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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AASDHPPT-ABTB2 (FusionGDB2 ID:113)

Fusion Gene Summary for AASDHPPT-ABTB2

Fusion gene summary

Fusion gene information	Fusion gene name: AASDHPPT-ABTB2
	Fusion gene ID: 113
		Hgene	Tgene
	Gene symbol	AASDHPPT	ABTB2
	Gene ID	60496	25841
	Gene name	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	ankyrin repeat and BTB domain containing 2
	Synonyms	AASD-PPT\|ACPS\|CGI-80\|LYS2\|LYS5	ABTB2A\|BTBD22
	Cytomap	11q22.3	11p13
	Type of gene	protein-coding	protein-coding
	Description	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase4'-phosphopantetheinyl transferaseLYS5 orthologalpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferaseholo ACP synthaseholo-[acyl-carrier-protein] synthase	ankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2
	Modification date	20200313	20200313
	UniProtAcc	Q9NRN7	Q8N961
	Ensembl transtripts involved in fusion gene	ENST00000278618,	ENST00000530814, ENST00000298992, ENST00000435224,
Fusion gene scores	* DoF score	3 X 1 X 2=6	7 X 5 X 5=175
	# samples	2	7
	** MAII score	log2(2/6*10)=1.73696559416621	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AASDHPPT [Title/Abstract] AND ABTB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AASDHPPT(105950419)-ABTB2(34226237), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AASDHPPT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABTB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A4NN-01A	AASDHPPT	chr11	105950419	-	ABTB2	chr11	34226237	-
ChimerDB4	LIHC	TCGA-DD-A4NN-01A	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-

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Fusion Gene ORF analysis for AASDHPPT-ABTB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000278618	ENST00000530814	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-
In-frame	ENST00000278618	ENST00000298992	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-
In-frame	ENST00000278618	ENST00000435224	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000278618

AASDHPPT

chr11

105950419

ENST00000298992

ABTB2

chr11

34226237

4225

631

2825

918

ENST00000278618

AASDHPPT

chr11

105950419

ENST00000435224

ABTB2

chr11

34226237

4225

631

2825

918

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000278618	ENST00000298992	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-	0.005606681	0.99439335
ENST00000278618	ENST00000435224	AASDHPPT	chr11	105950419	+	ABTB2	chr11	34226237	-	0.005606681	0.99439335

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Fusion Genomic Features for AASDHPPT-ABTB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AASDHPPT-ABTB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:105950419/chr11:34226237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AASDHPPT Q9NRN7	ABTB2 Q8N961
FUNCTION: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. {ECO:0000269\|PubMed:11286508, ECO:0000269\|PubMed:12815048, ECO:0000269\|PubMed:18022563}.	FUNCTION: May be involved in the initiation of hepatocyte growth. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AASDHPPT

chr11:105950419

chr11:34226237

ENST00000278618

108_111

136

310.0

Region

Coenzyme A binding

Hgene

AASDHPPT

chr11:105950419

chr11:34226237

ENST00000278618

86_91

136

310.0

Region

Coenzyme A binding

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000298992

845_914

108

840.0

Domain

BTB

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000435224

845_914

294

1026.0

Domain

BTB

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000298992

521_550

108

840.0

Repeat

Note=ANK 1

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000298992

567_596

108

840.0

Repeat

Note=ANK 2

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000298992

606_635

108

840.0

Repeat

Note=ANK 3

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000298992

649_678

108

840.0

Repeat

Note=ANK 4

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000435224

521_550

294

1026.0

Repeat

Note=ANK 1

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000435224

567_596

294

1026.0

Repeat

Note=ANK 2

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000435224

606_635

294

1026.0

Repeat

Note=ANK 3

Tgene

ABTB2

chr11:105950419

chr11:34226237

ENST00000435224

649_678

294

1026.0

Repeat

Note=ANK 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AASDHPPT

chr11:105950419

chr11:34226237

ENST00000278618

181_185

136

310.0

Region

Coenzyme A binding

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Fusion Gene Sequence for AASDHPPT-ABTB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>113_113_1_AASDHPPT-ABTB2_AASDHPPT_chr11_105950419_ENST00000278618_ABTB2_chr11_34226237_ENST00000298992_length(transcript)=4225nt_BP=631nt
ATACAATGCCGCAAAGCGCAGGGCTGATCTCCGTCTCCGCCCCCAGCTGCTTTCTCCGAGAGGAGGTGGCTGAGTCGGGGGCGGGCTGGG
AGGGCTGTCGGTGGGCCAGTCTGCGTAGCGACGGCCCGTCCCCTGCGCACGGACGCCGGGAAGAAGGGGGTGGGGCCACGTTTGCGTCCG
CGCCATCAGGCCCGAGATAGCGGCGAGGTCCGCTTTCAGTGTATGGTTTTCCCTGCCAAACGGTTCTGCTTGGTGCCATCCATGGAGGGC
GTGCGCTGGGCCTTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATTCAGCCCGAGGAGAAGGAG
CGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCCATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAAT
ATCCCTTGGAATCATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAATCCTTACCCGAATTTCAAC
TTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCTGAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCA
GGTGTCCTCTCCCTCCCCGCATACTTCAGCCCCTACAACGGCGGGTCCCTGGGCCATGACGAGCGAGCCGATGCCTATGCCCAGCTGGAG
CTCCGAACCCTGGAGCAGTCCCTCCTGGCCACCTGCGTGGGCAGCATCTCGGAGCTGAGTGACTTGGTCTCCCGTGCCATGCACCACATG
CAGGGGCGTCACCCCCTGTGCCCGGGTGCCAGCCCTGCCCGCCAGGCCCGCCAGCCGCCACAGCCCATCACTTGGTCCCCCGACGCCCTC
CACACGCTCTACTACTTTCTGCGGTGTCCACAGATGGAGTCCATGGAGAACCCCAACCTGGACCCCCCGAGAATGACCTTGAACAATGAA
CGGCCCTTCATGCTGCTGCCGCCCCTCATGGAGTGGATGCGCGTGGCCATCACCTACGCAGAGCACCGCCGCAGCCTCACCGTGGACAGC
GGCGACATCCGGCAGGCAGCCCGGCTGCTGCTGCCTGGTCTGGACTGTGAACCTCGGCAGCTCAAACCCGAACACTGTTTCAGTTCCTTC
CGGAGGCTGGATGCCCGAGCAGCTACTGAAAAATTCAACCAGGACCTGGGTTTCCGCATGCTCAACTGTGGGAGGACGGACCTCATCAAC
CAAGCCATCGAGGCCTTGGGTCCGGATGGGGTTAACACCATGGATGACCAGGGTATGACGCCACTGATGTACGCCTGCGCTGCTGGGGAC
GAAGCGATGGTCCAGATGTTGATTGATGCTGGGGCAAACTTGGACATCCAGGTTCCAAGCAACTCCCCCAGGCACCCTTCCATCCACCCC
GACAGCCGGCACTGGACCTCACTGACATTCGCTGTGCTGCATGGACACATCTCTGTGGTCCAGTTGCTGCTGGATGCTGGTGCCCATGTC
GAGGGCTCGGCAGTGAACGGCGGCGAGGACAGCTATGCGGAGACGCCCCTGCAGCTGGCCTCTGCGGCAGGGAACTATGAGCTGGTCAGT
TTGTTGCTGAGCCGAGGCGCCGACCCCCTCCTCAGCATGCTGGAGGCCCACGGCATGGGCTCCTCCCTCCACGAGGACATGAACTGCTTC
AGCCACTCAGCTGCCCACGGCCACAGGAACGTCCTGAGGAAGCTCCTGACGCAGCCACAGCAGGCTAAAGCGGACGTGCTGTCCCTGGAG
GAGATCCTGGCCGAGGGTGTGGAGGAAAGTGATGCGTCGAGCCAGGGCAGTGGCAGCGAGGGGCCCGTGCGGCTGAGCCGGACCCGCACC
AAGGCCCTACAGGAGGCCATGTACTACAGCGCTGAGCACGGCTACGTGGACATCACCATGGAGCTGAGGGCACTGGGAGTCCCCTGGAAG
CTGCACATCTGGATCGAGTCTCTGAGGACCTCGTTCTCGCAGTCGCGGTACTCGGTGGTGCAGAGCCTCCTGCGGGACTTCAGCTCCATC
AGAGAGGAGGAGTACAACGAGGAGCTGGTGACCGAGGGCTTGCAGCTCATGTTCGACATCCTCAAGACCAGCAAAAACGACTCCGTCATC
CAGCAACTGGCTACCATCTTCACCCACTGCTATGGCAGCAGTCCCATCCCCAGCATCCCAGAGATCCGGAAGACCCTGCCGGCCAGGCTA
GATCCACACTTTTTGAACAATAAGGAGATGTCAGATGTGACCTTCCTGGTGGAAGGAAAGCTGTTTTATGCACATAAAGTCCTGCTGGTG
ACAGCTTCTAACAGGTTCAAGACACTAATGACCAATAAATCAGAACAGGATGGGGACAGCAGCAAGACCATCGAGATCAGCGACATGAAG
TACCACATTTTTCAGATGATGATGCAGTATCTGTACTACGGAGGAACAGAATCCATGGAGATCCCCACCACTGACATCCTGGAGCTGCTG
TCAGCTGCCAGCCTGTTCCAGCTGGATGCCCTGCAGAGGCACTGCGAGATCCTGTGCTCCCAGACCCTCAGCATGGAGAGTGCCGTGAAC
ACCTACAAATATGCCAAGATCCACAATGCCCCAGAACTGGCCCTGTTCTGTGAGGGCTTCTTCCTCAAGCACATGAAGGCCCTACTGGAG
CAGGATGCCTTCCGGCAGCTCATCTACGGCCGCAGCAGCAAAGTGCAGGGCCTGGATCCACTGCAGGACCTGCAGAACACCCTGGCAGAG
CGCGTGCACTCTGTCTACATCACCTCCCGGGTGTGAGGCAGGGGGCGGAGGCTGCCGAGGCCAGGGCCTGTGGAGGTGCCAGGGCCCACC
ATGTCGGGGTATGGTTGTAGGCCCTCTTGGAGCCAGGTTCACGGGGCTGTTTCCTCCTCCTCCCCCAGATGTCCCCCCTGTCACCGGGCA
GCTCACCCTCATCTCCTCTGCCCTAGAGCTGTTTGTTCAATCACTGATGGGCAAAGGGGAGATGTAGCTAACTGGTGGCCCTCCTCCCCA
TCTCAGTTTGCAACTCAAGGGCAGCCATGCACTCCCCCGGGGTGTCGCTCTCCCCTCCTGCAGGTCAGCAGCTGATCCTGATCCACCTCC
GCCCAGGCCCTCCAAGCTCTACTCACCCCTAGGGCCTCAGTAAACTCAGACCATCCCAACTGGGGCTCCTGGGGGTACAGGAATCCTTAT
GAATGTATAGAATGCATACTGCCTAGGCCCCCAGTCGTCTGCAGTAATTCAAAAGCTGGTATTTTTCTTCCTAAATGTCACATAGCAAAG
GCTGCCCAAATCCCCAAACTTGTTCTTCAAAGGTTTGACAGGCTTAATGTGGGCATCCAGTGGCCTGTGGACCCCCCCCTGCCACCACGA
CTGCTGCCACCCGGAGTTCCCCCATTGTCTTTGGTGCCTGGGCTTCCAGAGTCCCTCCCATCAGGACTACCAGCTTGCTCAGTTAGCAGC
AGAGGGCAGTTCCCCAGCTTGATGGTTTCTGAGCTAAGTCTGGCATGGAGGGGCAAGGGGTAGGGGATGGGGTGCTGTGTAGGAATGGCC
TCAGCTCTTGTTTTGCTGCTGGTTTTAGGGGCCAAAGTAAATGGGTGGATTCTGGAACCTCAGGCCTAGACTAGGTTGCCTTTGTGGGGG
CGATGAAGCAGAGTCCCCTGGTCAAGTCTCTCGGCTCCTTTAATGTAGGATTGAGAGCTGGGCAAACAGGTCCCACTGGGGACTGTGACT
CTTGGAGATTAAAGGACAGGGCATTGATGGAAGGTAAGGGCCAGGAGAAGAGGCCTTTCTGCTGTGTCCCCTCACGGCCTTGCCCTCGAA
TTCTGCAGGCCCTGGGCTCCCCTGACACCTGTCATATTTATGGACCAGACACTGGGGCAGCATCAGGCACAGTCTGTCTGGGTGCAACTT
CTTCAGCTGTCTGGCCGCACCTTAAAAACTATTTATTCACCAAAAGCCCCAGGCATTTCAGAAGGTGGCACTCAGGTCACCCTGAAAAGC
CCCCAGGGGCTTGCAATTCTGGAAAATATTTTGACTAGCTGCTTGGCTGGATGTACAAAGAAATAGGCATTATTTTATTGCTGTAATATT

>113_113_1_AASDHPPT-ABTB2_AASDHPPT_chr11_105950419_ENST00000278618_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=918AA_BP=187
MSRGRAGRAVGGPVCVATARPLRTDAGKKGVGPRLRPRHQARDSGEVRFQCMVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRS
IQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGID
IMKTSFPGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPI
TWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKP
EHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP
RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSL
HEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELR
ALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIR
KTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPT
TDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQD

--------------------------------------------------------------
>113_113_2_AASDHPPT-ABTB2_AASDHPPT_chr11_105950419_ENST00000278618_ABTB2_chr11_34226237_ENST00000435224_length(transcript)=4225nt_BP=631nt
ATACAATGCCGCAAAGCGCAGGGCTGATCTCCGTCTCCGCCCCCAGCTGCTTTCTCCGAGAGGAGGTGGCTGAGTCGGGGGCGGGCTGGG
AGGGCTGTCGGTGGGCCAGTCTGCGTAGCGACGGCCCGTCCCCTGCGCACGGACGCCGGGAAGAAGGGGGTGGGGCCACGTTTGCGTCCG
CGCCATCAGGCCCGAGATAGCGGCGAGGTCCGCTTTCAGTGTATGGTTTTCCCTGCCAAACGGTTCTGCTTGGTGCCATCCATGGAGGGC
GTGCGCTGGGCCTTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATTCAGCCCGAGGAGAAGGAG
CGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCCATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAAT
ATCCCTTGGAATCATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAATCCTTACCCGAATTTCAAC
TTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCTGAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCA
GGTGTCCTCTCCCTCCCCGCATACTTCAGCCCCTACAACGGCGGGTCCCTGGGCCATGACGAGCGAGCCGATGCCTATGCCCAGCTGGAG
CTCCGAACCCTGGAGCAGTCCCTCCTGGCCACCTGCGTGGGCAGCATCTCGGAGCTGAGTGACTTGGTCTCCCGTGCCATGCACCACATG
CAGGGGCGTCACCCCCTGTGCCCGGGTGCCAGCCCTGCCCGCCAGGCCCGCCAGCCGCCACAGCCCATCACTTGGTCCCCCGACGCCCTC
CACACGCTCTACTACTTTCTGCGGTGTCCACAGATGGAGTCCATGGAGAACCCCAACCTGGACCCCCCGAGAATGACCTTGAACAATGAA
CGGCCCTTCATGCTGCTGCCGCCCCTCATGGAGTGGATGCGCGTGGCCATCACCTACGCAGAGCACCGCCGCAGCCTCACCGTGGACAGC
GGCGACATCCGGCAGGCAGCCCGGCTGCTGCTGCCTGGTCTGGACTGTGAACCTCGGCAGCTCAAACCCGAACACTGTTTCAGTTCCTTC
CGGAGGCTGGATGCCCGAGCAGCTACTGAAAAATTCAACCAGGACCTGGGTTTCCGCATGCTCAACTGTGGGAGGACGGACCTCATCAAC
CAAGCCATCGAGGCCTTGGGTCCGGATGGGGTTAACACCATGGATGACCAGGGTATGACGCCACTGATGTACGCCTGCGCTGCTGGGGAC
GAAGCGATGGTCCAGATGTTGATTGATGCTGGGGCAAACTTGGACATCCAGGTTCCAAGCAACTCCCCCAGGCACCCTTCCATCCACCCC
GACAGCCGGCACTGGACCTCACTGACATTCGCTGTGCTGCATGGACACATCTCTGTGGTCCAGTTGCTGCTGGATGCTGGTGCCCATGTC
GAGGGCTCGGCAGTGAACGGCGGCGAGGACAGCTATGCGGAGACGCCCCTGCAGCTGGCCTCTGCGGCAGGGAACTATGAGCTGGTCAGT
TTGTTGCTGAGCCGAGGCGCCGACCCCCTCCTCAGCATGCTGGAGGCCCACGGCATGGGCTCCTCCCTCCACGAGGACATGAACTGCTTC
AGCCACTCAGCTGCCCACGGCCACAGGAACGTCCTGAGGAAGCTCCTGACGCAGCCACAGCAGGCTAAAGCGGACGTGCTGTCCCTGGAG
GAGATCCTGGCCGAGGGTGTGGAGGAAAGTGATGCGTCGAGCCAGGGCAGTGGCAGCGAGGGGCCCGTGCGGCTGAGCCGGACCCGCACC
AAGGCCCTACAGGAGGCCATGTACTACAGCGCTGAGCACGGCTACGTGGACATCACCATGGAGCTGAGGGCACTGGGAGTCCCCTGGAAG
CTGCACATCTGGATCGAGTCTCTGAGGACCTCGTTCTCGCAGTCGCGGTACTCGGTGGTGCAGAGCCTCCTGCGGGACTTCAGCTCCATC
AGAGAGGAGGAGTACAACGAGGAGCTGGTGACCGAGGGCTTGCAGCTCATGTTCGACATCCTCAAGACCAGCAAAAACGACTCCGTCATC
CAGCAACTGGCTACCATCTTCACCCACTGCTATGGCAGCAGTCCCATCCCCAGCATCCCAGAGATCCGGAAGACCCTGCCGGCCAGGCTA
GATCCACACTTTTTGAACAATAAGGAGATGTCAGATGTGACCTTCCTGGTGGAAGGAAAGCTGTTTTATGCACATAAAGTCCTGCTGGTG
ACAGCTTCTAACAGGTTCAAGACACTAATGACCAATAAATCAGAACAGGATGGGGACAGCAGCAAGACCATCGAGATCAGCGACATGAAG
TACCACATTTTTCAGATGATGATGCAGTATCTGTACTACGGAGGAACAGAATCCATGGAGATCCCCACCACTGACATCCTGGAGCTGCTG
TCAGCTGCCAGCCTGTTCCAGCTGGATGCCCTGCAGAGGCACTGCGAGATCCTGTGCTCCCAGACCCTCAGCATGGAGAGTGCCGTGAAC
ACCTACAAATATGCCAAGATCCACAATGCCCCAGAACTGGCCCTGTTCTGTGAGGGCTTCTTCCTCAAGCACATGAAGGCCCTACTGGAG
CAGGATGCCTTCCGGCAGCTCATCTACGGCCGCAGCAGCAAAGTGCAGGGCCTGGATCCACTGCAGGACCTGCAGAACACCCTGGCAGAG
CGCGTGCACTCTGTCTACATCACCTCCCGGGTGTGAGGCAGGGGGCGGAGGCTGCCGAGGCCAGGGCCTGTGGAGGTGCCAGGGCCCACC
ATGTCGGGGTATGGTTGTAGGCCCTCTTGGAGCCAGGTTCACGGGGCTGTTTCCTCCTCCTCCCCCAGATGTCCCCCCTGTCACCGGGCA
GCTCACCCTCATCTCCTCTGCCCTAGAGCTGTTTGTTCAATCACTGATGGGCAAAGGGGAGATGTAGCTAACTGGTGGCCCTCCTCCCCA
TCTCAGTTTGCAACTCAAGGGCAGCCATGCACTCCCCCGGGGTGTCGCTCTCCCCTCCTGCAGGTCAGCAGCTGATCCTGATCCACCTCC
GCCCAGGCCCTCCAAGCTCTACTCACCCCTAGGGCCTCAGTAAACTCAGACCATCCCAACTGGGGCTCCTGGGGGTACAGGAATCCTTAT
GAATGTATAGAATGCATACTGCCTAGGCCCCCAGTCGTCTGCAGTAATTCAAAAGCTGGTATTTTTCTTCCTAAATGTCACATAGCAAAG
GCTGCCCAAATCCCCAAACTTGTTCTTCAAAGGTTTGACAGGCTTAATGTGGGCATCCAGTGGCCTGTGGACCCCCCCCTGCCACCACGA
CTGCTGCCACCCGGAGTTCCCCCATTGTCTTTGGTGCCTGGGCTTCCAGAGTCCCTCCCATCAGGACTACCAGCTTGCTCAGTTAGCAGC
AGAGGGCAGTTCCCCAGCTTGATGGTTTCTGAGCTAAGTCTGGCATGGAGGGGCAAGGGGTAGGGGATGGGGTGCTGTGTAGGAATGGCC
TCAGCTCTTGTTTTGCTGCTGGTTTTAGGGGCCAAAGTAAATGGGTGGATTCTGGAACCTCAGGCCTAGACTAGGTTGCCTTTGTGGGGG
CGATGAAGCAGAGTCCCCTGGTCAAGTCTCTCGGCTCCTTTAATGTAGGATTGAGAGCTGGGCAAACAGGTCCCACTGGGGACTGTGACT
CTTGGAGATTAAAGGACAGGGCATTGATGGAAGGTAAGGGCCAGGAGAAGAGGCCTTTCTGCTGTGTCCCCTCACGGCCTTGCCCTCGAA
TTCTGCAGGCCCTGGGCTCCCCTGACACCTGTCATATTTATGGACCAGACACTGGGGCAGCATCAGGCACAGTCTGTCTGGGTGCAACTT
CTTCAGCTGTCTGGCCGCACCTTAAAAACTATTTATTCACCAAAAGCCCCAGGCATTTCAGAAGGTGGCACTCAGGTCACCCTGAAAAGC
CCCCAGGGGCTTGCAATTCTGGAAAATATTTTGACTAGCTGCTTGGCTGGATGTACAAAGAAATAGGCATTATTTTATTGCTGTAATATT

>113_113_2_AASDHPPT-ABTB2_AASDHPPT_chr11_105950419_ENST00000278618_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=918AA_BP=187
MSRGRAGRAVGGPVCVATARPLRTDAGKKGVGPRLRPRHQARDSGEVRFQCMVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRS
IQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGID
IMKTSFPGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPI
TWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKP
EHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP
RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSL
HEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELR
ALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIR
KTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPT
TDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQD

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Fusion Gene PPI Analysis for AASDHPPT-ABTB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for AASDHPPT-ABTB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for AASDHPPT-ABTB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source