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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C3orf17-RPN2 (FusionGDB2 ID:11703)

Fusion Gene Summary for C3orf17-RPN2

Fusion gene summary

Fusion gene information	Fusion gene name: C3orf17-RPN2
	Fusion gene ID: 11703
		Hgene	Tgene
	Gene symbol	C3orf17	RPN2
	Gene ID	25871	6185
	Gene name	nucleolus and neural progenitor protein	ribophorin II
	Synonyms	C3orf17\|NET17	RIBIIR\|RPN-II\|RPNII\|SWP1
	Cytomap	3q13.2	20q11.23
	Type of gene	protein-coding	protein-coding
	Description	nucleolus and neural progenitor proteinprotein nepro homolog	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000314400, ENST00000383675, ENST00000393857, ENST00000472762,	ENST00000470352, ENST00000237530, ENST00000373622,
Fusion gene scores	* DoF score	2 X 2 X 2=8	12 X 13 X 9=1404
	# samples	2	17
	** MAII score	log2(2/8*10)=1.32192809488736	log2(17/1404*10)=-3.04593628416686 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C3orf17 [Title/Abstract] AND RPN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C3orf17(112738389)-RPN2(35852281), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across C3orf17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-KR-A7K0-01A	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+

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Fusion Gene ORF analysis for C3orf17-RPN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000314400	ENST00000470352	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
5CDS-intron	ENST00000383675	ENST00000470352	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
5UTR-3CDS	ENST00000393857	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
5UTR-3CDS	ENST00000393857	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
5UTR-intron	ENST00000393857	ENST00000470352	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
In-frame	ENST00000314400	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
In-frame	ENST00000314400	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
In-frame	ENST00000383675	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
In-frame	ENST00000383675	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
intron-3CDS	ENST00000472762	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
intron-3CDS	ENST00000472762	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+
intron-intron	ENST00000472762	ENST00000470352	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000314400	C3orf17	chr3	112738389	-	ENST00000237530	RPN2	chr20	35852281	+	1406	298	295	1101	268
ENST00000314400	C3orf17	chr3	112738389	-	ENST00000373622	RPN2	chr20	35852281	+	1454	298	295	1149	284
ENST00000383675	C3orf17	chr3	112738389	-	ENST00000237530	RPN2	chr20	35852281	+	1300	192	189	995	268
ENST00000383675	C3orf17	chr3	112738389	-	ENST00000373622	RPN2	chr20	35852281	+	1348	192	189	1043	284

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000314400	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+	0.7354273	0.2645727
ENST00000314400	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+	0.18002543	0.8199746
ENST00000383675	ENST00000237530	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+	0.5732517	0.42674825
ENST00000383675	ENST00000373622	C3orf17	chr3	112738389	-	RPN2	chr20	35852281	+	0.16721568	0.8327843

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Fusion Genomic Features for C3orf17-RPN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C3orf17	chr3	112738388	-	RPN2	chr20	35852280	+	0.000159755	0.99984026
C3orf17	chr3	112738388	-	RPN2	chr20	35852280	+	0.000159755	0.99984026

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C3orf17-RPN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:112738389/chr20:35852281)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

562_571

364

632.0

Topological domain

Cytoplasmic

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

593_596

364

632.0

Topological domain

Lumenal

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

618_631

364

632.0

Topological domain

Cytoplasmic

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

562_571

332

616.0

Topological domain

Cytoplasmic

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

593_596

332

616.0

Topological domain

Lumenal

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

618_631

332

616.0

Topological domain

Cytoplasmic

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

541_561

364

632.0

Transmembrane

Helical

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

572_592

364

632.0

Transmembrane

Helical

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

597_617

364

632.0

Transmembrane

Helical

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

541_561

332

616.0

Transmembrane

Helical

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

572_592

332

616.0

Transmembrane

Helical

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

597_617

332

616.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

C3orf17

chr3:112738389

chr20:35852281

ENST00000314400

442_460

568.0

Region

Nuclear localization signal

Hgene

C3orf17

chr3:112738389

chr20:35852281

ENST00000383675

442_460

498.0

Region

Nuclear localization signal

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000237530

23_540

364

632.0

Topological domain

Lumenal

Tgene

RPN2

chr3:112738389

chr20:35852281

ENST00000373622

23_540

332

616.0

Topological domain

Lumenal

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Fusion Gene Sequence for C3orf17-RPN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11703_11703_1_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000237530_length(transcript)=1406nt_BP=298nt
AATATACAGATGACTGGGTCCTTCCCAGTCCCACGCGTTTACTCGATGAAGGCAGCCTCCCGCCGGGCTCCTGGCCCCGCCCGAGCCCCA
CCCCCTGCTCCCTTCCGGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTC
CCCCCGCCTCGCATGATGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTG
ACAGTGCAGAACCCCGGCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAA
GGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGC
CTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCA
GGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGC
CTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTT
CCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAA
GAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGC
CAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGAC
TCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGC
AGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTA
TGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCA
ACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTG

>11703_11703_1_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=268AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN

--------------------------------------------------------------
>11703_11703_2_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000373622_length(transcript)=1454nt_BP=298nt
AATATACAGATGACTGGGTCCTTCCCAGTCCCACGCGTTTACTCGATGAAGGCAGCCTCCCGCCGGGCTCCTGGCCCCGCCCGAGCCCCA
CCCCCTGCTCCCTTCCGGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTC
CCCCCGCCTCGCATGATGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTG
ACAGTGCAGAACCCCGGCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAA
GGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGC
CTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCA
GGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGC
CTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTT
CCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAA
GAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGC
CAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGAC
TCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGC
AGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAAGATGGAAA
TTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAA
AAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTC
TGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGTAATTGTTTTGGAATAAAGAG

>11703_11703_2_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=284AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN
TFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRIAAEQ

--------------------------------------------------------------
>11703_11703_3_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000237530_length(transcript)=1300nt_BP=192nt
GGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTCCCCCCGCCTCGCATGA
TGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTGACAGTGCAGAACCCCG
GCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCA
CCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTG
GTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTT
GCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACT
CTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCT
CCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTG
GTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTC
ACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTC
CAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGAACAGCA
CATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGA
AAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACC
TGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAA

>11703_11703_3_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=268AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN

--------------------------------------------------------------
>11703_11703_4_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000373622_length(transcript)=1348nt_BP=192nt
GGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTCCCCCCGCCTCGCATGA
TGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTGACAGTGCAGAACCCCG
GCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCA
CCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTG
GTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTT
GCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACT
CTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCT
CCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTG
GTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTC
ACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTC
CAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCT
GCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATG
TCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTA
GTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAA

>11703_11703_4_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=284AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN
TFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRIAAEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C3orf17-RPN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C3orf17-RPN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C3orf17-RPN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source