCTCCCCTGCCCCCCATACATTTCTATCCTTGAGTTAGTTTTG
GAGGGGCAGGAAGTACTTAACATCTCAGAAGCTAGATTGGGAAACATGCTCAGCTATAAGAACTGAGCTTTAAATTTTGAGTTTAAAAAT
GTACATCAGGAGCAGCTGGGGAGGGTCTTTTTTTAAAAAAATCTTTCAAATTTGGTTTTCTGTGCATATGGCCGTTTTGTAAATACTTTG
GGGTTTTTCATTTTTTTGAAAGTAGATGAAATCTGTTGTGGGATTTTTTTCCCGAAACATTACAAAATAACCTGTTTATTTACATGCAAA

>11172_11172_2_C19orf25-MED1_C19orf25_chr19_1478772_ENST00000585675_MED1_chr17_37604157_ENST00000394287_length(amino acids)=591AA_BP=43
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGH
QHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREK
NFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDK
TASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCT
GIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQV
AYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIP

--------------------------------------------------------------
>11172_11172_3_C19orf25-MED1_C19orf25_chr19_1478773_ENST00000585675_MED1_chr17_37604157_ENST00000300651_length(transcript)=5769nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGAGTCAG
AAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGC
GTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAG
TAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAAT
GTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGA
ATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGT
ATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGT
ACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGA
ACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTT
TGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTG
ACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAA
TCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATG
AACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGC
AGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACC
CTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGA
AAGAAGATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGGTATGGCATGA
CCACAGGCAACAACCCAATGAGTGGTACCACTACACCAACCAACACCTTTCCGGGGGGTCCCATTACCACCTTGTTTAATATGAGCATGA
GCATCAAAGATCGGCATGAGTCGGTGGGCCATGGGGAGGACTTCAGCAAGGTGTCTCAGAACCCAATTCTTACCAGTTTGTTGCAAATCA
CAGGGAACGGGGGGTCTACCATTGGCTCGAGTCCGACCCCTCCTCATCACACGCCGCCACCTGTCTCTTCGATGGCCGGCAACACCAAGA
ACCACCCGATGCTCATGAACCTTCTTAAAGATAATCCTGCCCAGGATTTCTCAACCCTTTATGGAAGCAGCCCTTTAGAAAGGCAGAACT
CCTCTTCCGGCTCACCCCGCATGGAAATATGCTCGGGGAGCAACAAGACCAAGAAAAAGAAGTCATCAAGATTACCACCTGAGAAACCAA
AGCACCAGACTGAAGATGACTTTCAGAGGGAGCTATTTTCAATGGATGTTGACTCACAGAACCCTATCTTTGATGTCAACATGACAGCTG
ACACGCTGGATACGCCACACATCACTCCAGCTCCAAGCCAGTGTAGCACTCCCCCAACAACTTACCCACAACCAGTACCTCACCCCCAAC
CCAGTATTCAAAGGATGGTCCGACTATCCAGTTCAGACAGCATTGGCCCAGATGTAACTGACATCCTTTCAGACATTGCAGAAGAAGCTT
CTAAACTTCCCAGCACTAGTGATGATTGCCCAGCCATTGGCACCCCTCTTCGAGATTCTTCAAGCTCTGGGCATTCTCAGAGTACCCTGT
TTGACTCTGATGTCTTTCAAACTAACAATAATGAAAATCCATACACTGATCCAGCTGATCTTATTGCAGATGCTGCTGGAAGCCCCAGTA
GTGACTCTCCTACCAATCATTTTTTTCATGATGGAGTAGATTTCAATCCTGATTTATTGAACAGCCAGAGCCAAAGTGGTTTTGGAGAAG
AATATTTTGATGAAAGCAGCCAAAGTGGGGATAATGATGATTTCAAAGGATTTGCATCTCAGGCACTAAATACTTTGGGGGTGCCAATGC
TTGGAGGTGATAATGGGGAGACCAAGTTTAAGGGCAATAACCAAGCCGACACAGTTGATTTCAGTATTATTTCAGTAGCCGGCAAAGCTT
TAGCTCCTGCAGATCTTATGGAGCATCACAGTGGTAGTCAGGGTCCTTTACTGACCACTGGGGACTTAGGGAAAGAAAAGACTCAAAAGA
GGGTAAAGGAAGGCAATGGCACCAGTAATAGTACTCTCTCGGGGCCCGGATTAGACAGCAAACCAGGGAAGCGCAGTCGGACCCCTTCTA
ATGATGGGAAAAGCAAAGATAAGCCTCCAAAGCGGAAGAAGGCAGACACTGAGGGAAAGTCTCCATCTCATAGTTCTTCTAACAGACCTT
TTACCCCACCTACCAGTACAGGTGGATCTAAATCGCCAGGCAGTGCAGGAAGATCTCAGACTCCCCCAGGTGTTGCCACACCACCCATTC
CCAAAATCACTATTCAGATTCCTAAGGGAACAGTGATGGTGGGCAAGCCTTCCTCTCACAGTCAGTATACCAGCAGTGGTTCTGTGTCTT
CCTCAGGCAGCAAAAGCCACCATAGCCATTCTTCCTCCTCTTCCTCATCTGCTTCCACCTCAGGGAAGATGAAAAGCAGTAAATCAGAAG
GTTCATCAAGTTCCAAGTTAAGTAGCAGTATGTATTCTAGCCAGGGGTCTTCTGGATCTAGCCAGTCCAAAAATTCATCCCAGTCTGGGG
GGAAGCCAGGCTCCTCTCCCATAACCAAGCATGGACTGAGCAGTGGCTCTAGCAGCACCAAGATGAAACCTCAAGGAAAGCCATCATCAC
TTATGAATCCTTCTTTAAGTAAACCAAACATATCCCCTTCTCATTCAAGGCCACCTGGAGGCTCTGACAAGCTTGCCTCTCCAATGAAGC
CTGTTCCTGGAACTCCTCCATCCTCTAAAGCCAAGTCCCCTATCAGTTCAGGTTCTGGTGGTTCTCATATGTCTGGAACTAGTTCAAGCT
CTGGCATGAAGTCATCTTCAGGGTTAGGATCCTCAGGCTCGTTGTCCCAGAAAACTCCCCCATCATCTAATTCCTGTACGGCATCTTCCT
CCTCCTTTTCCTCAAGTGGCTCTTCCATGTCATCCTCTCAGAACCAGCATGGGAGTTCTAAAGGAAAATCTCCCAGCAGAAACAAGAAGC
CGTCCTTGACAGCTGTCATAGATAAACTGAAGCATGGGGTTGTCACCAGTGGCCCTGGGGGTGAAGACCCACTGGACGGCCAGATGGGGG
TGAGCACAAATTCTTCCAGCCATCCTATGTCCTCCAAACATAACATGTCAGGAGGAGAGTTTCAGGGCAAGCGTGAGAAAAGTGATAAAG
ACAAATCAAAGGTTTCCACCTCCGGGAGTTCAGTGGATTCTTCTAAGAAGACCTCAGAGTCAAAAAATGTGGGGAGCACAGGTGTGGCAA
AAATTATCATCAGTAAGCATGATGGAGGCTCCCCTAGCATTAAAGCCAAAGTGACTTTGCAGAAACCTGGGGAAAGTAGTGGAGAAGGGC
TTAGGCCTCAAATGGCTTCTTCTAAAAACTATGGCTCTCCACTCATCAGTGGTTCCACTCCAAAGCATGAGCGTGGCTCTCCCAGCCATA
GTAAGTCACCAGCATATACCCCCCAGAATCTGGACAGTGAAAGTGAGTCAGGCTCCTCCATAGCAGAGAAATCTTATCAGAATAGTCCCA
GCTCAGACGATGGTATCCGACCACTTCCAGAATACAGCACAGAGAAACATAAGAAGCACAAAAAGGAAAAGAAGAAAGTAAAAGACAAAG
ATAGGGACCGAGACCGGGACAAAGACCGAGACAAGAAAAAATCTCATAGCATCAAGCCAGAGAGTTGGTCCAAATCACCCATCTCTTCAG
ACCAGTCCTTGTCTATGACAAGTAACACAATCTTATCTGCAGACAGACCCTCAAGGCTCAGCCCAGACTTTATGATTGGGGAGGAAGATG
ATGATCTTATGGATGTGGCCCTGATTGGGAATTAGGAACCTTATTTCCTAAAAGAAACAGGGCCAGAGGAAAAAAAACTATTGATAAGTT
TATAGGCAAACCACCATAAGGGGTGAGTCAGACAGGTCTGATTTGGTTAAGAATCCTAAATGGCATGGCTTTGACATCAAGCTGGGTGAA
TTAGAAAGGCATATCCAGACCCTATTAAAGAAACCACAGGGTTTGATTCTGGTTACCAGGAAGTCTTCTTTGTTCCTGTGCCAGAAAGAA
AGTTAAAATACTTGCTTAAGAAAGGGAGGGGGGTGGGAGGGGTGTAGGGAGAGGGAAGGGAGGGAAACAGTTTTGTGGGAAATATTCATA
TATATTTTCTTCTCCCTTTTTCCATTTTTAGGCCATGTTTTAAACTCATTTTAGTGCATGTATATGAAGGGCTGGGCAGAAAATGAAAAA
GCAATACATTCCTTGATGCATTTGCATGAAGGTTGTTCAACTTTGTTTGAGGTAGTTGTCCGTTTGAGTCATGGGCAAATGAAGGACTTT
GGTCATTTTGGACACTTAAGTAATGTTTGGTGTCTGTTTCTTAGGAGTGACTGGGGGAGGGAAGATTATTTTAGCTATTTATTTGTAATA
TTTTAACCCTTTATCTGTTTGTTTTTATACAGTGTTTCGTTCTAAATCTATGAGGTTTAGGGTTCAAAATGATGGAAGGCCGAAGAGCAA
GGCTTATATGGTGGTAGGGAGCTTATAGCTTGTGCTAATACTGTAGCATCAAGCCCAAGCAAATTAGTCAGAGCCCGCCTTTAGAGTTAA
ATATAATAGAAAAACCAAAATGATATTTTTATTTTAGGAGGGTTTAAATAGGGTTCAGAGATCATAGGAATATTAGGAGTTACCTCTCTG

>11172_11172_3_C19orf25-MED1_C19orf25_chr19_1478773_ENST00000585675_MED1_chr17_37604157_ENST00000300651_length(amino acids)=1616AA_BP=43
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGH
QHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREK
NFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDK
TASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCT
GIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQV
AYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIP
VTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDF
SKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSN
KTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSI
GPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDF
NPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQG
PLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGS
AGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQ
GSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPI
SSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVV
TSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIK
AKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTE

--------------------------------------------------------------
>11172_11172_4_C19orf25-MED1_C19orf25_chr19_1478773_ENST00000585675_MED1_chr17_37604157_ENST00000394287_length(transcript)=2813nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGAGTCAG
AAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGC
GTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAG
TAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAAT
GTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGA
ATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGT
ATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGT
ACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGA
ACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTT
TGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTG
ACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAA
TCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATG
AACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGC
AGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACC
CTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGA
AAGAAGATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGATCAAAGAATC
CCGAGTTAGGATCTGGATGAAGGATAAGCCCCTGAATTGTCGATGGGCTCACCCCCACACTGACCCAGCATCTGAACTTGCTTAACAGGG
AGCCGGGGCTAAACTGCTTCACCCTGCCTGAGAACCAGGGAGCACTGCATTTCTCCACAGGGTGGAGGAGAAGAGGCAGAATAAACCAAG
CCTGGGACACCTCCCTCCTGTCTAGGTGTACTCATTCTTCTGTTTCAAAAGAAGGCAAGGACATGAAGTCAACTTCTACCTATCTTCTGC
TGCTGGTGTCTTATGTATTCTCAGTTTGACCTGATTCCTCTTCTGTCTTTTGACTTAACATTAGGGGTTCTTGGTCATAACCTGCTCTGA
TGTACATAAAGATTTCAGGTTCAATATCAATGTGTCTTAAAACAGAAGTATTTTAGCGGGTGGGGGGTGGGGTGGTGGGGACAAACAACG
CAGGATATAATTGCCAAAACCAGGCTTGAGGTTGGTGACTCTTGAAAGATTTTCTTTCTTCAGGCCTAGATCAGAAAATTAAGTGCAGCA
ATATCATGAATTCTCAGAAGCCCTTTCAGGGAGCCAGTGAGTCATACAGTATCCACAGTTGAGTCACTTAAAGATGTCAGTATACGAAAC
ATTATTCACAATCCTTGGGCAATCTCATTTTTTTTTCCTTCTCCCCTCCTCCCCTGCCCCCCATACATTTCTATCCTTGAGTTAGTTTTG
GAGGGGCAGGAAGTACTTAACATCTCAGAAGCTAGATTGGGAAACATGCTCAGCTATAAGAACTGAGCTTTAAATTTTGAGTTTAAAAAT
GTACATCAGGAGCAGCTGGGGAGGGTCTTTTTTTAAAAAAATCTTTCAAATTTGGTTTTCTGTGCATATGGCCGTTTTGTAAATACTTTG
GGGTTTTTCATTTTTTTGAAAGTAGATGAAATCTGTTGTGGGATTTTTTTCCCGAAACATTACAAAATAACCTGTTTATTTACATGCAAA

>11172_11172_4_C19orf25-MED1_C19orf25_chr19_1478773_ENST00000585675_MED1_chr17_37604157_ENST00000394287_length(amino acids)=591AA_BP=43
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGH
QHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREK
NFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDK
TASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCT
GIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQV
AYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIP

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Fusion Gene PPI Analysis for C19orf25-MED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMED1chr19:1478772chr17:37604157ENST0000030065101716_5908.3333333333333341582.0ESR1
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017656_10668.3333333333333341582.0ESR1
TgeneMED1chr19:1478772chr17:37604157ENST0000039428701816_5908.333333333333334557.0ESR1
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018656_10668.333333333333334557.0ESR1
TgeneMED1chr19:1478773chr17:37604157ENST0000030065101716_5908.3333333333333341582.0ESR1
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017656_10668.3333333333333341582.0ESR1
TgeneMED1chr19:1478773chr17:37604157ENST0000039428701816_5908.333333333333334557.0ESR1
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018656_10668.333333333333334557.0ESR1
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017681_7158.3333333333333341582.0GATA1
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018681_7158.333333333333334557.0GATA1
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017681_7158.3333333333333341582.0GATA1
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018681_7158.333333333333334557.0GATA1
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017622_7018.3333333333333341582.0PPARGC1A and THRA
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018622_7018.333333333333334557.0PPARGC1A and THRA
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017622_7018.3333333333333341582.0PPARGC1A and THRA
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018622_7018.333333333333334557.0PPARGC1A and THRA
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017108_2128.3333333333333341582.0the Mediator complex
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017215_3908.3333333333333341582.0the Mediator complex
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018108_2128.333333333333334557.0the Mediator complex
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018215_3908.333333333333334557.0the Mediator complex
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017108_2128.3333333333333341582.0the Mediator complex
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017215_3908.3333333333333341582.0the Mediator complex
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018108_2128.333333333333334557.0the Mediator complex
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018215_3908.333333333333334557.0the Mediator complex
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017405_6448.3333333333333341582.0THRA
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018405_6448.333333333333334557.0THRA
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017405_6448.3333333333333341582.0THRA
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018405_6448.333333333333334557.0THRA
TgeneMED1chr19:1478772chr17:37604157ENST000003006510171249_14218.3333333333333341582.0TP53
TgeneMED1chr19:1478772chr17:37604157ENST000003942870181249_14218.333333333333334557.0TP53
TgeneMED1chr19:1478773chr17:37604157ENST000003006510171249_14218.3333333333333341582.0TP53
TgeneMED1chr19:1478773chr17:37604157ENST000003942870181249_14218.333333333333334557.0TP53
TgeneMED1chr19:1478772chr17:37604157ENST00000300651017542_7898.3333333333333341582.0VDR
TgeneMED1chr19:1478772chr17:37604157ENST00000394287018542_7898.333333333333334557.0VDR
TgeneMED1chr19:1478773chr17:37604157ENST00000300651017542_7898.3333333333333341582.0VDR
TgeneMED1chr19:1478773chr17:37604157ENST00000394287018542_7898.333333333333334557.0VDR


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMED1chr19:1478772chr17:37604157ENST000003006510171_6708.3333333333333341582.0the Mediator complex and THRA
TgeneMED1chr19:1478772chr17:37604157ENST000003942870181_6708.333333333333334557.0the Mediator complex and THRA
TgeneMED1chr19:1478773chr17:37604157ENST000003006510171_6708.3333333333333341582.0the Mediator complex and THRA
TgeneMED1chr19:1478773chr17:37604157ENST000003942870181_6708.333333333333334557.0the Mediator complex and THRA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf25-MED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf25-MED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource