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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACACA-FAM104A (FusionGDB2 ID:1151)

Fusion Gene Summary for ACACA-FAM104A

Fusion gene summary

Fusion gene information	Fusion gene name: ACACA-FAM104A
	Fusion gene ID: 1151
		Hgene	Tgene
	Gene symbol	ACACA	FAM104A
	Gene ID	31	84923
	Gene name	acetyl-CoA carboxylase alpha	family with sequence similarity 104 member A
	Synonyms	ACAC\|ACACAD\|ACC\|ACC1\|ACCA	-
	Cytomap	17q12	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha	protein FAM104A
	Modification date	20200313	20200313
	UniProtAcc	Q13085	Q969W3
	Ensembl transtripts involved in fusion gene	ENST00000335166, ENST00000353139, ENST00000360679, ENST00000394406, ENST00000361253, ENST00000416895, ENST00000588142, ENST00000589665,	ENST00000580032, ENST00000581110, ENST00000583024, ENST00000583178, ENST00000403627, ENST00000405159,
Fusion gene scores	* DoF score	44 X 35 X 17=26180	5 X 18 X 9=810
	# samples	51	20
	** MAII score	log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/810*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACACA [Title/Abstract] AND FAM104A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACACA(35631084)-FAM104A(71205907), # samples:2
Anticipated loss of major functional domain due to fusion event.	ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACACA-FAM104A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM104A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0DD-01A	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-

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Fusion Gene ORF analysis for ACACA-FAM104A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000335166	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000335166	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000335166	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000335166	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000353139	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000353139	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000353139	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000353139	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000360679	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000360679	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000360679	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000360679	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000394406	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000394406	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000394406	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
5CDS-5UTR	ENST00000394406	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000335166	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000335166	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000353139	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000360679	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000394406	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
Frame-shift	ENST00000394406	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
In-frame	ENST00000353139	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
In-frame	ENST00000360679	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000361253	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000361253	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000416895	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000416895	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000588142	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000588142	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000589665	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-3CDS	ENST00000589665	ENST00000405159	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000361253	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000361253	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000361253	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000361253	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000416895	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000416895	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000416895	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000416895	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000588142	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000588142	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000588142	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000588142	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000589665	ENST00000580032	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000589665	ENST00000581110	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000589665	ENST00000583024	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-
intron-5UTR	ENST00000589665	ENST00000583178	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000353139	ACACA	chr17	35631084	-	ENST00000403627	FAM104A	chr17	71205907	-	3906	1490	461	1729	422
ENST00000360679	ACACA	chr17	35631084	-	ENST00000403627	FAM104A	chr17	71205907	-	3574	1158	297	1397	366

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000353139	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-	0.001205363	0.99879456
ENST00000360679	ENST00000403627	ACACA	chr17	35631084	-	FAM104A	chr17	71205907	-	0.000605264	0.9993948

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Fusion Genomic Features for ACACA-FAM104A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACACA-FAM104A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35631084/chr17:71205907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACACA Q13085	FAM104A Q969W3
FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269\|PubMed:20457939, ECO:0000269\|PubMed:20952656, ECO:0000269\|PubMed:29899443}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

315_320

336

2384.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

117_618

221

2269.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

1576_1914

221

2269.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

1918_2234

221

2269.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

275_466

221

2269.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

745_819

221

2269.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

117_618

336

2384.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

1576_1914

336

2384.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

1918_2234

336

2384.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

275_466

336

2384.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

745_819

336

2384.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

117_618

241

2289.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

1576_1914

241

2289.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

1918_2234

241

2289.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

275_466

241

2289.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

745_819

241

2289.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

117_618

299

2347.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

1576_1914

299

2347.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

1918_2234

299

2347.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

275_466

299

2347.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

745_819

299

2347.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

315_320

221

2269.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

315_320

241

2289.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

315_320

299

2347.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000335166

1576_2234

221

2269.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000353139

1576_2234

336

2384.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000360679

1576_2234

241

2289.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35631084

chr17:71205907

ENST00000394406

1576_2234

299

2347.0

Region

Carboxyltransferase

Tgene

FAM104A

chr17:35631084

chr17:71205907

ENST00000403627

94_145

107

187.0

Compositional bias

Note=Ser-rich

Tgene

FAM104A

chr17:35631084

chr17:71205907

ENST00000405159

94_145

128

208.0

Compositional bias

Note=Ser-rich

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Fusion Gene Sequence for ACACA-FAM104A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1151_1151_1_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000353139_FAM104A_chr17_71205907_ENST00000403627_length(transcript)=3906nt_BP=1490nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGG
CTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAAT
GCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTA
AAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAA
TTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCT
TGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTG
CAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCC
AGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGTGACAGTGGTGGGAGCAGCAGCAGCAGCA
GCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATGGCCGGATCCAGCCCTAACACGCCTCAGC
CCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGGGAGGCCCACTTCCACAGCCTACAGCACC
GAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGTGCAGATTTGATATTTCAACTTACAACTT
GTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATAACAGGTTAACAGGCAGTTGTTTACTTGT
GGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTTGAGGGAGGGTATCAAATCTATGTCAAGG
TAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGATTTCCAAATCTGTCAACTAGAAACTCTAC
TTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTAAAGAGTATCTAGTTTCCATGAAAAAACA
TAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATACTACCTCTCAGTATGTAGATGTTCTATTG
AAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCACACTCCCTAATAATAGTCTCTACTCTTT
GTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCTGTGTCACTATTCCACCAGAGTCTGCACC
TCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTGTCCTACAAACTTGGTCAGTCAGCAGCTT
ACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGATAAAATGTAAGCTACCTGAACTGATGTC
TAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCCAACAGTAACTAGGGGGCCACATTCCATC
AGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAATAATGTGGTAGTATTTATTTAGGGAGAG
ACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGGTGCAGACGTGTTGTCTTCTTCACTGACA
AGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGACAACCTGCCATTGGATGTAGAGAAAAGTG
CCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCACACGGCACACACAAGCGGAGCTGAGAAG
CACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGCATGAGCCTTTGTGACAAAACTAGAATTT
GGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAACCTAATGTGGGCAGAACTGAAAGATCACT
GCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTTTGCAAGAGCTTTTTTTTTTTTTAAACTA
CCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATGGTAGGGAATACGGAAAGGATACACTGCT
AATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCTTTCAAACACACATGCACACAGCACAATT
CAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTGTATTAACAAGAAAATGTCAAACTTTTGG
GGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAGAACAAAACAGATTTTCTCCAAACAAGTA
CAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCCACCCTGTCCTGTATATTTTCTACATTTC
TATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTAGTAAAACCTTGTACTTCTCTATTGCGCC

>1151_1151_1_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000353139_FAM104A_chr17_71205907_ENST00000403627_length(amino acids)=422AA_BP=342
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS
IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG
IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSI

--------------------------------------------------------------
>1151_1151_2_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000360679_FAM104A_chr17_71205907_ENST00000403627_length(transcript)=3574nt_BP=1158nt
GGCAGCCAGGAGAGGCAGTGGAGCTTTTCTCCGTTGACTGTCAGAAGAAAGTGACTGTTGTTGAAAATGTTTGCTGCAACTAAAGGAGAG
CTGCTAAGATCTACTTTCTAGTTAAACAAGCTTTTATATTTCTCCCCGGCTCCTCTCAGTTCCCTTGGGAAATCAACTAATTGTGTGTGT
AAGCTAAGTGTGTGGAGGAGAGAAGATGCAAAAAGGAAGAGAAAGGTGGGGAAAGAAGGAAATTGGGAACAATTAGACAAAAAGACTATA
GTTTGAGGCCATCAGGAGTATTCTAGTCTGACTGAAGCCAGGCAGAAGGCACAGTATCTCTTGTCCTCCTGGGTTTTAAGCAGCTGCAAC
AGGAGGAGGAACTGCGGCTTGTGTTTACAAGGCCGAAATCTGAAGAAAAAGCTTCCATTCTTTTCCCATCTTGATATGGAGGGTTCTCCA
GAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAA
ATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATT
GCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTC
GTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAAC
AACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCT
GAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAG
ATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGAT
TTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGT
GACAGTGGTGGGAGCAGCAGCAGCAGCAGCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATG
GCCGGATCCAGCCCTAACACGCCTCAGCCCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGG
GAGGCCCACTTCCACAGCCTACAGCACCGAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGT
GCAGATTTGATATTTCAACTTACAACTTGTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATA
ACAGGTTAACAGGCAGTTGTTTACTTGTGGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTT
GAGGGAGGGTATCAAATCTATGTCAAGGTAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGAT
TTCCAAATCTGTCAACTAGAAACTCTACTTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTA
AAGAGTATCTAGTTTCCATGAAAAAACATAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATAC
TACCTCTCAGTATGTAGATGTTCTATTGAAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCA
CACTCCCTAATAATAGTCTCTACTCTTTGTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCT
GTGTCACTATTCCACCAGAGTCTGCACCTCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTG
TCCTACAAACTTGGTCAGTCAGCAGCTTACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGA
TAAAATGTAAGCTACCTGAACTGATGTCTAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCC
AACAGTAACTAGGGGGCCACATTCCATCAGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAA
TAATGTGGTAGTATTTATTTAGGGAGAGACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGG
TGCAGACGTGTTGTCTTCTTCACTGACAAGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGAC
AACCTGCCATTGGATGTAGAGAAAAGTGCCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCA
CACGGCACACACAAGCGGAGCTGAGAAGCACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGC
ATGAGCCTTTGTGACAAAACTAGAATTTGGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAAC
CTAATGTGGGCAGAACTGAAAGATCACTGCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTT
TGCAAGAGCTTTTTTTTTTTTTAAACTACCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATG
GTAGGGAATACGGAAAGGATACACTGCTAATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCT
TTCAAACACACATGCACACAGCACAATTCAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTG
TATTAACAAGAAAATGTCAAACTTTTGGGGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAG
AACAAAACAGATTTTCTCCAAACAAGTACAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCC
ACCCTGTCCTGTATATTTTCTACATTTCTATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTA

>1151_1151_2_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000360679_FAM104A_chr17_71205907_ENST00000403627_length(amino acids)=366AA_BP=286
MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV
ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP
QELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSINSPDRASGPEGSLSQTMAGSSPNTPQPVPEQSALCQGLYFHINQTLREAHFHSLQH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACACA-FAM104A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ACACA-FAM104A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ACACA-FAM104A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source