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	Fusion Gene Summary
	Fusion Gene ORF analysis
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Fusion gene:C20orf194-ASPH (FusionGDB2 ID:11470)

Fusion Gene Summary for C20orf194-ASPH

Fusion gene summary

Fusion gene information	Fusion gene name: C20orf194-ASPH
	Fusion gene ID: 11470
		Hgene	Tgene
	Gene symbol	C20orf194	ASPH
	Gene ID	25943	444
	Gene name	chromosome 20 open reading frame 194	aspartate beta-hydroxylase
	Synonyms	-	AAH\|BAH\|CASQ2BP1\|FDLAB\|HAAH\|JCTN\|junctin
	Cytomap	20p13	8q12.3
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein C20orf194	aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
	Modification date	20200313	20200315
	UniProtAcc	.	Q6ICH7
	Ensembl transtripts involved in fusion gene	ENST00000252032, ENST00000453730, ENST00000498079,	ENST00000356457, ENST00000379449, ENST00000389204, ENST00000445642, ENST00000517661, ENST00000517847, ENST00000517856, ENST00000517903, ENST00000518068, ENST00000522603, ENST00000522835, ENST00000522919, ENST00000523897, ENST00000379454, ENST00000541428,
Fusion gene scores	* DoF score	12 X 13 X 7=1092	17 X 17 X 5=1445
	# samples	13	19
	** MAII score	log2(13/1092*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1445*10)=-2.92699816905709 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C20orf194 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C20orf194(3285087)-ASPH(62559437), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ASPH	GO:0045862	positive regulation of proteolysis	18387192
Tgene	ASPH	GO:0097202	activation of cysteine-type endopeptidase activity	18387192

Fusion gene breakpoints across C20orf194 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-A6-2677-01A	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-

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Fusion Gene ORF analysis for C20orf194-ASPH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000252032	ENST00000356457	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000379449	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000389204	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000445642	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000517661	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000517847	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000517856	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000517903	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000518068	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000522603	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000522835	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000522919	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000252032	ENST00000523897	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000356457	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000379449	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000389204	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000445642	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000517661	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000517847	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000517856	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000517903	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000518068	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000522603	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000522835	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000522919	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5CDS-intron	ENST00000453730	ENST00000523897	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-3CDS	ENST00000498079	ENST00000379454	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-3CDS	ENST00000498079	ENST00000541428	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000356457	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000379449	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000389204	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000445642	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000517661	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000517847	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000517856	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000517903	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000518068	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000522603	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000522835	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000522919	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
5UTR-intron	ENST00000498079	ENST00000523897	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
Frame-shift	ENST00000252032	ENST00000379454	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
Frame-shift	ENST00000252032	ENST00000541428	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
In-frame	ENST00000453730	ENST00000379454	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-
In-frame	ENST00000453730	ENST00000541428	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000453730	C20orf194	chr20	3285087	-	ENST00000541428	ASPH	chr8	62559437	-	5845	1256	1270	3042	590
ENST00000453730	C20orf194	chr20	3285087	-	ENST00000379454	ASPH	chr8	62559437	-	5173	1256	1270	3042	590

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000453730	ENST00000541428	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-	0.000504433	0.9994955
ENST00000453730	ENST00000379454	C20orf194	chr20	3285087	-	ASPH	chr8	62559437	-	0.000969952	0.9990301

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Fusion Genomic Features for C20orf194-ASPH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C20orf194-ASPH

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3285087/chr8:62559437)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASPH Q6ICH7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May function as 2-oxoglutarate-dependent dioxygenase. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

90_102

204.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

90_102

226.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

90_102

271.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

90_102

211.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

90_102

257.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

323_332

163

314.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

111_312

204.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

323_332

204.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

9_29

204.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

323_332

163

759.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

111_312

226.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

323_332

226.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

9_29

226.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

323_332

149

651.6666666666666

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

323_332

149

300.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

323_332

149

299.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

111_312

271.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

323_332

271.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

9_29

271.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

111_312

211.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

323_332

211.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

9_29

211.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

111_312

257.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

323_332

257.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

9_29

257.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

323_332

134

730.0

Compositional bias

Note=Poly-Lys

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

688_690

163

314.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

688_690

204.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

688_690

163

759.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

688_690

226.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

688_690

149

651.6666666666666

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

688_690

149

300.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

688_690

149

299.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

688_690

271.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

688_690

211.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

688_690

257.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

688_690

134

730.0

Region

2-oxoglutarate binding

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

341_374

163

314.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

454_487

163

314.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

489_521

163

314.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

525_557

163

314.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

341_374

204.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

454_487

204.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

489_521

204.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

525_557

204.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

341_374

163

759.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

454_487

163

759.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

489_521

163

759.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

525_557

163

759.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

341_374

226.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

454_487

226.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

489_521

226.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

525_557

226.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

341_374

149

651.6666666666666

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

454_487

149

651.6666666666666

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

489_521

149

651.6666666666666

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

525_557

149

651.6666666666666

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

341_374

149

300.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

454_487

149

300.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

489_521

149

300.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

525_557

149

300.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

341_374

149

299.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

454_487

149

299.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

489_521

149

299.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

525_557

149

299.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

341_374

271.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

454_487

271.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

489_521

271.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

525_557

271.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

341_374

211.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

454_487

211.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

489_521

211.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

525_557

211.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

341_374

257.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

454_487

257.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

489_521

257.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

525_557

257.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

341_374

134

730.0

Repeat

Note=TPR 1

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

454_487

134

730.0

Repeat

Note=TPR 2

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

489_521

134

730.0

Repeat

Note=TPR 3

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

525_557

134

730.0

Repeat

Note=TPR 4

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

1_53

204.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

75_758

204.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

1_53

226.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

75_758

226.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

1_53

271.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

75_758

271.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

1_53

211.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

75_758

211.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

1_53

257.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

75_758

257.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379449

54_74

204.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000389204

54_74

226.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000518068

54_74

271.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522603

54_74

211.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000522835

54_74

257.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

90_102

163

314.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

90_102

163

759.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

90_102

149

651.6666666666666

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

90_102

149

300.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

90_102

149

299.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

90_102

134

730.0

Calcium binding

Ontology_term=ECO:0000305

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

111_312

163

314.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

9_29

163

314.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

111_312

163

759.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

9_29

163

759.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

111_312

149

651.6666666666666

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

9_29

149

651.6666666666666

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

111_312

149

300.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

9_29

149

300.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

111_312

149

299.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

9_29

149

299.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

111_312

134

730.0

Compositional bias

Note=Glu-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

9_29

134

730.0

Compositional bias

Note=Ser-rich

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

1_53

163

314.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

75_758

163

314.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

1_53

163

759.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

75_758

163

759.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

1_53

149

651.6666666666666

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

75_758

149

651.6666666666666

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

1_53

149

300.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

75_758

149

300.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

1_53

149

299.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

75_758

149

299.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

1_53

134

730.0

Topological domain

Cytoplasmic

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

75_758

134

730.0

Topological domain

Lumenal

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000356457

54_74

163

314.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000379454

54_74

163

759.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000445642

54_74

149

651.6666666666666

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517847

54_74

149

300.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000517903

54_74

149

299.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ASPH

chr20:3285087

chr8:62559437

ENST00000541428

54_74

134

730.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Top

Fusion Gene Sequence for C20orf194-ASPH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11470_11470_1_C20orf194-ASPH_C20orf194_chr20_3285087_ENST00000453730_ASPH_chr8_62559437_ENST00000379454_length(transcript)=5173nt_BP=1256nt
ATACCGGAGTTTTGCTCTATCACTGTATCATGGACAGCAAGCTTATGGAACTTATTCCTCAAAAAGTGGGACATGCTGAAAATACAAACC
TAGCTTGAGTTTAGTTATGTCCCTAAATGTTAACTGATCCCTGTGGGTCAGTAGGGAGACAGCTGGCATCCGTTTCCAACCAGCCAAGGA
TATTCGGTCGACTGTACTGACTGACCACTTTGCTCAGGCCGCAAGTGTCCCTCAGAAAAGCCTGAGGACTTATTAAGGTCATGGAAGGTT
GCCTTGGCCAGGAACTCTTTTCTAATCACATGTTTTTGACTTCCCTCTCTAGCCCTAACCGGCAGCCATTTGTTCTCTTTGGTAATCACT
CCACACGAGAAAACCTGAATGCTGGCAACTTTAACTTCCCTTCTGAAGGACATCTGGTACGAAGCACTGGTCCCGGCGGGAGCTTTGCCA
AGCACATGGTAGCCCAGTGTGTCTCACCAAAGGGACCTCTTGCTTGTTCGAGAACATACTTTTTTGGAGCTACTCATGTTCCTTACTTGG
GTGGTGACAGCAAGCTGCCCAAGAAAACTGAACAAATGCTATTGTCCCAGATATATGCTGCTGTTATTGAGGCTGTTTTGGCTGGCATTG
CATGTTATGCTAAAACTTCCAGTCTAACAAAGGCCAAGGAGGTAGCAGAGCAAACTCTGGGATCTGGGTTAGATTCCTTTGAGTTGATTC
CGTTTAAGGCAGCCCTGCGCTCCAAGATGACTTTTCATATACATGCTGTGAATAATCAGGGAAGAATTGTACCGCTGGACAGTGAAGATA
GCTTATCCTTTGTGAAGACGGCTTGTATGGCCGTCTATGACATTCCTGACTTACTGGGAGGCAATGGTTGTTTAGGATCTGTGGTTTTCT
CTGAATCATTTTTGACTTCTCAGATCTTAGTTAAAGAAAAGGATGGCACTGTTACCACAGAAACCAGCTCCGTAGTCCTGACTGCTGCTG
TACCCAGATTCTGCTCCTGGCTGGTGGAAGATAATGAAGTAAAATTGTCTGAGAAAACCCAGCAAGCAGTGAGGGGGGATGAGTCTTTCC
TGGGCACTTATCTAACAGGAGGAGAAGGAGCATATCTTTATTCCAGCAATCTACAGTCCTGGCCTGAGGAAGGGAATGTTCATTTCTTCT
CTAGTGGCCTTCTGTTTTCTCACTGTCGTCATAGAAGTATCATCATTTCCAAGGATCACATGAATTCCATTTCCTTCTATGATGGGTTGA
GGGAGAAGACTTGCAACAAGAAGATGGACCCACAGGAGAACCACAACAAGAGGATGATGAGTTTCTTATGGCGACTGATGTAGATGATAG
ATTTGAGACCCTGGAACCTGAAGTATCTCATGAAGAAACCGAGCATAGTTACCACGTGGAAGAGACAGTTTCACAAGACTGTAATCAGGA
TATGGAAGAGATGATGTCTGAGCAGGAAAATCCAGATTCCAGTGAACCAGTAGTAGAAGATGAAAGATTGCACCATGATACAGATGATGT
AACATACCAAGTCTATGAGGAACAAGCAGTATATGAACCTCTAGAAAATGAAGGGATAGAAATCACAGAAGTAACTGCTCCCCCTGAGGA
TAATCCTGTAGAAGATTCACAGGTAATTGTAGAAGAAGTAAGCATTTTTCCTGTGGAAGAACAGCAGGAAGTACCACCAGAAACAAATAG
AAAAACAGATGATCCAGAACAAAAAGCAAAAGTTAAGAAAAAGAAGCCTAAACTTTTAAATAAATTTGATAAGACTATTAAAGCTGAACT
TGATGCTGCAGAAAAACTCCGTAAAAGGGGAAAAATTGAGGAAGCAGTGAATGCATTTAAAGAACTAGTACGCAAATACCCTCAGAGTCC
ACGAGCAAGATATGGGAAGGCGCAGTGTGAGGATGATTTGGCTGAGAAGAGGAGAAGTAATGAGGTGCTACGTGGAGCCATCGAGACCTA
CCAAGAGGTGGCCAGCCTACCTGATGTCCCTGCAGACCTGCTGAAGCTGAGTTTGAAGCGTCGCTCAGACAGGCAACAATTTCTAGGTCA
TATGAGAGGTTCCCTGCTTACCCTGCAGAGATTAGTTCAACTATTTCCCAATGATACTTCCTTAAAAAATGACCTTGGCGTGGGATACCT
CTTGATAGGAGATAATGACAATGCAAAGAAAGTTTATGAAGAGGTGCTGAGTGTGACACCTAATGATGGCTTTGCTAAAGTCCATTATGG
CTTCATCCTGAAGGCACAGAACAAAATTGCTGAGAGCATCCCATATTTAAAGGAAGGAATAGAATCCGGAGATCCTGGCACTGATGATGG
GAGATTTTATTTCCACCTGGGGGATGCCATGCAGAGGGTTGGGAACAAAGAGGCATATAAGTGGTATGAGCTTGGGCACAAGAGAGGACA
CTTTGCATCTGTCTGGCAACGCTCACTCTACAATGTGAATGGACTGAAAGCACAGCCTTGGTGGACCCCAAAAGAAACGGGCTACACAGA
GTTAGTAAAGTCTTTAGAAAGAAACTGGAAGTTAATCCGAGATGAAGGCCTTGCAGTGATGGATAAAGCCAAAGGTCTCTTCCTGCCTGA
GGATGAAAACCTGAGGGAAAAAGGGGACTGGAGCCAGTTCACGCTGTGGCAGCAAGGAAGAAGAAATGAAAATGCCTGCAAAGGAGCTCC
TAAAACCTGTACCTTACTAGAAAAGTTCCCCGAGACAACAGGATGCAGAAGAGGACAGATCAAATATTCCATCATGCACCCCGGGACTCA
CGTGTGGCCGCACACAGGGCCCACAAACTGCAGGCTCCGAATGCACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATTCGATGTGC
CAACGAGACCAAGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCG
GCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGC
TTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGA
CTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACC
CTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATT
TTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATG
CAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTT
TACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCA
GTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTT
TATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAA
AAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTA
TAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATG
AGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTG
CTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTA
CTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCA
ATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATC
AAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATG
ATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAA
AAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTT
TTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCC
CACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAA
GGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCAC
TTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTA
ATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAG
TATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCA

>11470_11470_1_C20orf194-ASPH_C20orf194_chr20_3285087_ENST00000453730_ASPH_chr8_62559437_ENST00000379454_length(amino acids)=590AA_BP=
MQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQ
VYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAA
EKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRG
SLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFY
FHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDEN
LREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANET

--------------------------------------------------------------
>11470_11470_2_C20orf194-ASPH_C20orf194_chr20_3285087_ENST00000453730_ASPH_chr8_62559437_ENST00000541428_length(transcript)=5845nt_BP=1256nt
ATACCGGAGTTTTGCTCTATCACTGTATCATGGACAGCAAGCTTATGGAACTTATTCCTCAAAAAGTGGGACATGCTGAAAATACAAACC
TAGCTTGAGTTTAGTTATGTCCCTAAATGTTAACTGATCCCTGTGGGTCAGTAGGGAGACAGCTGGCATCCGTTTCCAACCAGCCAAGGA
TATTCGGTCGACTGTACTGACTGACCACTTTGCTCAGGCCGCAAGTGTCCCTCAGAAAAGCCTGAGGACTTATTAAGGTCATGGAAGGTT
GCCTTGGCCAGGAACTCTTTTCTAATCACATGTTTTTGACTTCCCTCTCTAGCCCTAACCGGCAGCCATTTGTTCTCTTTGGTAATCACT
CCACACGAGAAAACCTGAATGCTGGCAACTTTAACTTCCCTTCTGAAGGACATCTGGTACGAAGCACTGGTCCCGGCGGGAGCTTTGCCA
AGCACATGGTAGCCCAGTGTGTCTCACCAAAGGGACCTCTTGCTTGTTCGAGAACATACTTTTTTGGAGCTACTCATGTTCCTTACTTGG
GTGGTGACAGCAAGCTGCCCAAGAAAACTGAACAAATGCTATTGTCCCAGATATATGCTGCTGTTATTGAGGCTGTTTTGGCTGGCATTG
CATGTTATGCTAAAACTTCCAGTCTAACAAAGGCCAAGGAGGTAGCAGAGCAAACTCTGGGATCTGGGTTAGATTCCTTTGAGTTGATTC
CGTTTAAGGCAGCCCTGCGCTCCAAGATGACTTTTCATATACATGCTGTGAATAATCAGGGAAGAATTGTACCGCTGGACAGTGAAGATA
GCTTATCCTTTGTGAAGACGGCTTGTATGGCCGTCTATGACATTCCTGACTTACTGGGAGGCAATGGTTGTTTAGGATCTGTGGTTTTCT
CTGAATCATTTTTGACTTCTCAGATCTTAGTTAAAGAAAAGGATGGCACTGTTACCACAGAAACCAGCTCCGTAGTCCTGACTGCTGCTG
TACCCAGATTCTGCTCCTGGCTGGTGGAAGATAATGAAGTAAAATTGTCTGAGAAAACCCAGCAAGCAGTGAGGGGGGATGAGTCTTTCC
TGGGCACTTATCTAACAGGAGGAGAAGGAGCATATCTTTATTCCAGCAATCTACAGTCCTGGCCTGAGGAAGGGAATGTTCATTTCTTCT
CTAGTGGCCTTCTGTTTTCTCACTGTCGTCATAGAAGTATCATCATTTCCAAGGATCACATGAATTCCATTTCCTTCTATGATGGGTTGA
GGGAGAAGACTTGCAACAAGAAGATGGACCCACAGGAGAACCACAACAAGAGGATGATGAGTTTCTTATGGCGACTGATGTAGATGATAG
ATTTGAGACCCTGGAACCTGAAGTATCTCATGAAGAAACCGAGCATAGTTACCACGTGGAAGAGACAGTTTCACAAGACTGTAATCAGGA
TATGGAAGAGATGATGTCTGAGCAGGAAAATCCAGATTCCAGTGAACCAGTAGTAGAAGATGAAAGATTGCACCATGATACAGATGATGT
AACATACCAAGTCTATGAGGAACAAGCAGTATATGAACCTCTAGAAAATGAAGGGATAGAAATCACAGAAGTAACTGCTCCCCCTGAGGA
TAATCCTGTAGAAGATTCACAGGTAATTGTAGAAGAAGTAAGCATTTTTCCTGTGGAAGAACAGCAGGAAGTACCACCAGAAACAAATAG
AAAAACAGATGATCCAGAACAAAAAGCAAAAGTTAAGAAAAAGAAGCCTAAACTTTTAAATAAATTTGATAAGACTATTAAAGCTGAACT
TGATGCTGCAGAAAAACTCCGTAAAAGGGGAAAAATTGAGGAAGCAGTGAATGCATTTAAAGAACTAGTACGCAAATACCCTCAGAGTCC
ACGAGCAAGATATGGGAAGGCGCAGTGTGAGGATGATTTGGCTGAGAAGAGGAGAAGTAATGAGGTGCTACGTGGAGCCATCGAGACCTA
CCAAGAGGTGGCCAGCCTACCTGATGTCCCTGCAGACCTGCTGAAGCTGAGTTTGAAGCGTCGCTCAGACAGGCAACAATTTCTAGGTCA
TATGAGAGGTTCCCTGCTTACCCTGCAGAGATTAGTTCAACTATTTCCCAATGATACTTCCTTAAAAAATGACCTTGGCGTGGGATACCT
CTTGATAGGAGATAATGACAATGCAAAGAAAGTTTATGAAGAGGTGCTGAGTGTGACACCTAATGATGGCTTTGCTAAAGTCCATTATGG
CTTCATCCTGAAGGCACAGAACAAAATTGCTGAGAGCATCCCATATTTAAAGGAAGGAATAGAATCCGGAGATCCTGGCACTGATGATGG
GAGATTTTATTTCCACCTGGGGGATGCCATGCAGAGGGTTGGGAACAAAGAGGCATATAAGTGGTATGAGCTTGGGCACAAGAGAGGACA
CTTTGCATCTGTCTGGCAACGCTCACTCTACAATGTGAATGGACTGAAAGCACAGCCTTGGTGGACCCCAAAAGAAACGGGCTACACAGA
GTTAGTAAAGTCTTTAGAAAGAAACTGGAAGTTAATCCGAGATGAAGGCCTTGCAGTGATGGATAAAGCCAAAGGTCTCTTCCTGCCTGA
GGATGAAAACCTGAGGGAAAAAGGGGACTGGAGCCAGTTCACGCTGTGGCAGCAAGGAAGAAGAAATGAAAATGCCTGCAAAGGAGCTCC
TAAAACCTGTACCTTACTAGAAAAGTTCCCCGAGACAACAGGATGCAGAAGAGGACAGATCAAATATTCCATCATGCACCCCGGGACTCA
CGTGTGGCCGCACACAGGGCCCACAAACTGCAGGCTCCGAATGCACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATTCGATGTGC
CAACGAGACCAAGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCG
GCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGC
TTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGA
CTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACC
CTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATT
TTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATG
CAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTT
TACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCA
GTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTT
TATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAA
AAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTA
TAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATG
AGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTG
CTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTA
CTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCA
ATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATC
AAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATG
ATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAA
AAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTT
TTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCC
CACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAA
GGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCAC
TTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTA
ATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAG
TATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCA
CAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGA
AAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAAT
TTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTA
TTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATT
ATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTA
AAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGC
AGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTT

>11470_11470_2_C20orf194-ASPH_C20orf194_chr20_3285087_ENST00000453730_ASPH_chr8_62559437_ENST00000541428_length(amino acids)=590AA_BP=
MQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQ
VYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAA
EKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRG
SLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFY
FHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDEN
LREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANET

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for C20orf194-ASPH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for C20orf194-ASPH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for C20orf194-ASPH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source