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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACACA-GLIPR1L2 (FusionGDB2 ID:1153)

Fusion Gene Summary for ACACA-GLIPR1L2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA-GLIPR1L2
Fusion gene ID: 1153
HgeneTgene
Gene symbol

ACACA

GLIPR1L2

Gene ID

31

144321

Gene nameacetyl-CoA carboxylase alphaGLIPR1 like 2
SynonymsACAC|ACACAD|ACC|ACC1|ACCA-
Cytomap

17q12

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphaGLIPR1-like protein 2GLI pathogenesis related 1 like 2
Modification date2020031320200313
UniProtAcc

Q13085

Q4G1C9

Ensembl transtripts involved in fusion geneENST00000353139, ENST00000394406, 
ENST00000416895, ENST00000588142, 
ENST00000335166, ENST00000360679, 
ENST00000361253, ENST00000589665, 
ENST00000320460, ENST00000378689, 
ENST00000378692, ENST00000435775, 
ENST00000441218, ENST00000547164, 
ENST00000550916, 
Fusion gene scores* DoF score44 X 35 X 17=261806 X 4 X 4=96
# samples 516
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACACA [Title/Abstract] AND GLIPR1L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACACA(35687113)-GLIPR1L2(75816684), # samples:2
Anticipated loss of major functional domain due to fusion event.ACACA-GLIPR1L2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACACA-GLIPR1L2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLIPR1L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01AACACAchr17

35687113

-GLIPR1L2chr12

75816684

+


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Fusion Gene ORF analysis for ACACA-GLIPR1L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000353139ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000353139ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000353139ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000353139ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000353139ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000353139ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000394406ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000416895ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
5CDS-intronENST00000588142ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
Frame-shiftENST00000394406ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
Frame-shiftENST00000416895ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
Frame-shiftENST00000588142ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
In-frameENST00000353139ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-3CDSENST00000335166ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-3CDSENST00000360679ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-3CDSENST00000361253ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-3CDSENST00000589665ENST00000550916ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000335166ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000360679ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000361253ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000320460ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000378689ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000378692ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000435775ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000441218ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+
intron-intronENST00000589665ENST00000547164ACACAchr17

35687113

-GLIPR1L2chr12

75816684

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353139ACACAchr1735687113-ENST00000550916GLIPR1L2chr1275816684+27988204611270269

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353139ENST00000550916ACACAchr1735687113-GLIPR1L2chr1275816684+0.0002630010.99973696

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Fusion Genomic Features for ACACA-GLIPR1L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACACAchr1735687112-GLIPR1L2chr1275816683+1.43E-070.9999999
ACACAchr1735687112-GLIPR1L2chr1275816683+1.43E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACACA-GLIPR1L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35687113/chr12:75816684)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

GLIPR1L2

Q4G1C9

FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000032046024292_343194254.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000037868902292_3430107.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000037869237292_34387238.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000043577515292_343160335.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000044121826292_343129280.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000054716413292_343160169.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000055091626292_343194345.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000003786890258_1920107.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000032046024254_274194254.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000037868902254_2740107.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000037869237254_27487238.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000043577515254_274160335.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000044121826254_274129280.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000054716413254_274160169.0TransmembraneHelical
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST0000055091626254_274194345.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-155117_61802269.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-1551576_191402269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-1551918_223402269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-155275_46602269.0DomainATP-grasp
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-155745_81902269.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-356117_6181122384.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-3561576_19141122384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-3561918_22341122384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-356275_4661122384.0DomainATP-grasp
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-356745_8191122384.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-154117_61802289.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-1541576_191402289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-1541918_223402289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-154275_46602289.0DomainATP-grasp
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-154745_81902289.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-356117_618752347.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-3561576_1914752347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-3561918_2234752347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-356275_466752347.0DomainATP-grasp
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-356745_819752347.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-155315_32002269.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-356315_3201122384.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-154315_32002289.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-356315_320752347.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr12:75816684ENST00000335166-1551576_223402269.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr12:75816684ENST00000353139-3561576_22341122384.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr12:75816684ENST00000360679-1541576_223402289.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr12:75816684ENST00000394406-3561576_2234752347.0RegionCarboxyltransferase
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000003204602458_192194254.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000003786923758_19287238.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000004357751558_192160335.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000004412182658_192129280.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000005471641358_192160169.0DomainNote=SCP
TgeneGLIPR1L2chr17:35687113chr12:75816684ENST000005509162658_192194345.0DomainNote=SCP


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Fusion Gene Sequence for ACACA-GLIPR1L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1153_1153_1_ACACA-GLIPR1L2_ACACA_chr17_35687113_ENST00000353139_GLIPR1L2_chr12_75816684_ENST00000550916_length(transcript)=2798nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGAGGAACACTGACGAGAAGACCTTATGAACCAGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCACAGATTTTC
TATGCAGTAATGCAGATCGTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTGTGATCCAC
TGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGATAGTACAGTCTCAGTTTCCAAATATCT
TGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGAGAAAGAGG
AAATGGAAATGGAAATAATGGAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAACACAAAAAGAAAAGATGGAGGAAG
AGGAAAAATAAGAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATACAAAAAAAGACAGAAAAAAAAAAAA
AGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCACCATTGGAATGTTTTTTATTCCCTTCTCTCCTATACTTATTCAATCA
ATTTAAATTTGTAAAACAAAGAAACAAAAAACATGTAAGGTGGGCTCTTTGACACTAAGAACAGATAAAGACATGACAGGAAAAACACTG
AAAAACATTTGACCAGTCTAATTAATCTTAAGATTTCACCATGTTATTCTAATAAAGTAGGGAATTTTCATTTTCTAAACATGTTTCCAT
CTCTGTGTTTTAAATAGTAAGGTGCTTAAGATCATTCCAAGTTCATAACAACCATTGAATAAAATTTGTATTTTTTTGTTTTTACTGTTA
CTGTCATAGTTTTTATTGGTGGTAGTGGTATTTTCATGTGATATTAAGGTATCTAATATTATTATTTGTCTTTGTGGTTTTTGGAATAGT
TTAAGTGGTACCTGTACATCCTGCTAGGATGCAAACTTATTATTTATAATTAATGTTCAATATTTCATTAAAGACTTGCTGTAATTTTCT
GCCACCAAGGGCTAATAAATGCCATAATTTTAATTAGTTGTGGTAGAGGAATCTGGGTGCTTCCAAATTTATATGATAAAATAAATAAAT
TTTTTAAAAACTATTAACTTGTTATTCAATAGGTATAGTAAAAGTTAACAGATTAATAAGATAACTGCTTACCACTAGTAATACTAATAA
ATGAACTAAATAAAAATACCTAGCATAGGAGATTTCTTTATCTATAAAATAAATGGATAGCACTAGATGACCACTAAGACCTCTTCCATC
AATGAATATTCATGGATCAACTTTGTAAAGGAATCAATAGTAGTTGTGAAGTACACTAAGCAAACACCTGAGGGAAAAACTTGATTCCCA
TGAAAATATTCCTGAACTCAGCACCTTATATGGCAAAATAATAAATACCTTTTATTACTCAATTTTAAAATAGGCAAAAAGCAATGTATA
ATATTTTTCCAATTGCCATTCCATACTCAGCTGTCTTATTGTTGCACACTTATTAGAACTCAATGTGACTGAGATGTGAAAGGTTGATAT
AATTCTATTTATGACAGGGACTTAGGGAACTTATTCTAATTGAGAATCAGAGGCTTAATAAACCTGAAGGTTTAAGTGAAAGAAATGACA
TTGAAAGAATCACTGCATATCTGATGTTTTCAAATAAAACAATCTCTGTTTTCTGGTTTTGATAGAATATTGTGTTCTAAAGCTATATTT
CTCAATGTGTGGTTCCACTGAGGGAAAGAAAAAAAAAAAAACCTAGCATAGCCAAATACCTCAAATGGTATAAATGCTATGTGTATTTAC
TCTGTTGTTCTTTAGTTGTATCAATATTCTGTTAAAAACCTGTTCGAAGTAGGGCAAGATGAGAATTATATTAAAAAGCCCTGAGCTATC

>1153_1153_1_ACACA-GLIPR1L2_ACACA_chr17_35687113_ENST00000353139_GLIPR1L2_chr12_75816684_ENST00000550916_length(amino acids)=269AA_BP=119
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTF

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Fusion Gene PPI Analysis for ACACA-GLIPR1L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACACA-GLIPR1L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACACA-GLIPR1L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource