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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C1QC-MYO1F (FusionGDB2 ID:11426)

Fusion Gene Summary for C1QC-MYO1F

Fusion gene summary

Fusion gene information	Fusion gene name: C1QC-MYO1F
	Fusion gene ID: 11426
		Hgene	Tgene
	Gene symbol	C1QC	MYO1F
	Gene ID	714	4542
	Gene name	complement C1q C chain	myosin IF
	Synonyms	C1Q-C\|C1QG	-
	Cytomap	1p36.12	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	complement C1q subcomponent subunit Ccomplement component 1, q subcomponent, C chaincomplement component 1, q subcomponent, gamma polypeptide	unconventional myosin-Ifmyosin-IDmyosin-Ie
	Modification date	20200313	20200313
	UniProtAcc	P02747	O00160
	Ensembl transtripts involved in fusion gene	ENST00000374637, ENST00000374639, ENST00000374640,	ENST00000595046, ENST00000338257,
Fusion gene scores	* DoF score	4 X 5 X 4=80	9 X 9 X 5=405
	# samples	5	10
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C1QC [Title/Abstract] AND MYO1F [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C1QC(22974184)-MYO1F(8617015), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	C1QC	GO:0030853	negative regulation of granulocyte differentiation	10961870
Hgene	C1QC	GO:0045650	negative regulation of macrophage differentiation	10961870

Fusion gene breakpoints across C1QC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO1F (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CD370183	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+

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Fusion Gene ORF analysis for C1QC-MYO1F

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000374637	ENST00000595046	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+
5CDS-intron	ENST00000374639	ENST00000595046	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+
5CDS-intron	ENST00000374640	ENST00000595046	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+
Frame-shift	ENST00000374637	ENST00000338257	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+
In-frame	ENST00000374639	ENST00000338257	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+
In-frame	ENST00000374640	ENST00000338257	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000374640

C1QC

chr1

22974184

ENST00000338257

MYO1F

chr19

8617015

4196

698

2058

3227

389

ENST00000374639

C1QC

chr1

22974184

ENST00000338257

MYO1F

chr19

8617015

4216

718

2078

3247

389

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374640	ENST00000338257	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+	0.28153875	0.7184612
ENST00000374639	ENST00000338257	C1QC	chr1	22974184	-	MYO1F	chr19	8617015	+	0.2831338	0.71686625

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Fusion Genomic Features for C1QC-MYO1F

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C1QC-MYO1F

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:22974184/chr19:8617015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C1QC P02747	MYO1F O00160
FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

1041_1098

1099.0

Domain

SH3

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

17_690

1099.0

Domain

Myosin motor

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

693_722

1099.0

Domain

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

728_917

1099.0

Domain

TH1

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

110_117

1099.0

Nucleotide binding

ATP

Tgene

MYO1F

chr1:22974184

chr19:8617015

ENST00000338257

579_589

1099.0

Region

Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374637

115_245

246.0

Domain

C1q

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374637

31_112

246.0

Domain

Note=Collagen-like

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374639

115_245

246.0

Domain

C1q

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374639

31_112

246.0

Domain

Note=Collagen-like

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374640

115_245

246.0

Domain

C1q

Hgene

C1QC

chr1:22974184

chr19:8617015

ENST00000374640

31_112

246.0

Domain

Note=Collagen-like

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Fusion Gene Sequence for C1QC-MYO1F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11426_11426_1_C1QC-MYO1F_C1QC_chr1_22974184_ENST00000374639_MYO1F_chr19_8617015_ENST00000338257_length(transcript)=4216nt_BP=718nt
AGACACCGTGTCCTCTTGCCTGGGAGAGGGGAAGCAGATCTGAGGACATCTCTGTGCCAGGCCAGAAACCGCCCACCTGCAGGTGAGGCC
CGGACCCCTGCCCAGTTCCTTCTCCGGGATGGACGTGGGGCCCAGCTCCCTGCCCCACCTTGGGCTGAAGCTGCTGCTGCTCCTGCTGCT
GCTGCCCCTCAGGGGCCAAGCCAACACAGGCTGCTACGGGATCCCAGGGATGCCCGGCCTGCCCGGGGCACCAGGGAAGGATGGGTACGA
CGGACTGCCGGGGCCCAAGGGGGAGCCAGAGGTGTGGCTGGCTGTCAATGACTACTACGACATGGTGGGCATCCAGGGCTCTGACAGCGT
CTTCTCCGGCTTCCTGCTCTTCCCCGACTAGGGCGGGCAGATGCGCTCGAGCCCCACGGGCCTTCCACCTCCCTCAGCTTCCTGCATGGA
CCCACCTTACTGGCCAGTCTGCATCCTTGCCTAGACCATTCTCCCCACCAGATGGACTTCTCCTCCAGGGAGCCCACCCTGACCCACCCC
CACTGCACCCCCTCCCCATGGGTTCTCTCCTTCCTCTGAACTTCTTTAGGAGTCACTGCTTGTGTGGTTCCTGGGACACTTAACCAATGC
CTTCTGGTACTGCCATTCTTTTTTTTTTTTTTTTCAAGTATTGGAAGGGGTGGGGAGATATATAAATAAATCATGAAATCAATACATAAT
CCCTCGGGCTGGTGGAAGGGCCGGCTTCACGGCCAGGAGGGCCTTTTCCCAGGAAACTACGTGGAGAAGATCTGAGCTGGGCCCTGGGAT
ACTGCCTTCTCTTTCGCCCGCCTATCTGCCTGCCGGCCTGGTGGGGAGCCAGGCCCTGCCAATGAGAGCCTCGTTTACCTGGGCTGCAAT
AGCCTAAAAGTCCAGTCCTTTGGCCTCCAGTCCTGCCCAGGCCCTGGGTCACCAGGTCACTGCTGCAGCCCCCGCCCCTGGGCCCTGGTC
TTCCTCCAACATCACACCTGCTGCCCATTCTCCATTTCTGTGTGTGTCAAAGGGGACTAACAGCAGAATCTACCTCCCAACTGCCATGTG
ATTAAGAAATGGGTCTTGAGTCCTGTGCTGTTGGCAAAGTGCCAGGCACAGTTGGGGAGGGGGGGGTCCTTAACAAGCGTGACTTTGCTC
ATTCTGTCATCACTAAGGCAATAAACCTTTGCCAGGTGAAAGCACGAGTTAACTTACTAAGTGCCCAACAAGGACGATGTTTTCACAGCC
CTGTGAGGTAGGAGCTGTGAAGGACCCCATCTTACAGGTGGAACAATGGAGGTTCAGAGAGGTTCACTGACCCAAGACTGCACAGAGCCA
TGCCTTGCATTCATATGTGACCATAAAGCTTGAATTTGTCCCAGTTTGGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGG
GAGGCTGAGGCGGGCAGATCACGTGAGACCAGGAGTTCAAGACCAGCCTGGATAACACAGCAAAACCCTGTTTCTACTAAAAATTTAAAA
AAGCATGCAGAGGAAGCGCAGCGTGGGGCAACGGCCAGTGCCTGGTGTGGGCCGACCCAAGCCCCAGCCTCGGACACATGGTCCCAGGTG
CCGGGCCCTATACCAGTACGTGGGCCAAGATGTGGACGAGCTGAGCTTCAACGTGAACGAGGTCATTGAGATCCTCATGGAAGGCATGGA
TCGCAATGGGGTGCCCCCCTCTGCCAGAGGGGGCCCCCTGCCCCTGGAGATCATGTCTGGAGGGGGCACCCACAGGCCTCCCCGGGGCCC
TCCGTCCACATCCCTGGGAGCCAGCAGACGACCCCGGGCACGTCCGCCCTCAGAGCACAACACAGAATTCCTCAACGTGCCTGACCAGGG
CATGGCCGGAGCCTACGCGGAAGGGAATGGCCAAGGGAAAACCTCGGAGGTCGTCCCAAGCCCCTACCCGGGCGGCCCCTGCGCCCCCCA
GAGACTACAGTTTCGGGTGAAGAAGGAGGGCTGGGGCGGTGGCGGCACCCGCAGCGTCACCTTCTCCCGCGGCTTCGGCGACTTGGCAGT
GCTCAAGGTTGGCGGTCGGACCCTCACGGTCAGCGTGGGCGATGGGCTGCCCAAGAGCTCCACACGCGACAGGACGACTTCTTCATCCTC
CAAGAGGATGCCGCCGACAGCTTCCTGGAGAGCGTCTTCAAGACCGAGTTTGTCAGCCTTCTGTGCAAGCGCTTCGAGGAGGCGACGCGG
AGGCCCCTGCCCCTCACCTTCAGCGACACCCCATCAAGCGGGACTTGATCCTGACGCCCAAGTGTGTGTATGTGATTGGGCGAGAGAAAG
TGAAGAAGGGACCTGAGAAGGGCCAGGTGTGTGAAGTCTTGAAGAAGAAAGTGGACATCCAGGCTCTGCGGGGAGTCTCCCTCAGCTTCC
AACATCCTGCTGAACAAGAAGGAGCGGAGGCGCAACAGCATCAATCGGAACTTCGTCGGGGACTACCTGGGGCTGGAGGAGCGGCCCGAG
CTGCGTCAGTTCCTGGGCAAGAGGGAGCGGGTGGACTTCGCCGATTCGGTCACCAAGTACGACCGCCGCTTCAAGCTTTTCCTCCTGGAG
GAGGTGCGAGAGCGAAAGTTCGATGGCTTTGCCCGAACCATCCAGAAGGCCTGGCGGCGCCACGTGGCTGTCCGGAAGTACGAGGAGATG
CGGGAGGAAGGTATGCCATTCTGACCCCCGAGACGTGGCCGCGGTGGCGTGGGGACGAACGCCAGGGCGTCCAGCACCTGCTTCGGGCGG
TCAACATGGAGCCCGACCAGTACCAGATGGGGAGCACCAAGGTCTTTGTCAAGAACCCAGAGTCGAGTCAAGCACCAGGTGGAATACCTG
GGCCTGAAGGAGAACATCAGGGTGCGCAGAGCCGGCTTCGCCTACCGCCGCCAGTTCGCCAAATTCCTGCAGAGAAACAAGCCAACGACC
TGGTGGCCACACTGATGAGGTGCACACCCCACTACATCCGCTGCATCAAACCCAACGAGACCAAGAGGCCCCGAGACTGGGAGGAGAACA
GGGCCTTCCTCCGGATGCTCTTCCCCGAGAAGCTGGATGGAGACAAGAAGGGGCGCCCCAGCACCGCCGGCTCCAAGATCAAGGTCTCCT
ACGACGTCAGCGGCTTCTGCGAGAGGAACCGAGACGTTCTCTTCTCCGACCTCATAGAGCTGATGCAGACCAGTGAGCAAGCCCCCCAGG
CATCATGAGCGTCTTGGACGACGTGTGCGCCACCATGCACGCCACGGGCGGGGGAGCAGACCAGACACTGCTGCAGAAGCTGCAGGCGGC
TGTGGGGACCCACGAGCATTTCAACAGCTGGAGCGCCGGCTTCGTCATCCACCACTACGCTGGCAAGGAGGAGTATGTGCAGGAAGGCAT
CCGCTGGACTCCAATCCAGTACTTCAACAACAAGGTCGTCTGTGACCTCATCGAAAACAAGCTGAAAAATGGCTTCGAGCAGTTTTGCAT
CAACTTCGTCAATGAGAAGCTGCAGCAAATCTTTATCGAACTTACCCTGAAGGCCGAGCAGGCCATCAACCGTGCTATGCAGAAACCCCA
GGAAGAGTACAGCATCGGTGTGCTGGACATTTACGGCTTCGAGATCTTCCAGTCCTGGCCTTTCCCGCCTACCTGCTGGGCATTGACAGC
GGGCGACTGCAGGAGAAGCTGACCAGCCGCAAGATGGACAGCCGCTGGGGCGGGCGCAGCGAGTCCATCAATGTGACCCTCAACGTGGAG
CAGGCAGCCTACACCCGTGATGCCCTGGCCAAGGGGCTCTATGCCCGCCTCTTCGACTTCCTCGTGGAGAGTGCTATGCAGGTTATTGGG
ATCCCGCCCAGCATCCAGCAGCTGGTCCTGCAGCTCGTGGCGGGGATCTTGCACCTGGGGAACATCAGTTTCTGTGAAGACGGGAATTAC
GCCCGAGTGGAGAGTGTGGACCCTGCTGGAAGGGGCCTCCCAGGAGCAAAGGCAGAACCTGGGCCTCATGACACCGGACTACTATTACTA
CCTCAACCAATCGGACACCTACCAGGTGGACGGCACGGACGACAGAAGCGACTTTGGTGAGACTCTGGGGGAGCCAGATGGGGGCAAGAT

>11426_11426_1_C1QC-MYO1F_C1QC_chr1_22974184_ENST00000374639_MYO1F_chr19_8617015_ENST00000338257_length(amino acids)=389AA_BP=164
MAVGPSRSAWAMGCPRAPHATGRLLHPPRGCRRQLPGERLQDRVCQPSVQALRGGDAEAPAPHLQRHPIKRDLILTPKCVYVIGREKVKK
GPEKGQVCEVLKKKVDIQALRGVSLSFQHPAEQEGAEAQQHQSELRRGLPGAGGAARAASVPGQEGAGGLRRFGHQVRPPLQAFPPGGGA
RAKVRWLCPNHPEGLAAPRGCPEVRGDAGGRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESSQAPGGIPGPE
GEHQGAQSRLRLPPPVRQIPAEKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRAFLRMLFPEKLDGDKKGRPSTAGSKIKVSYDV

--------------------------------------------------------------
>11426_11426_2_C1QC-MYO1F_C1QC_chr1_22974184_ENST00000374640_MYO1F_chr19_8617015_ENST00000338257_length(transcript)=4196nt_BP=698nt
CTCAGACACCGTGTCCTCTTGCCTGGGAGAGGGGAAGCAGATCTGAGGACATCTCTGTGCCAGGCCAGAAACCGCCCACCTGCAGTTCCT
TCTCCGGGATGGACGTGGGGCCCAGCTCCCTGCCCCACCTTGGGCTGAAGCTGCTGCTGCTCCTGCTGCTGCTGCCCCTCAGGGGCCAAG
CCAACACAGGCTGCTACGGGATCCCAGGGATGCCCGGCCTGCCCGGGGCACCAGGGAAGGATGGGTACGACGGACTGCCGGGGCCCAAGG
GGGAGCCAGAGGTGTGGCTGGCTGTCAATGACTACTACGACATGGTGGGCATCCAGGGCTCTGACAGCGTCTTCTCCGGCTTCCTGCTCT
TCCCCGACTAGGGCGGGCAGATGCGCTCGAGCCCCACGGGCCTTCCACCTCCCTCAGCTTCCTGCATGGACCCACCTTACTGGCCAGTCT
GCATCCTTGCCTAGACCATTCTCCCCACCAGATGGACTTCTCCTCCAGGGAGCCCACCCTGACCCACCCCCACTGCACCCCCTCCCCATG
GGTTCTCTCCTTCCTCTGAACTTCTTTAGGAGTCACTGCTTGTGTGGTTCCTGGGACACTTAACCAATGCCTTCTGGTACTGCCATTCTT
TTTTTTTTTTTTTTCAAGTATTGGAAGGGGTGGGGAGATATATAAATAAATCATGAAATCAATACATAATCCCTCGGGCTGGTGGAAGGG
CCGGCTTCACGGCCAGGAGGGCCTTTTCCCAGGAAACTACGTGGAGAAGATCTGAGCTGGGCCCTGGGATACTGCCTTCTCTTTCGCCCG
CCTATCTGCCTGCCGGCCTGGTGGGGAGCCAGGCCCTGCCAATGAGAGCCTCGTTTACCTGGGCTGCAATAGCCTAAAAGTCCAGTCCTT
TGGCCTCCAGTCCTGCCCAGGCCCTGGGTCACCAGGTCACTGCTGCAGCCCCCGCCCCTGGGCCCTGGTCTTCCTCCAACATCACACCTG
CTGCCCATTCTCCATTTCTGTGTGTGTCAAAGGGGACTAACAGCAGAATCTACCTCCCAACTGCCATGTGATTAAGAAATGGGTCTTGAG
TCCTGTGCTGTTGGCAAAGTGCCAGGCACAGTTGGGGAGGGGGGGGTCCTTAACAAGCGTGACTTTGCTCATTCTGTCATCACTAAGGCA
ATAAACCTTTGCCAGGTGAAAGCACGAGTTAACTTACTAAGTGCCCAACAAGGACGATGTTTTCACAGCCCTGTGAGGTAGGAGCTGTGA
AGGACCCCATCTTACAGGTGGAACAATGGAGGTTCAGAGAGGTTCACTGACCCAAGACTGCACAGAGCCATGCCTTGCATTCATATGTGA
CCATAAAGCTTGAATTTGTCCCAGTTTGGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATC
ACGTGAGACCAGGAGTTCAAGACCAGCCTGGATAACACAGCAAAACCCTGTTTCTACTAAAAATTTAAAAAAGCATGCAGAGGAAGCGCA
GCGTGGGGCAACGGCCAGTGCCTGGTGTGGGCCGACCCAAGCCCCAGCCTCGGACACATGGTCCCAGGTGCCGGGCCCTATACCAGTACG
TGGGCCAAGATGTGGACGAGCTGAGCTTCAACGTGAACGAGGTCATTGAGATCCTCATGGAAGGCATGGATCGCAATGGGGTGCCCCCCT
CTGCCAGAGGGGGCCCCCTGCCCCTGGAGATCATGTCTGGAGGGGGCACCCACAGGCCTCCCCGGGGCCCTCCGTCCACATCCCTGGGAG
CCAGCAGACGACCCCGGGCACGTCCGCCCTCAGAGCACAACACAGAATTCCTCAACGTGCCTGACCAGGGCATGGCCGGAGCCTACGCGG
AAGGGAATGGCCAAGGGAAAACCTCGGAGGTCGTCCCAAGCCCCTACCCGGGCGGCCCCTGCGCCCCCCAGAGACTACAGTTTCGGGTGA
AGAAGGAGGGCTGGGGCGGTGGCGGCACCCGCAGCGTCACCTTCTCCCGCGGCTTCGGCGACTTGGCAGTGCTCAAGGTTGGCGGTCGGA
CCCTCACGGTCAGCGTGGGCGATGGGCTGCCCAAGAGCTCCACACGCGACAGGACGACTTCTTCATCCTCCAAGAGGATGCCGCCGACAG
CTTCCTGGAGAGCGTCTTCAAGACCGAGTTTGTCAGCCTTCTGTGCAAGCGCTTCGAGGAGGCGACGCGGAGGCCCCTGCCCCTCACCTT
CAGCGACACCCCATCAAGCGGGACTTGATCCTGACGCCCAAGTGTGTGTATGTGATTGGGCGAGAGAAAGTGAAGAAGGGACCTGAGAAG
GGCCAGGTGTGTGAAGTCTTGAAGAAGAAAGTGGACATCCAGGCTCTGCGGGGAGTCTCCCTCAGCTTCCAACATCCTGCTGAACAAGAA
GGAGCGGAGGCGCAACAGCATCAATCGGAACTTCGTCGGGGACTACCTGGGGCTGGAGGAGCGGCCCGAGCTGCGTCAGTTCCTGGGCAA
GAGGGAGCGGGTGGACTTCGCCGATTCGGTCACCAAGTACGACCGCCGCTTCAAGCTTTTCCTCCTGGAGGAGGTGCGAGAGCGAAAGTT
CGATGGCTTTGCCCGAACCATCCAGAAGGCCTGGCGGCGCCACGTGGCTGTCCGGAAGTACGAGGAGATGCGGGAGGAAGGTATGCCATT
CTGACCCCCGAGACGTGGCCGCGGTGGCGTGGGGACGAACGCCAGGGCGTCCAGCACCTGCTTCGGGCGGTCAACATGGAGCCCGACCAG
TACCAGATGGGGAGCACCAAGGTCTTTGTCAAGAACCCAGAGTCGAGTCAAGCACCAGGTGGAATACCTGGGCCTGAAGGAGAACATCAG
GGTGCGCAGAGCCGGCTTCGCCTACCGCCGCCAGTTCGCCAAATTCCTGCAGAGAAACAAGCCAACGACCTGGTGGCCACACTGATGAGG
TGCACACCCCACTACATCCGCTGCATCAAACCCAACGAGACCAAGAGGCCCCGAGACTGGGAGGAGAACAGGGCCTTCCTCCGGATGCTC
TTCCCCGAGAAGCTGGATGGAGACAAGAAGGGGCGCCCCAGCACCGCCGGCTCCAAGATCAAGGTCTCCTACGACGTCAGCGGCTTCTGC
GAGAGGAACCGAGACGTTCTCTTCTCCGACCTCATAGAGCTGATGCAGACCAGTGAGCAAGCCCCCCAGGCATCATGAGCGTCTTGGACG
ACGTGTGCGCCACCATGCACGCCACGGGCGGGGGAGCAGACCAGACACTGCTGCAGAAGCTGCAGGCGGCTGTGGGGACCCACGAGCATT
TCAACAGCTGGAGCGCCGGCTTCGTCATCCACCACTACGCTGGCAAGGAGGAGTATGTGCAGGAAGGCATCCGCTGGACTCCAATCCAGT
ACTTCAACAACAAGGTCGTCTGTGACCTCATCGAAAACAAGCTGAAAAATGGCTTCGAGCAGTTTTGCATCAACTTCGTCAATGAGAAGC
TGCAGCAAATCTTTATCGAACTTACCCTGAAGGCCGAGCAGGCCATCAACCGTGCTATGCAGAAACCCCAGGAAGAGTACAGCATCGGTG
TGCTGGACATTTACGGCTTCGAGATCTTCCAGTCCTGGCCTTTCCCGCCTACCTGCTGGGCATTGACAGCGGGCGACTGCAGGAGAAGCT
GACCAGCCGCAAGATGGACAGCCGCTGGGGCGGGCGCAGCGAGTCCATCAATGTGACCCTCAACGTGGAGCAGGCAGCCTACACCCGTGA
TGCCCTGGCCAAGGGGCTCTATGCCCGCCTCTTCGACTTCCTCGTGGAGAGTGCTATGCAGGTTATTGGGATCCCGCCCAGCATCCAGCA
GCTGGTCCTGCAGCTCGTGGCGGGGATCTTGCACCTGGGGAACATCAGTTTCTGTGAAGACGGGAATTACGCCCGAGTGGAGAGTGTGGA
CCCTGCTGGAAGGGGCCTCCCAGGAGCAAAGGCAGAACCTGGGCCTCATGACACCGGACTACTATTACTACCTCAACCAATCGGACACCT
ACCAGGTGGACGGCACGGACGACAGAAGCGACTTTGGTGAGACTCTGGGGGAGCCAGATGGGGGCAAGATCTCCAACTTCTTGCTGGAGA

>11426_11426_2_C1QC-MYO1F_C1QC_chr1_22974184_ENST00000374640_MYO1F_chr19_8617015_ENST00000338257_length(amino acids)=389AA_BP=164
MAVGPSRSAWAMGCPRAPHATGRLLHPPRGCRRQLPGERLQDRVCQPSVQALRGGDAEAPAPHLQRHPIKRDLILTPKCVYVIGREKVKK
GPEKGQVCEVLKKKVDIQALRGVSLSFQHPAEQEGAEAQQHQSELRRGLPGAGGAARAASVPGQEGAGGLRRFGHQVRPPLQAFPPGGGA
RAKVRWLCPNHPEGLAAPRGCPEVRGDAGGRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESSQAPGGIPGPE
GEHQGAQSRLRLPPPVRQIPAEKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRAFLRMLFPEKLDGDKKGRPSTAGSKIKVSYDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C1QC-MYO1F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for C1QC-MYO1F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for C1QC-MYO1F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source