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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C21orf59-BACE2 (FusionGDB2 ID:11531)

Fusion Gene Summary for C21orf59-BACE2

check button Fusion gene summary
Fusion gene informationFusion gene name: C21orf59-BACE2
Fusion gene ID: 11531
HgeneTgene
Gene symbol

C21orf59

BACE2

Gene ID

56683

25825

Gene namecilia and flagella associated protein 298beta-secretase 2
SynonymsC21orf48|C21orf59|CILD26|FBB18|KurAEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP
Cytomap

21q22.11

21q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptioncilia- and flagella-associated protein 298UPF0769 protein C21orf59kurly homologprostate cancer upregulated protein 1protein kurly homologbeta-secretase 256 kDa aspartic-like proteaseDown syndrome region aspartic proteaseSLCO3A1/BACE2 fusionaspartyl protease 1beta-site APP-cleaving enzyme 2beta-site amyloid beta A4 precursor protein-cleaving enzyme 2memapsin-1membrane-associated asp
Modification date2020031320200313
UniProtAcc.

Q9Y5Z0

Ensembl transtripts involved in fusion geneENST00000290155, ENST00000382549, 
ENST00000540881, 		ENST00000466122, 
ENST00000328735, ENST00000330333, 
ENST00000347667, 
Fusion gene scores* DoF score3 X 3 X 3=2714 X 9 X 8=1008
# samples 414
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C21orf59 [Title/Abstract] AND BACE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC21orf59(33975471)-BACE2(42598193), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBACE2

GO:0006509

membrane protein ectodomain proteolysis

10591213


check buttonFusion gene breakpoints across C21orf59 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BACE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87-01AC21orf59chr21

33975471

-BACE2chr21

42598193

+


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Fusion Gene ORF analysis for C21orf59-BACE2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000290155ENST00000466122C21orf59chr21

33975471

-BACE2chr21

42598193

+
In-frameENST00000290155ENST00000328735C21orf59chr21

33975471

-BACE2chr21

42598193

+
In-frameENST00000290155ENST00000330333C21orf59chr21

33975471

-BACE2chr21

42598193

+
In-frameENST00000290155ENST00000347667C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000382549ENST00000328735C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000382549ENST00000330333C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000382549ENST00000347667C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000540881ENST00000328735C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000540881ENST00000330333C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-3CDSENST00000540881ENST00000347667C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-intronENST00000382549ENST00000466122C21orf59chr21

33975471

-BACE2chr21

42598193

+
intron-intronENST00000540881ENST00000466122C21orf59chr21

33975471

-BACE2chr21

42598193

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290155C21orf59chr2133975471-ENST00000328735BACE2chr2142598193+33381289322167711
ENST00000290155C21orf59chr2133975471-ENST00000330333BACE2chr2142598193+35071289322533833
ENST00000290155C21orf59chr2133975471-ENST00000347667BACE2chr2142598193+92781289322383783

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290155ENST00000328735C21orf59chr2133975471-BACE2chr2142598193+0.0058252760.9941748
ENST00000290155ENST00000330333C21orf59chr2133975471-BACE2chr2142598193+0.0024239110.99757606
ENST00000290155ENST00000347667C21orf59chr2133975471-BACE2chr2142598193+0.0009363450.9990637

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Fusion Genomic Features for C21orf59-BACE2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C21orf59chr2133975470-BACE2chr2142598192+0.0002001030.9997999
C21orf59chr2133975470-BACE2chr2142598192+0.0002001030.9997999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C21orf59-BACE2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:33975471/chr21:42598193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BACE2

Q9Y5Z0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBACE2chr21:33975471chr21:42598193ENST0000032873508495_518104397.0Topological domainCytoplasmic
TgeneBACE2chr21:33975471chr21:42598193ENST0000033033309495_518104519.0Topological domainCytoplasmic
TgeneBACE2chr21:33975471chr21:42598193ENST0000034766708495_518104469.0Topological domainCytoplasmic
TgeneBACE2chr21:33975471chr21:42598193ENST0000032873508474_494104397.0TransmembraneHelical
TgeneBACE2chr21:33975471chr21:42598193ENST0000033033309474_494104519.0TransmembraneHelical
TgeneBACE2chr21:33975471chr21:42598193ENST0000034766708474_494104469.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBACE2chr21:33975471chr21:42598193ENST000003287350892_429104397.0DomainPeptidase A1
TgeneBACE2chr21:33975471chr21:42598193ENST000003303330992_429104519.0DomainPeptidase A1
TgeneBACE2chr21:33975471chr21:42598193ENST000003476670892_429104469.0DomainPeptidase A1
TgeneBACE2chr21:33975471chr21:42598193ENST000003287350821_473104397.0Topological domainExtracellular
TgeneBACE2chr21:33975471chr21:42598193ENST000003303330921_473104519.0Topological domainExtracellular
TgeneBACE2chr21:33975471chr21:42598193ENST000003476670821_473104469.0Topological domainExtracellular


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Fusion Gene Sequence for C21orf59-BACE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11531_11531_1_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000328735_length(transcript)=3338nt_BP=1289nt
TGGAGACTGAAAGCGGCGGAAGGGACGCTGGAATGTGGAGCGGTTGTGGGGCGGCAGCTGCGGAACTGCGCGATTGTGGTTCCCGCCGTA
TTTCCCGTTCCCCATCTAGTAACTCCCATCTCAGCCCACGTATCTCCCTGAGTGGAAATCTCGGGCCCCAGACCAGTCGATTGGGAGGTC
CGCCCTCCCCTTCAGCGACTTGGTCTGTGTTTTGGCAGTTGCCGCGACAACAGTCACTTCCGGGAAGGGGCTCTGCGAATCTCCTTCCGT
CGGTCCGCTCAGAATCAGCTGTCCTCTCAGACTGTGTGGGTGGTTTCCCCGGCCGCAGCTCCGTACGGGCTTGGATTGCTGGGCCTCGGT
GCACCCCAGCCTCCCCCACTCGGGTTCTGAGCTTGAGCTGGCGGCTCTTTAACTCTGCTTCACTGTTGCTCTTGGCAACATCCACTTCCG
GGAGCGAGTGCCGTTTCCCCCGCTCACCGCGGGCTAGGGAGCGTGGGATTCCGGACTGTGAGCGGCTGTTAGTGCGTCGCAGCTGCTGGC
GATCCGGCGACCCTCGGCCGGCAGGACCCGCGGGCCACGCAGCCGGGGCCTTCTCAACGCCTCAGTACCTCGGCGGGACCGCCATGGTTC
TGCTGCACGTGAAGCGGGGCGACGAGAGCCAGTTCCTGCTGCAGGCGCCTGGGAGTACCGAGCTGGAGGAGCTCACGGTGCAGGTGGCCC
GGGTCTATAATGGGCGGCTCAAGGTGCAGCGCCTCTGCTCAGAAATGGAAGAATTAGCCGAACATGGCATATTTCTCCCTCCTAATATGC
AAGGACTGACCGATGATCAGATTGAAGAATTGAAATTGAAGGATGAATGGGGTGAAAAATGCGTACCCAGCGGAGGTGCAGTGTTTAAAA
AGGATGATATTGGACGAAGGAATGGGCAAGCTCCAAATGAGAAGATGAAGCAAGTGTTAAAGAAGACTATAGAAGAAGCCAAAGCAATAA
TATCTAAGAAACAAGTGGAAGCCGGTGTCTGTGTTACCATGGAGATGGTGAAAGATGCCTTGGACCAGCTTCGAGGCGCGGTGATGATTG
TTTACCCCATGGGGTTGCCACCGTATGATCCCATCCGCATGGAGTTTGAAAATAAGGAAGACTTGTCGGGAACACAGGCAGGGCTCAACG
TCATTAAAGAGGCAGAGGCGCAGCTGTGGTGGGCAGCCAAGGAGCTGAGAAGAACGAAGAAGCTTTCAGACTACGTGGGGAAGAATGAAA
AAACCAAAATTATCGCCAAGATTCAGCAACTACAGATTCTCGTTGACACTGGAAGCAGTAACTTTGCCGTGGCAGGAACCCCGCACTCCT
ACATAGACACGTACTTTGACACAGAGAGGTCTAGCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGA
CGGGCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCAACATTGCCACTATTTTTGAATCAGAGA
ATTTCTTTTTGCCTGGGATTAAATGGAATGGAATACTTGGCCTAGCTTATGCCACACTTGCCAAGCCATCAAGTTCTCTGGAGACCTTCT
TCGACTCCCTGGTGACACAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCGGCTTGCCCGTTGCTGGATCTGGGACCA
ACGGAGGTAGTCTTGTCTTGGGTGGAATTGAACCAAGTTTGTATAAAGGAGACATCTGGTATACCCCTATTAAGGAAGAGTGGTACTACC
AGATAGAAATTCTGAAATTGGAAATTGGAGGCCAAAGCCTTAATCTGGACTGCAGAGAGTATAACGCAGACAAGGCCATCGTGGACAGTG
GCACCACGCTGCTGCGCCTGCCCCAGAAGGTGTTTGATGCGGTGGTGGAAGCTGTGGCCCGCGCATCTCTGATTCCAGAATTCTCTGATG
GTTTCTGGACTGGGTCCCAGCTGGCGTGCTGGACGAATTCGGAAACACCTTGGTCTTACTTCCCTAAAATCTCCATCTACCTGAGAGACG
AGAACTCCAGCAGGTCATTCCGTATCACAATCCTGCCTCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGA
GGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGC
CATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTC
TCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAG
CAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTT
TGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGA
TTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTT
CTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTT
ATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTA
ACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAG
GAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTT
TGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGG
GTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATC
AACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTTTTGATGAGAAAAAA

>11531_11531_1_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=711AA_BP=419
MWSGCGAAAAELRDCGSRRISRSPSSNSHLSPRISLSGNLGPQTSRLGGPPSPSATWSVFWQLPRQQSLPGRGSANLLPSVRSESAVLSD
CVGGFPGRSSVRAWIAGPRCTPASPTRVLSLSWRLFNSASLLLLATSTSGSECRFPRSPRARERGIPDCERLLVRRSCWRSGDPRPAGPA
GHAAGAFSTPQYLGGTAMVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEEL
KLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDP
IRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQLQILVDTGSSNFAVAGTPHSYIDTYFDTERS
STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP
NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV

--------------------------------------------------------------
>11531_11531_2_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000330333_length(transcript)=3507nt_BP=1289nt
TGGAGACTGAAAGCGGCGGAAGGGACGCTGGAATGTGGAGCGGTTGTGGGGCGGCAGCTGCGGAACTGCGCGATTGTGGTTCCCGCCGTA
TTTCCCGTTCCCCATCTAGTAACTCCCATCTCAGCCCACGTATCTCCCTGAGTGGAAATCTCGGGCCCCAGACCAGTCGATTGGGAGGTC
CGCCCTCCCCTTCAGCGACTTGGTCTGTGTTTTGGCAGTTGCCGCGACAACAGTCACTTCCGGGAAGGGGCTCTGCGAATCTCCTTCCGT
CGGTCCGCTCAGAATCAGCTGTCCTCTCAGACTGTGTGGGTGGTTTCCCCGGCCGCAGCTCCGTACGGGCTTGGATTGCTGGGCCTCGGT
GCACCCCAGCCTCCCCCACTCGGGTTCTGAGCTTGAGCTGGCGGCTCTTTAACTCTGCTTCACTGTTGCTCTTGGCAACATCCACTTCCG
GGAGCGAGTGCCGTTTCCCCCGCTCACCGCGGGCTAGGGAGCGTGGGATTCCGGACTGTGAGCGGCTGTTAGTGCGTCGCAGCTGCTGGC
GATCCGGCGACCCTCGGCCGGCAGGACCCGCGGGCCACGCAGCCGGGGCCTTCTCAACGCCTCAGTACCTCGGCGGGACCGCCATGGTTC
TGCTGCACGTGAAGCGGGGCGACGAGAGCCAGTTCCTGCTGCAGGCGCCTGGGAGTACCGAGCTGGAGGAGCTCACGGTGCAGGTGGCCC
GGGTCTATAATGGGCGGCTCAAGGTGCAGCGCCTCTGCTCAGAAATGGAAGAATTAGCCGAACATGGCATATTTCTCCCTCCTAATATGC
AAGGACTGACCGATGATCAGATTGAAGAATTGAAATTGAAGGATGAATGGGGTGAAAAATGCGTACCCAGCGGAGGTGCAGTGTTTAAAA
AGGATGATATTGGACGAAGGAATGGGCAAGCTCCAAATGAGAAGATGAAGCAAGTGTTAAAGAAGACTATAGAAGAAGCCAAAGCAATAA
TATCTAAGAAACAAGTGGAAGCCGGTGTCTGTGTTACCATGGAGATGGTGAAAGATGCCTTGGACCAGCTTCGAGGCGCGGTGATGATTG
TTTACCCCATGGGGTTGCCACCGTATGATCCCATCCGCATGGAGTTTGAAAATAAGGAAGACTTGTCGGGAACACAGGCAGGGCTCAACG
TCATTAAAGAGGCAGAGGCGCAGCTGTGGTGGGCAGCCAAGGAGCTGAGAAGAACGAAGAAGCTTTCAGACTACGTGGGGAAGAATGAAA
AAACCAAAATTATCGCCAAGATTCAGCAACTACAGATTCTCGTTGACACTGGAAGCAGTAACTTTGCCGTGGCAGGAACCCCGCACTCCT
ACATAGACACGTACTTTGACACAGAGAGGTCTAGCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGA
CGGGCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCAACATTGCCACTATTTTTGAATCAGAGA
ATTTCTTTTTGCCTGGGATTAAATGGAATGGAATACTTGGCCTAGCTTATGCCACACTTGCCAAGCCATCAAGTTCTCTGGAGACCTTCT
TCGACTCCCTGGTGACACAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCGGCTTGCCCGTTGCTGGATCTGGGACCA
ACGGAGGTAGTCTTGTCTTGGGTGGAATTGAACCAAGTTTGTATAAAGGAGACATCTGGTATACCCCTATTAAGGAAGAGTGGTACTACC
AGATAGAAATTCTGAAATTGGAAATTGGAGGCCAAAGCCTTAATCTGGACTGCAGAGAGTATAACGCAGACAAGGCCATCGTGGACAGTG
GCACCACGCTGCTGCGCCTGCCCCAGAAGGTGTTTGATGCGGTGGTGGAAGCTGTGGCCCGCGCATCTCTGATTCCAGAATTCTCTGATG
GTTTCTGGACTGGGTCCCAGCTGGCGTGCTGGACGAATTCGGAAACACCTTGGTCTTACTTCCCTAAAATCTCCATCTACCTGAGAGACG
AGAACTCCAGCAGGTCATTCCGTATCACAATCCTGCCTCAGCTTTACATTCAGCCCATGATGGGGGCCGGCCTGAATTATGAATGTTACC
GATTCGGCATTTCCCCATCCACAAATGCGCTGGTGATCGGTGCCACGGTGATGGAGGGCTTCTACGTCATCTTCGACAGAGCCCAGAAGA
GGGTGGGCTTCGCAGCGAGCCCCTGTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCA
GCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTG
TCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGAC
ATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATC
GATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGAT
TTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAG
GCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAAT
CTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCA
GACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTA
CCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAA
CCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATA
CTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGC
CTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGA

>11531_11531_2_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=833AA_BP=419
MWSGCGAAAAELRDCGSRRISRSPSSNSHLSPRISLSGNLGPQTSRLGGPPSPSATWSVFWQLPRQQSLPGRGSANLLPSVRSESAVLSD
CVGGFPGRSSVRAWIAGPRCTPASPTRVLSLSWRLFNSASLLLLATSTSGSECRFPRSPRARERGIPDCERLLVRRSCWRSGDPRPAGPA
GHAAGAFSTPQYLGGTAMVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEEL
KLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDP
IRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQLQILVDTGSSNFAVAGTPHSYIDTYFDTERS
STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP
NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV
FDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNAL
VIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFR

--------------------------------------------------------------
>11531_11531_3_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000347667_length(transcript)=9278nt_BP=1289nt
TGGAGACTGAAAGCGGCGGAAGGGACGCTGGAATGTGGAGCGGTTGTGGGGCGGCAGCTGCGGAACTGCGCGATTGTGGTTCCCGCCGTA
TTTCCCGTTCCCCATCTAGTAACTCCCATCTCAGCCCACGTATCTCCCTGAGTGGAAATCTCGGGCCCCAGACCAGTCGATTGGGAGGTC
CGCCCTCCCCTTCAGCGACTTGGTCTGTGTTTTGGCAGTTGCCGCGACAACAGTCACTTCCGGGAAGGGGCTCTGCGAATCTCCTTCCGT
CGGTCCGCTCAGAATCAGCTGTCCTCTCAGACTGTGTGGGTGGTTTCCCCGGCCGCAGCTCCGTACGGGCTTGGATTGCTGGGCCTCGGT
GCACCCCAGCCTCCCCCACTCGGGTTCTGAGCTTGAGCTGGCGGCTCTTTAACTCTGCTTCACTGTTGCTCTTGGCAACATCCACTTCCG
GGAGCGAGTGCCGTTTCCCCCGCTCACCGCGGGCTAGGGAGCGTGGGATTCCGGACTGTGAGCGGCTGTTAGTGCGTCGCAGCTGCTGGC
GATCCGGCGACCCTCGGCCGGCAGGACCCGCGGGCCACGCAGCCGGGGCCTTCTCAACGCCTCAGTACCTCGGCGGGACCGCCATGGTTC
TGCTGCACGTGAAGCGGGGCGACGAGAGCCAGTTCCTGCTGCAGGCGCCTGGGAGTACCGAGCTGGAGGAGCTCACGGTGCAGGTGGCCC
GGGTCTATAATGGGCGGCTCAAGGTGCAGCGCCTCTGCTCAGAAATGGAAGAATTAGCCGAACATGGCATATTTCTCCCTCCTAATATGC
AAGGACTGACCGATGATCAGATTGAAGAATTGAAATTGAAGGATGAATGGGGTGAAAAATGCGTACCCAGCGGAGGTGCAGTGTTTAAAA
AGGATGATATTGGACGAAGGAATGGGCAAGCTCCAAATGAGAAGATGAAGCAAGTGTTAAAGAAGACTATAGAAGAAGCCAAAGCAATAA
TATCTAAGAAACAAGTGGAAGCCGGTGTCTGTGTTACCATGGAGATGGTGAAAGATGCCTTGGACCAGCTTCGAGGCGCGGTGATGATTG
TTTACCCCATGGGGTTGCCACCGTATGATCCCATCCGCATGGAGTTTGAAAATAAGGAAGACTTGTCGGGAACACAGGCAGGGCTCAACG
TCATTAAAGAGGCAGAGGCGCAGCTGTGGTGGGCAGCCAAGGAGCTGAGAAGAACGAAGAAGCTTTCAGACTACGTGGGGAAGAATGAAA
AAACCAAAATTATCGCCAAGATTCAGCAACTACAGATTCTCGTTGACACTGGAAGCAGTAACTTTGCCGTGGCAGGAACCCCGCACTCCT
ACATAGACACGTACTTTGACACAGAGAGGTCTAGCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACACACAAGGAAGCTGGA
CGGGCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGGCTTCAATACTTCTTTTCTTGTCAACATTGCCACTATTTTTGAATCAGAGA
ATTTCTTTTTGCCTGGGATTAAATGGAATGGAATACTTGGCCTAGCTTATGCCACACTTGCCAAGCCATCAAGTTCTCTGGAGACCTTCT
TCGACTCCCTGGTGACACAAGCAAACATCCCCAACGTTTTCTCCATGCAGATGTGTGGAGCCGGCTTGCCCGTTGCTGGATCTGGGACCA
ACGGAGGTAGTCTTGTCTTGGGTGGAATTGAACCAAGTTTGTATAAAGGAGACATCTGGTATACCCCTATTAAGGAAGAGTGGTACTACC
AGATAGAAATTCTGAAATTGGAAATTGGAGGCCAAAGCCTTAATCTGGACTGCAGAGAGTATAACGCAGACAAGGCCATCGTGGACAGTG
GCACCACGCTGCTGCGCCTGCCCCAGAAGGTGTTTGATGCGGTGGTGGAAGCTGTGGCCCGCGCATCTCTGCTTTACATTCAGCCCATGA
TGGGGGCCGGCCTGAATTATGAATGTTACCGATTCGGCATTTCCCCATCCACAAATGCGCTGGTGATCGGTGCCACGGTGATGGAGGGCT
TCTACGTCATCTTCGACAGAGCCCAGAAGAGGGTGGGCTTCGCAGCGAGCCCCTGTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTT
CCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGC
TCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGG
TCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAA
AATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCC
TTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTC
TAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCA
AGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGT
ATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAG
CCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAAT
GGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGG
GGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGG
GTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAAC
AGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATC
ATGTTTTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTG
TTGGGAAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACG
TCTACTTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTC
AGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCT
ACTTTCTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGAGAA
GAGTTAAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACA
GAATTCCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCT
CTGCTCCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGT
CCTGGAAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACG
GCACGGAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATT
TCACACGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAA
GCCAACACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTA
GTTTTCCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGAT
GAACAGGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATT
TCATATCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTTCGC
AACAAGAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGT
GACACCCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACC
CTTTGAGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTT
GTTATCAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCT
GCCTTCAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCA
CAAGTGATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAAC
AGATGCCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAA
ACACAGAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCC
GCAGTGCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTT
AATACGCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACT
AGTGCCACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCTGAT
TAGTGGAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAA
ACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGA
GAGGTACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTG
AACTTTACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGC
TAACAAAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGC
CGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTA
GCCAACGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGT
GAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCC
ATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGAATA
TTCAAGCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTG
GTTCATTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGA
GAGGTCCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCC
ACGTTTTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAA
ACTTGCTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGT
CATGCACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGG
CTCCTGGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCC
CATGCATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTG
TCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCA
GGAGGGAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTG
GGCTCTTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGT
TGCATCAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCT
CTGGGTTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTGTGC
TTAAAAAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTG
CGGGTACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTG
CCAGCATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACA
GATGGATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAAAAT
ATTTTTTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATC
AATAAAAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAAT
AAAAATGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGT
TGAGTGCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTACAC
AAGCCTCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGT
GAACAAAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGG
TATAAAACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAG
TTACTCAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTT
TCTACTATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCT
TAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAA
AGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAA
ATGCTTAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGT
TGGAGTAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAG
TTTTCTAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATATATACCATTGAAAGGGAAATAAAACATTTTTGTTTATT

>11531_11531_3_C21orf59-BACE2_C21orf59_chr21_33975471_ENST00000290155_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=783AA_BP=419
MWSGCGAAAAELRDCGSRRISRSPSSNSHLSPRISLSGNLGPQTSRLGGPPSPSATWSVFWQLPRQQSLPGRGSANLLPSVRSESAVLSD
CVGGFPGRSSVRAWIAGPRCTPASPTRVLSLSWRLFNSASLLLLATSTSGSECRFPRSPRARERGIPDCERLLVRRSCWRSGDPRPAGPA
GHAAGAFSTPQYLGGTAMVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEEL
KLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDP
IRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQLQILVDTGSSNFAVAGTPHSYIDTYFDTERS
STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP
NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV
FDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVAS

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Fusion Gene PPI Analysis for C21orf59-BACE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C21orf59-BACE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C21orf59-BACE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource