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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C4orf29-SRP72 (FusionGDB2 ID:11793)

Fusion Gene Summary for C4orf29-SRP72

check button Fusion gene summary
Fusion gene informationFusion gene name: C4orf29-SRP72
Fusion gene ID: 11793
HgeneTgene
Gene symbol

C4orf29

SRP72

Gene ID

80167

6731

Gene nameabhydrolase domain containing 18signal recognition particle 72
SynonymsC4orf29BMFF|BMFS1|HEL103
Cytomap

4q28.2

4q12

Type of geneprotein-codingprotein-coding
Descriptionprotein ABHD18abhydrolase domain-containing protein 18alpha/beta hydrolase domain-containing protein 18signal recognition particle subunit SRP72epididymis luminal protein 103signal recognition particle 72 kDa proteinsignal recognition particle 72kDsignal recognition particle 72kDa
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000388795, ENST00000398965, 
ENST00000444616, 		ENST00000504757, 
ENST00000342756, ENST00000510663, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 5 X 3=75
# samples 25
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C4orf29 [Title/Abstract] AND SRP72 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC4orf29(128951827)-SRP72(57361523), # samples:1
Anticipated loss of major functional domain due to fusion event.C4orf29-SRP72 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
C4orf29-SRP72 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRP72

GO:0042493

response to drug

18089836


check buttonFusion gene breakpoints across C4orf29 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRP72 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01AC4orf29chr4

128951827

+SRP72chr4

57361523

+


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Fusion Gene ORF analysis for C4orf29-SRP72

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000388795ENST00000504757C4orf29chr4

128951827

+SRP72chr4

57361523

+
5CDS-intronENST00000398965ENST00000504757C4orf29chr4

128951827

+SRP72chr4

57361523

+
5CDS-intronENST00000444616ENST00000504757C4orf29chr4

128951827

+SRP72chr4

57361523

+
Frame-shiftENST00000444616ENST00000342756C4orf29chr4

128951827

+SRP72chr4

57361523

+
Frame-shiftENST00000444616ENST00000510663C4orf29chr4

128951827

+SRP72chr4

57361523

+
In-frameENST00000388795ENST00000342756C4orf29chr4

128951827

+SRP72chr4

57361523

+
In-frameENST00000388795ENST00000510663C4orf29chr4

128951827

+SRP72chr4

57361523

+
In-frameENST00000398965ENST00000342756C4orf29chr4

128951827

+SRP72chr4

57361523

+
In-frameENST00000398965ENST00000510663C4orf29chr4

128951827

+SRP72chr4

57361523

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398965C4orf29chr4128951827+ENST00000342756SRP72chr457361523+36362014691490473
ENST00000398965C4orf29chr4128951827+ENST00000510663SRP72chr457361523+30112014691490473
ENST00000388795C4orf29chr4128951827+ENST00000342756SRP72chr457361523+312215003281875515
ENST00000388795C4orf29chr4128951827+ENST00000510663SRP72chr457361523+249715003281875515

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398965ENST00000342756C4orf29chr4128951827+SRP72chr457361523+0.002090360.9979096
ENST00000398965ENST00000510663C4orf29chr4128951827+SRP72chr457361523+0.0025770110.99742305
ENST00000388795ENST00000342756C4orf29chr4128951827+SRP72chr457361523+0.0003458110.9996542
ENST00000388795ENST00000510663C4orf29chr4128951827+SRP72chr457361523+0.0003927070.99960726

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Fusion Genomic Features for C4orf29-SRP72


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C4orf29chr4128951827+SRP72chr457361522+6.45E-050.9999355
C4orf29chr4128951827+SRP72chr457361522+6.45E-050.9999355

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C4orf29-SRP72


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:128951827/chr4:57361523)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519552_561546672.0Compositional biasNote=Poly-Lys
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519662_665546672.0Compositional biasNote=Poly-Lys
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317552_561485611.0Compositional biasNote=Poly-Lys
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317662_665485611.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519109_142546672.0RepeatNote=TPR 2
TgeneSRP72chr4:128951827chr4:57361523ENST00000342756151911_44546672.0RepeatNote=TPR 1
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519226_259546672.0RepeatNote=TPR 3
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519406_439546672.0RepeatNote=TPR 4
TgeneSRP72chr4:128951827chr4:57361523ENST000003427561519447_480546672.0RepeatNote=TPR 5
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317109_142485611.0RepeatNote=TPR 2
TgeneSRP72chr4:128951827chr4:57361523ENST00000510663131711_44485611.0RepeatNote=TPR 1
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317226_259485611.0RepeatNote=TPR 3
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317406_439485611.0RepeatNote=TPR 4
TgeneSRP72chr4:128951827chr4:57361523ENST000005106631317447_480485611.0RepeatNote=TPR 5


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Fusion Gene Sequence for C4orf29-SRP72


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11793_11793_1_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000388795_SRP72_chr4_57361523_ENST00000342756_length(transcript)=3122nt_BP=1500nt
GCCGCGCCGCCCTGCTCCGGGTTTGTCTTCCTCCCTCCGTTTCTCCTTCCGCTGTATCTAGCATTTCGGTTCCTGGAAAGGTTACCGGAG
CTGCGATTGGGGCTGGGACCAAAGTTGAGTCCTGGAAAGGGAGCCTGGAGAGCGGCGGTGCTGGGAGGCCCGGCCAGCTCGATCGCAGGC
TTCCACCTGGCGGCCAATGCTTGTTTGCTACTGATGGGTGTGAGCAAGTTAGATATTCTATACCGGAGACTTCTCCTAACAAAACTTTTT
ATCAGAGGATGGGGAAGGCCAGAAGATCTCAAAAGACTCTTTGAATTCAGAAAGATGATTGGAAATCGGGAAAGATGCCAGAATCTGGTT
TCAAGCGATTATCCAGTACACATTGATAAGGATTATTGATGAAATGCTTGATACCAACTTGATTCTTCTACCTTTGTTCCAATTTATTGT
GCCTAAAGAATGGAACAGCAAATATAGACCTGTATGCATTCATCTTGCTGGAACAGGAGATCATCATTACTGGAGGCGACGAACACTAAT
GGCCCGTCCTATGATTAAAGAAGCCCGAATGGCTTCTTTATTGTTAGAAAACCCTTATTATGGCTGCAGGAAACCCAAGGACCAAGTAAG
GTCCAGCTTAAAAAATGTGTCCGACCTTTTTGTGATGGGAGGAGCTCTTGTTTTAGAATCTGCAGCTCTCTTGCACTGGCTAGAGAGGGA
AGGTTACGGCCCTTTAGGAATGACTGGAATATCCATGGGAGGACACATGGCTTCCTTAGCGGTATCCAACTGGCCTAAGCCCATGCCATT
GATTCCATGCCTGTCTTGGTCCACAGCATCTGGGGTCTTCACTACGGGTGTGTTGAGTAAATCAATTAATTGGAGGGAGCTGGAAAAGCA
ATATTATACCCAGACAGTTTATGAAGAAGAAATTATTCACATGCTTGAATACTGTGGAACAGATTCTTTCAAAATGGGACAAGAGTTTGT
GAAACACTTCACTAGCAGTGCAGACAAGCTAACTAACCTTAATCTGGTTTCCAGAACTTTAAATTTAGATATATCAAACCAAGTTGTATC
CCAAAAACCTGCTGACTGCCATAATTCTAGCAAAACATCTGTCAGTGCGACATCAGAAGGACTCTTATTGCAAGATACCTCTAAGATGAA
GCGCTTCAATCAAACACTTTCAACCAACAAAAGTGGTTATACAAGTCGCAACCCTCAGTCATACCACCTACTTAGTAAAGAACAAAGCAG
AAACAGTCTTCGGAAAGAGTCTTTAATATTTATGAAAGGAGTCATGGATGAATGTACTCATGTAGCAAATTTCTCAGTCCCAGTTGATCC
AAGCCTCATTATAGTGGTTCAAGCCAAAGAAGATGCCTATATTCCACGAACAGGAGTTCGAAGTTTACAAGAAATTTGGCCTGGTTGTGA
AATCCGATACTTAGAAGGGGGTCATATTAGTGCTTATCTTTTTAAACAAGGACTCTTCAGACAGGGAGATTTGAAAAAGAAGAAAAAGAA
AAAGAAGGGAAAATTGCCTAAGAATTATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCG
GGGAAGAAAGAAGGGTAAAAAGAAGGATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAA
AACTGTGAGCAGCCCACCCACCTCCCCAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCA
GAAACCTGCAGGGGCTCCAGCAACAAAAAAGAAACAGCAACAGAAAAAGAAGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTG
TTGCAGGCTGTTTTTAAACTAGTGTCAGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCT
CCATATTTTCATAATTTCTTGTGTTTCAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAG
CTTTGTACAGATTATGAGGACTGAAAATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATC
TTTTTTCAGTTTCACATACCTTATCTAAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTG
TTTCTGTTCAAGTCCCACTTTAAATTATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCAT
GTGATAAAGAGGGACCTTCTTAATACACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAA
CCATAAATTTTCTGTCATGTGATACTGGAATATGGGATACTTTTCATGTTTATATATATATATATATGTATATATATATACATATATATA
TATATATAAACATGAAATATATATATATGGCTCCTTTGTGCCCCATGTCATTTTCAGATTATGGTAGCATGCTGATACAGCACCATGAAA
GAACTCAAGGAAAATATATCAATGTAAGAAGTTCACTCTTAGACCCAGTGTTCTGAGGTCACATGGGTTTGGACTGTCTCAATCAGAAAG
ATTAATGACTGTTATCAAGAACATGAACATTGGCTTCCTCCATAGAGAAGAAATCAGTATCTGAGTTGCATACCAGGCAGTATTAAAATC
TAACAGGTCTGTTTGGCCCATTGATAGATACTCAAATGGTGTCTCCTTCTGGTTATGGATTTTGACCATTGATTACCTTTCTCAATGTAA
TGAAGTATTTTACAGTCAATTTGTGGTGTAAATGTTGCTCTTGTCTTTCCTTGCTTACAAACTACTTTCACATTGAACAGCTGTGAGACA
GACATATTGAGATGCCTGCCCTTGTTAGTATTCATTTTATGCTGCCCAAGATATCATTTAATTTAGACTTAACAAGTATTTCCTTGTGAT

>11793_11793_1_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000388795_SRP72_chr4_57361523_ENST00000342756_length(amino acids)=515AA_BP=
MEIGKDARIWFQAIIQYTLIRIIDEMLDTNLILLPLFQFIVPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPY
YGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLS
KSINWRELEKQYYTQTVYEEEIIHMLEYCGTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPADCHNSSKTSVSATSE
GLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGV
RSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGAT

--------------------------------------------------------------
>11793_11793_2_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000388795_SRP72_chr4_57361523_ENST00000510663_length(transcript)=2497nt_BP=1500nt
GCCGCGCCGCCCTGCTCCGGGTTTGTCTTCCTCCCTCCGTTTCTCCTTCCGCTGTATCTAGCATTTCGGTTCCTGGAAAGGTTACCGGAG
CTGCGATTGGGGCTGGGACCAAAGTTGAGTCCTGGAAAGGGAGCCTGGAGAGCGGCGGTGCTGGGAGGCCCGGCCAGCTCGATCGCAGGC
TTCCACCTGGCGGCCAATGCTTGTTTGCTACTGATGGGTGTGAGCAAGTTAGATATTCTATACCGGAGACTTCTCCTAACAAAACTTTTT
ATCAGAGGATGGGGAAGGCCAGAAGATCTCAAAAGACTCTTTGAATTCAGAAAGATGATTGGAAATCGGGAAAGATGCCAGAATCTGGTT
TCAAGCGATTATCCAGTACACATTGATAAGGATTATTGATGAAATGCTTGATACCAACTTGATTCTTCTACCTTTGTTCCAATTTATTGT
GCCTAAAGAATGGAACAGCAAATATAGACCTGTATGCATTCATCTTGCTGGAACAGGAGATCATCATTACTGGAGGCGACGAACACTAAT
GGCCCGTCCTATGATTAAAGAAGCCCGAATGGCTTCTTTATTGTTAGAAAACCCTTATTATGGCTGCAGGAAACCCAAGGACCAAGTAAG
GTCCAGCTTAAAAAATGTGTCCGACCTTTTTGTGATGGGAGGAGCTCTTGTTTTAGAATCTGCAGCTCTCTTGCACTGGCTAGAGAGGGA
AGGTTACGGCCCTTTAGGAATGACTGGAATATCCATGGGAGGACACATGGCTTCCTTAGCGGTATCCAACTGGCCTAAGCCCATGCCATT
GATTCCATGCCTGTCTTGGTCCACAGCATCTGGGGTCTTCACTACGGGTGTGTTGAGTAAATCAATTAATTGGAGGGAGCTGGAAAAGCA
ATATTATACCCAGACAGTTTATGAAGAAGAAATTATTCACATGCTTGAATACTGTGGAACAGATTCTTTCAAAATGGGACAAGAGTTTGT
GAAACACTTCACTAGCAGTGCAGACAAGCTAACTAACCTTAATCTGGTTTCCAGAACTTTAAATTTAGATATATCAAACCAAGTTGTATC
CCAAAAACCTGCTGACTGCCATAATTCTAGCAAAACATCTGTCAGTGCGACATCAGAAGGACTCTTATTGCAAGATACCTCTAAGATGAA
GCGCTTCAATCAAACACTTTCAACCAACAAAAGTGGTTATACAAGTCGCAACCCTCAGTCATACCACCTACTTAGTAAAGAACAAAGCAG
AAACAGTCTTCGGAAAGAGTCTTTAATATTTATGAAAGGAGTCATGGATGAATGTACTCATGTAGCAAATTTCTCAGTCCCAGTTGATCC
AAGCCTCATTATAGTGGTTCAAGCCAAAGAAGATGCCTATATTCCACGAACAGGAGTTCGAAGTTTACAAGAAATTTGGCCTGGTTGTGA
AATCCGATACTTAGAAGGGGGTCATATTAGTGCTTATCTTTTTAAACAAGGACTCTTCAGACAGGGAGATTTGAAAAAGAAGAAAAAGAA
AAAGAAGGGAAAATTGCCTAAGAATTATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCG
GGGAAGAAAGAAGGGTAAAAAGAAGGATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAA
AACTGTGAGCAGCCCACCCACCTCCCCAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCA
GAAACCTGCAGGGGCTCCAGCAACAAAAAAGAAACAGCAACAGAAAAAGAAGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTG
TTGCAGGCTGTTTTTAAACTAGTGTCAGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCT
CCATATTTTCATAATTTCTTGTGTTTCAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAG
CTTTGTACAGATTATGAGGACTGAAAATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATC
TTTTTTCAGTTTCACATACCTTATCTAAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTG
TTTCTGTTCAAGTCCCACTTTAAATTATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCAT
GTGATAAAGAGGGACCTTCTTAATACACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAA

>11793_11793_2_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000388795_SRP72_chr4_57361523_ENST00000510663_length(amino acids)=515AA_BP=
MEIGKDARIWFQAIIQYTLIRIIDEMLDTNLILLPLFQFIVPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPY
YGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLS
KSINWRELEKQYYTQTVYEEEIIHMLEYCGTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPADCHNSSKTSVSATSE
GLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGV
RSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGAT

--------------------------------------------------------------
>11793_11793_3_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000398965_SRP72_chr4_57361523_ENST00000342756_length(transcript)=3636nt_BP=2014nt
AGCGCAGGGCGAAAGGAGGCTGTGTCCTCAGCCTCCTCCCTCGGCACGCGCCTCCCATCCTGACGGGGACTGAGAGCCCAGGAGAGCTCG
GGGCGTGTCCAAACTGCCGCGCCGCCCTGCTCCGGGTTTGTCTTCCTCCCTCCGTTTCTCCTTCCGCTGTATCTAGCATTTCGGTTCCTG
GAAAGGTTACCGGAGCTGCGATTGGGGCTGGGACCAAAGTTGAGTCCTGGAAAGGGAGCCTGGAGAGCGGCGGTGCTGGGAGGCCCGGCC
AGCTCGATCGCAGGCTTCCACCTGGCGGCCAATGCTTGTTTGCTACTGATGGGTGTGAGCAAGTTAGATATTCTATACCGGAGACTTCTC
CTAACAAAACTTTTTATCAGAGGATGGGGAAGGCCAGAAGATCTCAAAAGACTCTTTGAATTCAGAAAGATGATTGGAAATCGGGAAAGA
TGCCAGAATCTGGTTTCAAGCGATTATCCAGTACACATTGATAAGATTGAAGAGCAATCAGATTGTAAGATCTTAGATGGACACTTTGTT
TCCCCCATGGCTCACTATGTGCCTGATATCATGCCAATTGAATCTGTTATTGCAAGGTTCCAATTTATTGTGCCTAAAGAATGGAACAGC
AAATATAGACCTGTATGCATTCATCTTGCTGGAACAGGAGATCATCATTACTGGAGGCGACGAACACTAATGGCCCGTCCTATGATTAAA
GAAGCCCGAATGGCTTCTTTATTGTTAGAAAACCCTTATTATGGCTGCAGGAAACCCAAGGACCAAGTAAGGTCCAGCTTAAAAAATGTG
TCCGACCTTTTTGTGATGGGAGGAGCTCTTGTTTTAGAATCTGCAGCTCTCTTGCACTGGCTAGAGAGGGAAGGTTACGGCCCTTTAGGA
ATGACTGGAATATCCATGGGAGGACACATGGCTTCCTTAGCGGTATCCAACTGGCCTAAGCCCATGCCATTGATTCCATGCCTGTCTTGG
TCCACAGCATCTGGGGTCTTCACTACGACAGATTCTTTCAAAATGGGACAAGAGTTTGTGAAACACTTCACTAGCAGTGCAGACAAGCTA
ACTAACCTTAATCTGGTTTCCAGAACTTTAAATTTAGATATATCAAACCAAGTTGTATCCCAAAAACCTGCTGACTGCCATAATTCTAGC
AAAACATCTGTCAGTGCGACATCAGAAGGACTCTTATTGCAAGATACCTCTAAGATGAAGCGCTTCAATCAAACACTTTCAACCAACAAA
AGTGGTTATACAAGTCGCAACCCTCAGTCATACCACCTACTTAGTAAAGAACAAAGCAGAAACAGTCTTCGGAAAGAGTCTTTAATATTT
ATGAAAGGAGTCATGGATGAATGTACTCATGTAGCAAATTTCTCAGGTAAGACGGCTGGTCTAAACATGTATTCGTTCATTTGTTGTTTG
TTTTCTGGATTTTTTGCTTCAACAAATGTAAAAGATCACATATTTTTATAGTCTGTTTCAATCTTTGAATTCCCTCCTCACCTCCCACAA
ATCTCACAGAGTTACTTTTCCCTCTTTCCTAGAATTTGATCTTCTTATTTTCTTCTAGAGAACTAAGCATGATGCATATTATAGGCATGC
TTTATCGTGTGGCTTTCCCCTCTTCAAATATTAATGGCCAGGTATTTTAGGATGTGAGAAGGAAGATCATGGCTTGTTAAAGTTGCTTTG
GTGCATCAAGAGTTTTTTCACTCTATTCTGATGTTTTTTCAGAATGGCCTGAACATCTGTGGAATAATTTAGCAATGTTTTTCAGTTAGC
AAGTGAATATTGAACCTTAAATAAGAAGTGCTTTTAATGTGAACAACCTTATATGACTCCACTATTTTAGTTAGAACTTATAAAAACTTT
TATGCTGGCTGGGCGCGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGCGGGTGTATCACGAGGTCAGGAGATCAAGGCC
ATCCTGGCTAACACGGTGAAACCCCGTCTCTAGTACAGGGAGATTTGAAAAAGAAGAAAAAGAAAAAGAAGGGAAAATTGCCTAAGAATT
ATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCGGGGAAGAAAGAAGGGTAAAAAGAAGG
ATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAAAACTGTGAGCAGCCCACCCACCTCCC
CAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCAGAAACCTGCAGGGGCTCCAGCAACAA
AAAAGAAACAGCAACAGAAAAAGAAGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTGTTGCAGGCTGTTTTTAAACTAGTGTC
AGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCTCCATATTTTCATAATTTCTTGTGTTT
CAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAGCTTTGTACAGATTATGAGGACTGAAA
ATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATCTTTTTTCAGTTTCACATACCTTATCT
AAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTGTTTCTGTTCAAGTCCCACTTTAAATT
ATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCATGTGATAAAGAGGGACCTTCTTAATAC
ACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAACCATAAATTTTCTGTCATGTGATACT
GGAATATGGGATACTTTTCATGTTTATATATATATATATATGTATATATATATACATATATATATATATATAAACATGAAATATATATAT
ATGGCTCCTTTGTGCCCCATGTCATTTTCAGATTATGGTAGCATGCTGATACAGCACCATGAAAGAACTCAAGGAAAATATATCAATGTA
AGAAGTTCACTCTTAGACCCAGTGTTCTGAGGTCACATGGGTTTGGACTGTCTCAATCAGAAAGATTAATGACTGTTATCAAGAACATGA
ACATTGGCTTCCTCCATAGAGAAGAAATCAGTATCTGAGTTGCATACCAGGCAGTATTAAAATCTAACAGGTCTGTTTGGCCCATTGATA
GATACTCAAATGGTGTCTCCTTCTGGTTATGGATTTTGACCATTGATTACCTTTCTCAATGTAATGAAGTATTTTACAGTCAATTTGTGG
TGTAAATGTTGCTCTTGTCTTTCCTTGCTTACAAACTACTTTCACATTGAACAGCTGTGAGACAGACATATTGAGATGCCTGCCCTTGTT
AGTATTCATTTTATGCTGCCCAAGATATCATTTAATTTAGACTTAACAAGTATTTCCTTGTGATTATATTACTCTGTCCTTGTTAATAAA

>11793_11793_3_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000398965_SRP72_chr4_57361523_ENST00000342756_length(amino acids)=473AA_BP=
MRAQESSGRVQTAAPPCSGFVFLPPFLLPLYLAFRFLERLPELRLGLGPKLSPGKGAWRAAVLGGPASSIAGFHLAANACLLLMGVSKLD
ILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKIEEQSDCKILDGHFVSPMAHYVPDIMPIESVIARFQFI
VPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLER
EGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKP
ADCHNSSKTSVSATSEGLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSGKTAGLNM

--------------------------------------------------------------
>11793_11793_4_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000398965_SRP72_chr4_57361523_ENST00000510663_length(transcript)=3011nt_BP=2014nt
AGCGCAGGGCGAAAGGAGGCTGTGTCCTCAGCCTCCTCCCTCGGCACGCGCCTCCCATCCTGACGGGGACTGAGAGCCCAGGAGAGCTCG
GGGCGTGTCCAAACTGCCGCGCCGCCCTGCTCCGGGTTTGTCTTCCTCCCTCCGTTTCTCCTTCCGCTGTATCTAGCATTTCGGTTCCTG
GAAAGGTTACCGGAGCTGCGATTGGGGCTGGGACCAAAGTTGAGTCCTGGAAAGGGAGCCTGGAGAGCGGCGGTGCTGGGAGGCCCGGCC
AGCTCGATCGCAGGCTTCCACCTGGCGGCCAATGCTTGTTTGCTACTGATGGGTGTGAGCAAGTTAGATATTCTATACCGGAGACTTCTC
CTAACAAAACTTTTTATCAGAGGATGGGGAAGGCCAGAAGATCTCAAAAGACTCTTTGAATTCAGAAAGATGATTGGAAATCGGGAAAGA
TGCCAGAATCTGGTTTCAAGCGATTATCCAGTACACATTGATAAGATTGAAGAGCAATCAGATTGTAAGATCTTAGATGGACACTTTGTT
TCCCCCATGGCTCACTATGTGCCTGATATCATGCCAATTGAATCTGTTATTGCAAGGTTCCAATTTATTGTGCCTAAAGAATGGAACAGC
AAATATAGACCTGTATGCATTCATCTTGCTGGAACAGGAGATCATCATTACTGGAGGCGACGAACACTAATGGCCCGTCCTATGATTAAA
GAAGCCCGAATGGCTTCTTTATTGTTAGAAAACCCTTATTATGGCTGCAGGAAACCCAAGGACCAAGTAAGGTCCAGCTTAAAAAATGTG
TCCGACCTTTTTGTGATGGGAGGAGCTCTTGTTTTAGAATCTGCAGCTCTCTTGCACTGGCTAGAGAGGGAAGGTTACGGCCCTTTAGGA
ATGACTGGAATATCCATGGGAGGACACATGGCTTCCTTAGCGGTATCCAACTGGCCTAAGCCCATGCCATTGATTCCATGCCTGTCTTGG
TCCACAGCATCTGGGGTCTTCACTACGACAGATTCTTTCAAAATGGGACAAGAGTTTGTGAAACACTTCACTAGCAGTGCAGACAAGCTA
ACTAACCTTAATCTGGTTTCCAGAACTTTAAATTTAGATATATCAAACCAAGTTGTATCCCAAAAACCTGCTGACTGCCATAATTCTAGC
AAAACATCTGTCAGTGCGACATCAGAAGGACTCTTATTGCAAGATACCTCTAAGATGAAGCGCTTCAATCAAACACTTTCAACCAACAAA
AGTGGTTATACAAGTCGCAACCCTCAGTCATACCACCTACTTAGTAAAGAACAAAGCAGAAACAGTCTTCGGAAAGAGTCTTTAATATTT
ATGAAAGGAGTCATGGATGAATGTACTCATGTAGCAAATTTCTCAGGTAAGACGGCTGGTCTAAACATGTATTCGTTCATTTGTTGTTTG
TTTTCTGGATTTTTTGCTTCAACAAATGTAAAAGATCACATATTTTTATAGTCTGTTTCAATCTTTGAATTCCCTCCTCACCTCCCACAA
ATCTCACAGAGTTACTTTTCCCTCTTTCCTAGAATTTGATCTTCTTATTTTCTTCTAGAGAACTAAGCATGATGCATATTATAGGCATGC
TTTATCGTGTGGCTTTCCCCTCTTCAAATATTAATGGCCAGGTATTTTAGGATGTGAGAAGGAAGATCATGGCTTGTTAAAGTTGCTTTG
GTGCATCAAGAGTTTTTTCACTCTATTCTGATGTTTTTTCAGAATGGCCTGAACATCTGTGGAATAATTTAGCAATGTTTTTCAGTTAGC
AAGTGAATATTGAACCTTAAATAAGAAGTGCTTTTAATGTGAACAACCTTATATGACTCCACTATTTTAGTTAGAACTTATAAAAACTTT
TATGCTGGCTGGGCGCGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGCGGGTGTATCACGAGGTCAGGAGATCAAGGCC
ATCCTGGCTAACACGGTGAAACCCCGTCTCTAGTACAGGGAGATTTGAAAAAGAAGAAAAAGAAAAAGAAGGGAAAATTGCCTAAGAATT
ATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCGGGGAAGAAAGAAGGGTAAAAAGAAGG
ATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAAAACTGTGAGCAGCCCACCCACCTCCC
CAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCAGAAACCTGCAGGGGCTCCAGCAACAA
AAAAGAAACAGCAACAGAAAAAGAAGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTGTTGCAGGCTGTTTTTAAACTAGTGTC
AGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCTCCATATTTTCATAATTTCTTGTGTTT
CAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAGCTTTGTACAGATTATGAGGACTGAAA
ATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATCTTTTTTCAGTTTCACATACCTTATCT
AAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTGTTTCTGTTCAAGTCCCACTTTAAATT
ATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCATGTGATAAAGAGGGACCTTCTTAATAC
ACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAACCATAAATTTTCTGTCATGTGATACT

>11793_11793_4_C4orf29-SRP72_C4orf29_chr4_128951827_ENST00000398965_SRP72_chr4_57361523_ENST00000510663_length(amino acids)=473AA_BP=
MRAQESSGRVQTAAPPCSGFVFLPPFLLPLYLAFRFLERLPELRLGLGPKLSPGKGAWRAAVLGGPASSIAGFHLAANACLLLMGVSKLD
ILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKIEEQSDCKILDGHFVSPMAHYVPDIMPIESVIARFQFI
VPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLER
EGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKP
ADCHNSSKTSVSATSEGLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSGKTAGLNM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C4orf29-SRP72


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C4orf29-SRP72


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C4orf29-SRP72


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource