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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf33-SYNPO2 (FusionGDB2 ID:11193)

Fusion Gene Summary for C19orf33-SYNPO2

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf33-SYNPO2
Fusion gene ID: 11193
HgeneTgene
Gene symbol

C19orf33

SYNPO2

Gene ID

64073

171024

Gene namechromosome 19 open reading frame 33synaptopodin 2
SynonymsH2RSP|IMUP|IMUP-1|IMUP-2-
Cytomap

19q13.2

4q26

Type of geneprotein-codingprotein-coding
Descriptionimmortalization up-regulated proteinHAI-2 related small proteinhepatocyte growth factor activator inhibitor type 2-related small proteinimmortalization-upregulated proteinsynaptopodin-2genethonin-2myopodin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000588605, ENST00000301246, 
ENST00000307142, ENST00000429713, 
ENST00000434046, ENST00000448416, 
Fusion gene scores* DoF score1 X 1 X 1=111 X 11 X 4=484
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/484*10)=-2.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf33 [Title/Abstract] AND SYNPO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf33(38795326)-SYNPO2(119944584), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C19orf33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYNPO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4292C19orf33chr19

38795326

+SYNPO2chr4

119944584

+


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Fusion Gene ORF analysis for C19orf33-SYNPO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000588605ENST00000307142C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
3UTR-3CDSENST00000588605ENST00000429713C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
3UTR-3CDSENST00000588605ENST00000434046C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
3UTR-3CDSENST00000588605ENST00000448416C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
In-frameENST00000301246ENST00000307142C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
In-frameENST00000301246ENST00000429713C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
In-frameENST00000301246ENST00000434046C19orf33chr19

38795326

+SYNPO2chr4

119944584

+
In-frameENST00000301246ENST00000448416C19orf33chr19

38795326

+SYNPO2chr4

119944584

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301246C19orf33chr1938795326+ENST00000307142SYNPO2chr4119944584+729630210139821293
ENST00000301246C19orf33chr1938795326+ENST00000448416SYNPO2chr4119944584+1346302101568155
ENST00000301246C19orf33chr1938795326+ENST00000429713SYNPO2chr4119944584+725730210134781125
ENST00000301246C19orf33chr1938795326+ENST00000434046SYNPO2chr4119944584+372130210135261141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301246ENST00000307142C19orf33chr1938795326+SYNPO2chr4119944584+0.000136050.999864
ENST00000301246ENST00000448416C19orf33chr1938795326+SYNPO2chr4119944584+0.0071071770.99289286
ENST00000301246ENST00000429713C19orf33chr1938795326+SYNPO2chr4119944584+0.0002142550.9997857
ENST00000301246ENST00000434046C19orf33chr1938795326+SYNPO2chr4119944584+0.0011890470.998811

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Fusion Genomic Features for C19orf33-SYNPO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C19orf33chr1938795326+SYNPO2chr4119944584+9.55E-101
C19orf33chr1938795326+SYNPO2chr4119944584+9.55E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C19orf33-SYNPO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:38795326/chr4:119944584)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205400_405351262.0Compositional biasNote=Poly-Arg
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205423_426351262.0Compositional biasNote=Poly-Glu
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205591_658351262.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205756_818351262.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205767_770351262.0Compositional biasNote=Poly-Ser
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304400_405351094.0Compositional biasNote=Poly-Arg
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304423_426351094.0Compositional biasNote=Poly-Glu
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304591_658351094.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304756_818351094.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304767_770351094.0Compositional biasNote=Poly-Ser
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605400_405351110.0Compositional biasNote=Poly-Arg
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605423_426351110.0Compositional biasNote=Poly-Glu
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605591_658351110.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605756_818351110.0Compositional biasNote=Pro-rich
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605767_770351110.0Compositional biasNote=Poly-Ser
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205398_406351262.0MotifNuclear localization signal
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205619_622351262.0MotifPPPY motif
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304398_406351094.0MotifNuclear localization signal
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304619_622351094.0MotifPPPY motif
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605398_406351110.0MotifNuclear localization signal
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605619_622351110.0MotifPPPY motif
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205534_663351262.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205664_803351262.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205664_916351262.0RegionF-actin bundling activity
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205751_900351262.0RegionActin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304534_663351094.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304664_803351094.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304664_916351094.0RegionF-actin bundling activity
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304751_900351094.0RegionActin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605534_663351110.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605664_803351110.0RegionF-actin binding
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605664_916351110.0RegionF-actin bundling activity
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605751_900351110.0RegionActin binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000307142056_88351262.0DomainPDZ
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000429713046_88351094.0DomainPDZ
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000434046056_88351110.0DomainPDZ


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Fusion Gene Sequence for C19orf33-SYNPO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11193_11193_1_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000307142_length(transcript)=7296nt_BP=302nt
AGCATTCCTCCAACGGGCAGGTCTCAGCGCTCCTCCCCCTGCTCCGCTCCTCTGCAGGGCCCAGGCGCCCTTGGCCTTAGGACCCAACTT
CTCTTACCGCCATGGAGTTCGACCTGGGAGCAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGGCGGGCCACGGGGGAGATCCCA
AGCTCAGTCCCCACAAAGTTCAGGGCCGGTCGGAGGCAGGGGCAGGTCCGGGTCCAAAGCAAGGACACCACAGCTCTTCCGACTCCAGCA
GCAGCTCCAGCGATTCGGACACGGATGTGAAGATTCGAAATCAGAGCAAAGCCTCTGGGTCTGGGCTCTGTGAGGGAGATGAAGTGGTTT
CCATCAATGGCAACCCTTGTGCAGATCTCACCTACCCTGAAGTCATCAAGCTCATGGAAAGCATAACAGACTCTCTCCAAATGCTCATCA
AAAGACCATCCAGTGGAATAAGTGAGGCTTTGATATCTGAAAATGAAAACAAAAACCTCGAGCATCTCACACATGGGGGTTATGTGGAAA
GTACCACCCTGCAGATTCGACCGGCCACAAAGACCCAGTGCACAGAATTCTTCCTCGCCCCTGTCAAGACTGAAGTTCCCCTAGCTGAGA
ACCAAAGAAGTGGTCCCGACTGTGCAGGCAGCTTGAAAGAAGAAACAGGCCCGAGCTACCAAAGGGCTCCCCAAATGCCTGACTCCCAAA
GAGGACGCGTGGCAGAAGAGCTGATCTTAAGGGAGAAGGTAGAAGCGGTACAGCCTGGGCCTGTGGTTGAGCTGCAACTGTCCCTTTCAC
AGGAGAGACATAAGGGCGCTAGTGGCCCTTTAGTGGCTCTCCCGGGAGCTGAAAAATCTAAGTCTCCTGACCCAGACCCTAACTTGTCAC
ATGACAGGATTGTCCACATAAATTCGATCCCTACTAATGAGAAAGCAGACCCTTTCCTGAGGTCCAGCAAGATAATCCAGATCTCCAGTG
GCAGAGAGTTGAGAGTGATCCAGGAAAGTGAAGCAGGAGATGCGGGACTGCCCCGGGTGGAAGTGATCCTCGACTGCTCTGACAGGCAGA
AGACAGAAGGGTGCAGGCTTCAGGCAGGAAAGGAGTGTGTGGATTCTCCAGTGGAAGGAGGGCAGTCAGAAGCACCTCCTTCTCTGGTAT
CCTTTGCCGTCTCATCAGAAGGCACAGAGCAGGGAGAAGATCCACGCTCGGAAAAAGATCACAGCAGACCTCACAAGCACCGAGCGCGGC
ATGCACGGCTCAGGAGGAGTGAAAGCCTGTCAGAAAAACAAGTGAAGGAAGCAAAATCTAAATGCAAAAGCATTGCCCTTCTTCTAACGG
ATGCTCCCAACCCCAACTCCAAGGGGGTGTTGATGTTTAAGAAGCGACGTCGGAGGGCCAGGAAATACACCCTAGTTAGCTACGGTACTG
GCGAGCTTGAGCGAGAGGCGGACGAGGAGGAAGAAGGTGACAAGGAGGATACATGTGAAGTAGCATTTCTTGGTGCAAGCGAATCAGAGG
TGGATGAAGAGTTATTGTCTGACGTTGACGACAACACACAAGTTGTGAACTTTGACTGGGATTCTGGACTGGTGGACATTGAAAAGAAAC
TGAACAGAGGGGACAAGATGGAGATGTTACCAGACACCACAGGCAAGGGAGCCCTCATGTTTGCCAAGAGGAGGGAGAGAATGGATCAGA
TCACAGCCCAAAAAGAAGAGGACAAGGTAGGTGGAACGCCAAGCAGAGAACAAGATGCTGCCCAGACCGATGGCCTGAGAACCACGACTT
CTTACCAAAGAAAGGAGGAAGAGTCGGTAAGAACGCAGAGCTCTGTGAGCAAAAGCTACATCGAGGTGAGTCATGGTCTTGGCCATGTTC
CCCAACAGAATGGCTTCAGTGGGACATCTGAGACAGCAAACATCCAGAGGATGGTCCCCATGAATAGAACGGCCAAACCCTTCCCAGGGT
CTGTGAATCAGCCAGCTACCCCCTTCTCGCCAACCCGAAACATGACGAGTCCCATTGCTGACTTTCCTGCACCTCCACCTTACTCTGCAG
TCACTCCTCCCCCTGACGCCTTCTCCAGAGGGGTTTCAAGTCCGATTGCTGGCCCAGCACAGCCCCCTCCATGGCCCCAGCCTGCCCCGT
GGTCCCAGCCAGCCTTTTACGATTCGTCTGAGCGAATAGCTTCCCGAGATGAGAGGATCTCAGTGCCAGCAAAAAGAACAGGAATATTGC
AGGAGGCCAAAAGGAGAAGCACGACAAAACCCATGTTTACTTTTAAAGAGCCCAAAGTAAGCCCAAATCCTGAACTCTTGTCACTCCTTC
AAAATTCAGAAGGCAAACGGGGCACTGGAGCTGGAGGTGATTCCGGACCGGAAGAAGACTACCTCAGCTTGGGGGCAGAGGCTTGTAATT
TCATGCAAAGCTCCTCTGCCAAACAAAAGACCCCTCCTCCTGTTGCTCCAAAACCTGCAGTCAAGTCCTCATCCTCCCAACCAGTAACTC
CAGTTTCCCCAGTCTGGTCTCCAGGAGTGGCTCCCACCCAACCTCCTGCCTTCCCCACATCCAACCCATCAAAGGGCACCGTTGTCTCCT
CCATCAAAATAGCCCAGCCTTCTTACCCTCCTGCCCGGCCTGCAAGTACTTTGAACGTGGCTGGTCCCTTCAAAGGACCACAAGCAGCAG
TAGCCAGTCAGAATTACACACCCAAACCAACAGTTTCCACACCAACAGTCAATGCTGTTCAGCCTGGTGCAGTGGGACCATCCAATGAGC
TTCCAGGAATGAGTGGGAGAGGAGCTCAGCTCTTTGCTAAAAGGCAGTCGAGAATGGAGAAGTATGTGGTCGATTCAGACACGGTGCAGG
CCCACGCTGCTCGAGCTCAGTCTCCCACTCCATCTCTCCCGGCCAGTTGGAAGTACTCCTCCAATGTCCGAGCACCTCCTCCTGTGGCCT
ATAATCCTATCCACTCGCCGTCTTACCCACTGGCTGCTCTCAAGTCTCAGCCATCAGCTGCACAGCCCTCCAAAATGGGCAAGAAAAAGG
GAAAGAAACCCCTCAATGCATTAGATGTCATGAAGCACCAACCGTATCAGCTCAATGCATCCTTGTTTACTTTCCAACCTCCAGATGCAA
AGGATGGCCTCCCCCAGAAGTCATCAGTCAAGGTCAATTCAGCCCTGGCCATGAAGCAAGCTCTTCCTCCCCGGCCAGTGAATGCTGCCT
CACCTACGAATGTGCAGGCTTCGTCAGTGTACTCGGTACCAGCCTATACCTCTCCTCCTTCCTTCTTTGCAGAGGCCTCCTCACCAGTCA
GTGCATCCCCAGTGCCTGTGGGCATTCCCACCTCGCCAAAGCAAGAATCAGCCTCATCATCTTATTTTGTGGCACCAAGGCCAAAGTTCT
CAGCCAAGAAAAGTGGTGTCACAATTCAGGAGAGTGGGCGCTCCCTTTCTCTTCCTGGAAGATCAGTCCCACCCCCCATTTCTACATCTC
CTTGGGTATACCAGCCTACTTATAGTTACTCTAGTAAACCAACCGATGGACTAGAGAAAGCAAACAAGAGACCAACTCCTTGGGAAGCAG
CAGCAAAGTCTCCTCTCGGTCTAGTGGATGATGCTTTCCAACCCAGAAACATCCAGGAATCCATTGTGGCAAATGTGGTTTCAGCAGCTC
GGAGGAAGGTGCTTCCAGGGCCTCCAGAGGATTGGAATGAAAGACTGTCCTATATTCCTCAAACCCAGAAGGCCTATATGGGCTCATGTG
GAAGGCAAGAGTATAATGTCACAGCCAATAATAATATGTCCACCACCTCCCAATATGGTTCACAGTTGCCATATGCATATTATAGGCAGG
CTTCAAGAAATGATTCTGCAATCATGTCCATGGAAACCAGGTCTGATTACTGTCTTCCAGTAGCTGATTACAACTACAACCCACACCCAA
GGGGATGGAGACGCCAAACATGAAAGTTAGAAGAACGGATCATGTGCCAACTGTAGTTTTTTAAAAAAAACGCTCCTTTGTAGGGTTTTA
AACTTTTCTAATAGATTTAGATTCACTTTTGGTCTTGGCTTGTTCTCATAAGTCATTTATCTAAGTTTGTGTTTCTGTGTGTGTGTGTGT
GTGTGTATGTATGTGAATATACACACACACACACACACAGGTGAGTGTGAATACTTCCTTGTTGGCTGATCCATAGAGCATTACTTGGAA
GAAAATTTCACTATTTGCATTGATGTGCTGGCATTTATATGTAATTCATAATTTTGATTCCATTAATAGGTAGTCTATGCAACAAACTCT
ACTCAATTAAAGTAAAACTAAGTATTTCTTCATTGTACCTTAGTCCAGGAAGAAATTAATGGAATATGGTGTGCTAATTATCACTACCTA
TAACATGAGGAATATAACATTGCAGAAATTTCTCATAGGGGCATGCCAGTGAGCAATTACTTTATAAAAATATTTTCCTTGGTGTTAAGT
ATTTCTCTGCAACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCCCACCCAGTCTGGAGTGCAATGGTGCGATC
TTGGCTCACTGCAACCTGCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGAACCACCAC
ACCTGGATAATTTTTGTATTTTTAGTAGACACAAAGTTTCACCATGTTGGTCAGACTGGTCTTGAACTCCTGACCTCGTGATCTGCCCGC
CTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCTGGCCTTTCTGCAACATTTTTTTAAAAAAATCTAATAAATCTTA
GATTTTTAAAAAAGAATTAAAATGTGGGAGTTCTCAGAAAGAAATAAACACATGAGAATAAGATTATTACACATTTTGGAAGGACTTTTG
AGGAATGATGTGATGTGTAGAGAATAGAAAGATTTAGATATATGCCTGTGACAGGAATAGATTCTGGGTTCAGGGGTCCCCATCTGTCAA
ATGAGAAGATTGGATTATCTAATCTTTTAGATCCTTAACAACTCTGATATTCTGAGATTCTCTCATTTGTAGAATGCCCGCTGATGCATT
GTTTATTTTTTTTGCTCATAATATAAATATCAGATTATGTTTAGGAGTGGATTAGGTAATTAGTGTCACTACATGTATCATTAAAGGTCC
TAAAAGGAATTGTTAGGCGGCAGGCTTTGTGTTACGTGTTACATGGAGTGAGGGTAGATGTGAAGATTTAAAACGATTGATGGATTTAAG
GAAGTGGTACATAAATATGTCTGTTATTATGCAATCGTAGGTCATGATAATTTATTCAGTTATAGAAAACATGCCACAGAAGCCTATGTA
ACAAGTGGTGCTTCTTTAGAAAGTTGTCATTAGAATGTTCTGAGGAAGTTAAGCAGCTGCTTCATCAATCCCATGACACATGCCTTGTTA
GCATGCCCATCAAATAATCAGATCAAACACCTGCTCCTTATTGCCATACCCACGAACTGTTAAATATAAAAAAATTCAAAGTATTTGACA
TCTTAAGCAAATATCCAGAATATTTTTAAGTAAAAAACCATCTTAAGTATTCAAAATTTCCTTGGTTTTTTAAAGGTGATAATTTTGCTT
TGTGTTACTTTTTTGCTCTTGAATGTATCGTTATGATGGTCTCTTATAATCATGGTATCTTTCACAGAATAAAAATTAAAAATAATGCCA
GGGTGCAAGTGACCAAGGCCTTATCTTGAAAGTTAAAAAAAAAAAGTAAAGAAATCACAGTAAGTTCTATTAGTGATGATAGAACCAGAT
ATAAAATTGTTCAGTGATGGAGAAAAGAAACGATAAATACTTTCCAAGGTTATATTGTTAAATTATCTTAAATTATCAAGGTGTAAGATG
TAATGATCCCAAGAGTTTTTATAGAATCCTAAAAAATAACGCCTGATGTATAGATTAGTTAGCAAATTCTCAGAAATCCCCCACATAAAA
GCCTTACTTTGTTCAAAATTTATTATAGTGGTTTAATCATTTTAGATTTGAATGTTTTAAGATAGGAGAGACTTAGCAGAAAATACTTGG
CTTGCCAGGGCCACGTTCTACTTCATTGCTTTCTTTTATAAGTGCAAGGAGTTATTTCCATCAGTTGACATAGATATTATTCACTAAAAT
TTTCAGCAGACTCAAAATAGAGAGGAGACTTTAAACTTACATGTTAGCATAAAACAGACTTCTCTCTCATTGCATGCACTAGATCAATAT
TATCATCTGTATTAAGCTATCTGAATTTATTCGAGACATTAAGAAAAAGACAGTACATGGTGGGAAAGCTGCACATTTCTCACAAGGAAA
AAAACATTCTATATTTGTAGCAGAAATCAGTGGTTTGAAAAGTCATACTTTGCAGATATGAACCTGAAAATCAAAGTGCCATTGTTAAAT
CATCCTAAAGTGTACTGTGGGTATTCTCCAGCATACTTGAAAATGAATAAAGTTAGATTGCTCACATTGAAGCTAATGGTTGAGACAAGA
CACCTGCCAGAGTGAAGTTTGATTCCTATGGGTGAGAAGATGTAGATGACTATTGTTCTCACTAAAGTTCTAAAATAATAGCAAGTGTAG
AGAAGAGCCGTTGCTTTGAAAATACATACCACATTTGTTATAAAGCATTTGTTTGTTAGTATCAATCACATAGGTAGAAAGAGTTTGAGT
TTTACTGTGGATTAAAAAGCCTTCCCTAAAAAGAGAGCATGCCAGTCATAGAGACACTAATTTGGCACTTTTCCTCCTTCTTAGGTTTAA
ATGTTATACCAATGCATGTGTTTGAAATATCCATTAAGATGATTTAAAATTTGTCTTGTATTTTGAGTTTCTTAAATGCGTGGATTCTTG
TTCATTTATCTCTGAATATGTCTCTTTTATATTTTGGCACAATTATACACATTGGAAAGGGCCAACCTATTAGGGCTCAAGTATGTATAT
GCAAAAAAAAAAAGTTATATCAAACAGGCACAGTTATTACAACTAGAGAGAAATTCCAGAAATATTTGTTTTTTTAAGAGAAAGTAAATT
TTCACATTAGATTTCTATTCAAAGTACTAATATCTACATGGTCCACACTTTTCTATTTTAAAAAATTGTGTTCTCTTGTTAAATAGATTA
ACATTTCCACTTCTGTTTATCACAAAAGACTGTATTTGAAATATGCATACGGAAAATTGAAATTATATTAGTAATAAATGTAACTTGAAA

>11193_11193_1_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000307142_length(amino acids)=1293AA_BP=67
MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQGHHSSSDSSSSSSDSDTDVKIRNQSKASGSGLCEGDEVVSING
NPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRS
GPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRI
VHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAV
SSEGTEQGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELE
READEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQ
KEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQ
PATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAK
RRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSP
VWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGM
SGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKP
LNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASP
VPVGIPTSPKQESASSSYFVAPRPKFSAKKSGVTIQESGRSLSLPGRSVPPPISTSPWVYQPTYSYSSKPTDGLEKANKRPTPWEAAAKS
PLGLVDDAFQPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQKAYMGSCGRQEYNVTANNNMSTTSQYGSQLPYAYYRQASRN

--------------------------------------------------------------
>11193_11193_2_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000429713_length(transcript)=7257nt_BP=302nt
AGCATTCCTCCAACGGGCAGGTCTCAGCGCTCCTCCCCCTGCTCCGCTCCTCTGCAGGGCCCAGGCGCCCTTGGCCTTAGGACCCAACTT
CTCTTACCGCCATGGAGTTCGACCTGGGAGCAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGGCGGGCCACGGGGGAGATCCCA
AGCTCAGTCCCCACAAAGTTCAGGGCCGGTCGGAGGCAGGGGCAGGTCCGGGTCCAAAGCAAGGACACCACAGCTCTTCCGACTCCAGCA
GCAGCTCCAGCGATTCGGACACGGATGTGAAGATTCGAAATCAGAGCAAAGCCTCTGGGTCTGGGCTCTGTGAGGGAGATGAAGTGGTTT
CCATCAATGGCAACCCTTGTGCAGATCTCACCTACCCTGAAGTCATCAAGCTCATGGAAAGCATAACAGACTCTCTCCAAATGCTCATCA
AAAGACCATCCAGTGGAATAAGTGAGGCTTTGATATCTGAAAATGAAAACAAAAACCTCGAGCATCTCACACATGGGGGTTATGTGGAAA
GTACCACCCTGCAGATTCGACCGGCCACAAAGACCCAGTGCACAGAATTCTTCCTCGCCCCTGTCAAGACTGAAGTTCCCCTAGCTGAGA
ACCAAAGAAGTGGTCCCGACTGTGCAGGCAGCTTGAAAGAAGAAACAGGCCCGAGCTACCAAAGGGCTCCCCAAATGCCTGACTCCCAAA
GAGGACGCGTGGCAGAAGAGCTGATCTTAAGGGAGAAGGTAGAAGCGGTACAGCCTGGGCCTGTGGTTGAGCTGCAACTGTCCCTTTCAC
AGGAGAGACATAAGGGCGCTAGTGGCCCTTTAGTGGCTCTCCCGGGAGCTGAAAAATCTAAGTCTCCTGACCCAGACCCTAACTTGTCAC
ATGACAGGATTGTCCACATAAATTCGATCCCTACTAATGAGAAAGCAGACCCTTTCCTGAGGTCCAGCAAGATAATCCAGATCTCCAGTG
GCAGAGAGTTGAGAGTGATCCAGGAAAGTGAAGCAGGAGATGCGGGACTGCCCCGGGTGGAAGTGATCCTCGACTGCTCTGACAGGCAGA
AGACAGAAGGGTGCAGGCTTCAGGCAGGAAAGGAGTGTGTGGATTCTCCAGTGGAAGGAGGGCAGTCAGAAGCACCTCCTTCTCTGGTAT
CCTTTGCCGTCTCATCAGAAGGCACAGAGCAGGGAGAAGATCCACGCTCGGAAAAAGATCACAGCAGACCTCACAAGCACCGAGCGCGGC
ATGCACGGCTCAGGAGGAGTGAAAGCCTGTCAGAAAAACAAGTGAAGGAAGCAAAATCTAAATGCAAAAGCATTGCCCTTCTTCTAACGG
ATGCTCCCAACCCCAACTCCAAGGGGGTGTTGATGTTTAAGAAGCGACGTCGGAGGGCCAGGAAATACACCCTAGTTAGCTACGGTACTG
GCGAGCTTGAGCGAGAGGCGGACGAGGAGGAAGAAGGTGACAAGGAGGATACATGTGAAGTAGCATTTCTTGGTGCAAGCGAATCAGAGG
TGGATGAAGAGTTATTGTCTGACGTTGACGACAACACACAAGTTGTGAACTTTGACTGGGATTCTGGACTGGTGGACATTGAAAAGAAAC
TGAACAGAGGGGACAAGATGGAGATGTTACCAGACACCACAGGCAAGGGAGCCCTCATGTTTGCCAAGAGGAGGGAGAGAATGGATCAGA
TCACAGCCCAAAAAGAAGAGGACAAGGTAGGTGGAACGCCAAGCAGAGAACAAGATGCTGCCCAGACCGATGGCCTGAGAACCACGACTT
CTTACCAAAGAAAGGAGGAAGAGTCGGTAAGAACGCAGAGCTCTGTGAGCAAAAGCTACATCGAGGTGAGTCATGGTCTTGGCCATGTTC
CCCAACAGAATGGCTTCAGTGGGACATCTGAGACAGCAAACATCCAGAGGATGGTCCCCATGAATAGAACGGCCAAACCCTTCCCAGGGT
CTGTGAATCAGCCAGCTACCCCCTTCTCGCCAACCCGAAACATGACGAGTCCCATTGCTGACTTTCCTGCACCTCCACCTTACTCTGCAG
TCACTCCTCCCCCTGACGCCTTCTCCAGAGGGGTTTCAAGTCCGATTGCTGGCCCAGCACAGCCCCCTCCATGGCCCCAGCCTGCCCCGT
GGTCCCAGCCAGCCTTTTACGATTCGTCTGAGCGAATAGCTTCCCGAGATGAGAGGATCTCAGTGCCAGCAAAAAGAACAGGAATATTGC
AGGAGGCCAAAAGGAGAAGCACGACAAAACCCATGTTTACTTTTAAAGAGCCCAAAGTAAGCCCAAATCCTGAACTCTTGTCACTCCTTC
AAAATTCAGAAGGCAAACGGGGCACTGGAGCTGGAGGTGATTCCGGACCGGAAGAAGACTACCTCAGCTTGGGGGCAGAGGCTTGTAATT
TCATGCAAAGCTCCTCTGCCAAACAAAAGACCCCTCCTCCTGTTGCTCCAAAACCTGCAGTCAAGTCCTCATCCTCCCAACCAGTAACTC
CAGTTTCCCCAGTCTGGTCTCCAGGAGTGGCTCCCACCCAACCTCCTGCCTTCCCCACATCCAACCCATCAAAGGGCACCGTTGTCTCCT
CCATCAAAATAGCCCAGCCTTCTTACCCTCCTGCCCGGCCTGCAAGTACTTTGAACGTGGCTGGTCCCTTCAAAGGACCACAAGCAGCAG
TAGCCAGTCAGAATTACACACCCAAACCAACAGTTTCCACACCAACAGTCAATGCTGTTCAGCCTGGTGCAGTGGGACCATCCAATGAGC
TTCCAGGAATGAGTGGGAGAGGAGCTCAGCTCTTTGCTAAAAGGCAGTCGAGAATGGAGAAGTATGTGGTCGATTCAGACACGGTGCAGG
CCCACGCTGCTCGAGCTCAGTCTCCCACTCCATCTCTCCCGGCCAGTTGGAAGTACTCCTCCAATGTCCGAGCACCTCCTCCTGTGGCCT
ATAATCCTATCCACTCGCCGTCTTACCCACTGGCTGCTCTCAAGTCTCAGCCATCAGCTGCACAGCCCTCCAAAATGGGCAAGAAAAAGG
GAAAGAAACCCCTCAATGCATTAGATGTCATGAAGCACCAACCGTATCAGCTCAATGCATCCTTGTTTACTTTCCAACCTCCAGATGCAA
AGGATGGCCTCCCCCAGAAGTCATCAGTCAAGGTCAATTCAGCCCTGGCCATGAAGCAAGCTCTTCCTCCCCGGCCAGTGAATGCTGCCT
CACCTACGAATGTGCAGGCTTCGTCAGTGTACTCGGTACCAGCCTATACCTCTCCTCCTTCCTTCTTTGCAGAGGCCTCCTCACCAGTCA
GTGCATCCCCAGTGCCTGTGGGCATTCCCACCTCGCCAAAGCAAGAATCAGCCTCATCATCTTATTTTGTGGCACCAAGGCCAAAGTTCT
CAGCCAAGAAAAGTGGTGTCACAATTCAGGTGTGGAAACCATCTGTTGTGGAAGAGTAATCTTGTAGCTGAAGCTGAGTGTCCACTTTGC
TTGAAATGAATTGTTTGCAGTGTTTCTTGAGTCCCTGAGAATGCCTAGCAAAGTCCTCAACTTACTTAATTTCAGATATGTCACCTCCTA
ATCTGGGTCCAAGGAGTATAATATTTTTAATGAGTCAAAAATCCAACTCAGATTGACCTAAAATATATTTATCTTCTTTGCACACTTAAA
AAATCCAGGAGCACCCCAAAATAGACATGTACCGTTATATTAAGTAAGCAGGAGACTTAGGATTTGTGCTGTAGCCACAAGAAAGACAGT
GATCAGTGATATCAAACATCAGGAATCAGCCTTTATGTAACATAACAGCTGTCCTCCTATGGTGAAAGGTTCAAATGTAGTGAAGGTATA
ACCTATATTGACTGAGATTTCCCTTTTAGGTAGTGCCTTATCTCTATTACTAGTGTTAAAGGAATAAGGAATCTATGAAGGACAGGGAGC
AGCTCTGGTCTGTCAATCTCAGCCACCTGTTTGATATCACAGAGAAGATACTCGGAGGATTGTTGGAATGTATATAGTTTAGTAAGAAGT
GGGTAAGAAAGAGGGTCTTAATTACTGAGCACTTATTATGTATTAGGTTCTTTGCCAGATGTTTTTACATATATAAACTCATTTCAGAAA
ACTTATTTAAAGTAAATGGGGCCGGGTATGGTGGTTCATGCCTGGAATCCTAGCACTTTGGGAGGCTGAGGTAGGAGGACTGCTTGAGGC
CGGGAGTTGGAGACCAGCCTGAGCAACATAGTGAGACCCTGTCTCAATAATAATAATAATAATAGTAATAATGAAGTAAATGGGATAAGG
AAAGAAGGATAATTATCTTTAAAGGTTGATTCCCACCCTCCCTCCCCAGTTACTTAAGGAACTAAGTGAGTACATCTCCAGTTGCCCATG
AAAGCATAAGTTTGTTTTCCTCAGCTGAGGCAAGTGGTAGAGTATACAGGATAACGAAGTAACATGTAAAAGGCAGGACGCACATAAAGG
TGTACATGGCTATTGTTTCACCTGGAGAAACCACATGATTGGGACCTGAAGGTTTACTGACTGACTACAGGGGCTGATTGTGAAGCACGA
GGAACCCCATGTGTGTGGAGACTGTAGGGTGAGAGCACACAATTATTAGCATCATTTCTGAGTGATCTCACAGATTTTTTTTCTTGTGTT
TGCTTTGCTTTTTGACAACTGCTTCTCCCACGTTCCTTGCAATTCTATTCTCTCACCTTCACTTTACTATTTGTATTCGATGGACCAGGA
TAATTCAGGCAAGGTTACCTTGTAAACTTTAATTGGCCACACACCATGTTGTCACCCAGCTGGCTATGAAGTGAATAATGGTACTGAAAG
TAAACCTGAAGACCTTTCTCAGATCTATTTTAAGTCTGAGTCTGACCAACCATGGAAAATATTCGACATGAATTAATGTAGAGAACTATA
AAGCATTTATGACAGCTCCAAGAAAAATCATCTACTCTATGCAGGAGATATGTTTAGAGACCTCTCAGAAAAACTTGCCTGGTTTGAGGG
TACACAGTACCATTTTAATCTTCTGAAAATATCTGTATTCCTGCTCTTTTTCTGCTGTCACTGTCAATCTGCTATATTTTTCACTATCCT
ATTAAAATATTACTGTCTCCTTTATCTGTTCAATGTCCATATTTTAAAAAAATCTTCCTTGTATGAGCTATTCTGATCTAAATAATTTCT
CTGATATTTCTCTATATGGCTCCCACAACAATTTCATTGTTGTTAGCATATCTATTTCTCCATACATTGTAAAACTGTAATCCTTAGGTA
TTTCTAAAACATAAAGAGGAGAATTAAGTCAGCTGCAGAACAATGGGGCTGATTCTTCTGCTTTTTCTCTGGAAAATCTTTCATTGCTTT
TGGTGGAAATTTACCTAGAGGTTACAACCACAGGATGTAGCTTGGTCTCTTATTTGCCTTTTTGGGAAACCAATTAAGATTAATACAGGA
TAAAGGAAAAAAGCAATCTATTCATTATATAACACAGTTGTTTGTATTACTTGTTCCCTGCAAAGGAAATCTGTTGAATGCTTGCATTTT
GAATTCTTTTCTAATAGAACAACCAAAAAAGGCTTCTTATGGTGCAGCAGGAAAAAAGATCATTTTTATAGCTTTGCATTCTTAACATAG
CATTTAAAGAGCGGCATGAATTAGAGGAAAGACATGGAACACACAGGTAGTCGGTTTGAGATCATCGGCTTAAAAGTATCCTAGGATGGT
AATGACCCAGAAGTATTTCCAGTTGTCTAGTGGTGTGGTATGCAGGAATGAGAAGTGTTTTCTTTCCATTTCCTGTTGGACAGGTGGCAA
TCTTAGCAGAGCCACTATTTGGAGTTGATAACTAAAGATGCAAATAACATGACTATGCCTTCTGGTCATCCTAGGACTATTTGGAGTTCT
CCAAAACCTTGTAAGAGGCATGTCAGGCATGCAGTAAAAGCATCTACAACTTCAGCTGGGCACTGGCAGCATAGGTCTCATCTTGGACCA
TACAGTCCCACTTTATAGAAGAGGGTGGAAGTTCTCCAAAACAATATCCACAACAAAGTCTGACCTCACTCTGAGGGAGATGGGAAGTGG
GAGGAAGAAGGACTAACCAGCTCCCTGGAGTAAGAGGAATTTGCTTTCCCTGTCTGCCCACCAGGGGCTATATGTGCCACCTTTCAGGTT
GGGGCCAAGGAAGTGATGTCAGTGTGACAGAAGGGAGAGTTAGACCTCCAGACGTCAGCCTCCCTCCCATGGGGTACATTTTCAATCTGA
GTGTTGTTGCCTTAGCTGTGTTGGTATTAGCTTGATTGGTTGGTCCGCTGGTTATGAGGTGTAGGGAGGCAGTTTTTGTTTAGTTTTTAG
GACTTTGCCTCTTCCTTTGTCCTTAGCATAATTTCTAGGCAGAGCATCCACGAAGTCGGTTTTCATTGCCAGCTCAAGAGCGACAATCAT
TTACGAGTTCCTATGTTATGTTAGGTGCCTTATGTATATTATCCCAAATCCACTGCATGGTTTAAATACAGGCACTGGAATATAAATGAA
AAAGGTCATTACAGTCACTGACTTTCTGCAGGACCTTAAACATTTCTCTTTCCACAAGTTTCCCCTTAATCATGTGTCAAACCTCTCTTC
CTGACGGGAATGTTGTGCTATAATGAATCTGCATAACGCTTGGGATTCTAGGAGGAAGGAAGGTTCCATGGACATGTAAGTACAGCATAT
TCCCCTCAGTCTTCTAGGAGGGCAGAGTGAATCCCAGAACTGGTAAGATTGGGAATCTGAGCATTGCCACTTTAATCTTAGAATATTTAT
CATTTTGACACATCCTGTTTTTTAGAGAGGAAAACAAACACAGTTTCTGCATTGGTAGTGTAAAGCATACCTTGTTAGGAACGTGTTTTG
TAAGACACATTTGGGTTGTCACTCTAGAGCATGTCAAACTTTGTACTTCAAAATATATTTAGTATGATTGTTAGTGGTAACATATATCAA
GGCTTTGAATTAACTGTTTTATTTAATTTTCACAAGAAGCACTTATTTTAGCCATAGGAAAACCAATCTGAGCTACAAATAGTTCTTTAA
AATAAGCCCAGGTTATTTAGCTATTCTAGAAAGTGCCGACTTCTTTCAAGAAGCAGGCATTGTAGGACAGCTGAGAATTATCACATAGCC

>11193_11193_2_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000429713_length(amino acids)=1125AA_BP=67
MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQGHHSSSDSSSSSSDSDTDVKIRNQSKASGSGLCEGDEVVSING
NPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRS
GPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRI
VHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAV
SSEGTEQGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELE
READEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQ
KEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQ
PATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAK
RRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSP
VWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGM
SGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKP
LNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASP

--------------------------------------------------------------
>11193_11193_3_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000434046_length(transcript)=3721nt_BP=302nt
AGCATTCCTCCAACGGGCAGGTCTCAGCGCTCCTCCCCCTGCTCCGCTCCTCTGCAGGGCCCAGGCGCCCTTGGCCTTAGGACCCAACTT
CTCTTACCGCCATGGAGTTCGACCTGGGAGCAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGGCGGGCCACGGGGGAGATCCCA
AGCTCAGTCCCCACAAAGTTCAGGGCCGGTCGGAGGCAGGGGCAGGTCCGGGTCCAAAGCAAGGACACCACAGCTCTTCCGACTCCAGCA
GCAGCTCCAGCGATTCGGACACGGATGTGAAGATTCGAAATCAGAGCAAAGCCTCTGGGTCTGGGCTCTGTGAGGGAGATGAAGTGGTTT
CCATCAATGGCAACCCTTGTGCAGATCTCACCTACCCTGAAGTCATCAAGCTCATGGAAAGCATAACAGACTCTCTCCAAATGCTCATCA
AAAGACCATCCAGTGGAATAAGTGAGGCTTTGATATCTGAAAATGAAAACAAAAACCTCGAGCATCTCACACATGGGGGTTATGTGGAAA
GTACCACCCTGCAGATTCGACCGGCCACAAAGACCCAGTGCACAGAATTCTTCCTCGCCCCTGTCAAGACTGAAGTTCCCCTAGCTGAGA
ACCAAAGAAGTGGTCCCGACTGTGCAGGCAGCTTGAAAGAAGAAACAGGCCCGAGCTACCAAAGGGCTCCCCAAATGCCTGACTCCCAAA
GAGGACGCGTGGCAGAAGAGCTGATCTTAAGGGAGAAGGTAGAAGCGGTACAGCCTGGGCCTGTGGTTGAGCTGCAACTGTCCCTTTCAC
AGGAGAGACATAAGGGCGCTAGTGGCCCTTTAGTGGCTCTCCCGGGAGCTGAAAAATCTAAGTCTCCTGACCCAGACCCTAACTTGTCAC
ATGACAGGATTGTCCACATAAATTCGATCCCTACTAATGAGAAAGCAGACCCTTTCCTGAGGTCCAGCAAGATAATCCAGATCTCCAGTG
GCAGAGAGTTGAGAGTGATCCAGGAAAGTGAAGCAGGAGATGCGGGACTGCCCCGGGTGGAAGTGATCCTCGACTGCTCTGACAGGCAGA
AGACAGAAGGGTGCAGGCTTCAGGCAGGAAAGGAGTGTGTGGATTCTCCAGTGGAAGGAGGGCAGTCAGAAGCACCTCCTTCTCTGGTAT
CCTTTGCCGTCTCATCAGAAGGCACAGAGCAGGGAGAAGATCCACGCTCGGAAAAAGATCACAGCAGACCTCACAAGCACCGAGCGCGGC
ATGCACGGCTCAGGAGGAGTGAAAGCCTGTCAGAAAAACAAGTGAAGGAAGCAAAATCTAAATGCAAAAGCATTGCCCTTCTTCTAACGG
ATGCTCCCAACCCCAACTCCAAGGGGGTGTTGATGTTTAAGAAGCGACGTCGGAGGGCCAGGAAATACACCCTAGTTAGCTACGGTACTG
GCGAGCTTGAGCGAGAGGCGGACGAGGAGGAAGAAGGTGACAAGGAGGATACATGTGAAGTAGCATTTCTTGGTGCAAGCGAATCAGAGG
TGGATGAAGAGTTATTGTCTGACGTTGACGACAACACACAAGTTGTGAACTTTGACTGGGATTCTGGACTGGTGGACATTGAAAAGAAAC
TGAACAGAGGGGACAAGATGGAGATGTTACCAGACACCACAGGCAAGGGAGCCCTCATGTTTGCCAAGAGGAGGGAGAGAATGGATCAGA
TCACAGCCCAAAAAGAAGAGGACAAGGTAGGTGGAACGCCAAGCAGAGAACAAGATGCTGCCCAGACCGATGGCCTGAGAACCACGACTT
CTTACCAAAGAAAGGAGGAAGAGTCGGTAAGAACGCAGAGCTCTGTGAGCAAAAGCTACATCGAGGTGAGTCATGGTCTTGGCCATGTTC
CCCAACAGAATGGCTTCAGTGGGACATCTGAGACAGCAAACATCCAGAGGATGGTCCCCATGAATAGAACGGCCAAACCCTTCCCAGGGT
CTGTGAATCAGCCAGCTACCCCCTTCTCGCCAACCCGAAACATGACGAGTCCCATTGCTGACTTTCCTGCACCTCCACCTTACTCTGCAG
TCACTCCTCCCCCTGACGCCTTCTCCAGAGGGGTTTCAAGTCCGATTGCTGGCCCAGCACAGCCCCCTCCATGGCCCCAGCCTGCCCCGT
GGTCCCAGCCAGCCTTTTACGATTCGTCTGAGCGAATAGCTTCCCGAGATGAGAGGATCTCAGTGCCAGCAAAAAGAACAGGAATATTGC
AGGAGGCCAAAAGGAGAAGCACGACAAAACCCATGTTTACTTTTAAAGAGCCCAAAGTAAGCCCAAATCCTGAACTCTTGTCACTCCTTC
AAAATTCAGAAGGCAAACGGGGCACTGGAGCTGGAGGTGATTCCGGACCGGAAGAAGACTACCTCAGCTTGGGGGCAGAGGCTTGTAATT
TCATGCAAAGCTCCTCTGCCAAACAAAAGACCCCTCCTCCTGTTGCTCCAAAACCTGCAGTCAAGTCCTCATCCTCCCAACCAGTAACTC
CAGTTTCCCCAGTCTGGTCTCCAGGAGTGGCTCCCACCCAACCTCCTGCCTTCCCCACATCCAACCCATCAAAGGGCACCGTTGTCTCCT
CCATCAAAATAGCCCAGCCTTCTTACCCTCCTGCCCGGCCTGCAAGTACTTTGAACGTGGCTGGTCCCTTCAAAGGACCACAAGCAGCAG
TAGCCAGTCAGAATTACACACCCAAACCAACAGTTTCCACACCAACAGTCAATGCTGTTCAGCCTGGTGCAGTGGGACCATCCAATGAGC
TTCCAGGAATGAGTGGGAGAGGAGCTCAGCTCTTTGCTAAAAGGCAGTCGAGAATGGAGAAGTATGTGGTCGATTCAGACACGGTGCAGG
CCCACGCTGCTCGAGCTCAGTCTCCCACTCCATCTCTCCCGGCCAGTTGGAAGTACTCCTCCAATGTCCGAGCACCTCCTCCTGTGGCCT
ATAATCCTATCCACTCGCCGTCTTACCCACTGGCTGCTCTCAAGTCTCAGCCATCAGCTGCACAGCCCTCCAAAATGGGCAAGAAAAAGG
GAAAGAAACCCCTCAATGCATTAGATGTCATGAAGCACCAACCGTATCAGCTCAATGCATCCTTGTTTACTTTCCAACCTCCAGATGCAA
AGGATGGCCTCCCCCAGAAGTCATCAGTCAAGGTCAATTCAGCCCTGGCCATGAAGCAAGCTCTTCCTCCCCGGCCAGTGAATGCTGCCT
CACCTACGAATGTGCAGGCTTCGTCAGTGTACTCGGTACCAGCCTATACCTCTCCTCCTTCCTTCTTTGCAGAGGCCTCCTCACCAGTCA
GTGCATCCCCAGTGCCTGTGGGCATTCCCACCTCGCCAAAGCAAGAATCAGCCTCATCATCTTATTTTGTGGCACCAAGGCCAAAGTTCT
CAGCCAAGAAAAGTGGTGTCACAATTCAGGTGAAATGTAAATCTGGGATCCATAGTCAAGATATCATAAGGACCTACTTCCCAGCCTACC
TTTCTTCCTCTACCTGATAATGATAATACTCAAAATAACAACATTCAAAGGAAACACAAAGAAATCCTGCTTTCACATCTCCTATTTCTT
GGGCTCCTTAATAACTACTGATGGTTTGTTCATGAAAAAAAATTTTTAAATCAAAAGATTGTACTTGGCCCTGAGTTGAAAAAATTTCAA

>11193_11193_3_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000434046_length(amino acids)=1141AA_BP=67
MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQGHHSSSDSSSSSSDSDTDVKIRNQSKASGSGLCEGDEVVSING
NPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRS
GPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRI
VHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAV
SSEGTEQGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELE
READEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQ
KEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQ
PATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAK
RRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSP
VWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGM
SGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKP
LNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASP

--------------------------------------------------------------
>11193_11193_4_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000448416_length(transcript)=1346nt_BP=302nt
AGCATTCCTCCAACGGGCAGGTCTCAGCGCTCCTCCCCCTGCTCCGCTCCTCTGCAGGGCCCAGGCGCCCTTGGCCTTAGGACCCAACTT
CTCTTACCGCCATGGAGTTCGACCTGGGAGCAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGGCGGGCCACGGGGGAGATCCCA
AGCTCAGTCCCCACAAAGTTCAGGGCCGGTCGGAGGCAGGGGCAGGTCCGGGTCCAAAGCAAGGACACCACAGCTCTTCCGACTCCAGCA
GCAGCTCCAGCGATTCGGACACGGATGTGAAGATTCGAAATCAGAGCAAAGCCTCTGGGTCTGGGCTCTGTGAGGGAGATGAAGTGGTTT
CCATCAATGGCAACCCTTGTGCAGATCTCACCTACCCTGAAGTCATCAAGCTCATGGAAAGCATAACAGACTCTCTCCAAATGCTCATCA
AAAGGAGAGTGGGCGCTCCCTTTCTCTTCCTGGAAGATCAGTCCCACCCCCCATTTCTACATCTCCTTGGGTATACCAGCCTACTTATAG
TTACTCTAGTAAACCAACCGATGGACTAGAGAAAGCAAACAAGAGACCAACTCCTTGGGAAGCAGCAGCAAAGTCTCCTCTCGGTCTAGT
GGATGATGCTTTCCAACCCAGAAACATCCAGGAATCCATTGTGGCAAATGTGGTTTCAGCAGCTCGGAGGAAGGTGCTTCCAGGGCCTCC
AGAGGATTGGAATGAAAGACTGTCCTATATTCCTCAAACCCAGAAGGCCTATATGGGCTCATGTGGAAGGCAAGAGTATAATGTCACAGC
CAATAATAATATGTCCACCACCTCCCAATATGGTTCACAGTTGCCATATGCATATTATAGGCAGGCTTCAAGAAATGATTCTGCAATCAT
GTCCATGGAAACCAGGTCTGATTACTGTCTTCCAGTAGCTGATTACAACTACAACCCACACCCAAGGGGATGGAGACGCCAAACATGAAA
GTTAGAAGAACGGATCATGTGCCAACTGTAGTTTTTTAAAAAAAACGCTCCTTTGTAGGGTTTTAAACTTTTCTAATAGATTTAGATTCA
CTTTTGGTCTTGGCTTGTTCTCATAAGTCATTTATCTAAGTTTGTGTTTCTGTGTGTGTGTGTGTGTGTGTATGTATGTGAATATACACA
CACACACACACACAGGTGAGTGTGAATACTTCCTTGTTGGCTGATCCATAGAGCATTACTTGGAAGAAAATTTCACTATTTGCATTGATG

>11193_11193_4_C19orf33-SYNPO2_C19orf33_chr19_38795326_ENST00000301246_SYNPO2_chr4_119944584_ENST00000448416_length(amino acids)=155AA_BP=67
MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQGHHSSSDSSSSSSDSDTDVKIRNQSKASGSGLCEGDEVVSING

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Fusion Gene PPI Analysis for C19orf33-SYNPO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205481_66335.01262.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205664_92435.01262.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205901_109335.01262.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304481_66335.01094.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304664_92435.01094.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304901_109335.01094.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605481_66335.01110.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605664_92435.01110.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605901_109335.01110.0ACTN2
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205615_62635.01262.0BAG3
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304615_62635.01094.0BAG3
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605615_62635.01110.0BAG3
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205810_109335.01262.0FLNC
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304810_109335.01094.0FLNC
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605810_109335.01110.0FLNC
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000030714205607_81135.01262.0YWHAB
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000042971304607_81135.01094.0YWHAB
TgeneSYNPO2chr19:38795326chr4:119944584ENST0000043404605607_81135.01110.0YWHAB
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000307142051000_101935.01262.0ZYX
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000429713041000_101935.01094.0ZYX
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000434046051000_101935.01110.0ZYX


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000307142051_18035.01262.0VPS18
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000429713041_18035.01094.0VPS18
TgeneSYNPO2chr19:38795326chr4:119944584ENST00000434046051_18035.01110.0VPS18


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf33-SYNPO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf33-SYNPO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource