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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:C5orf42-SEMA5A (FusionGDB2 ID:11860) |
Fusion Gene Summary for C5orf42-SEMA5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C5orf42-SEMA5A | Fusion gene ID: 11860 | Hgene | Tgene | Gene symbol | C5orf42 | SEMA5A | Gene ID | 65250 | 9037 |
| Gene name | ciliogenesis and planar polarity effector 1 | semaphorin 5A | |
| Synonyms | C5orf42|Hug|JBTS17|OFD6 | SEMAF|semF | |
| Cytomap | 5p13.2 | 5p15.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ciliogenesis and planar polarity effector 1protein JBTS17transmembrane protein ENSP00000382582 | semaphorin-5Asema Fsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Asemaphorin F | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000425232, ENST00000274258, ENST00000508244, ENST00000512288, | ENST00000382496, | |
| Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 13 X 13 X 5=845 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/845*10)=-2.59352451422458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C5orf42 [Title/Abstract] AND SEMA5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | C5orf42(37165641)-SEMA5A(9238002), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across C5orf42 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SEMA5A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A1Q3-06A | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - |
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Fusion Gene ORF analysis for C5orf42-SEMA5A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000425232 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - |
| In-frame | ENST00000274258 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - |
| In-frame | ENST00000508244 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - |
| intron-3CDS | ENST00000512288 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000508244 | C5orf42 | chr5 | 37165641 | - | ENST00000382496 | SEMA5A | chr5 | 9238002 | - | 18453 | 7627 | 70 | 10581 | 3503 |
| ENST00000274258 | C5orf42 | chr5 | 37165641 | - | ENST00000382496 | SEMA5A | chr5 | 9238002 | - | 18587 | 7761 | 207 | 10715 | 3502 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000508244 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - | 0.000172708 | 0.9998273 |
| ENST00000274258 | ENST00000382496 | C5orf42 | chr5 | 37165641 | - | SEMA5A | chr5 | 9238002 | - | 0.000210092 | 0.9997899 |
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Fusion Genomic Features for C5orf42-SEMA5A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for C5orf42-SEMA5A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:37165641/chr5:9238002) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000425232 | - | 36 | 52 | 2457_2487 | 2511 | 3198.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000508244 | - | 35 | 51 | 2457_2487 | 2511 | 3198.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000425232 | - | 36 | 52 | 592_612 | 2511 | 3198.0 | Transmembrane | Helical |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000425232 | - | 36 | 52 | 631_651 | 2511 | 3198.0 | Transmembrane | Helical |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000508244 | - | 35 | 51 | 592_612 | 2511 | 3198.0 | Transmembrane | Helical |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000508244 | - | 35 | 51 | 631_651 | 2511 | 3198.0 | Transmembrane | Helical |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 540_593 | 90 | 1075.0 | Domain | TSP type-1 1 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 595_651 | 90 | 1075.0 | Domain | TSP type-1 2 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 653_702 | 90 | 1075.0 | Domain | TSP type-1 3 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 707_765 | 90 | 1075.0 | Domain | TSP type-1 4 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 784_839 | 90 | 1075.0 | Domain | TSP type-1 5 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 841_896 | 90 | 1075.0 | Domain | TSP type-1 6 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 897_944 | 90 | 1075.0 | Domain | TSP type-1 7 | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 990_1074 | 90 | 1075.0 | Topological domain | Cytoplasmic | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 969_989 | 90 | 1075.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000425232 | - | 36 | 52 | 2691_2724 | 2511 | 3198.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | C5orf42 | chr5:37165641 | chr5:9238002 | ENST00000508244 | - | 35 | 51 | 2691_2724 | 2511 | 3198.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 35_484 | 90 | 1075.0 | Domain | Sema | |
| Tgene | SEMA5A | chr5:37165641 | chr5:9238002 | ENST00000382496 | 4 | 23 | 23_968 | 90 | 1075.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for C5orf42-SEMA5A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >11860_11860_1_C5orf42-SEMA5A_C5orf42_chr5_37165641_ENST00000274258_SEMA5A_chr5_9238002_ENST00000382496_length(transcript)=18587nt_BP=7761nt GGTTCTGAGCAGGCGCCGTGGCAGCGCCCGCGCCCCCTGCCCGCCCTCCGCCGTCGCCAGGACGCAGGCTCGCGTCAGGGCTGGCGGTAG GGCCCGCAGCTGTCGGCCTGGCGTCTTCACCCCGCGCAGTCGGCCTCGCCTAGCCTTCTCGCGCCTGACTGGCCGGACCCTGCCCCTGGC GGAGAATCTTGGGACTGTTTTACTTAATTGGTCATTGATAGCTTAACAAACATGGAGATAAGATTAGAAATCTTGACATCAACAGGTATT AAGCAGAAAAAACCATGGCCACGTGTCTCCTGGTTGGGAAAGGAAAAAGAAGCCGTTTTTCTTTTGGATGATAAATTCATAAATGAAATT AATTTGCTATCAGGAAAGATAAAGAAGAAAATTCCTAGTCTGCAGCCTTTCTTGAAGGATGTTATTGTCCTAACAACATCCAGTAATGAT GCCTGGCTGGCTGGGGTACTAACTACAGGAGAGCTTTTCCTTTGGAACAAAGATCAAGATTGTTTGAAAACTATACCAATAACTGAAAAG CCTAAGGAAATGATCAAAGCTACAGTCGCAAGCTCTTTGAGACTGTACTTGTATGTATCTGGAAATGGGAAAAGAATTGTGCTCATAACA CCTTCTGGATGCATATTTCTTTGGGAATATTTGGAATTAAAGAATATCTTATCTTCTAAAAGCCTTTCATTGGCGGGTCGGTGGTCCCAG GTCATACCTGAAGAAGCAGTTCTCTTGCCTTCCACCGAAGATAAAGAAGCTGTAGTGAATGCTGTTTTTATAAAAAATGAGTTATTTGGA GACTGCTGCCTGTGTTCATTTACTTTTTATTCTGGGGAATGCCTGAAGTTAACATTTCTAGCAATTCGGTGGCATGAGAATGTATTTACA TCTGTAAGATCATTGCCATACCATGTTCATTGGGCTCAACAAGACTGTCATCTCTGTAGTTTAATTCCTAAATGTGAATCAGTAAAGTCA AGAGGAGCTCTAATTTCTGCCTTTTCAAGAGATGGCCTTACCCTGGCAGTAACTCTTAATCAGAAAGACCCCAAGGCAACTCAGGTATTA TTTATAAACACACTGAATTTTGTTACTCTCTGTGGTAGCCTTAAAGGATGTAGTAACAAGAGTCCCGTGGTTCCAGCTACACTTATTAGG TCCTACTGGGTAGGTGATATCAGCTGGACGCATGATAGTCTTTTTCTGGCTTGTATGTTAAAACGTGGCTCTCTGGTTTTATTGACCTGC CAAGGTGAATTGCTAACATTAATTACATTTGGTTGCTCTATAGAATTTGGCCCAGCAGAATTTATTCCTCTTCATCCACTAATAACGTAT AGACCACAGCAGTTTACGTTTCAAGATTCAAATAATTCTGTTGATTCATCAGCTTCTGATAGTGACCCTATGAGACAGAGATTTTCTATA AAAGCACACTCACGGTTACCCTACCTCGTTATATCTGATGGATATATGGTCACAACCCTTCGATTTCTTGATAGCCTATCTCCATCAGTA CACATGAGATCACTTCTACTTGATTCAACCCAGAGGCTTGAGAAAATATATCAAAGTGTGATATTGTCTAAGCCAAAAGGCAAAGGACTG AACTTGCGATCACTGAATTCCCTAAGGTCTAGCCTGTTAGAACACCAAGGAAATGAAAGTTCAGCCGATTTCACTGTCCCCAAATTCTTG CAGGCAGAAGAAACAATAAATGAAAATGCAGCAGATTTTCAGGATTTTGAAGCAGAAGAAACTAACGAAGGCAGACACTTTCCAGACAAC TTATGTCCTTTTTGGAACAAAAGAGATGATGTGCTGTGTAGTAGTATGAAGGAAGGAAGATTGGAATTTGCATCTATGTTTGATACGATA CATGCAAAGGATGATAGTGAGGAGACAGATAGAACCATTACAGAACTGCATTCTATCCAGAAAAGTCTACTTGCAGCGTGGACTATAGGA ATTTCAAAAACTGTGACAGAAAAAAATTTAATGTTAAATTACATAGTAGTTTGTATCACTCATTTTTTTTACATTCTTCAATTTATAAAA TGTCCTTTTCCTAAACTTGATCTTGTTTTAAGCAAAAGCTCAAGACATAATGCATGGATACTTTGTATCTTTCAACTTTTTCATCAGTGT TTATCAATCCATTATTGGGATATAAGATACAAACAAGATGTGGGGCATTTGATAAAGCTGACCTCAAATACTGTAAAACTTTTGCTGACT CAGCAACAAAAGGGTCAGTTATTCTCAGAGAAACTTTTAGCTTGTTTTTATTTACTCAAAATGGTAGCTGACAATTTAAATGGTGTATAC ATTCTTCAACCTGAAGTTATTTCAGCATCAGCTGATGGAAGTAAAATAACAGCTCAAGACTCATTGGTGGTACCTATTTTTCAGATGTTT CAAGATAGTGGTTTTCAGAAAAACTGGTCTTGGAACTCATTTTTCAAGATTCATCCTCAAGTAGTAAATCCTGTGCAACAGCCAGGACAC AGATTGCTTATTCTCTGGAGAATACTGTACAAAAAAACTTTATGGTATCAAGCACAATTAAATCGAAGAGTTCCTGAAGCTGATAGTCAG TTAACTGAAAAGATGACACATGAAGCATCTACTGTCAAGTCCCTGTTATGTCATTTGCAGGCTAACCTACAGAGTACTGGAGATTGCTTG AATCAAACCTTAGAACTTAAATCTATCAATGGGGAAGAATGTTTTTTATTAGGATCATATGAAAAGTCTGTTCAGCTGTGGAAAAAAGCT CTACAAGAAATCGAAGAGAAAGGAGGAAGAAGGACGTATTTTCTTCAGATACGCTATTATCTTTCTCTCTTATACTGCCACCTCTATAGC TATAATTTAAATGATGCTCAAGGATTGTGTGATCAGCTAGCAAGAGAAATCCTGAGATGGTCCCAACTACCTGTAAAAGAAAATAAAGAT TTTTCAGGTGCTGCAAAGTCTCATTTTGAGTGTGGAATGGTGGGCGGTGTTCATCCTGAGGCAGCAGTGAGAGTCGTCCAGTCCATGGCT CGTTTCATGGCTGCCTATTTCACCAATCAGCAGCTTTGCATTTTGCCCCCTCATCATGTGAATGTTCTTCCCCCACTTCATATTAAAACA GAGCAGTCCTTTCGACTTATTCCTCTGCAACACTCTAAGGTGGCCAGTGTTGTTAGAGATCAGAATCTCTCTAATGTGTGGACAGTTGAA TATGCACTTGAATTACTATTTATTGGTGGCCTGGTTCCAGAGGCTGTGTGGTTGGCATATAAACTTGGAGACTGGAAGACGTCTGTTTCA ATTGGTGTGGCTTTCCAGCTGTTCTGTAAACGTGATAGCAATTTCATGAGGTCCAAGAAAAAGAGTCTGAATCTACCACTCCGTATGACT CCAGCACAGATTTTTCAGGAAAAACTGCAGTGTGTTTTAGGTCAACCAGCCTCTTTGGAAGCAAAAAATGAAATGGGCTCAAAATATAAA CAGTTTACAGATCCCATTGAAGAGGAAGATGCAAATCTGCTATTTGGTTCAGTACAAGAAGTACTGAAAGCATCAGTTATGGCCGATGCA GATATTCTTTCGGAGACATTTCAACTTCTGATAGACTCTGCCAAGGACTTCAGTAAAAGACTGTGGGGCTTAGTGCCATTCGGCTTGTAT CTTCCAGCTCCTCCATTGTACTGTCCCCAGCCAGCTATTCTTAGTGAAGAAGATGGTGATGATCTTCTTTTAAAAGCTGAAAAAAATAAT CGCCAGAAGGTATCTGGAATCCTTCAGCGTGTTCTCCTGCTTTTCCGGGCGGCTCAGTGTTCTTTTCCTGTAGCACAGTGGTATATATTG CAGTTGAGGTGGGCAAGAAAAGTCATGCAGAAGATTCGAATGAAAGGATCCCTTCCTTCACTGAGTCCTTTTCCTCAGTCATTACTTAAT TACTGTAAAGGAGGTATCGCATTTTTTAGACCTGGAGCAGCTGGAGACCACAAGCTTGATGAAGTTTCCATTAGAGCAATAGGTTGCTTC AGAGAACTTTGTGCTCTGTGTTGGATGCTGCATGTCCGTGATAAGTTATCCTATAGTTGCAGGCAATATCAGAAAGCAAGAGAAAATGTA AAAGGAGAAAAGGACCTTGAAGTGGAGTTTGATTCTTGTATGATTGAGCACTGTCTTAGTGCAGTGGAATGGGCTTATAGAATGCTGCCT TTCTCTCGGTTTTTTAATATGGAAGAACTTATTCAGGATATAATTTTGAGCCTTATTGGAGAACTGCCACCAATCAGAAAGGTAGCAGAA ATTTTCGTGAAAGCATTTCCCTATCCTGAGGACGTGAGGGTTCCTTTAAGAGACAAATATCACTCTCTTCACCAGAGACTCAGACACTGT GTTGTGAAAGGACCCCAGACTGAGGAAATGATGTCTGTTGTCATGCATTCTATCCAGAAAGTGAGGGTGAAAGCTCTAAAACGTGTGCAG AGAAATATAGGCTCTTTTGAAGTGAATATATGGGAACCAATTGAAGAAGAGAAACCAGATGAGGCTCCAGGTGTTGACAGATATTCCCTG GGGACTAGTTTGAGCAGAAGTACACTCACAGAACTAGGAGATTCTGTGGTTCACAGTGATGCAGATACGTTCTCTGAAGCTTTGTCGGTT GAAGAAAAAAGTAGGATAAATATCTATCAAAGAAATGCCCCAAATCACATGGAATTAACATCAATTCATAAGCCAACTGATAAAAGGAAA ATGTGTAATCAGAAAGAAAATCCTACAAAGAAAGAAGATCATGAAAAGTTATCACAAAATACACTTCCTGTAATAGGTGTTTGGGAATTT GAACGTGATGATGATGAATATATTAAATTCCTTGATCTGTTTTTGAGTTACATTCTTGAAAGAGACCTACCTTATTCCAGGGATGCTGAC ATTCCATTTCTAACTAGTTTTTCTGGAAAGCTTAGAGAACATGAACTTAATTCTTTACTTTTTGATGTACATACAACATTAAAACGACAT CAGAGCAAAACTAAAAGCCAGAATGTGTTTAGAGCTGGTTCTTGCTTTGTTGTTGCTCCTGAGTCCTATGAATCAGAAAAATCATCCTCT TTAAATGATGAATATGGCATGCATTTAGAAAACCAGAAACTTTCATCATCAGTACTGGTTAATCAAGGGATCAAACCTTTTTTACAATAT CCTTCGAATGAAGTCAATAAGAATGAAGGAATGAGTGGATTATTTGGTTTAAAACAAAGGTCAATTTACAAAATACAAGATGACACTAGA GAGAAATGTCTAATCCAGAGATCATCAAACCACATTTTTTGGACTCCCAAGTCCATTAAAACTAGAAGATGTATTTTCAAAGCTATTCAG TGCAATGATATTAACCCTCAAGAAGATCTTCCTTTAGCACTAAACACTTTTGGCAGTATAGGAAGACTGCTGGAATGGATGATAAGGTGG TCTAATAGAAGGCTACTCTGTGATTCTGGTATAACTGAGTCATCCTCTGAGTACAGTCCAGTAATTCGTGTAAAGACCTCTACAGCTGCC ATTCTTACATCATTATGGCTTTTGGAACAACCCTATTTTGCTACATATAAGGCAAAAAATGCCATTATTAAGATGGTAGAGAATCGTGAC ACTGGGTGTCAGATTGGACCCAATATTGAGAGGGAGAGCAAATCAGATGCTGGCGGTTCAGTTGCAGTAGCAACTCCAGGTGGAACTGAG GAAAGAAATGGTCAGAATAAATCTTGTCAAAATATCTTGAAAATGCCAACTGAAGCAAAAAATCCTGATATAAAAGAAATCAATGATGAT ATTATTTCCATCACTCATAATACTAAAAAAGAATTTATAGATATTGATGAGAATCTTTTAGAAGTAGAAGCATTTACAGAAGAGGAAATG GATATGCACATATCAGACTATGAAGAAGACATTGAAGAATCTGTTGGAGGTTTCAGAAGTCCCAGTCTTGCCATTTGCATGATGACTTTA CCACAGCAGTTAGAAGAAGAGTTCACAGAAGAGGTTCAGTGTCAAAGGGAAGAACCACTGGAGACAATTATGGAGGAAAAATCGACTGAA CAAAAAGGTATGATCGAAGCCTTTTCACATCCTGGGCATACCACTCCTCAATCAATGCAAGTAGATACGAGTTCAGAAATTTCTAGTGCA CAGATTTCTACATATAAAGAAAAATCTTCCTCAGTTCCACTTCTGATATCAAATGGAGTCAATGTTGCTTCACAACCACCTGCTCCAACA CCTCAGAAGACCCAGAGAAATGAATTCACGGCTCAGTTACCAGATTGTTCGGAGTCCGTTAGGCAGATGCTGCAAGATGAAATGTTTAAA TTAGTTCAGCTGCAACAGATCAACTTCATGAGCCTAATGCAAATAGTAGGATCATCCTTTGCTAATCTCCCAGATACACAACAACTTGTA CAGCAGTCTCAGTCTGTGCATTTAGGGGAAAGCCAAGAATCAAACCTAAGAGGATGTGGTGATGTTGAAGACAGCAACAAAAATCTTAAG GAGAGATTTTTTATTAAACCACAGTCAATGGGAGAGAACGCCAGAGAGCCTCGCAAGAACAGCCCACACTGCCATGAAGGAACTATCCCA TCTGGTCAAAATAGTACTGGAAACGTACAGAATGTTCCACATGGGAGTATTCCTTTATGTCAATTAAATGGCCAGCCCCGGAAAAAAGGA CCAATTCCATCATCTCAAAACTTACCATCCACTTCGTTTTATCCAGCTCCTGCTGGAAATACTCACCTCTACCTTTTGTCCACACCTTCT GTTGTTCAGAAGGCACCTAGACTTATCCCACATGCAAAAACATTTAGTCCTGGTGATGGCTTTCCTTTGCTTCAATTTAAGTCTAAACAA GAATTCCAGCCCCTTTTCTTACATACAGGAAGTATTCCACAAGTTCCCTTCAGGCCTTTGCCACAACCAAGAGAGGCTTGGGGATTATCT GACTCCTTCCAACCTGCTCTGCCACAGAGAGCAGCACAAACTACTCCAGCATCCCATTTGAATGTAAGCCAGTATAACACTGAAGCCAGA AAAAAAGAAGTTGAGCAGAAGACGTGGGCAGAAACTGTAATTACAGAAATTCCTAATCATGTGAACTTGGATCAATATGTTGGACAAGAA AATTTGACACCTCAACAGGACTCTTCAGTGTTTATAAAACCAGAAAAACTATTTGATGTTAAGCCAGGGACCCTTGAGATATCTCCTCAC CATTCCTTTGGACTTCCGTTACTATACCTGCCACTTAAACCTCCTAATATGTTTCCATCAACCTCAAGAGCATCTATTACAGTTCCCTCA ACACCTATCCAACCTATAGCAGAAGAAAGAAAATACCCAAGATTGTCATTACTTCATTCACATTTGTCCCCAGAAAATAGGTGCAAAAAA ACACAACTTATCCCACTTGAAAACCTCATTGCGTTTAAACAAAGCCAACAGAAACTAACACATAATTTATTTGAACAAGGTGATGCTGGA CACCTTCAACTTCTAAAGGTCAAAATAGAACCACCTGAAGTAAGACAAGGAAAGGACAGTAAAAAAAGGCAAAGAAGAAGAGCTGAGAAA GAGCTGCAAGAAAAAAGATGTGAGAAACTGAGGAGAAAACCAAATGTGACTTTTCGACCAGAGAATTCCATAATTAATAATGATGATTCA GAAATCATTAAGAAACCCAAGGCTGTGGAATGGGAGTGTGATGAAGCTACCAAAAAGGCCTGTTACAGCAAAGGCAAATCAAAGGAGGAA TGTCAGAACTACATCCGGGTGCTTCTGGTGGGTGGCGACCGGTTATTCACCTGTGGGACCAATGCATTCACGCCTGTCTGCACCAACCGC TCGTTGAGCAACCTGACTGAGATCCATGATCAGATCAGTGGCATGGCCCGCTGTCCCTACAGTCCCCAGCACAATTCCACAGCGCTCCTC ACAGCTGGTGGGGAGCTCTATGCTGCTACAGCCATGGATTTTCCAGGACGTGATCCTGCCATTTACCGAAGCCTAGGCATTTTACCTCCT CTCCGCACGGCGCAGTACAACTCCAAATGGCTCAATGAGCCAAACTTTGTGTCATCTTATGACATCGGAAATTTTACCTACTTCTTTTTC CGAGAAAATGCAGTAGAGCATGACTGTGGGAAAACAGTGTTCTCCAGAGCTGCCCGGGTGTGCAAGAACGATATTGGTGGGCGCTTCCTG CTGGAAGACACCTGGACCACATTCATGAAGGCTCGCCTGAACTGCTCCCGTCCTGGGGAAGTCCCCTTTTACTACAACGAATTGCAGAGT ACTTTCTTCCTGCCTGAGCTGGATTTGATCTATGGCATCTTTACCACCAATGTGAACAGCATTGCGGCCTCAGCTGTGTGCGTCTTCAAC CTGAGCGCCATCGCGCAGGCCTTCTCTGGGCCCTTCAAGTACCAAGAAAACTCGCGCTCGGCCTGGCTACCGTATCCCAACCCAAACCCC CACTTCCAGTGTGGCACCGTGGACCAGGGCCTGTACGTGAACCTGACCGAGAGAAATCTGCAGGATGCTCAGAAGTTCATTCTGATGCAT GAGGTGGTACAGCCAGTGACCACAGTGCCCTCCTTCATGGAGGACAATAGCCGCTTTTCCCACGTGGCAGTCGACGTGGTGCAGGGCAGA GAAGCGCTCGTCCACATCATCTATTTGGCCACAGATTACGGAACCATTAAGAAAGTGCGGGTACCCCTGAATCAGACCTCAAGCAGCTGT TTGCTGGAAGAGATTGAGCTCTTCCCTGAGAGGCGGAGGGAGCCCATCAGGAGCCTGCAGATCCTGCACAGCCAGAGTGTCCTGTTCGTG GGCCTGCGGGAGCACGTGGTCAAGATCCCCCTGAAGAGGTGCCAGTTCTACCGCACACGCAGCACCTGCATTGGGGCCCAGGACCCTTAC TGTGGCTGGGATGTGGTAATGAAGAAATGCACAAGCCTGGAGGAGAGCCTGAGCATGACGCAGTGGGAACAGAGCATCTCTGCGTGTCCG ACCAGGAATCTCACCGTGGATGGGCACTTTGGTGTGTGGTCTCCGTGGACGCCTTGCACGCACACAGATGGCAGCGCCGTGGGATCCTGC CTCTGTCGAACCCGCTCCTGCGACAGCCCGGCCCCGCAGTGTGGTGGCTGGCAGTGCGAGGGCCCTGGCATGGAGATCGCCAACTGTTCC AGGAACGGAGGCTGGACTCCCTGGACCTCGTGGTCTCCCTGCAGCACTACCTGTGGGATCGGCTTCCAGGTGCGGCAGCGCTCCTGCAGC AACCCCACTCCCAGGCACGGGGGCCGGGTGTGCGTGGGACAGAACCGCGAGGAAAGATACTGCAATGAACATTTGCTATGTCCCCCACAC ATGTTCTGGACAGGCTGGGGTCCTTGGGAACGGTGCACAGCCCAATGCGGGGGTGGCATTCAAGCTCGCCGCAGGATCTGTGAGAATGGG CCTGACTGTGCAGGCTGCAATGTGGAGTACCAGTCTTGCAACACCAACCCGTGTCCTGAGCTGAAGAAGACCACGCCCTGGACACCCTGG ACACCTGTCAACATCTCTGACAACGGCGGCCACTATGAGCAACGATTCCGATACACATGCAAAGCCCGCCTGGCTGATCCGAATTTGCTG GAAGTGGGAAGACAGAGAATCGAAATGCGGTACTGTTCTAGCGACGGCACCAGTGGCTGCTCCACAGATGGGCTTTCTGGGGATTTCCTG CGTGCTGGGAGATACTCTGCCCACACGGTCAACGGGGCTTGGTCAGCCTGGACGTCGTGGTCACAGTGCAGCCGTGACTGCAGCAGGGGC ATTCGGAACCGGAAGCGTGTTTGCAACAACCCCGAACCCAAGTATGGGGGAATGCCTTGCCTTGGCCCATCTCTGGAATACCAGGAATGC AACATTTTGCCCTGCCCAGTGGATGGCGTGTGGTCTTGCTGGTCCCCCTGGACAAAATGTTCAGCAACATGCGGCGGTGGACACTATATG AGGACCCGCTCTTGCTCCAATCCAGCCCCGGCCTATGGAGGGGACATCTGCCTGGGGCTGCACACAGAAGAGGCACTCTGCAACACGCAG CCCTGCCCAGAGAGCTGGTCGGAGTGGTCGGACTGGTCTGAGTGTGAAGCCTCTGGCGTCCAAGTCCGCGCCCGCCAGTGCATCCTCCTG TTCCCCATGGGCAGCCAGTGCTCCGGGAACACCACGGAGAGCCGGCCGTGTGTGTTTGACTCTAATTTCATCCCAGAAGTATCTGTGGCA AGATCCAGTAGCGTAGAAGAGAAAAGGTGTGGAGAGTTCAACATGTTCCACATGATCGCCGTGGGGCTGAGCAGCTCCATCCTCGGCTGC CTCCTCACCCTGCTCGTCTATACTTACTGCCAGCGGTACCAGCAGCAATCCCACGATGCGACTGTCATCCACCCCGTCTCACCTGCCCCC CTTAATACCAGCATAACCAACCACATCAACAAACTGGACAAGTACGACTCGGTGGAGGCCATCAAGGCATTTAACAAAAACAACTTGATC CTAGAGGAAAGAAACAAATACTTCAACCCACATCTCACTGGGAAGACCTATTCTAATGCCTACTTTACAGATCTCAATAATTATGATGAG TACTAACAGCTTTCATGTTTTTGGCTTCTTGTAAATCCCCAGTTCCTCAAGGCCTGTGCCCCATGACTGCCCATGTTTCTGAGGCTTCAG AGTCGAAGTTTGGATACATTTCAAGTGCATTTCAAGCCACCAGAGTGTCCCATTGCTGCCAAAAATACACGTCTTTAAAAGCAACAAAAA TTGAAATAAGACATCGTGAAAATCTTGACCATTGTTGAATGAGCCAGGGTGTGAAGTTTTTAATTGTGTTCATCCTATTTTTCTGACAAG TCCATTGGTTTGTTTTTTGAGCATTATTTTATAAATGTGCCACCCACATTGGAAGGAGTCTTTCTTTAGAACTTTGGAGTGTAAATCTTC ATGATGTTGTAATTCAAGAAAATAGGCACTTTCTCTGAAAGACCTGCTCCTTCCACAAGAAGTGCATAGGTCCATAATATTTCATAAAAT GAAGAAAAAGAATGTGGCCAAACAATTATTCACCATGGATTGCCCAACTTTCCAAATCTGGATAAAGCTGTGGGATTCTTGGAAGCAGCT TGAGTGTTTTCATCTTGCCTGGGAAGCCCAGGAATTCCACCTGGTCCACACCGGCAGAAGTTACAGTAGACTGTGAGGCACCCCACCTTG CTCCTGATGCAGTTTCTGTGCCATTGCTGGTGCTGGTGGAGGCAGCGGAGCAGAGGCTCAGGCACAATGAAGCGTGGATGTGTTCTGCAG GTTGCTGCAAAACTCACCTTATTCTGACTTTTGGATTTCATGGCATTCCAGGAAGCTCCTTGCCATGCTGTTGGCCTGGAAGTCCACCTG TCTGGTCCATAGTGACGTCCTGAAGAGCCAGTCTGTAAAATAACCAACCACTTACTTAGCGTTTGGATAGACTCCATGCCTTCTCTCTCC CTGCAAAGAAAAATCTTGAACATTTATGATGTCAATTAGTGAAAGTATTGAAAATACTAAATTATAACTAAAAGCAACTTTTTATGTTAT TGAAAATATTGAAAGAACTGATATTAATGATAATCATTTTATTTTTCATCTCTCTGATATACCCAATGTGTGGCAATCAGCCCCTACCAC GAGCATTAATACCATGTAAAGCTGGCTTTCTGGAGTCTGCCAGGTCCACACGAAGTGCTACCCCCAGTTTCTGCTGTTACTTGCTGCCTC CAGGCCAGGGGAGCAGGAGATGCTCAGCTCTGGTGCCTTTTCTTTTATTTCAGTGCTGCCTTCCCACCCACCCAGTCCATTCACCCTCAC CTCTCCCTGCATGGAGGCAACAGCATTTCAAGATGTACCTTGGGAAGTCAGGATAGCTGGAAGTAAGGGTTTTTGGGATCCCTGTGGTCT CTTCACTGATCATCGATAAGCATTTAAGAGTGTGCTAACACCATTCACAGAGGTCCCTGGAAAAAAATATATAATTTTCTCACAAACAAC CAATACATAACCTATGGCAGTTGGTTGAATAATTATTGAAAAAAAGAACACGACTGAAAAAGTTCATCTGATGCCTCTGAGCATGTGATA AAGTCCTGGGTAGACACGGAAACGTGTTCTTACAAATGAACCTTCGGATCTATGAAAGAAAATATAGTAGGGGGACTAAGGAACATAGAA TTTTATTAGCATATGTGATTTTACCCTTATCTTTGTTTCTAATTTAAAGAAACAATTTCAGAAAGTGTTAGAAGAATTCTATGTTTAATA ATGAATATTGTTGAGTTCAAAATATTCTCATATACCCAGATTTACAGAGATGACACAGTATTGAAATGGCAGGTGGGCTCTGTAAGTTAT TTTGGATTAATGACATTCAGGGTCTTTGCAGTGGGGACTTCATGTTGCCTCTCACTCATTCCTCATATGTCAGAGTCTTCTGTCTATATG CACATGCTCAAAGTCCATACTCAGTAGGGGAAATCTAGCCGGATGGTTCTCCAATTGTTCCTCGGCTGGATTTTCATCATCAGATATTTC AACTCATCTCATCAGTTTCTTGTAAGAAAAAAACATTTTCACTTTGTAGCACATTTTAGTTATTTTTGAGTCTTCTTCCCTAATAGTTTG TAAGCTTAAAGGGACATTTTATTTTCCCTGGTAAAGAGGATTCTAATATTTCAAGAATGTTTCACTGGAATTGATGGGAAATGGTTTCTA AATGGCATCGAAGCTGGTCTTTAATGAGTCTTTTGCAATGACTTGGGAAAAACACCCTCCCTCACTACAGGATCTTCATGTTGTTAATAA TATAAACAAACCTTTGAAATTAGCATTGCAAAAGAATCCCATTTTTGTTTCGTACCACACTGTTCAAAGGAAAATTGTTTATCTCTCTTC CTTTCTCTCTCTCTCTTATTTGACAGAATAGCAAGTGTTTAGATAATTTCAGATATATTCTAAGTATTTTACCAGCTGTGGAATAAGTTG TGTTTGTCCATCACTGTGTAGCTACCGTTCACATGTTCTGGCTCTGTACTCCACGCTTATCGCGTGAACCCTCACATGTTGGACTTTCAC AGTGTGATCTCTCACCTGTCTTGGAAACTCCTTCATAAAGCCGCTCTTCCTTAGGCCTGGGCTGTTTGGAAGTCCTGGTGAAACTTTGCG GTTCACATTTTAAATTCCTGAATGACCTTTTCATTCTCTCTTTCTTTATCTTTGTTTTTGTCCTTCATTCCCTCCTTTTGTTCTTCCTTC CTGCCTTCTTTTCTTCTTTCCTTTCTTCTTTCTTTAATTCTTCCTTTCTTCCTATTTTCTTGGTACAAGTGGAACAAAAACCAACACATA GTTTTAAGCTACACCTTTCTGCACCTGATGTAAAATGACATTAATCACTATTTAACTTCTAAAATTATTTCTGAATACAGTTGGAGATAG GCTGGTTTTCATGAGGAAGCTGGCTTGGCTTTAGTCTTACATTTAAATTCTTTGAAAGTGGCTCCCAGTGCTATTCAGGGTCCTTTCTTG AGGCCAGACTCATCACCATCTACTATTGATTTTACAGTGCACTGACAGTTTACAGGAAGGAGAAGAACAGAATTTCTGCACACTACACAA CATGTGGGCTTCCTGTAGCTCCAGGGACATGTAGCTTTGGTGAAACTGGGGTTTTGTAACCTCTGAATGATATGGACTTAGTGAATTCTA AGGAACTCAGGGGGCACGTGGTCAGGCTCCACCGCACAGAAGAGCCACAGTCTCCAGACTCATGGCGTTCCCTCCAGAACTCCCCATTCC CCTCTGAGCATATTTCTATGCTGCTGCTTCTTGTGACTTACATGAGGCATCTCAGCTTCTTCATGTTTGTAGGGATGGTTCCCTAAGCCT GTTCAAGTAGGCTCTCACTAGAGTTACCATTCATATTTGAGAAGAAAAGAACATTTAATAAATGTATGTGTGGGGCTGAGGTTCTAAAGG AATTGAAAAGAGACGATAAACATTGAATGAGGGTGAGGGCATCCCTGCTGGGGAGAAACCTCTGTCCCTAGGAAGAGTCCGTTCATGTCA TGTGGTTTGGGATGAACCAGGGGTCTGGCCCCATCGGGTCACAGGTGATGGCAAATAGAAAAGAAGCAAATGGAGGAAATAGTCGGATAA GTAGGTGACGTGAAAGGCAGGACCTGGTCACCCCAGCAAGTGCTATGGACAGTTCCCGGAAACGGTTGCCCACTTCACAGGTCCATGGGT CTGACCCTTGGACTCTGCCAGGATCAACTGCCCAGAGTGCCAGAGTTTTAGCCAAAGGTGTACTTACTTCCTTATTTATCTGCAAAAGGA TGGAAACTGTGGGAGTCAAAGCCTATTTTGCTGAGTGTTCCCACTGGAGTCTCTGGTAGAATTAGCAGGTCATGCTGTCAAAATCATGGA CAAAGGCTGGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACCTGAGCTCAGGAGTTTGAGACC AGCCTGGGCAACATGGGGAAACTCCATCTCTACAAAATATACAAAATATTAGCCAGCCATCGTGGTGCGTGCCTGTGGTCCCAGTTTCTT GGGAGGCTGAGGCGGGAGTATCATTTGAGCCAGGAGGTTGAGGTTGCAGTGAGCTGAGATCACATCACTGCACTCCATCCTGGGTGACAG AGAGAGACCCTGTCTCAAAAAAAAAAAAAAAGAACAAAGTCTTAGCGGGGGGTCTCTATGTCCCCAAGTGGCTCTCTAAGGGGATCCATT AGCGTATAATTGAATATCAAAGGGAATTTTACCTTAAACATATATCAAGTCTATACTCAGCTAATCGTTTTGTCTAAACACAGCCTTGTT AGCATTTGAATTTACAAATATTCATTTGCTTATTTGCAGTGTTCCTTTTGCTTTTAGAATAAATCATAAATATTTCCCCAATACTGTCAA GATACTTCTTCAACTTTGTCCCTGAACCATCAGCTTTCTTTAGGGTCCGGGTATCCTTTACACTTCAATGGGGTTTTCTTGTGTGTGTCA TTGGGGGTAACTCCATTGACCTCAGCATTTCTATCTCAAGAGATGGCTCTGGAACACAGAACCAGAGGCAACAGGTACTAATGGTTGATA AAATTAACAGCGACTGCATAACCATTTTCCACATGGCAGGGCTGTGCTTAAGCCCCACACCTCCAATAATCAATTTCTATGACGGTACTA ATAACCTTAACTATATGCAAATTCTTCACCACTTATGATATGGTACAAACTGGAGTTTACAGATGGCCTTGGCCTTGCCTAGCCCATTTG TTCATCCTAACTTCTTCATCACTTCCTGATGCACTTGGGGAAGCATGTTGACACAACGTTACCAATATTTGATTACCTATGGTTATCTGC AATTACCTACGCTTATCTTATCAGACCCTAGATGCCATTTGAGCCCCTTACTTCTTTGGGCAGTGGGTGAAATGGGAGAACATAGAGAAA TGTTCACTTTGACCTAAGAAACGCATAAAAGGGAATGCCATGCACAATGTAAGATAAAATGTTTGGGGACAGGGGATCATCGTGAAATTT ATTTCTGCTATTCTGCCCTATTGAGGTCATTAATTATAATGGATTTAAAGATTTTTTTTTAAACTCTACAAACACTAAGCCAAGGAATTC AGGTTATCTGCTATGTTAACCTAATAAAGCAAAGGAAAATAAGTTGCTTTAATCCTTGCTTGTTAACCTAATAAAGCAAAGGAAAATATG TTGCTTTAATCCTTGCTTCTTTTCTCTTTTGGTAATAGAAAAGGTAAATAAGATGTAATGTTGAACTGCTGGTGATGATTTCTAAAACGA CTCTTTAAATACTCCTTTCCTATGGACTTATATTAAAGATGCATTGTACACATTGTTTTAGCAGATAGATCAAAGATATACTCAGTGGTC ATCTGTTGCATTATCAGAAATTTGATACATGTTACAGAAGCATGAGGAAGGGAATCCTATCCACTTTTGAAAATAGAGTTCACATTGCAA GCGACATAGGGCATTATCAAAACCAATTCAGAGCCTGGCACAAAATGTATACTTCCTAGTGAAAGCTGTCTCAAAACACAGCCTTTTTGA TGGATCATATTAGCTCATATCTGCCATAGAAAGGCAATCAAGCTTACTCCCTGCAATCGGAGTCAATATCAATTCTTGCTCAAGCAAACA TGTTTTACAGTGTTGGCGCAATGGCAGGAACTAGTCAAGGGCACTTTCAGATCTGGAAAGAGGAAAGAGGAGGTAGAAAATCACTCTTTT GTGTTTCTTAAACTGTCAATCAAGCAAGAAAATTTATTCCACCCCTTCATATTTGCTCTAAAATCTGGGGCCAGTAGTTGAAATGTGATC TTGTTCTTTCTCAGCCTTTTGGCAATTTAATGCCAAATATTCCAAATGTTAGATGAATGGCAGTAATAAAATGATTCAAATGTTTGATAA ATACAAGCTGAGAGCAAAATCTGGACTCTGAAAAATCGGAACTATTTTATCATGTTGCTAAAATGAGAGCATCATTTTCTTCCCTCTCTG TAAGTGCGGTAGTTTAATTTCCTAGAAAAAGTTGCTAGTGCCTTGTTTAAGATGATCATTTATCATTTCATGTGGATATTATTGGTCTAA TTAGAAGGAGAAGATTGATTGGATTTACTTTAAAGAAAATTATTCTCCTATGTCTCTTTGAACTCAGGAATAGAAAATGACCAAGAAGCA CATCATCTTCAGATGTGATTTTTGCCCTCACTGGGGATGTAGAACCAGAATAGGTACAACATATGCTCAGAAGAGAGGTGACTTCAGTAT TAGCCTTCTAGAAACTAACATCACTTTAATTTTTACATGTTCCAAAAAAAATCATAGTGATTGTTCTGTAATAAGAATGTTAACGTGATG CCTATAGAAGTTAGAGGTTTTTGTTTCTGTTTCTCTTCAGGCAAGTCCATAGATAGAGGAAAATCAGACACAGGCTGGTGACAACTGGTA TAGATACAGTGAGCATGGAATGAGAACCACCTACAACATTGCCTGATTATTTTTAAGTTTATATCAAAACTGCTTCACAAGTTCACAAAA GTTGTCACTCTTAATTTGGGTTAAGAAAAGTAATAGTATTATCTCTGCTGAAGTTGATTGTTTTTCTCTTTTACCATGACTGTTGGCCAA AAGCAAGCTGAACCTCTGCACTTTGAAACAAAGCACAGTATGAATCTTTAACCCAAGCACTTAGTTTCACCACTGAGATTCTACATCATC TGCAAGAAAATGCACAAACTTTTGGTCCAATGTTGGATTCTTCAAAAGTGCATAGCAAAACTTTTGTGCTATGCCGCTTGATGTAACTTT TAAAGATGTTATCAAATGTTAAATGCCTCATTCTGCGTTAATTTGCTGTTGGCTGTTTTGTGAACACAAAATAAACTTGAGATTTTTTTT TTTTTTTTTTTTTGTGAAACTCCTCCAAAGCCAATTTCAGCCCTTGGTAAGCTTGCAGACAGTTACTGATCTTAAATTTAATTTTAAAAG ACAATGTATCTTAATTATAATTTAGCTTTTTAAAACAATGAGATAGCTTTACATTTCCCCTTTGTTTGAATGAGAAAATGGATCTTGGGT TGCTATGCTAGAACACTTGTAGATTGCTGGGTCCTTTGTAAGGGGGCCATGGACACACCACACTTTCTTTCAATCCTTACATTTGAAGCA TTGATATTCTTCAAAACCTTCTTGTTACATGTGCGCAATAGAAATTTCTAATGTTCATGACTTTTATCTTTCCTGTCCATCAATTCACTG GTTGTAAATGCTTCCTGAGAGCTGTCTAGGTCTGTATCCCAGATTGTTGCTTAATGACATCTGACAGATGCATTGTTTTCTGAAATCAGC TTAAGACACCAATTGTGGCAACTGGAAACTCATTACCTGCTGCATTGGATCAACTATGGAAGTTGGAGCAGGGGTGGGCGGAGGTCACCT AACCAATCAATGGAAGGCAACTCACACCTGCTCCAAGCCTCAGCTTTGAGAAACAAACACGTTTATAAGAAAAAATATATAGCTATTATT ACAGAAGTGAATATGTTGTGCTCTCTTACTGCTCTTGGTGCATTGACAGTTTCTGTATCTCAACCCTATTCATCTTTATGAAAAAGCATT CTGAAGATCTATCCTCAGCACTGCTGAGTGTGCAGTCACACTTTCCTACCAACCCCCTTCTTACCATCTCTAGCTGCCATTTGTGGGGGG AACAAAACAAGGGAATCCTGATTGTGTACAGTATAAATTGTATTATATTTTTTGTACTTATGTTTTATGTAAATAGTTTGTCTCATTCAA >11860_11860_1_C5orf42-SEMA5A_C5orf42_chr5_37165641_ENST00000274258_SEMA5A_chr5_9238002_ENST00000382496_length(amino acids)=3502AA_BP=2518 MVIDSLTNMEIRLEILTSTGIKQKKPWPRVSWLGKEKEAVFLLDDKFINEINLLSGKIKKKIPSLQPFLKDVIVLTTSSNDAWLAGVLTT GELFLWNKDQDCLKTIPITEKPKEMIKATVASSLRLYLYVSGNGKRIVLITPSGCIFLWEYLELKNILSSKSLSLAGRWSQVIPEEAVLL PSTEDKEAVVNAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTSVRSLPYHVHWAQQDCHLCSLIPKCESVKSRGALISAFS RDGLTLAVTLNQKDPKATQVLFINTLNFVTLCGSLKGCSNKSPVVPATLIRSYWVGDISWTHDSLFLACMLKRGSLVLLTCQGELLTLIT FGCSIEFGPAEFIPLHPLITYRPQQFTFQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLVISDGYMVTTLRFLDSLSPSVHMRSLLLDS TQRLEKIYQSVILSKPKGKGLNLRSLNSLRSSLLEHQGNESSADFTVPKFLQAEETINENAADFQDFEAEETNEGRHFPDNLCPFWNKRD DVLCSSMKEGRLEFASMFDTIHAKDDSEETDRTITELHSIQKSLLAAWTIGISKTVTEKNLMLNYIVVCITHFFYILQFIKCPFPKLDLV LSKSSRHNAWILCIFQLFHQCLSIHYWDIRYKQDVGHLIKLTSNTVKLLLTQQQKGQLFSEKLLACFYLLKMVADNLNGVYILQPEVISA SADGSKITAQDSLVVPIFQMFQDSGFQKNWSWNSFFKIHPQVVNPVQQPGHRLLILWRILYKKTLWYQAQLNRRVPEADSQLTEKMTHEA STVKSLLCHLQANLQSTGDCLNQTLELKSINGEECFLLGSYEKSVQLWKKALQEIEEKGGRRTYFLQIRYYLSLLYCHLYSYNLNDAQGL CDQLAREILRWSQLPVKENKDFSGAAKSHFECGMVGGVHPEAAVRVVQSMARFMAAYFTNQQLCILPPHHVNVLPPLHIKTEQSFRLIPL QHSKVASVVRDQNLSNVWTVEYALELLFIGGLVPEAVWLAYKLGDWKTSVSIGVAFQLFCKRDSNFMRSKKKSLNLPLRMTPAQIFQEKL QCVLGQPASLEAKNEMGSKYKQFTDPIEEEDANLLFGSVQEVLKASVMADADILSETFQLLIDSAKDFSKRLWGLVPFGLYLPAPPLYCP QPAILSEEDGDDLLLKAEKNNRQKVSGILQRVLLLFRAAQCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPQSLLNYCKGGIAFF RPGAAGDHKLDEVSIRAIGCFRELCALCWMLHVRDKLSYSCRQYQKARENVKGEKDLEVEFDSCMIEHCLSAVEWAYRMLPFSRFFNMEE LIQDIILSLIGELPPIRKVAEIFVKAFPYPEDVRVPLRDKYHSLHQRLRHCVVKGPQTEEMMSVVMHSIQKVRVKALKRVQRNIGSFEVN IWEPIEEEKPDEAPGVDRYSLGTSLSRSTLTELGDSVVHSDADTFSEALSVEEKSRINIYQRNAPNHMELTSIHKPTDKRKMCNQKENPT KKEDHEKLSQNTLPVIGVWEFERDDDEYIKFLDLFLSYILERDLPYSRDADIPFLTSFSGKLREHELNSLLFDVHTTLKRHQSKTKSQNV FRAGSCFVVAPESYESEKSSSLNDEYGMHLENQKLSSSVLVNQGIKPFLQYPSNEVNKNEGMSGLFGLKQRSIYKIQDDTREKCLIQRSS NHIFWTPKSIKTRRCIFKAIQCNDINPQEDLPLALNTFGSIGRLLEWMIRWSNRRLLCDSGITESSSEYSPVIRVKTSTAAILTSLWLLE QPYFATYKAKNAIIKMVENRDTGCQIGPNIERESKSDAGGSVAVATPGGTEERNGQNKSCQNILKMPTEAKNPDIKEINDDIISITHNTK KEFIDIDENLLEVEAFTEEEMDMHISDYEEDIEESVGGFRSPSLAICMMTLPQQLEEEFTEEVQCQREEPLETIMEEKSTEQKGMIEAFS HPGHTTPQSMQVDTSSEISSAQISTYKEKSSSVPLLISNGVNVASQPPAPTPQKTQRNEFTAQLPDCSESVRQMLQDEMFKLVQLQQINF MSLMQIVGSSFANLPDTQQLVQQSQSVHLGESQESNLRGCGDVEDSNKNLKERFFIKPQSMGENAREPRKNSPHCHEGTIPSGQNSTGNV QNVPHGSIPLCQLNGQPRKKGPIPSSQNLPSTSFYPAPAGNTHLYLLSTPSVVQKAPRLIPHAKTFSPGDGFPLLQFKSKQEFQPLFLHT GSIPQVPFRPLPQPREAWGLSDSFQPALPQRAAQTTPASHLNVSQYNTEARKKEVEQKTWAETVITEIPNHVNLDQYVGQENLTPQQDSS VFIKPEKLFDVKPGTLEISPHHSFGLPLLYLPLKPPNMFPSTSRASITVPSTPIQPIAEERKYPRLSLLHSHLSPENRCKKTQLIPLENL IAFKQSQQKLTHNLFEQGDAGHLQLLKVKIEPPEVRQGKDSKKRQRRRAEKELQEKRCEKLRRKPNVTFRPENSIINNDDSEIIKKPKAV EWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAA TAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFM KARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQ GLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELFP ERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGH FGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGR VCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNG GHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCN NPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEW SDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTY -------------------------------------------------------------- >11860_11860_2_C5orf42-SEMA5A_C5orf42_chr5_37165641_ENST00000508244_SEMA5A_chr5_9238002_ENST00000382496_length(transcript)=18453nt_BP=7627nt GTGAATATTATGCATCATTTATATTTTATTACTATTATTGTTTACAGAATCTTGGGACTGTTTTACTTAATTGGTCATTGATAGCTTAAC AAACATGGAGATAAGATTAGAAATCTTGACATCAACAGGTATTAAGCAGAAAAAACCATGGCCACGTGTCTCCTGGTTGGGAAAGGAAAA AGAAGCCGTTTTTCTTTTGGATGATAAATTCATAAATGAAATTAATTTGCTATCAGGAAAGATAAAGAAGAAAATTCCTAGTCTGCAGCC TTTCTTGAAGGATGTTATTGTCCTAACAACATCCAGTAATGATGCCTGGCTGGCTGGGGTACTAACTACAGGAGAGCTTTTCCTTTGGAA CAAAGATCAAGATTGTTTGAAAACTATACCAATAACTGAAAAGCCTAAGGAAATGATCAAAGCTACAGTCGCAAGCTCTTTGAGACTGTA CTTGTATGTATCTGGAAATGGGAAAAGAATTGTGCTCATAACACCTTCTGGATGCATATTTCTTTGGGAATATTTGGAATTAAAGAATAT CTTATCTTCTAAAAGCCTTTCATTGGCGGGTCGGTGGTCCCAGGTCATACCTGAAGAAGCAGTTCTCTTGCCTTCCACCGAAGATAAAGA AGCTGTAGTGAATGCTGTTTTTATAAAAAATGAGTTATTTGGAGACTGCTGCCTGTGTTCATTTACTTTTTATTCTGGGGAATGCCTGAA GTTAACATTTCTAGCAATTCGGTGGCATGAGAATGTATTTACATCTGTAAGATCATTGCCATACCATGTTCATTGGGCTCAACAAGACTG TCATCTCTGTAGTTTAATTCCTAAATGTGAATCAGTAAAGTCAAGAGGAGCTCTAATTTCTGCCTTTTCAAGAGATGGCCTTACCCTGGC AGTAACTCTTAATCAGAAAGACCCCAAGGCAACTCAGGTATTATTTATAAACACACTGAATTTTGTTACTCTCTGTGGTAGCCTTAAAGG ATGTAGTAACAAGAGTCCCGTGGTTCCAGCTACACTTATTAGGTCCTACTGGGTAGGTGATATCAGCTGGACGCATGATAGTCTTTTTCT GGCTTGTATGTTAAAACGTGGCTCTCTGGTTTTATTGACCTGCCAAGGTGAATTGCTAACATTAATTACATTTGGTTGCTCTATAGAATT TGGCCCAGCAGAATTTATTCCTCTTCATCCACTAATAACGTATAGACCACAGCAGTTTACGTTTCAAGATTCAAATAATTCTGTTGATTC ATCAGCTTCTGATAGTGACCCTATGAGACAGAGATTTTCTATAAAAGCACACTCACGGTTACCCTACCTCGTTATATCTGATGGATATAT GGTCACAACCCTTCGATTTCTTGATAGCCTATCTCCATCAGTACACATGAGATCACTTCTACTTGATTCAACCCAGAGGCTTGAGAAAAT ATATCAAAGTGTGATATTGTCTAAGCCAAAAGGCAAAGGACTGAACTTGCGATCACTGAATTCCCTAAGGTCTAGCCTGTTAGAACACCA AGGAAATGAAAGTTCAGCCGATTTCACTGTCCCCAAATTCTTGCAGGCAGAAGAAACAATAAATGAAAATGCAGCAGATTTTCAGGATTT TGAAGCAGAAGAAACTAACGAAGGCAGACACTTTCCAGACAACTTATGTCCTTTTTGGAACAAAAGAGATGATGTGCTGTGTAGTAGTAT GAAGGAAGGAAGATTGGAATTTGCATCTATGTTTGATACGATACATGCAAAGGATGATAGTGAGGAGACAGATAGAACCATTACAGAACT GCATTCTATCCAGAAAAGTCTACTTGCAGCGTGGACTATAGGAATTTCAAAAACTGTGACAGAAAAAAATTTAATGTTAAATTACATAGT AGTTTGTATCACTCATTTTTTTTACATTCTTCAATTTATAAAATGTCCTTTTCCTAAACTTGATCTTGTTTTAAGCAAAAGCTCAAGACA TAATGCATGGATACTTTGTATCTTTCAACTTTTTCATCAGTGTTTATCAATCCATTATTGGGATATAAGATACAAACAAGATGTGGGGCA TTTGATAAAGCTGACCTCAAATACTGTAAAACTTTTGCTGACTCAGCAACAAAAGGGTCAGTTATTCTCAGAGAAACTTTTAGCTTGTTT TTATTTACTCAAAATGGTAGCTGACAATTTAAATGGTGTATACATTCTTCAACCTGAAGTTATTTCAGCATCAGCTGATGGAAGTAAAAT AACAGCTCAAGACTCATTGGTGGTACCTATTTTTCAGATGTTTCAAGATAGTGGTTTTCAGAAAAACTGGTCTTGGAACTCATTTTTCAA GATTCATCCTCAAGTAGTAAATCCTGTGCAACAGCCAGGACACAGATTGCTTATTCTCTGGAGAATACTGTACAAAAAAACTTTATGGTA TCAAGCACAATTAAATCGAAGAGTTCCTGAAGCTGATAGTCAGTTAACTGAAAAGATGACACATGAAGCATCTACTGTCAAGTCCCTGTT ATGTCATTTGCAGGCTAACCTACAGAGTACTGGAGATTGCTTGAATCAAACCTTAGAACTTAAATCTATCAATGGGGAAGAATGTTTTTT ATTAGGATCATATGAAAAGTCTGTTCAGCTGTGGAAAAAAGCTCTACAAGAAATCGAAGAGAAAGGAGGAAGAAGGACGTATTTTCTTCA GATACGCTATTATCTTTCTCTCTTATACTGCCACCTCTATAGCTATAATTTAAATGATGCTCAAGGATTGTGTGATCAGCTAGCAAGAGA AATCCTGAGATGGTCCCAACTACCTGTAAAAGAAAATAAAGATTTTTCAGGTGCTGCAAAGTCTCATTTTGAGTGTGGAATGGTGGGCGG TGTTCATCCTGAGGCAGCAGTGAGAGTCGTCCAGTCCATGGCTCGTTTCATGGCTGCCTATTTCACCAATCAGCAGCTTTGCATTTTGCC CCCTCATCATGTGAATGTTCTTCCCCCACTTCATATTAAAACAGAGCAGTCCTTTCGACTTATTCCTCTGCAACACTCTAAGGTGGCCAG TGTTGTTAGAGATCAGAATCTCTCTAATGTGTGGACAGTTGAATATGCACTTGAATTACTATTTATTGGTGGCCTGGTTCCAGAGGCTGT GTGGTTGGCATATAAACTTGGAGACTGGAAGACGTCTGTTTCAATTGGTGTGGCTTTCCAGCTGTTCTGTAAACGTGATAGCAATTTCAT GAGGTCCAAGAAAAAGAGTCTGAATCTACCACTCCGTATGACTCCAGCACAGATTTTTCAGGAAAAACTGCAGTGTGTTTTAGGTCAACC AGCCTCTTTGGAAGCAAAAAATGAAATGGGCTCAAAATATAAACAGTTTACAGATCCCATTGAAGAGGAAGATGCAAATCTGCTATTTGG TTCAGTACAAGAAGTACTGAAAGCATCAGTTATGGCCGATGCAGATATTCTTTCGGAGACATTTCAACTTCTGATAGACTCTGCCAAGGA CTTCAGTAAAAGACTGTGGGGCTTAGTGCCATTCGGCTTGTATCTTCCAGCTCCTCCATTGTACTGTCCCCAGCCAGCTATTCTTAGTGA AGAAGATGGTGATGATCTTCTTTTAAAAGCTGAAAAAAATAATCGCCAGAAGGTATCTGGAATCCTTCAGCGTGTTCTCCTGCTTTTCCG GGCGGCTCAGTGTTCTTTTCCTGTAGCACAGTGGTATATATTGCAGTTGAGGTGGGCAAGAAAAGTCATGCAGAAGATTCGAATGAAAGG ATCCCTTCCTTCACTGAGTCCTTTTCCTCAGTCATTACTTAATTACTGTAAAGGAGGTATCGCATTTTTTAGACCTGGAGCAGCTGGAGA CCACAAGCTTGATGAAGTTTCCATTAGAGCAATAGGTTGCTTCAGAGAACTTTGTGCTCTGTGTTGGATGCTGCATGTCCGTGATAAGTT ATCCTATAGTTGCAGGCAATATCAGAAAGCAAGAGAAAATGTAAAAGGAGAAAAGGACCTTGAAGTGGAGTTTGATTCTTGTATGATTGA GCACTGTCTTAGTGCAGTGGAATGGGCTTATAGAATGCTGCCTTTCTCTCGGTTTTTTAATATGGAAGAACTTATTCAGGATATAATTTT GAGCCTTATTGGAGAACTGCCACCAATCAGAAAGGTAGCAGAAATTTTCGTGAAAGCATTTCCCTATCCTGAGGACGTGAGGGTTCCTTT AAGAGACAAATATCACTCTCTTCACCAGAGACTCAGACACTGTGTTGTGAAAGGACCCCAGACTGAGGAAATGATGTCTGTTGTCATGCA TTCTATCCAGAAAGTGAGGGTGAAAGCTCTAAAACGTGTGCAGAGAAATATAGGCTCTTTTGAAGTGAATATATGGGAACCAATTGAAGA AGAGAAACCAGATGAGGCTCCAGGTGTTGACAGATATTCCCTGGGGACTAGTTTGAGCAGAAGTACACTCACAGAACTAGGAGATTCTGT GGTTCACAGTGATGCAGATACGTTCTCTGAAGCTTTGTCGGTTGAAGAAAAAAGTAGGATAAATATCTATCAAAGAAATGCCCCAAATCA CATGGAATTAACATCAATTCATAAGCCAACTGATAAAAGGAAAATGTGTAATCAGAAAGAAAATCCTACAAAGAAAGAAGATCATGAAAA GTTATCACAAAATACACTTCCTGTAATAGGTGTTTGGGAATTTGAACGTGATGATGATGAATATATTAAATTCCTTGATCTGTTTTTGAG TTACATTCTTGAAAGAGACCTACCTTATTCCAGGGATGCTGACATTCCATTTCTAACTAGTTTTTCTGGAAAGCTTAGAGAACATGAACT TAATTCTTTACTTTTTGATGTACATACAACATTAAAACGACATCAGAGCAAAACTAAAAGCCAGAATGTGTTTAGAGCTGGTTCTTGCTT TGTTGTTGCTCCTGAGTCCTATGAATCAGAAAAATCATCCTCTTTAAATGATGAATATGGCATGCATTTAGAAAACCAGAAACTTTCATC ATCAGTACTGGTTAATCAAGGGATCAAACCTTTTTTACAATATCCTTCGAATGAAGTCAATAAGAATGAAGGAATGAGTGGATTATTTGG TTTAAAACAAAGGTCAATTTACAAAATACAAGATGACACTAGAGAGAAATGTCTAATCCAGAGATCATCAAACCACATTTTTTGGACTCC CAAGTCCATTAAAACTAGAAGATGTATTTTCAAAGCTATTCAGTGCAATGATATTAACCCTCAAGAAGATCTTCCTTTAGCACTAAACAC TTTTGGCAGTATAGGAAGACTGCTGGAATGGATGATAAGGTGGTCTAATAGAAGGCTACTCTGTGATTCTGGTATAACTGAGTCATCCTC TGAGTACAGTCCAGTAATTCGTGTAAAGACCTCTACAGCTGCCATTCTTACATCATTATGGCTTTTGGAACAACCCTATTTTGCTACATA TAAGGCAAAAAATGCCATTATTAAGATGGTAGAGAATCGTGACACTGGGTGTCAGATTGGACCCAATATTGAGAGGGAGAGCAAATCAGA TGCTGGCGGTTCAGTTGCAGTAGCAACTCCAGGTGGAACTGAGGAAAGAAATGGTCAGAATAAATCTTGTCAAAATATCTTGAATAGAAT GCCAACTGAAGCAAAAAATCCTGATATAAAAGAAATCAATGATGATATTATTTCCATCACTCATAATACTAAAAAAGAATTTATAGATAT TGATGAGAATCTTTTAGAAGTAGAAGCATTTACAGAAGAGGAAATGGATATGCACATATCAGACTATGAAGAAGACATTGAAGAATCTGT TGGAGGTTTCAGAAGTCCCAGTCTTGCCATTTGCATGATGACTTTACCACAGCAGTTAGAAGAAGAGTTCACAGAAGAGGTTCAGTGTCA AAGGGAAGAACCACTGGAGACAATTATGGAGGAAAAATCGACTGAACAAAAAGGTATGATCGAAGCCTTTTCACATCCTGGGCATACCAC TCCTCAATCAATGCAAGTAGATACGAGTTCAGAAATTTCTAGTGCACAGATTTCTACATATAAAGAAAAATCTTCCTCAGTTCCACTTCT GATATCAAATGGAGTCAATGTTGCTTCACAACCACCTGCTCCAACACCTCAGAAGACCCAGAGAAATGAATTCACGGCTCAGTTACCAGA TTGTTCGGAGTCCGTTAGGCAGATGCTGCAAGATGAAATGTTTAAATTAGTTCAGCTGCAACAGATCAACTTCATGAGCCTAATGCAAAT AGTAGGATCATCCTTTGCTAATCTCCCAGATACACAACAACTTGTACAGCAGTCTCAGTCTGTGCATTTAGGGGAAAGCCAAGAATCAAA CCTAAGAGGATGTGGTGATGTTGAAGACAGCAACAAAAATCTTAAGGAGAGATTTTTTATTAAACCACAGTCAATGGGAGAGAACGCCAG AGAGCCTCGCAAGAACAGCCCACACTGCCATGAAGGAACTATCCCATCTGGTCAAAATAGTACTGGAAACGTACAGAATGTTCCACATGG GAGTATTCCTTTATGTCAATTAAATGGCCAGCCCCGGAAAAAAGGACCAATTCCATCATCTCAAAACTTACCATCCACTTCGTTTTATCC AGCTCCTGCTGGAAATACTCACCTCTACCTTTTGTCCACACCTTCTGTTGTTCAGAAGGCACCTAGACTTATCCCACATGCAAAAACATT TAGTCCTGGTGATGGCTTTCCTTTGCTTCAATTTAAGTCTAAACAAGAATTCCAGCCCCTTTTCTTACATACAGGAAGTATTCCACAAGT TCCCTTCAGGCCTTTGCCACAACCAAGAGAGGCTTGGGGATTATCTGACTCCTTCCAACCTGCTCTGCCACAGAGAGCAGCACAAACTAC TCCAGCATCCCATTTGAATGTAAGCCAGTATAACACTGAAGCCAGAAAAAAAGAAGTTGAGCAGAAGACGTGGGCAGAAACTGTAATTAC AGAAATTCCTAATCATGTGAACTTGGATCAATATGTTGGACAAGAAAATTTGACACCTCAACAGGACTCTTCAGTGTTTATAAAACCAGA AAAACTATTTGATGTTAAGCCAGGGACCCTTGAGATATCTCCTCACCATTCCTTTGGACTTCCGTTACTATACCTGCCACTTAAACCTCC TAATATGTTTCCATCAACCTCAAGAGCATCTATTACAGTTCCCTCAACACCTATCCAACCTATAGCAGAAGAAAGAAAATACCCAAGATT GTCATTACTTCATTCACATTTGTCCCCAGAAAATAGGTGCAAAAAAACACAACTTATCCCACTTGAAAACCTCATTGCGTTTAAACAAAG CCAACAGAAACTAACACATAATTTATTTGAACAAGGTGATGCTGGACACCTTCAACTTCTAAAGGTCAAAATAGAACCACCTGAAGTAAG ACAAGGAAAGGACAGTAAAAAAAGGCAAAGAAGAAGAGCTGAGAAAGAGCTGCAAGAAAAAAGATGTGAGAAACTGAGGAGAAAACCAAA TGTGACTTTTCGACCAGAGAATTCCATAATTAATAATGATGATTCAGAAATCATTAAGAAACCCAAGGCTGTGGAATGGGAGTGTGATGA AGCTACCAAAAAGGCCTGTTACAGCAAAGGCAAATCAAAGGAGGAATGTCAGAACTACATCCGGGTGCTTCTGGTGGGTGGCGACCGGTT ATTCACCTGTGGGACCAATGCATTCACGCCTGTCTGCACCAACCGCTCGTTGAGCAACCTGACTGAGATCCATGATCAGATCAGTGGCAT GGCCCGCTGTCCCTACAGTCCCCAGCACAATTCCACAGCGCTCCTCACAGCTGGTGGGGAGCTCTATGCTGCTACAGCCATGGATTTTCC AGGACGTGATCCTGCCATTTACCGAAGCCTAGGCATTTTACCTCCTCTCCGCACGGCGCAGTACAACTCCAAATGGCTCAATGAGCCAAA CTTTGTGTCATCTTATGACATCGGAAATTTTACCTACTTCTTTTTCCGAGAAAATGCAGTAGAGCATGACTGTGGGAAAACAGTGTTCTC CAGAGCTGCCCGGGTGTGCAAGAACGATATTGGTGGGCGCTTCCTGCTGGAAGACACCTGGACCACATTCATGAAGGCTCGCCTGAACTG CTCCCGTCCTGGGGAAGTCCCCTTTTACTACAACGAATTGCAGAGTACTTTCTTCCTGCCTGAGCTGGATTTGATCTATGGCATCTTTAC CACCAATGTGAACAGCATTGCGGCCTCAGCTGTGTGCGTCTTCAACCTGAGCGCCATCGCGCAGGCCTTCTCTGGGCCCTTCAAGTACCA AGAAAACTCGCGCTCGGCCTGGCTACCGTATCCCAACCCAAACCCCCACTTCCAGTGTGGCACCGTGGACCAGGGCCTGTACGTGAACCT GACCGAGAGAAATCTGCAGGATGCTCAGAAGTTCATTCTGATGCATGAGGTGGTACAGCCAGTGACCACAGTGCCCTCCTTCATGGAGGA CAATAGCCGCTTTTCCCACGTGGCAGTCGACGTGGTGCAGGGCAGAGAAGCGCTCGTCCACATCATCTATTTGGCCACAGATTACGGAAC CATTAAGAAAGTGCGGGTACCCCTGAATCAGACCTCAAGCAGCTGTTTGCTGGAAGAGATTGAGCTCTTCCCTGAGAGGCGGAGGGAGCC CATCAGGAGCCTGCAGATCCTGCACAGCCAGAGTGTCCTGTTCGTGGGCCTGCGGGAGCACGTGGTCAAGATCCCCCTGAAGAGGTGCCA GTTCTACCGCACACGCAGCACCTGCATTGGGGCCCAGGACCCTTACTGTGGCTGGGATGTGGTAATGAAGAAATGCACAAGCCTGGAGGA GAGCCTGAGCATGACGCAGTGGGAACAGAGCATCTCTGCGTGTCCGACCAGGAATCTCACCGTGGATGGGCACTTTGGTGTGTGGTCTCC GTGGACGCCTTGCACGCACACAGATGGCAGCGCCGTGGGATCCTGCCTCTGTCGAACCCGCTCCTGCGACAGCCCGGCCCCGCAGTGTGG TGGCTGGCAGTGCGAGGGCCCTGGCATGGAGATCGCCAACTGTTCCAGGAACGGAGGCTGGACTCCCTGGACCTCGTGGTCTCCCTGCAG CACTACCTGTGGGATCGGCTTCCAGGTGCGGCAGCGCTCCTGCAGCAACCCCACTCCCAGGCACGGGGGCCGGGTGTGCGTGGGACAGAA CCGCGAGGAAAGATACTGCAATGAACATTTGCTATGTCCCCCACACATGTTCTGGACAGGCTGGGGTCCTTGGGAACGGTGCACAGCCCA ATGCGGGGGTGGCATTCAAGCTCGCCGCAGGATCTGTGAGAATGGGCCTGACTGTGCAGGCTGCAATGTGGAGTACCAGTCTTGCAACAC CAACCCGTGTCCTGAGCTGAAGAAGACCACGCCCTGGACACCCTGGACACCTGTCAACATCTCTGACAACGGCGGCCACTATGAGCAACG ATTCCGATACACATGCAAAGCCCGCCTGGCTGATCCGAATTTGCTGGAAGTGGGAAGACAGAGAATCGAAATGCGGTACTGTTCTAGCGA CGGCACCAGTGGCTGCTCCACAGATGGGCTTTCTGGGGATTTCCTGCGTGCTGGGAGATACTCTGCCCACACGGTCAACGGGGCTTGGTC AGCCTGGACGTCGTGGTCACAGTGCAGCCGTGACTGCAGCAGGGGCATTCGGAACCGGAAGCGTGTTTGCAACAACCCCGAACCCAAGTA TGGGGGAATGCCTTGCCTTGGCCCATCTCTGGAATACCAGGAATGCAACATTTTGCCCTGCCCAGTGGATGGCGTGTGGTCTTGCTGGTC CCCCTGGACAAAATGTTCAGCAACATGCGGCGGTGGACACTATATGAGGACCCGCTCTTGCTCCAATCCAGCCCCGGCCTATGGAGGGGA CATCTGCCTGGGGCTGCACACAGAAGAGGCACTCTGCAACACGCAGCCCTGCCCAGAGAGCTGGTCGGAGTGGTCGGACTGGTCTGAGTG TGAAGCCTCTGGCGTCCAAGTCCGCGCCCGCCAGTGCATCCTCCTGTTCCCCATGGGCAGCCAGTGCTCCGGGAACACCACGGAGAGCCG GCCGTGTGTGTTTGACTCTAATTTCATCCCAGAAGTATCTGTGGCAAGATCCAGTAGCGTAGAAGAGAAAAGGTGTGGAGAGTTCAACAT GTTCCACATGATCGCCGTGGGGCTGAGCAGCTCCATCCTCGGCTGCCTCCTCACCCTGCTCGTCTATACTTACTGCCAGCGGTACCAGCA GCAATCCCACGATGCGACTGTCATCCACCCCGTCTCACCTGCCCCCCTTAATACCAGCATAACCAACCACATCAACAAACTGGACAAGTA CGACTCGGTGGAGGCCATCAAGGCATTTAACAAAAACAACTTGATCCTAGAGGAAAGAAACAAATACTTCAACCCACATCTCACTGGGAA GACCTATTCTAATGCCTACTTTACAGATCTCAATAATTATGATGAGTACTAACAGCTTTCATGTTTTTGGCTTCTTGTAAATCCCCAGTT CCTCAAGGCCTGTGCCCCATGACTGCCCATGTTTCTGAGGCTTCAGAGTCGAAGTTTGGATACATTTCAAGTGCATTTCAAGCCACCAGA GTGTCCCATTGCTGCCAAAAATACACGTCTTTAAAAGCAACAAAAATTGAAATAAGACATCGTGAAAATCTTGACCATTGTTGAATGAGC CAGGGTGTGAAGTTTTTAATTGTGTTCATCCTATTTTTCTGACAAGTCCATTGGTTTGTTTTTTGAGCATTATTTTATAAATGTGCCACC CACATTGGAAGGAGTCTTTCTTTAGAACTTTGGAGTGTAAATCTTCATGATGTTGTAATTCAAGAAAATAGGCACTTTCTCTGAAAGACC TGCTCCTTCCACAAGAAGTGCATAGGTCCATAATATTTCATAAAATGAAGAAAAAGAATGTGGCCAAACAATTATTCACCATGGATTGCC CAACTTTCCAAATCTGGATAAAGCTGTGGGATTCTTGGAAGCAGCTTGAGTGTTTTCATCTTGCCTGGGAAGCCCAGGAATTCCACCTGG TCCACACCGGCAGAAGTTACAGTAGACTGTGAGGCACCCCACCTTGCTCCTGATGCAGTTTCTGTGCCATTGCTGGTGCTGGTGGAGGCA GCGGAGCAGAGGCTCAGGCACAATGAAGCGTGGATGTGTTCTGCAGGTTGCTGCAAAACTCACCTTATTCTGACTTTTGGATTTCATGGC ATTCCAGGAAGCTCCTTGCCATGCTGTTGGCCTGGAAGTCCACCTGTCTGGTCCATAGTGACGTCCTGAAGAGCCAGTCTGTAAAATAAC CAACCACTTACTTAGCGTTTGGATAGACTCCATGCCTTCTCTCTCCCTGCAAAGAAAAATCTTGAACATTTATGATGTCAATTAGTGAAA GTATTGAAAATACTAAATTATAACTAAAAGCAACTTTTTATGTTATTGAAAATATTGAAAGAACTGATATTAATGATAATCATTTTATTT TTCATCTCTCTGATATACCCAATGTGTGGCAATCAGCCCCTACCACGAGCATTAATACCATGTAAAGCTGGCTTTCTGGAGTCTGCCAGG TCCACACGAAGTGCTACCCCCAGTTTCTGCTGTTACTTGCTGCCTCCAGGCCAGGGGAGCAGGAGATGCTCAGCTCTGGTGCCTTTTCTT TTATTTCAGTGCTGCCTTCCCACCCACCCAGTCCATTCACCCTCACCTCTCCCTGCATGGAGGCAACAGCATTTCAAGATGTACCTTGGG AAGTCAGGATAGCTGGAAGTAAGGGTTTTTGGGATCCCTGTGGTCTCTTCACTGATCATCGATAAGCATTTAAGAGTGTGCTAACACCAT TCACAGAGGTCCCTGGAAAAAAATATATAATTTTCTCACAAACAACCAATACATAACCTATGGCAGTTGGTTGAATAATTATTGAAAAAA AGAACACGACTGAAAAAGTTCATCTGATGCCTCTGAGCATGTGATAAAGTCCTGGGTAGACACGGAAACGTGTTCTTACAAATGAACCTT CGGATCTATGAAAGAAAATATAGTAGGGGGACTAAGGAACATAGAATTTTATTAGCATATGTGATTTTACCCTTATCTTTGTTTCTAATT TAAAGAAACAATTTCAGAAAGTGTTAGAAGAATTCTATGTTTAATAATGAATATTGTTGAGTTCAAAATATTCTCATATACCCAGATTTA CAGAGATGACACAGTATTGAAATGGCAGGTGGGCTCTGTAAGTTATTTTGGATTAATGACATTCAGGGTCTTTGCAGTGGGGACTTCATG TTGCCTCTCACTCATTCCTCATATGTCAGAGTCTTCTGTCTATATGCACATGCTCAAAGTCCATACTCAGTAGGGGAAATCTAGCCGGAT GGTTCTCCAATTGTTCCTCGGCTGGATTTTCATCATCAGATATTTCAACTCATCTCATCAGTTTCTTGTAAGAAAAAAACATTTTCACTT TGTAGCACATTTTAGTTATTTTTGAGTCTTCTTCCCTAATAGTTTGTAAGCTTAAAGGGACATTTTATTTTCCCTGGTAAAGAGGATTCT AATATTTCAAGAATGTTTCACTGGAATTGATGGGAAATGGTTTCTAAATGGCATCGAAGCTGGTCTTTAATGAGTCTTTTGCAATGACTT GGGAAAAACACCCTCCCTCACTACAGGATCTTCATGTTGTTAATAATATAAACAAACCTTTGAAATTAGCATTGCAAAAGAATCCCATTT TTGTTTCGTACCACACTGTTCAAAGGAAAATTGTTTATCTCTCTTCCTTTCTCTCTCTCTCTTATTTGACAGAATAGCAAGTGTTTAGAT AATTTCAGATATATTCTAAGTATTTTACCAGCTGTGGAATAAGTTGTGTTTGTCCATCACTGTGTAGCTACCGTTCACATGTTCTGGCTC TGTACTCCACGCTTATCGCGTGAACCCTCACATGTTGGACTTTCACAGTGTGATCTCTCACCTGTCTTGGAAACTCCTTCATAAAGCCGC TCTTCCTTAGGCCTGGGCTGTTTGGAAGTCCTGGTGAAACTTTGCGGTTCACATTTTAAATTCCTGAATGACCTTTTCATTCTCTCTTTC TTTATCTTTGTTTTTGTCCTTCATTCCCTCCTTTTGTTCTTCCTTCCTGCCTTCTTTTCTTCTTTCCTTTCTTCTTTCTTTAATTCTTCC TTTCTTCCTATTTTCTTGGTACAAGTGGAACAAAAACCAACACATAGTTTTAAGCTACACCTTTCTGCACCTGATGTAAAATGACATTAA TCACTATTTAACTTCTAAAATTATTTCTGAATACAGTTGGAGATAGGCTGGTTTTCATGAGGAAGCTGGCTTGGCTTTAGTCTTACATTT AAATTCTTTGAAAGTGGCTCCCAGTGCTATTCAGGGTCCTTTCTTGAGGCCAGACTCATCACCATCTACTATTGATTTTACAGTGCACTG ACAGTTTACAGGAAGGAGAAGAACAGAATTTCTGCACACTACACAACATGTGGGCTTCCTGTAGCTCCAGGGACATGTAGCTTTGGTGAA ACTGGGGTTTTGTAACCTCTGAATGATATGGACTTAGTGAATTCTAAGGAACTCAGGGGGCACGTGGTCAGGCTCCACCGCACAGAAGAG CCACAGTCTCCAGACTCATGGCGTTCCCTCCAGAACTCCCCATTCCCCTCTGAGCATATTTCTATGCTGCTGCTTCTTGTGACTTACATG AGGCATCTCAGCTTCTTCATGTTTGTAGGGATGGTTCCCTAAGCCTGTTCAAGTAGGCTCTCACTAGAGTTACCATTCATATTTGAGAAG AAAAGAACATTTAATAAATGTATGTGTGGGGCTGAGGTTCTAAAGGAATTGAAAAGAGACGATAAACATTGAATGAGGGTGAGGGCATCC CTGCTGGGGAGAAACCTCTGTCCCTAGGAAGAGTCCGTTCATGTCATGTGGTTTGGGATGAACCAGGGGTCTGGCCCCATCGGGTCACAG GTGATGGCAAATAGAAAAGAAGCAAATGGAGGAAATAGTCGGATAAGTAGGTGACGTGAAAGGCAGGACCTGGTCACCCCAGCAAGTGCT ATGGACAGTTCCCGGAAACGGTTGCCCACTTCACAGGTCCATGGGTCTGACCCTTGGACTCTGCCAGGATCAACTGCCCAGAGTGCCAGA GTTTTAGCCAAAGGTGTACTTACTTCCTTATTTATCTGCAAAAGGATGGAAACTGTGGGAGTCAAAGCCTATTTTGCTGAGTGTTCCCAC TGGAGTCTCTGGTAGAATTAGCAGGTCATGCTGTCAAAATCATGGACAAAGGCTGGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTT GGGAGGCCAAGGTGGGCGGATCACCTGAGCTCAGGAGTTTGAGACCAGCCTGGGCAACATGGGGAAACTCCATCTCTACAAAATATACAA AATATTAGCCAGCCATCGTGGTGCGTGCCTGTGGTCCCAGTTTCTTGGGAGGCTGAGGCGGGAGTATCATTTGAGCCAGGAGGTTGAGGT TGCAGTGAGCTGAGATCACATCACTGCACTCCATCCTGGGTGACAGAGAGAGACCCTGTCTCAAAAAAAAAAAAAAAGAACAAAGTCTTA GCGGGGGGTCTCTATGTCCCCAAGTGGCTCTCTAAGGGGATCCATTAGCGTATAATTGAATATCAAAGGGAATTTTACCTTAAACATATA TCAAGTCTATACTCAGCTAATCGTTTTGTCTAAACACAGCCTTGTTAGCATTTGAATTTACAAATATTCATTTGCTTATTTGCAGTGTTC CTTTTGCTTTTAGAATAAATCATAAATATTTCCCCAATACTGTCAAGATACTTCTTCAACTTTGTCCCTGAACCATCAGCTTTCTTTAGG GTCCGGGTATCCTTTACACTTCAATGGGGTTTTCTTGTGTGTGTCATTGGGGGTAACTCCATTGACCTCAGCATTTCTATCTCAAGAGAT GGCTCTGGAACACAGAACCAGAGGCAACAGGTACTAATGGTTGATAAAATTAACAGCGACTGCATAACCATTTTCCACATGGCAGGGCTG TGCTTAAGCCCCACACCTCCAATAATCAATTTCTATGACGGTACTAATAACCTTAACTATATGCAAATTCTTCACCACTTATGATATGGT ACAAACTGGAGTTTACAGATGGCCTTGGCCTTGCCTAGCCCATTTGTTCATCCTAACTTCTTCATCACTTCCTGATGCACTTGGGGAAGC ATGTTGACACAACGTTACCAATATTTGATTACCTATGGTTATCTGCAATTACCTACGCTTATCTTATCAGACCCTAGATGCCATTTGAGC CCCTTACTTCTTTGGGCAGTGGGTGAAATGGGAGAACATAGAGAAATGTTCACTTTGACCTAAGAAACGCATAAAAGGGAATGCCATGCA CAATGTAAGATAAAATGTTTGGGGACAGGGGATCATCGTGAAATTTATTTCTGCTATTCTGCCCTATTGAGGTCATTAATTATAATGGAT TTAAAGATTTTTTTTTAAACTCTACAAACACTAAGCCAAGGAATTCAGGTTATCTGCTATGTTAACCTAATAAAGCAAAGGAAAATAAGT TGCTTTAATCCTTGCTTGTTAACCTAATAAAGCAAAGGAAAATATGTTGCTTTAATCCTTGCTTCTTTTCTCTTTTGGTAATAGAAAAGG TAAATAAGATGTAATGTTGAACTGCTGGTGATGATTTCTAAAACGACTCTTTAAATACTCCTTTCCTATGGACTTATATTAAAGATGCAT TGTACACATTGTTTTAGCAGATAGATCAAAGATATACTCAGTGGTCATCTGTTGCATTATCAGAAATTTGATACATGTTACAGAAGCATG AGGAAGGGAATCCTATCCACTTTTGAAAATAGAGTTCACATTGCAAGCGACATAGGGCATTATCAAAACCAATTCAGAGCCTGGCACAAA ATGTATACTTCCTAGTGAAAGCTGTCTCAAAACACAGCCTTTTTGATGGATCATATTAGCTCATATCTGCCATAGAAAGGCAATCAAGCT TACTCCCTGCAATCGGAGTCAATATCAATTCTTGCTCAAGCAAACATGTTTTACAGTGTTGGCGCAATGGCAGGAACTAGTCAAGGGCAC TTTCAGATCTGGAAAGAGGAAAGAGGAGGTAGAAAATCACTCTTTTGTGTTTCTTAAACTGTCAATCAAGCAAGAAAATTTATTCCACCC CTTCATATTTGCTCTAAAATCTGGGGCCAGTAGTTGAAATGTGATCTTGTTCTTTCTCAGCCTTTTGGCAATTTAATGCCAAATATTCCA AATGTTAGATGAATGGCAGTAATAAAATGATTCAAATGTTTGATAAATACAAGCTGAGAGCAAAATCTGGACTCTGAAAAATCGGAACTA TTTTATCATGTTGCTAAAATGAGAGCATCATTTTCTTCCCTCTCTGTAAGTGCGGTAGTTTAATTTCCTAGAAAAAGTTGCTAGTGCCTT GTTTAAGATGATCATTTATCATTTCATGTGGATATTATTGGTCTAATTAGAAGGAGAAGATTGATTGGATTTACTTTAAAGAAAATTATT CTCCTATGTCTCTTTGAACTCAGGAATAGAAAATGACCAAGAAGCACATCATCTTCAGATGTGATTTTTGCCCTCACTGGGGATGTAGAA CCAGAATAGGTACAACATATGCTCAGAAGAGAGGTGACTTCAGTATTAGCCTTCTAGAAACTAACATCACTTTAATTTTTACATGTTCCA AAAAAAATCATAGTGATTGTTCTGTAATAAGAATGTTAACGTGATGCCTATAGAAGTTAGAGGTTTTTGTTTCTGTTTCTCTTCAGGCAA GTCCATAGATAGAGGAAAATCAGACACAGGCTGGTGACAACTGGTATAGATACAGTGAGCATGGAATGAGAACCACCTACAACATTGCCT GATTATTTTTAAGTTTATATCAAAACTGCTTCACAAGTTCACAAAAGTTGTCACTCTTAATTTGGGTTAAGAAAAGTAATAGTATTATCT CTGCTGAAGTTGATTGTTTTTCTCTTTTACCATGACTGTTGGCCAAAAGCAAGCTGAACCTCTGCACTTTGAAACAAAGCACAGTATGAA TCTTTAACCCAAGCACTTAGTTTCACCACTGAGATTCTACATCATCTGCAAGAAAATGCACAAACTTTTGGTCCAATGTTGGATTCTTCA AAAGTGCATAGCAAAACTTTTGTGCTATGCCGCTTGATGTAACTTTTAAAGATGTTATCAAATGTTAAATGCCTCATTCTGCGTTAATTT GCTGTTGGCTGTTTTGTGAACACAAAATAAACTTGAGATTTTTTTTTTTTTTTTTTTTTGTGAAACTCCTCCAAAGCCAATTTCAGCCCT TGGTAAGCTTGCAGACAGTTACTGATCTTAAATTTAATTTTAAAAGACAATGTATCTTAATTATAATTTAGCTTTTTAAAACAATGAGAT AGCTTTACATTTCCCCTTTGTTTGAATGAGAAAATGGATCTTGGGTTGCTATGCTAGAACACTTGTAGATTGCTGGGTCCTTTGTAAGGG GGCCATGGACACACCACACTTTCTTTCAATCCTTACATTTGAAGCATTGATATTCTTCAAAACCTTCTTGTTACATGTGCGCAATAGAAA TTTCTAATGTTCATGACTTTTATCTTTCCTGTCCATCAATTCACTGGTTGTAAATGCTTCCTGAGAGCTGTCTAGGTCTGTATCCCAGAT TGTTGCTTAATGACATCTGACAGATGCATTGTTTTCTGAAATCAGCTTAAGACACCAATTGTGGCAACTGGAAACTCATTACCTGCTGCA TTGGATCAACTATGGAAGTTGGAGCAGGGGTGGGCGGAGGTCACCTAACCAATCAATGGAAGGCAACTCACACCTGCTCCAAGCCTCAGC TTTGAGAAACAAACACGTTTATAAGAAAAAATATATAGCTATTATTACAGAAGTGAATATGTTGTGCTCTCTTACTGCTCTTGGTGCATT GACAGTTTCTGTATCTCAACCCTATTCATCTTTATGAAAAAGCATTCTGAAGATCTATCCTCAGCACTGCTGAGTGTGCAGTCACACTTT CCTACCAACCCCCTTCTTACCATCTCTAGCTGCCATTTGTGGGGGGAACAAAACAAGGGAATCCTGATTGTGTACAGTATAAATTGTATT ATATTTTTTGTACTTATGTTTTATGTAAATAGTTTGTCTCATTCAATTGTATGTGAGCATTGAAATAAATCCTACCATTTAGGGGACAAT >11860_11860_2_C5orf42-SEMA5A_C5orf42_chr5_37165641_ENST00000508244_SEMA5A_chr5_9238002_ENST00000382496_length(amino acids)=3503AA_BP=2519 MVIDSLTNMEIRLEILTSTGIKQKKPWPRVSWLGKEKEAVFLLDDKFINEINLLSGKIKKKIPSLQPFLKDVIVLTTSSNDAWLAGVLTT GELFLWNKDQDCLKTIPITEKPKEMIKATVASSLRLYLYVSGNGKRIVLITPSGCIFLWEYLELKNILSSKSLSLAGRWSQVIPEEAVLL PSTEDKEAVVNAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTSVRSLPYHVHWAQQDCHLCSLIPKCESVKSRGALISAFS RDGLTLAVTLNQKDPKATQVLFINTLNFVTLCGSLKGCSNKSPVVPATLIRSYWVGDISWTHDSLFLACMLKRGSLVLLTCQGELLTLIT FGCSIEFGPAEFIPLHPLITYRPQQFTFQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLVISDGYMVTTLRFLDSLSPSVHMRSLLLDS TQRLEKIYQSVILSKPKGKGLNLRSLNSLRSSLLEHQGNESSADFTVPKFLQAEETINENAADFQDFEAEETNEGRHFPDNLCPFWNKRD DVLCSSMKEGRLEFASMFDTIHAKDDSEETDRTITELHSIQKSLLAAWTIGISKTVTEKNLMLNYIVVCITHFFYILQFIKCPFPKLDLV LSKSSRHNAWILCIFQLFHQCLSIHYWDIRYKQDVGHLIKLTSNTVKLLLTQQQKGQLFSEKLLACFYLLKMVADNLNGVYILQPEVISA SADGSKITAQDSLVVPIFQMFQDSGFQKNWSWNSFFKIHPQVVNPVQQPGHRLLILWRILYKKTLWYQAQLNRRVPEADSQLTEKMTHEA STVKSLLCHLQANLQSTGDCLNQTLELKSINGEECFLLGSYEKSVQLWKKALQEIEEKGGRRTYFLQIRYYLSLLYCHLYSYNLNDAQGL CDQLAREILRWSQLPVKENKDFSGAAKSHFECGMVGGVHPEAAVRVVQSMARFMAAYFTNQQLCILPPHHVNVLPPLHIKTEQSFRLIPL QHSKVASVVRDQNLSNVWTVEYALELLFIGGLVPEAVWLAYKLGDWKTSVSIGVAFQLFCKRDSNFMRSKKKSLNLPLRMTPAQIFQEKL QCVLGQPASLEAKNEMGSKYKQFTDPIEEEDANLLFGSVQEVLKASVMADADILSETFQLLIDSAKDFSKRLWGLVPFGLYLPAPPLYCP QPAILSEEDGDDLLLKAEKNNRQKVSGILQRVLLLFRAAQCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPQSLLNYCKGGIAFF RPGAAGDHKLDEVSIRAIGCFRELCALCWMLHVRDKLSYSCRQYQKARENVKGEKDLEVEFDSCMIEHCLSAVEWAYRMLPFSRFFNMEE LIQDIILSLIGELPPIRKVAEIFVKAFPYPEDVRVPLRDKYHSLHQRLRHCVVKGPQTEEMMSVVMHSIQKVRVKALKRVQRNIGSFEVN IWEPIEEEKPDEAPGVDRYSLGTSLSRSTLTELGDSVVHSDADTFSEALSVEEKSRINIYQRNAPNHMELTSIHKPTDKRKMCNQKENPT KKEDHEKLSQNTLPVIGVWEFERDDDEYIKFLDLFLSYILERDLPYSRDADIPFLTSFSGKLREHELNSLLFDVHTTLKRHQSKTKSQNV FRAGSCFVVAPESYESEKSSSLNDEYGMHLENQKLSSSVLVNQGIKPFLQYPSNEVNKNEGMSGLFGLKQRSIYKIQDDTREKCLIQRSS NHIFWTPKSIKTRRCIFKAIQCNDINPQEDLPLALNTFGSIGRLLEWMIRWSNRRLLCDSGITESSSEYSPVIRVKTSTAAILTSLWLLE QPYFATYKAKNAIIKMVENRDTGCQIGPNIERESKSDAGGSVAVATPGGTEERNGQNKSCQNILNRMPTEAKNPDIKEINDDIISITHNT KKEFIDIDENLLEVEAFTEEEMDMHISDYEEDIEESVGGFRSPSLAICMMTLPQQLEEEFTEEVQCQREEPLETIMEEKSTEQKGMIEAF SHPGHTTPQSMQVDTSSEISSAQISTYKEKSSSVPLLISNGVNVASQPPAPTPQKTQRNEFTAQLPDCSESVRQMLQDEMFKLVQLQQIN FMSLMQIVGSSFANLPDTQQLVQQSQSVHLGESQESNLRGCGDVEDSNKNLKERFFIKPQSMGENAREPRKNSPHCHEGTIPSGQNSTGN VQNVPHGSIPLCQLNGQPRKKGPIPSSQNLPSTSFYPAPAGNTHLYLLSTPSVVQKAPRLIPHAKTFSPGDGFPLLQFKSKQEFQPLFLH TGSIPQVPFRPLPQPREAWGLSDSFQPALPQRAAQTTPASHLNVSQYNTEARKKEVEQKTWAETVITEIPNHVNLDQYVGQENLTPQQDS SVFIKPEKLFDVKPGTLEISPHHSFGLPLLYLPLKPPNMFPSTSRASITVPSTPIQPIAEERKYPRLSLLHSHLSPENRCKKTQLIPLEN LIAFKQSQQKLTHNLFEQGDAGHLQLLKVKIEPPEVRQGKDSKKRQRRRAEKELQEKRCEKLRRKPNVTFRPENSIINNDDSEIIKKPKA VEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYA ATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTF MKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVD QGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELF PERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDG HFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGG RVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDN GGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVC NNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSE WSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C5orf42-SEMA5A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C5orf42-SEMA5A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C5orf42-SEMA5A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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