FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:C6orf136-AKR1C1 (FusionGDB2 ID:11925)

Fusion Gene Summary for C6orf136-AKR1C1

check button Fusion gene summary
Fusion gene informationFusion gene name: C6orf136-AKR1C1
Fusion gene ID: 11925
HgeneTgene
Gene symbol

C6orf136

AKR1C1

Gene ID

221545

1645

Gene namechromosome 6 open reading frame 136aldo-keto reductase family 1 member C1
Synonyms-2-ALPHA-HSD|20-ALPHA-HSD|C9|DD1|DD1/DD2|DDH|DDH1|H-37|HAKRC|HBAB|MBAB
Cytomap

6p21.33

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C6orf136aldo-keto reductase family 1 member C120 alpha-hydroxysteroid dehydrogenasealdo-keto reductase Cchlordecone reductase homolog HAKRCdihydrodiol dehydrogenase 1dihydrodiol dehydrogenase 1/2dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid
Modification date2020031320200313
UniProtAcc.

Q04828

Ensembl transtripts involved in fusion geneENST00000293604, ENST00000376473, 
ENST00000528347, ENST00000376471, 
ENST00000383580, ENST00000383581, 
ENST00000415931, ENST00000417076, 
ENST00000417649, ENST00000419321, 
ENST00000422530, ENST00000425581, 
ENST00000430141, ENST00000447505, 
ENST00000455682, ENST00000456444, 
ENST00000459700, ENST00000466518, 
ENST00000472341, ENST00000486177, 
ENST00000491140, ENST00000493705, 
ENST00000496234, ENST00000546452, 
ENST00000547308, ENST00000549361, 
ENST00000549800, ENST00000549861, 
ENST00000552569, 		ENST00000380859, 
ENST00000380872, ENST00000477661, 
ENST00000434459, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 4=60
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C6orf136 [Title/Abstract] AND AKR1C1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC6orf136(30617736)-AKR1C1(5008106), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAKR1C1

GO:0007586

digestion

8486699

TgeneAKR1C1

GO:0008206

bile acid metabolic process

8486699

TgeneAKR1C1

GO:0030855

epithelial cell differentiation

21492153

TgeneAKR1C1

GO:0042448

progesterone metabolic process

21232532

TgeneAKR1C1

GO:0042574

retinal metabolic process

21851338

TgeneAKR1C1

GO:0055114

oxidation-reduction process

8486699|19442656|21232532

TgeneAKR1C1

GO:0071395

cellular response to jasmonic acid stimulus

19487289


check buttonFusion gene breakpoints across C6orf136 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKR1C1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A43N-01AC6orf136chr6

30617736

+AKR1C1chr10

5008106

+


Top

Fusion Gene ORF analysis for C6orf136-AKR1C1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000293604ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000293604ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000293604ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000376473ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000376473ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000376473ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000528347ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000528347ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
5CDS-3UTRENST00000528347ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
In-frameENST00000293604ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
In-frameENST00000376473ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
In-frameENST00000528347ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000376471ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000383580ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000383581ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000415931ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000417076ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000417649ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000419321ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000422530ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000425581ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000430141ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000447505ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000455682ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000456444ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000459700ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000466518ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000472341ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000486177ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000491140ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000493705ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000496234ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000546452ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000547308ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000549361ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000549800ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000549861ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3CDSENST00000552569ENST00000434459C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000376471ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000376471ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000376471ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383580ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383580ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383580ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383581ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383581ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000383581ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000415931ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000415931ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000415931ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417076ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417076ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417076ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417649ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417649ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000417649ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000419321ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000419321ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000419321ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000422530ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000422530ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000422530ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000425581ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000425581ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000425581ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000430141ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000430141ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000430141ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000447505ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000447505ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000447505ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000455682ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000455682ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000455682ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000456444ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000456444ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000456444ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000459700ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000459700ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000459700ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000466518ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000466518ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000466518ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000472341ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000472341ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000472341ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000486177ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000486177ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000486177ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000491140ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000491140ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000491140ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000493705ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000493705ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000493705ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000496234ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000496234ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000496234ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000546452ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000546452ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000546452ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000547308ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000547308ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000547308ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549361ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549361ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549361ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549800ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549800ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549800ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549861ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549861ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000549861ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000552569ENST00000380859C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000552569ENST00000380872C6orf136chr6

30617736

+AKR1C1chr10

5008106

+
intron-3UTRENST00000552569ENST00000477661C6orf136chr6

30617736

+AKR1C1chr10

5008106

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000293604C6orf136chr630617736+ENST00000434459AKR1C1chr105008106+230612101932097634
ENST00000376473C6orf136chr630617736+ENST00000434459AKR1C1chr105008106+17296331591520453
ENST00000528347C6orf136chr630617736+ENST00000434459AKR1C1chr105008106+1141450932310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000293604ENST00000434459C6orf136chr630617736+AKR1C1chr105008106+0.0257794150.9742206
ENST00000376473ENST00000434459C6orf136chr630617736+AKR1C1chr105008106+0.0116993250.9883007
ENST00000528347ENST00000434459C6orf136chr630617736+AKR1C1chr105008106+0.0012609560.99873906

Top

Fusion Genomic Features for C6orf136-AKR1C1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C6orf136chr630617736+AKR1C1chr105008105+0.0157995760.9842004
C6orf136chr630617736+AKR1C1chr105008105+0.0157995760.9842004

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for C6orf136-AKR1C1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30617736/chr10:5008106)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKR1C1

Q04828

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKR1C1chr6:30617736chr10:5008106ENST0000038087209166_16728324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST0000038087209216_22228324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST0000038087209270_28028324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST00000434459514166_16728324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST00000434459514216_22228324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST00000434459514270_28028324.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKR1C1chr6:30617736chr10:5008106ENST000003808720920_2428324.0Nucleotide bindingNADP
TgeneAKR1C1chr6:30617736chr10:5008106ENST0000043445951420_2428324.0Nucleotide bindingNADP


Top

Fusion Gene Sequence for C6orf136-AKR1C1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11925_11925_1_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000293604_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=2306nt_BP=1210nt
CTTCAGCCGCTTCCCTCGAGCCTGCAGTGCGCAAGCGCGGGACATCTCCGTTTCCCTCCCTCAGCCCCTTCCCCCCCTACCCCCCCGCCC
CGGCCTCCTTTCCCCTTCACGAAGCCGGCTCTGGGGCGCGCTCACCCCTGTGAGGAGGCCGGAGGTCGGACTCAGGAGGCTCCTTCTCCA
CTCCCGGAAGATCATGTACCAGCCCAGCCGGGGTGCGGCCCGGCGTCTCGGCCCTTGCCTGCGCGCCTACCAGGCTCGACCCCAGGTGAG
CGGAGGAGAAGAGGGAGGGAGGAGAGGGGGCGGGGAGAGACCCTCCTCAAAGCCGGTGCGTGGGGCGGAGCGCGCGCTGGGTTCCGCGCA
GGCGCAGAGACACCCGCCGCCCCTTCCCACCTGTGCCCTGCAGCGCGTGGACAGGCTAGGGGTCGCGGGAGCGGGAGGGAGGCGCTGCCG
GGCCTGTCGCGCAAGGACGTCGGTCCTCCCAGGTTTGAGGGCGGTCAGGCGGGGTCAAGGCCAGGCAGCGGGGCGCGTCTGCGTTGCGCC
CGACTCTCCGCGGTTACCTGTGCCTAGAGGTGATTTGAAGGGCAGGGGCCGAGAGATTCGTAGCCCTGCTGCGGCGCCGTCCCGGAGTTC
CCCGGCCCAGACCAGACCCGCGGGGCGCCCTCAGCAGCCCGCCCGTCTTGCACTCGGAGAGCGGTCCTGGCAGGAAGGCCGGCCAGTGTG
CACCCGGTTCGGGCCCCTGCGCCCGGGCTGGCAAGATGGCCACGCCCCCAGCAGAGACGGCGCCTCTAGGACACCATCGGGGACCGAGGA
CCAGCTTTATCCAGGGACTCTACCATTCCCACCCCTTTGGCCCCACTCCACGACAACCACTTCCCCATCTTCTCCTCTATTCTGGTCTCC
CCTGCCCCCACGCCTTCCCACCCAGCGTCTTCCCCAGGTTCCCCCACTACCTCTCCCTCAGATCCAGGCCCTCAGCTCAGCATGGGTGGT
TCTCCCTCCAGGAAAGGGGGAGGAGGGACCAGGACCTGAGTTGCATAGCGGCTGCCTGGATGGGCTTAGAAGCCTTTTTGAGGGACCTCC
CTGCCCCTATCCTGGGGCTTGGATACCTTTCCAAGTCCCTGGAACTGCCCACCCTTCCCCTGCCACCCCGTCAGGAGATCCTAGTATGGA
GGAACATCTGTCTGTCATGTATGAGAGACTGAGACAAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAAGCTGG
CTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAA
GAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTGAAAAA
TCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGG
AAAAATACTATTTGACACAGTGGATCTCTGTGCCACATGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATCGGGGT
GTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCC
TTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGAGAAGA
ACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGAT
TGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTGTTTGA
ATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCC
TAATTATCCATTTTCTGATGAATATTAACATGGAGGGCATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAGAGGAT
GGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTTAAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTGGCCAG

>11925_11925_1_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000293604_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=634AA_BP=346
MYQPSRGAARRLGPCLRAYQARPQVSGGEEGGRRGGGERPSSKPVRGAERALGSAQAQRHPPPLPTCALQRVDRLGVAGAGGRRCRACRA
RTSVLPGLRAVRRGQGQAAGRVCVAPDSPRLPVPRGDLKGRGREIRSPAAAPSRSSPAQTRPAGRPQQPARLALGERSWQEGRPVCTRFG
PLRPGWQDGHAPSRDGASRTPSGTEDQLYPGTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPG
KGEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHI
DSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILF
DTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVD
PNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPF

--------------------------------------------------------------
>11925_11925_2_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000376473_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=1729nt_BP=633nt
GCGCGGGACATCTCCGTTTCCCTCCCTCAGCCCCTTCCCCCCCTACCCCCCCGCCCCGGCCTCCTTTCCCCTTCACGAAGCCGGCTCTGG
GGCGCGCTCACCCCTGTGAGGAGGCCGGAGGTCGGACTCAGGAGGCTCCTTCTCCACTCCCGGAAGATCATGTACCAGCCCAGCCGGGGT
GCGGCCCGGCGTCTCGGCCCTTGCCTGCGCGCCTACCAGGCTCGACCCCAGGACCAGCTTTATCCAGGGACTCTACCATTCCCACCCCTT
TGGCCCCACTCCACGACAACCACTTCCCCATCTTCTCCTCTATTCTGGTCTCCCCTGCCCCCACGCCTTCCCACCCAGCGTCTTCCCCAG
GTTCCCCCACTACCTCTCCCTCAGATCCAGGCCCTCAGCTCAGCATGGGTGGTTCTCCCTCCAGGAAAGGGGGAGGAGGGACCAGGACCT
GAGTTGCATAGCGGCTGCCTGGATGGGCTTAGAAGCCTTTTTGAGGGACCTCCCTGCCCCTATCCTGGGGCTTGGATACCTTTCCAAGTC
CCTGGAACTGCCCACCCTTCCCCTGCCACCCCGTCAGGAGATCCTAGTATGGAGGAACATCTGTCTGTCATGTATGAGAGACTGAGACAA
GAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAAT
GAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGC
AATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCAT
TTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGACACAGTGGATCTCTGTGCCACA
TGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTC
AACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAG
TCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAG
GACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTC
CTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGAT
GGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCTGATGAATATTAACATGGAGGG
CATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAGAGGATGGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTT
AAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTGGCCAGAAAGGAAAGACAATAATTTTGTTTTTTCATTTTGAAA

>11925_11925_2_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000376473_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=453AA_BP=165
MYQPSRGAARRLGPCLRAYQARPQDQLYPGTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGK
GEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHID
SAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFD
TVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDP
NSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFS

--------------------------------------------------------------
>11925_11925_3_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000528347_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=1141nt_BP=45nt
ATGGAGGAACATCTGTCTGTCATGTATGAGAGACTGAGACAAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAA
GCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGT
GTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTG
AAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAA
AATGGAAAAATACTATTTGACACAGTGGATCTCTGTGCCACATGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATC
GGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGT
CATCCTTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGA
GAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCC
CTGATTGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTG
TTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGC
CCCCCTAATTATCCATTTTCTGATGAATATTAACATGGAGGGCATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAG
AGGATGGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTTAAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTG

>11925_11925_3_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000528347_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=310AA_BP=22
MEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSL
KNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVEC
HPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for C6orf136-AKR1C1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for C6orf136-AKR1C1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for C6orf136-AKR1C1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource