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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C4B-C4A (FusionGDB2 ID:11765)

Fusion Gene Summary for C4B-C4A

Fusion gene summary

Fusion gene information	Fusion gene name: C4B-C4A
	Fusion gene ID: 11765
		Hgene	Tgene
	Gene symbol	C4B	C4A
	Gene ID	721	720
	Gene name	complement C4B (Chido blood group)	complement C4A (Rodgers blood group)
	Synonyms	C4B1\|C4B12\|C4B2\|C4B3\|C4B5\|C4BD\|C4B_2\|C4F\|CH\|CO4\|CPAMD3	C4\|C4A2\|C4A3\|C4A4\|C4A6\|C4AD\|C4S\|CO4\|CPAMD2\|RG
	Cytomap	6p21.33	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	complement C4-BC3 and PZP-like alpha-2-macroglobulin domain-containing protein 3Chido form of C4basic complement C4complement C4B1acomplement component 4B (Chido blood group)	complement C4-AC3 and PZP-like alpha-2-macroglobulin domain-containing protein 2C4A anaphylatoxinMHC class III region complementRodgers form of C4acidic C4acidic complement C4complement component 4A (Rodgers blood group)
	Modification date	20200313	20200313
	UniProtAcc	P0C0L5	P0C0L4
	Ensembl transtripts involved in fusion gene	ENST00000435363, ENST00000375177, ENST00000411583, ENST00000425700, ENST00000445788, ENST00000449788, ENST00000485543, ENST00000487226, ENST00000488817, ENST00000494210, ENST00000546399, ENST00000548301, ENST00000548530, ENST00000550398,	ENST00000428956, ENST00000498271, ENST00000375295, ENST00000383325, ENST00000421274, ENST00000467948, ENST00000483562, ENST00000488693, ENST00000489963, ENST00000537134, ENST00000546746, ENST00000549812, ENST00000550297,
Fusion gene scores	* DoF score	9 X 7 X 6=378	1 X 1 X 1=1
	# samples	8	1
	** MAII score	log2(8/378*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: C4B [Title/Abstract] AND C4A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C4B(31982572)-C4A(31949920), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	C4B	GO:0032490	detection of molecule of bacterial origin	22333221

Fusion gene breakpoints across C4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	K02403	C4B	chr6	31982572	-	C4A	chr6	31949920	+

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Fusion Gene ORF analysis for C4B-C4A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000435363	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-3CDS	ENST00000435363	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
5UTR-intron	ENST00000435363	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000375177	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000375177	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000411583	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000411583	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000425700	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000425700	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000445788	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000445788	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000449788	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000449788	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000485543	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000485543	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000487226	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000487226	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000488817	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000488817	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000494210	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000494210	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000546399	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000546399	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000548301	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000548301	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000548530	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000548530	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000550398	ENST00000428956	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-3CDS	ENST00000550398	ENST00000498271	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000375177	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000411583	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000425700	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000445788	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000449788	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000485543	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000487226	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000488817	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000494210	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000546399	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548301	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000548530	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000375295	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000383325	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000421274	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000467948	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000483562	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000488693	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000489963	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000537134	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000546746	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000549812	C4B	chr6	31982572	-	C4A	chr6	31949920	+
intron-intron	ENST00000550398	ENST00000550297	C4B	chr6	31982572	-	C4A	chr6	31949920	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for C4B-C4A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C4B-C4A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31982572/:31949920)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C4B P0C0L5	C4A P0C0L4
FUNCTION: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.	FUNCTION: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for C4B-C4A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C4B-C4A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C4B-C4A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C4B-C4A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source