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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf47-SCN1B (FusionGDB2 ID:11213)

Fusion Gene Summary for C19orf47-SCN1B

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf47-SCN1B
Fusion gene ID: 11213
HgeneTgene
Gene symbol

C19orf47

SCN1B

Gene ID

126526

6324

Gene namechromosome 19 open reading frame 47sodium voltage-gated channel beta subunit 1
Synonyms-ATFB13|BRGDA5|EIEE52|GEFSP1
Cytomap

19q13.2

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C19orf47sodium channel subunit beta-1sodium channel, voltage gated, type I beta subunitsodium channel, voltage-gated, type I, beta
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000582783, ENST00000392035, 
ENST00000584868, 
ENST00000596348, 
ENST00000262631, ENST00000415950, 
ENST00000595652, 
Fusion gene scores* DoF score12 X 11 X 7=9244 X 2 X 4=32
# samples 135
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C19orf47 [Title/Abstract] AND SCN1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf47(40847746)-SCN1B(35523432), # samples:2
C19orf47(40847745)-SCN1B(35523431), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSCN1B

GO:0010765

positive regulation of sodium ion transport

19808477

TgeneSCN1B

GO:0035725

sodium ion transmembrane transport

18464934|19808477|21051419

TgeneSCN1B

GO:0051899

membrane depolarization

21051419

TgeneSCN1B

GO:2000649

regulation of sodium ion transmembrane transporter activity

19808477


check buttonFusion gene breakpoints across C19orf47 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCN1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1877-01AC19orf47chr19

40847746

-SCN1Bchr19

35523432

+
ChimerDB4OVTCGA-25-1877C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
ChimerDB4READTCGA-AG-3892C19orf47chr19

40847745

-SCN1Bchr19

35523431

+


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Fusion Gene ORF analysis for C19orf47-SCN1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000582783ENST00000596348C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
5CDS-3UTRENST00000582783ENST00000596348C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
In-frameENST00000582783ENST00000262631C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
In-frameENST00000582783ENST00000262631C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
In-frameENST00000582783ENST00000415950C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
In-frameENST00000582783ENST00000415950C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
In-frameENST00000582783ENST00000595652C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
In-frameENST00000582783ENST00000595652C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000392035ENST00000262631C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000392035ENST00000262631C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000392035ENST00000415950C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000392035ENST00000415950C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000392035ENST00000595652C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000392035ENST00000595652C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000584868ENST00000262631C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000584868ENST00000262631C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000584868ENST00000415950C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000584868ENST00000415950C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3CDSENST00000584868ENST00000595652C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3CDSENST00000584868ENST00000595652C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3UTRENST00000392035ENST00000596348C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3UTRENST00000392035ENST00000596348C19orf47chr19

40847745

-SCN1Bchr19

35523431

+
intron-3UTRENST00000584868ENST00000596348C19orf47chr19

40847746

-SCN1Bchr19

35523432

+
intron-3UTRENST00000584868ENST00000596348C19orf47chr19

40847745

-SCN1Bchr19

35523431

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000582783C19orf47chr1940847746-ENST00000262631SCN1Bchr1935523432+14171431362148404
ENST00000582783C19orf47chr1940847746-ENST00000595652SCN1Bchr1935523432+82914313546177
ENST00000582783C19orf47chr1940847746-ENST00000415950SCN1Bchr1935523432+108214313909298
ENST00000582783C19orf47chr1940847745-ENST00000262631SCN1Bchr1935523431+14171431362148404
ENST00000582783C19orf47chr1940847745-ENST00000595652SCN1Bchr1935523431+82914313546177
ENST00000582783C19orf47chr1940847745-ENST00000415950SCN1Bchr1935523431+108214313909298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582783ENST00000262631C19orf47chr1940847746-SCN1Bchr1935523432+0.0030764920.9969235
ENST00000582783ENST00000595652C19orf47chr1940847746-SCN1Bchr1935523432+0.0028299880.99717003
ENST00000582783ENST00000415950C19orf47chr1940847746-SCN1Bchr1935523432+0.1077310440.892269
ENST00000582783ENST00000262631C19orf47chr1940847745-SCN1Bchr1935523431+0.0030764920.9969235
ENST00000582783ENST00000595652C19orf47chr1940847745-SCN1Bchr1935523431+0.0028299880.99717003
ENST00000582783ENST00000415950C19orf47chr1940847745-SCN1Bchr1935523431+0.1077310440.892269

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Fusion Genomic Features for C19orf47-SCN1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C19orf47chr1940847745-SCN1Bchr1935523431+2.15E-141
C19orf47chr1940847745-SCN1Bchr1935523431+2.15E-141
C19orf47chr1940847745-SCN1Bchr1935523431+2.15E-141
C19orf47chr1940847745-SCN1Bchr1935523431+2.15E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C19orf47-SCN1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:40847746/chr19:35523432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSCN1Bchr19:40847745chr19:35523431ENST000002626310622_15013377.3333333333333DomainNote=Ig-like C2-type
TgeneSCN1Bchr19:40847745chr19:35523431ENST000004159500322_15013269.0DomainNote=Ig-like C2-type
TgeneSCN1Bchr19:40847746chr19:35523432ENST000002626310622_15013377.3333333333333DomainNote=Ig-like C2-type
TgeneSCN1Bchr19:40847746chr19:35523432ENST000004159500322_15013269.0DomainNote=Ig-like C2-type
TgeneSCN1Bchr19:40847745chr19:35523431ENST0000026263106183_21813377.3333333333333Topological domainCytoplasmic
TgeneSCN1Bchr19:40847745chr19:35523431ENST000002626310619_16013377.3333333333333Topological domainExtracellular
TgeneSCN1Bchr19:40847745chr19:35523431ENST0000041595003183_21813269.0Topological domainCytoplasmic
TgeneSCN1Bchr19:40847745chr19:35523431ENST000004159500319_16013269.0Topological domainExtracellular
TgeneSCN1Bchr19:40847746chr19:35523432ENST0000026263106183_21813377.3333333333333Topological domainCytoplasmic
TgeneSCN1Bchr19:40847746chr19:35523432ENST000002626310619_16013377.3333333333333Topological domainExtracellular
TgeneSCN1Bchr19:40847746chr19:35523432ENST0000041595003183_21813269.0Topological domainCytoplasmic
TgeneSCN1Bchr19:40847746chr19:35523432ENST000004159500319_16013269.0Topological domainExtracellular
TgeneSCN1Bchr19:40847745chr19:35523431ENST0000026263106161_18213377.3333333333333TransmembraneHelical
TgeneSCN1Bchr19:40847745chr19:35523431ENST0000041595003161_18213269.0TransmembraneHelical
TgeneSCN1Bchr19:40847746chr19:35523432ENST0000026263106161_18213377.3333333333333TransmembraneHelical
TgeneSCN1Bchr19:40847746chr19:35523432ENST0000041595003161_18213269.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC19orf47chr19:40847745chr19:35523431ENST00000392035-19284_2870356.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847745chr19:35523431ENST00000392035-19395_3980356.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847745chr19:35523431ENST00000582783-29284_28743423.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847745chr19:35523431ENST00000582783-29395_39843423.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847746chr19:35523432ENST00000392035-19284_2870356.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847746chr19:35523432ENST00000392035-19395_3980356.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847746chr19:35523432ENST00000582783-29284_28743423.0Compositional biasNote=Poly-Ser
HgeneC19orf47chr19:40847746chr19:35523432ENST00000582783-29395_39843423.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for C19orf47-SCN1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11213_11213_1_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000262631_length(transcript)=1417nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTT
CGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTC
GGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAGAAGATCCACATTGAGGT
AGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGC
AGAGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTCTGA
AAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTC
TCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGA
GGGGGCAGGGGGCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGC
AATACTGCCGCTGCCCCCACCCTGCTTCTGCTGCCTGTTTGGGGAGGGGGGCGGTGAGGTGGGGGCAGCGGCCCCGCACCCCTCCTCCTT
GCTGATTTGCACACATTGGCCGCTTCAGACACGCACTTCTGGGGCCAGCCCCTCCCCGCCTCCTCCCTGCCTGGCGGCAGGGGTCGCGAT
GATGGGCTGGAGCAGTTTGGGGCAGGGGGTTCTGGGACCCACTCCGACTCCCCCTCCCCGGCATCATTTCCCCTCCCGCTTCCTCCGGCT
GGACCTGGGGTCCCCCCTCCCTGTAATGCACTCCTGCCCCGGCCCAACCTCGCCCTCTCTCACCAGCCTTGAACTGTGGCCACCTAGAAA

>11213_11213_1_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000262631_length(amino acids)=404AA_BP=
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------
>11213_11213_2_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000415950_length(transcript)=1082nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTT
CGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTC
GGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAGAAGATCCACATTGAGGT
AGTGGACAAAGGTGAGTCGGGTGCTGCCTGCCCCTTTACCGTCACCCACCGGAGAGCCAGATGGAGGGACAGATGGCAGGCAGTGGACAG
GACAGGCTGGCTCTGTGCCTGGCCAGCCAACCGCCCACAGCAGCGGGCTGAGGGGGAGGGGAGCAGCCCCTCCTGCCCACTCCAGCTCTG
GCCTCTGTTTCTCTCCAGCCCACGGAGAGGTCAAAGCATGCCTGTCCCCCACAGACGCTCCGGGTACAGAACCCAGCTCTGTCACCTGTG
CTGTATGACCTCTGGCAGGTGCCTTCTGTCTCTGAGCCAAAGGGTTGTCCTGGGCTTGCCCGGGATAATAATCCGATGTGTTTCTCGGGG
TGTGGTTTGAGCCATTCTTCCATCATGGGGTTCATGAGGATTGAGCAGCTGCAGGCACACGCCTGGCTTCCAGCAGAGCCTTGCAGGTGG
TGGCGAGGGTGGCGGTTCTTACTGTTCGAGTAGCTCAGCCCTGCTGCCCTCTGTGGTGATGAGGCAAGAGAGCGTGCCACCTAGAGCAGA

>11213_11213_2_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000415950_length(amino acids)=298AA_BP=43
MVMAALSLVAACWGRAAADESVQLPAAPGSSVRARETMVSVTMVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKG
ESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTS

--------------------------------------------------------------
>11213_11213_3_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000595652_length(transcript)=829nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCAT
CGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTACTGCTACAAGAAGATCGCTGC
CGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGC
CGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTCTCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGG
CCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGAGGGGGCAGGGGGCTTGGCTCGCACCCCCACTTT
CGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGCAATACTGCCGCTGCCCCCACCCTGCTTCTGCTG

>11213_11213_3_C19orf47-SCN1B_C19orf47_chr19_40847745_ENST00000582783_SCN1B_chr19_35523431_ENST00000595652_length(amino acids)=177AA_BP=43
MVMAALSLVAACWGRAAADESVQLPAAPGSSVRARETMVSVTMVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR

--------------------------------------------------------------
>11213_11213_4_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000262631_length(transcript)=1417nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTT
CGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTC
GGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAGAAGATCCACATTGAGGT
AGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGC
AGAGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTCTGA
AAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTC
TCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGA
GGGGGCAGGGGGCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGC
AATACTGCCGCTGCCCCCACCCTGCTTCTGCTGCCTGTTTGGGGAGGGGGGCGGTGAGGTGGGGGCAGCGGCCCCGCACCCCTCCTCCTT
GCTGATTTGCACACATTGGCCGCTTCAGACACGCACTTCTGGGGCCAGCCCCTCCCCGCCTCCTCCCTGCCTGGCGGCAGGGGTCGCGAT
GATGGGCTGGAGCAGTTTGGGGCAGGGGGTTCTGGGACCCACTCCGACTCCCCCTCCCCGGCATCATTTCCCCTCCCGCTTCCTCCGGCT
GGACCTGGGGTCCCCCCTCCCTGTAATGCACTCCTGCCCCGGCCCAACCTCGCCCTCTCTCACCAGCCTTGAACTGTGGCCACCTAGAAA

>11213_11213_4_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------
>11213_11213_5_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000415950_length(transcript)=1082nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTT
CGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTC
GGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAGAAGATCCACATTGAGGT
AGTGGACAAAGGTGAGTCGGGTGCTGCCTGCCCCTTTACCGTCACCCACCGGAGAGCCAGATGGAGGGACAGATGGCAGGCAGTGGACAG
GACAGGCTGGCTCTGTGCCTGGCCAGCCAACCGCCCACAGCAGCGGGCTGAGGGGGAGGGGAGCAGCCCCTCCTGCCCACTCCAGCTCTG
GCCTCTGTTTCTCTCCAGCCCACGGAGAGGTCAAAGCATGCCTGTCCCCCACAGACGCTCCGGGTACAGAACCCAGCTCTGTCACCTGTG
CTGTATGACCTCTGGCAGGTGCCTTCTGTCTCTGAGCCAAAGGGTTGTCCTGGGCTTGCCCGGGATAATAATCCGATGTGTTTCTCGGGG
TGTGGTTTGAGCCATTCTTCCATCATGGGGTTCATGAGGATTGAGCAGCTGCAGGCACACGCCTGGCTTCCAGCAGAGCCTTGCAGGTGG
TGGCGAGGGTGGCGGTTCTTACTGTTCGAGTAGCTCAGCCCTGCTGCCCTCTGTGGTGATGAGGCAAGAGAGCGTGCCACCTAGAGCAGA

>11213_11213_5_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=298AA_BP=43
MVMAALSLVAACWGRAAADESVQLPAAPGSSVRARETMVSVTMVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKG
ESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTS

--------------------------------------------------------------
>11213_11213_6_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000595652_length(transcript)=829nt_BP=143nt
GGGCGGTCACGTGATGGTTATGGCCGCACTCTCGCTGGTGGCGGCCTGTTGGGGTAGAGCGGCCGCGGACGAGTCAGTTCAGCTTCCGGC
GGCTCCAGGGAGCAGTGTCAGGGCCAGGGAGACGATGGTCTCCGTGACTATGGTGTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTC
GGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGA
GTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCAT
CGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTACTGCTACAAGAAGATCGCTGC
CGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGC
CGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTCTCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGG
CCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGAGGGGGCAGGGGGCTTGGCTCGCACCCCCACTTT
CGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGCAATACTGCCGCTGCCCCCACCCTGCTTCTGCTG

>11213_11213_6_C19orf47-SCN1B_C19orf47_chr19_40847746_ENST00000582783_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=177AA_BP=43
MVMAALSLVAACWGRAAADESVQLPAAPGSSVRARETMVSVTMVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR

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Fusion Gene PPI Analysis for C19orf47-SCN1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf47-SCN1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf47-SCN1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource