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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C20orf112-COMMD7 (FusionGDB2 ID:11460)

Fusion Gene Summary for C20orf112-COMMD7

check button Fusion gene summary
Fusion gene informationFusion gene name: C20orf112-COMMD7
Fusion gene ID: 11460
HgeneTgene
Gene symbol

C20orf112

COMMD7

Gene ID

140688

149951

Gene namenucleolar protein 4 likeCOMM domain containing 7
SynonymsC20orf112|C20orf113C20orf92|dJ1085F17.3
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 4-likeCOMM domain-containing protein 7
Modification date2020031320200313
UniProtAcc.

Q86VX2

Ensembl transtripts involved in fusion geneENST00000326071, ENST00000359676, 
ENST00000475781, ENST00000201961, 
ENST00000375677, ENST00000375678, 
ENST00000278980, ENST00000446419, 
Fusion gene scores* DoF score4 X 7 X 4=1127 X 5 X 6=210
# samples 59
** MAII scorelog2(5/112*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C20orf112 [Title/Abstract] AND COMMD7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC20orf112(31071165)-COMMD7(31315949), # samples:2
C20orf112(31172372)-COMMD7(31294562), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOMMD7

GO:0032088

negative regulation of NF-kappaB transcription factor activity

15799966

TgeneCOMMD7

GO:0033209

tumor necrosis factor-mediated signaling pathway

15799966

TgeneCOMMD7

GO:0045892

negative regulation of transcription, DNA-templated

15799966


check buttonFusion gene breakpoints across C20orf112 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COMMD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08L-01AC20orf112chr20

31172372

-COMMD7chr20

31294562

-
ChimerDB4BRCATCGA-A8-A08L-01AC20orf112chr20

31172472

-COMMD7chr20

31294561

-
ChimerDB4BRCATCGA-E9-A5UP-01AC20orf112chr20

31071165

-COMMD7chr20

31315949

-
ChimerDB4BRCATCGA-E9-A5UP-01AC20orf112chr20

31099150

-COMMD7chr20

31315949

-


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Fusion Gene ORF analysis for C20orf112-COMMD7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000326071ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
5UTR-3CDSENST00000326071ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
5UTR-3CDSENST00000359676ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
5UTR-3CDSENST00000359676ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
5UTR-3CDSENST00000475781ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
5UTR-3CDSENST00000475781ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
Frame-shiftENST00000201961ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
Frame-shiftENST00000201961ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
In-frameENST00000201961ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
In-frameENST00000201961ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-
In-frameENST00000375677ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
In-frameENST00000375677ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-
In-frameENST00000375678ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
In-frameENST00000375678ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000201961ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000201961ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000201961ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000201961ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000326071ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000326071ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000326071ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000326071ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000326071ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000326071ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000359676ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000359676ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000359676ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000359676ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000359676ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000359676ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000375677ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000375677ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000375677ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000375677ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000375677ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000375677ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000375678ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000375678ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000375678ENST00000278980C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000375678ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000375678ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000375678ENST00000446419C20orf112chr20

31071165

-COMMD7chr20

31315949

-
intron-3CDSENST00000475781ENST00000278980C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000475781ENST00000278980C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000475781ENST00000278980C20orf112chr20

31099150

-COMMD7chr20

31315949

-
intron-3CDSENST00000475781ENST00000446419C20orf112chr20

31172372

-COMMD7chr20

31294562

-
intron-3CDSENST00000475781ENST00000446419C20orf112chr20

31172472

-COMMD7chr20

31294561

-
intron-3CDSENST00000475781ENST00000446419C20orf112chr20

31099150

-COMMD7chr20

31315949

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375677C20orf112chr2031099150-ENST00000278980COMMD7chr2031315949-12716119579186
ENST00000375677C20orf112chr2031099150-ENST00000446419COMMD7chr2031315949-12566119576185
ENST00000375678C20orf112chr2031099150-ENST00000278980COMMD7chr2031315949-2755154511792063294
ENST00000375678C20orf112chr2031099150-ENST00000446419COMMD7chr2031315949-2740154511792060293
ENST00000201961C20orf112chr2031099150-ENST00000278980COMMD7chr2031315949-184763741155383
ENST00000201961C20orf112chr2031099150-ENST00000446419COMMD7chr2031315949-183263741152382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375677ENST00000278980C20orf112chr2031099150-COMMD7chr2031315949-0.0096810230.990319
ENST00000375677ENST00000446419C20orf112chr2031099150-COMMD7chr2031315949-0.0135333840.9864666
ENST00000375678ENST00000278980C20orf112chr2031099150-COMMD7chr2031315949-0.0095677780.9904322
ENST00000375678ENST00000446419C20orf112chr2031099150-COMMD7chr2031315949-0.0080243960.9919756
ENST00000201961ENST00000278980C20orf112chr2031099150-COMMD7chr2031315949-0.0048202620.9951798
ENST00000201961ENST00000446419C20orf112chr2031099150-COMMD7chr2031315949-0.0045561140.99544394

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Fusion Genomic Features for C20orf112-COMMD7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C20orf112-COMMD7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31071165/chr20:31315949)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COMMD7

Q86VX2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD7chr20:31099150chr20:31315949ENST0000027898009133_20028201.0DomainCOMM
TgeneCOMMD7chr20:31099150chr20:31315949ENST0000044641909133_20028200.0DomainCOMM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC20orf112chr20:31099150chr20:31315949ENST00000359676-18161_1690437.0Compositional biasNote=Poly-Asp


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Fusion Gene Sequence for C20orf112-COMMD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11460_11460_1_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000201961_COMMD7_chr20_31315949_ENST00000278980_length(transcript)=1847nt_BP=637nt
GGAGCTGGGCCGCCAGTTCCGGGACTGGTGCTTGCGCACCTACGGCGACTCGGCCAAAACCAAGACGGTGACACGCAGCAAATACCAGCG
GATCGCCGAGGTCCTGCAGGGCGGCGGCGGGACTGGCGCGGGCAGCGGCCCCGCAGCCGGCGAGAAAGGCAAGTTCCAGTTCTGGGTGCG
CTCCAAGGGCTTCCGCCTGGGCAGCGGCCGGGAACCCAAGATGGGCCAAGTGGTGTATGTGCCGGTCAAGACGGGCTCGGGGGCAGATGG
CCTGTCGGAGCCAGAGGGCATCTCTCTGAAGCGGGTCGCTGTGGTGGAAGATTTCTTTGACATCATCTACTCGATGCATGTGGAGAGCTC
AGCGGAGCCAGGCAAAGCCCCCAAGCACGCTGGGCAGAAGAAAACCTACCGAGCGATCGCAGAGACCTATGCCTTCCTCCCGAGAGAGGC
CGTGACCCGGTTCCTGATGAGCTGTACGGAGTGTCAGAAGAGGATGCACTTTAACTCCAATGGCCTGGAACCCAAAGAAAACGAGCCTCC
ATCTCCACTGGTCTCTGGGATTATTGATTACAACATGCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATGAATTCCCA
GGAGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGA
ATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAG
TCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAA
TGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGG
GAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGA
ATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCA
TCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATG
GGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTG
TAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGG
AGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAA
AAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGT
CTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAA
ACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAACCACCT

>11460_11460_1_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000201961_COMMD7_chr20_31315949_ENST00000278980_length(amino acids)=383AA_BP=210
MGRQFRDWCLRTYGDSAKTKTVTRSKYQRIAEVLQGGGGTGAGSGPAAGEKGKFQFWVRSKGFRLGSGREPKMGQVVYVPVKTGSGADGL
SEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPPS
PLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSL
TAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIEL

--------------------------------------------------------------
>11460_11460_2_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000201961_COMMD7_chr20_31315949_ENST00000446419_length(transcript)=1832nt_BP=637nt
GGAGCTGGGCCGCCAGTTCCGGGACTGGTGCTTGCGCACCTACGGCGACTCGGCCAAAACCAAGACGGTGACACGCAGCAAATACCAGCG
GATCGCCGAGGTCCTGCAGGGCGGCGGCGGGACTGGCGCGGGCAGCGGCCCCGCAGCCGGCGAGAAAGGCAAGTTCCAGTTCTGGGTGCG
CTCCAAGGGCTTCCGCCTGGGCAGCGGCCGGGAACCCAAGATGGGCCAAGTGGTGTATGTGCCGGTCAAGACGGGCTCGGGGGCAGATGG
CCTGTCGGAGCCAGAGGGCATCTCTCTGAAGCGGGTCGCTGTGGTGGAAGATTTCTTTGACATCATCTACTCGATGCATGTGGAGAGCTC
AGCGGAGCCAGGCAAAGCCCCCAAGCACGCTGGGCAGAAGAAAACCTACCGAGCGATCGCAGAGACCTATGCCTTCCTCCCGAGAGAGGC
CGTGACCCGGTTCCTGATGAGCTGTACGGAGTGTCAGAAGAGGATGCACTTTAACTCCAATGGCCTGGAACCCAAAGAAAACGAGCCTCC
ATCTCCACTGGTCTCTGGGATTATTGATTACAACATGCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATGAATTCCCA
GGAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATT
TGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAGTCT
CACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAATGC
TCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGGGAG
CAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGAATT
AACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCATCT
CCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATGGGG
CCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTGTAA
ACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGGAGA
AAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAAAAA
GCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGTCTG
TGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAAACT
CTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAACCACCTCTG

>11460_11460_2_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000201961_COMMD7_chr20_31315949_ENST00000446419_length(amino acids)=382AA_BP=210
MGRQFRDWCLRTYGDSAKTKTVTRSKYQRIAEVLQGGGGTGAGSGPAAGEKGKFQFWVRSKGFRLGSGREPKMGQVVYVPVKTGSGADGL
SEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPPS
PLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLT
AKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELT

--------------------------------------------------------------
>11460_11460_3_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375677_COMMD7_chr20_31315949_ENST00000278980_length(transcript)=1271nt_BP=61nt
GCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATGAATTCCCAGGAGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTT
CCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCT
CAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAAC
TCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGAC
TCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTT
ACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGA
GATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCC
CTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGG
GTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCT
TCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAG
AGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGG
ATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATG
AGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTC
GTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAACCACCTCTGTTGGTTAGATGATGAATAAAAAGGTTCTGAAGA

>11460_11460_3_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375677_COMMD7_chr20_31315949_ENST00000278980_length(amino acids)=186AA_BP=13
MKQMKLRVMNSQEQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEE
KATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRT

--------------------------------------------------------------
>11460_11460_4_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375677_COMMD7_chr20_31315949_ENST00000446419_length(transcript)=1256nt_BP=61nt
GCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATGAATTCCCAGGAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCA
CTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAG
AAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCT
GGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCT
GATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACA
ACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGAT
GGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTG
GGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTT
TCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCC
AGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGT
AAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATT
GTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGG
CACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTA

>11460_11460_4_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375677_COMMD7_chr20_31315949_ENST00000446419_length(amino acids)=185AA_BP=13
MKQMKLRVMNSQEQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEK
ATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTS

--------------------------------------------------------------
>11460_11460_5_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375678_COMMD7_chr20_31315949_ENST00000278980_length(transcript)=2755nt_BP=1545nt
CCCCCTCCAGCCCCACCTCTTCCCCCGGCCCTGGGTGGGGCCCGCACCTGGGGCTCTCCGCTCGTTAGCGCGCCCAGGGCGCCTCCTCGG
CCCGAGAGGGACCCGCCCGCGGGGCCTGGCTGGCTCAGGGCTACCTCCTTCCGCCTAGGACCCCCCCTTCGGTGACTCCCGATTCCCTGT
CCTAGGCTGCGGTGCCCCGGGAGGCGGGTCGCCAGAGTAGCAGACAGAGCTCTTTAATGGGTGTCTTCTAGGGCGGGTGCTGTTTGTGCA
TCATTTGGGTTCCCACACACTTCCTATGAGGTGGCGAAAGCCATTATGCCTATGGTGTCTGCTCACACAGGGGGAAACTGAGGCCCAGGC
AGGACAGCCCCTTGCCTGGGGTGGGGGCTGGGTTGTCCTTAGGCCTGTGACTTCACCTCTACAGCACCCTCCTGTGGACCCTCTCCCTGC
CCCCGCCAGGCCAGAGTCCTGCAGCCAGGCCCAGACCCTGGCCTGTCCGTCCGGGGATGCTGGACAGTACTCCTCCCTCCAGCCCTCATA
AGTCATTGTCATTCGGATCTGCATTTCCCCAGCCCCTCTCCTTCTAACTGGGGGGCACTGTGGCCCACTGTGCCCCTTTCTCTTCCCATT
CCTTCCCCCTACACCCATTCCAGACATCCCAGAGTTAACAAAACCCAAAAGAAAGAGAAAAAAGACTCAGAGCTGCTTGGAGGAGATGAC
ATCCTCAAATGTAGCGCCGTTGTTTGAGGGGCTGGTCCCAGGCACCTTTCTCTGTGGCCTGGGGTGTGCGTTTTGGTCCCCAGCGTGATT
TGAAAGAAGATGGAGGTTCAGCGAAGCAGAAAGGAGGTCTTGGAATATGTGAGGCCTGTTCCAGATGGCAGGTGCGACTCGGTGGTGGCG
GTGGCGGCGGCAGCTACGCGCTAACAGTTGGAGATTGTGCACAAGGGTGGAGAAGAGTTACCTCCCTGGCTCAATCATGGAGACATTCTG
ATCAGCAGTTCTCAAAATCTGTCTTGCATCAGAATCATCTGGGGGGGCCTGTTAAAACCCCCAGCACATCAGATTTGGGTTCTCCTTGAA
GGCCACGTAGACATCCTGGCGTTCTTCCCCTAGGGTGTAGCACACATGGAATCCAGGTGGCCCTAGCTCACCAGAGGACAGTTCAAGGGG
GCAGATGGCCTGTCGGAGCCAGAGGGCATCTCTCTGAAGCGGGTCGCTGTGGTGGAAGATTTCTTTGACATCATCTACTCGATGCATGTG
GAGAGCTCAGCGGAGCCAGGCAAAGCCCCCAAGCACGCTGGGCAGAAGAAAACCTACCGAGCGATCGCAGAGACCTATGCCTTCCTCCCG
AGAGAGGCCGTGACCCGGTTCCTGATGAGCTGTACGGAGTGTCAGAAGAGGATGCACTTTAACTCCAATGGCCTGGAACCCAAAGAAAAC
GAGCCTCCATCTCCACTGGTCTCTGGGATTATTGATTACAACATGCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATG
AATTCCCAGGAGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAG
CTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTG
AAGAAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGG
AAGCAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTG
ACATCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTG
TATATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTG
TCCCTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGAT
GCTCCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAA
TTACCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGA
TTCAGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCT
CCTCCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACA
CTCTGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACT
GAGGCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCC

>11460_11460_5_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375678_COMMD7_chr20_31315949_ENST00000278980_length(amino acids)=294AA_BP=121
MSEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPP
SPLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKS
LTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIE

--------------------------------------------------------------
>11460_11460_6_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375678_COMMD7_chr20_31315949_ENST00000446419_length(transcript)=2740nt_BP=1545nt
CCCCCTCCAGCCCCACCTCTTCCCCCGGCCCTGGGTGGGGCCCGCACCTGGGGCTCTCCGCTCGTTAGCGCGCCCAGGGCGCCTCCTCGG
CCCGAGAGGGACCCGCCCGCGGGGCCTGGCTGGCTCAGGGCTACCTCCTTCCGCCTAGGACCCCCCCTTCGGTGACTCCCGATTCCCTGT
CCTAGGCTGCGGTGCCCCGGGAGGCGGGTCGCCAGAGTAGCAGACAGAGCTCTTTAATGGGTGTCTTCTAGGGCGGGTGCTGTTTGTGCA
TCATTTGGGTTCCCACACACTTCCTATGAGGTGGCGAAAGCCATTATGCCTATGGTGTCTGCTCACACAGGGGGAAACTGAGGCCCAGGC
AGGACAGCCCCTTGCCTGGGGTGGGGGCTGGGTTGTCCTTAGGCCTGTGACTTCACCTCTACAGCACCCTCCTGTGGACCCTCTCCCTGC
CCCCGCCAGGCCAGAGTCCTGCAGCCAGGCCCAGACCCTGGCCTGTCCGTCCGGGGATGCTGGACAGTACTCCTCCCTCCAGCCCTCATA
AGTCATTGTCATTCGGATCTGCATTTCCCCAGCCCCTCTCCTTCTAACTGGGGGGCACTGTGGCCCACTGTGCCCCTTTCTCTTCCCATT
CCTTCCCCCTACACCCATTCCAGACATCCCAGAGTTAACAAAACCCAAAAGAAAGAGAAAAAAGACTCAGAGCTGCTTGGAGGAGATGAC
ATCCTCAAATGTAGCGCCGTTGTTTGAGGGGCTGGTCCCAGGCACCTTTCTCTGTGGCCTGGGGTGTGCGTTTTGGTCCCCAGCGTGATT
TGAAAGAAGATGGAGGTTCAGCGAAGCAGAAAGGAGGTCTTGGAATATGTGAGGCCTGTTCCAGATGGCAGGTGCGACTCGGTGGTGGCG
GTGGCGGCGGCAGCTACGCGCTAACAGTTGGAGATTGTGCACAAGGGTGGAGAAGAGTTACCTCCCTGGCTCAATCATGGAGACATTCTG
ATCAGCAGTTCTCAAAATCTGTCTTGCATCAGAATCATCTGGGGGGGCCTGTTAAAACCCCCAGCACATCAGATTTGGGTTCTCCTTGAA
GGCCACGTAGACATCCTGGCGTTCTTCCCCTAGGGTGTAGCACACATGGAATCCAGGTGGCCCTAGCTCACCAGAGGACAGTTCAAGGGG
GCAGATGGCCTGTCGGAGCCAGAGGGCATCTCTCTGAAGCGGGTCGCTGTGGTGGAAGATTTCTTTGACATCATCTACTCGATGCATGTG
GAGAGCTCAGCGGAGCCAGGCAAAGCCCCCAAGCACGCTGGGCAGAAGAAAACCTACCGAGCGATCGCAGAGACCTATGCCTTCCTCCCG
AGAGAGGCCGTGACCCGGTTCCTGATGAGCTGTACGGAGTGTCAGAAGAGGATGCACTTTAACTCCAATGGCCTGGAACCCAAAGAAAAC
GAGCCTCCATCTCCACTGGTCTCTGGGATTATTGATTACAACATGCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATG
AATTCCCAGGAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTC
TCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAG
AAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAG
CAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACA
TCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTAT
ATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCC
CTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCT
CCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTA
CCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTC
AGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCT
CCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTC
TGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAG
GCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAAC

>11460_11460_6_C20orf112-COMMD7_C20orf112_chr20_31099150_ENST00000375678_COMMD7_chr20_31315949_ENST00000446419_length(amino acids)=293AA_BP=121
MSEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPP
SPLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSL
TAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C20orf112-COMMD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C20orf112-COMMD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C20orf112-COMMD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource