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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:C7orf50-MMD2 (FusionGDB2 ID:12040) |
Fusion Gene Summary for C7orf50-MMD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C7orf50-MMD2 | Fusion gene ID: 12040 | Hgene | Tgene | Gene symbol | C7orf50 | MMD2 | Gene ID | 84310 | 221938 |
| Gene name | chromosome 7 open reading frame 50 | monocyte to macrophage differentiation associated 2 | |
| Synonyms | YCR016W | PAQR10 | |
| Cytomap | 7p22.3 | 7p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C7orf50 | monocyte to macrophage differentiation factor 2monocyte-to-macrophage differentiation-associated protein 2progestin and adipoQ receptor family member 10progestin and adipoQ receptor family member X | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9BRJ6 | Q8IY49 | |
| Ensembl transtripts involved in fusion gene | ENST00000488073, ENST00000357429, ENST00000397098, ENST00000397100, | ENST00000401401, ENST00000404774, ENST00000406755, | |
| Fusion gene scores | * DoF score | 9 X 5 X 9=405 | 3 X 3 X 2=18 |
| # samples | 13 | 4 | |
| ** MAII score | log2(13/405*10)=-1.63941028474353 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C7orf50 [Title/Abstract] AND MMD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | C7orf50(1166893)-MMD2(4965163), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MMD2 | GO:0032880 | regulation of protein localization | 21968647 |
| Tgene | MMD2 | GO:0045666 | positive regulation of neuron differentiation | 21968647 |
| Tgene | MMD2 | GO:0045860 | positive regulation of protein kinase activity | 21968647 |
| Tgene | MMD2 | GO:0046579 | positive regulation of Ras protein signal transduction | 21968647 |
| Fusion gene breakpoints across C7orf50 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MMD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-KK-A8ID-01A | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
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Fusion Gene ORF analysis for C7orf50-MMD2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000488073 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| 5UTR-3CDS | ENST00000488073 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| 5UTR-3CDS | ENST00000488073 | ENST00000406755 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| Frame-shift | ENST00000357429 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| Frame-shift | ENST00000357429 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| Frame-shift | ENST00000357429 | ENST00000406755 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| Frame-shift | ENST00000397098 | ENST00000406755 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| Frame-shift | ENST00000397100 | ENST00000406755 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| In-frame | ENST00000397098 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| In-frame | ENST00000397098 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| In-frame | ENST00000397100 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| In-frame | ENST00000397100 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000397100 | C7orf50 | chr7 | 1166893 | - | ENST00000404774 | MMD2 | chr7 | 4965163 | - | 2343 | 170 | 132 | 935 | 267 |
| ENST00000397100 | C7orf50 | chr7 | 1166893 | - | ENST00000401401 | MMD2 | chr7 | 4965163 | - | 2262 | 170 | 132 | 863 | 243 |
| ENST00000397098 | C7orf50 | chr7 | 1166893 | - | ENST00000404774 | MMD2 | chr7 | 4965163 | - | 3229 | 1056 | 1018 | 1821 | 267 |
| ENST00000397098 | C7orf50 | chr7 | 1166893 | - | ENST00000401401 | MMD2 | chr7 | 4965163 | - | 3148 | 1056 | 1018 | 1749 | 243 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000397100 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - | 0.041472156 | 0.9585278 |
| ENST00000397100 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - | 0.02709687 | 0.97290313 |
| ENST00000397098 | ENST00000404774 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - | 0.05797852 | 0.9420215 |
| ENST00000397098 | ENST00000401401 | C7orf50 | chr7 | 1166893 | - | MMD2 | chr7 | 4965163 | - | 0.024229515 | 0.9757705 |
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Fusion Genomic Features for C7orf50-MMD2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for C7orf50-MMD2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:1166893/chr7:4965163) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C7orf50 | MMD2 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 124_132 | 15 | 247.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 154_182 | 15 | 247.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 204_205 | 15 | 247.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 227_233 | 15 | 247.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 255_270 | 15 | 247.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 60_65 | 15 | 247.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 87_102 | 15 | 247.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 124_132 | 15 | 271.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 154_182 | 15 | 271.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 204_205 | 15 | 271.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 227_233 | 15 | 271.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 255_270 | 15 | 271.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 60_65 | 15 | 271.0 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 87_102 | 15 | 271.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 124_132 | 15 | 646.6666666666666 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 154_182 | 15 | 646.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 204_205 | 15 | 646.6666666666666 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 227_233 | 15 | 646.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 255_270 | 15 | 646.6666666666666 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 60_65 | 15 | 646.6666666666666 | Topological domain | Lumenal | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 87_102 | 15 | 646.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 103_123 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 133_153 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 183_203 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 206_226 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 234_254 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 39_59 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 66_86 | 15 | 247.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 103_123 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 133_153 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 183_203 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 206_226 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 234_254 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 39_59 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 66_86 | 15 | 271.0 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 103_123 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 133_153 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 183_203 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 206_226 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 234_254 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 39_59 | 15 | 646.6666666666666 | Transmembrane | Helical | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 66_86 | 15 | 646.6666666666666 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000401401 | 0 | 7 | 1_38 | 15 | 247.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000404774 | 0 | 7 | 1_38 | 15 | 271.0 | Topological domain | Cytoplasmic | |
| Tgene | MMD2 | chr7:1166893 | chr7:4965163 | ENST00000406755 | 0 | 8 | 1_38 | 15 | 646.6666666666666 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for C7orf50-MMD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >12040_12040_1_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000401401_length(transcript)=3148nt_BP=1056nt GCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGTAGGCGCGTGGGGCGGCGGCGGGGTGGCCGGCGGGTC AGGGCGCCAGGAGACCCAGAGCCCCGGGGCGGGCTCCCGCGGGGCTCCGCCCCCTCCACGTGGGTGCGCGGAGGCCCGGCGCGGCGCGAC CGGGCGGCGGCCCTGGGGTCCGCGGTGCTGGGGAGGCTGGTGCGGCCGGTGCGGCCGGTGCGTCCCGGCGCGGGCTCCGACACCCGCACC CGCCTCTGGGTTAACTCAGCGCGGGCGAGTGGAAGGGACTCAGCTGGCTCCTAGGTTTCAGGCCGTCAGGGCTTGCAGTGGCTCTGGTTT CATTGTCTTTCTCTGAAGACGCCCTGATTGCCCTCCGAGGCTTTCAGCTCCCACTTTCTCTTTTTCAATTTTTGAGGCAGTGTCTCGCTG TGCCACCCAGGCTGGAGTGCAATGGCGTGATCATAGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGCCGTCCTCCCGCCTCATCCTCCC AAGTAGCTGGGACCACATGCGCGCGCCACCACACCCGGATAATTTTTAAAAATGTTTTTTGTAGAAATGGGGTCTCACCATGTTACCCAG GCTGGTCTCGAATTCTTGGGCTCAAGCGATGGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAACGCGCTTG GCCTCACTTTCCATCATAAGCATGCTTTCCGTTTCCTTCCTTCCGTCATTCATTCATTCATTTTTAAAAAACGTTCATTGGGTTCCTCCT GCACTGTTCGGGGCATTGGGCTACAGCTGTCAACAAGTGGAGACAAGTCTGTGATCTAGTGAACTTCCATTCTGGAGGGGAGAGACAGAT GAACAAGGTGCACAGAGCAGGTGATGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAG GCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAACCACCGAGTCCCTGC CCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGCATCCTGGGCAGCTC CAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTCTTCGTGGTGTCCAC TGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATGGTCATCTATTTCTT CATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTCTGGATTATGGCTTC CGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCT GGTCATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAG TGACGGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCT CTATCTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTT CTGTGAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGAC AGCCAGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTT TAGATGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAAT CTGTGTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAA GTCCAGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGAC ATCACCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCAT GATGGGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATG CCTATCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGC AGCCCCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAA AATCCAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTG ATGCCAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGG GCGACTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGC GGGGCCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGA TTCTCTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTAT >12040_12040_1_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000401401_length(amino acids)=243AA_BP=12 MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERYKLVELLCYVVMGFFPALVILSMPNTE -------------------------------------------------------------- >12040_12040_2_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000404774_length(transcript)=3229nt_BP=1056nt GCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGTAGGCGCGTGGGGCGGCGGCGGGGTGGCCGGCGGGTC AGGGCGCCAGGAGACCCAGAGCCCCGGGGCGGGCTCCCGCGGGGCTCCGCCCCCTCCACGTGGGTGCGCGGAGGCCCGGCGCGGCGCGAC CGGGCGGCGGCCCTGGGGTCCGCGGTGCTGGGGAGGCTGGTGCGGCCGGTGCGGCCGGTGCGTCCCGGCGCGGGCTCCGACACCCGCACC CGCCTCTGGGTTAACTCAGCGCGGGCGAGTGGAAGGGACTCAGCTGGCTCCTAGGTTTCAGGCCGTCAGGGCTTGCAGTGGCTCTGGTTT CATTGTCTTTCTCTGAAGACGCCCTGATTGCCCTCCGAGGCTTTCAGCTCCCACTTTCTCTTTTTCAATTTTTGAGGCAGTGTCTCGCTG TGCCACCCAGGCTGGAGTGCAATGGCGTGATCATAGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGCCGTCCTCCCGCCTCATCCTCCC AAGTAGCTGGGACCACATGCGCGCGCCACCACACCCGGATAATTTTTAAAAATGTTTTTTGTAGAAATGGGGTCTCACCATGTTACCCAG GCTGGTCTCGAATTCTTGGGCTCAAGCGATGGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAACGCGCTTG GCCTCACTTTCCATCATAAGCATGCTTTCCGTTTCCTTCCTTCCGTCATTCATTCATTCATTTTTAAAAAACGTTCATTGGGTTCCTCCT GCACTGTTCGGGGCATTGGGCTACAGCTGTCAACAAGTGGAGACAAGTCTGTGATCTAGTGAACTTCCATTCTGGAGGGGAGAGACAGAT GAACAAGGTGCACAGAGCAGGTGATGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAG GCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAACCACCGAGTCCCTGC CCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGCATCCTGGGCAGCTC CAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTCTTCGTGGTGTCCAC TGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATGGTCATCTATTTCTT CATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTCTGGATTATGGCTTC CGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGAACAGGGAGCTGTGTGCAGTTTCTTCGTGGGGAGGCATGTCCTAAGGCCGGCAC GGCTTGTCTTCCTGCCAGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCTGGTCATCCTCTCCATGCC CAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAGTGACGGGAGGATCCCCTT TGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCTCTATCTGCCCAGCACCCT GCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTTCTGTGAACGTTAACCCAG AGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGACAGCCAGATCATCCCTCGA GTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTTTAGATGAGTGTTTCCTAA TACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAATCTGTGTTTCCTAAGGTCC TGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAAGTCCAGGCTGGCGAATTG TCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGACATCACCAATCAAGTGCAG CACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCATGATGGGACCTCTTTGCCC TTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATGCCTATCTCCTCATCTCCC CCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGCAGCCCCTGATGTTCTGTT CCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAAAATCCAGAGACATTACGA GAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTGATGCCAACATTTGGATTC TCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGGGCGACTGTTCCAGGTCCT CCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGCGGGGCCAGCCTCTCTGTC CAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGATTCTCTGGATAAAGAATC TGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTATGCTTATCTCTAGCACATT >12040_12040_2_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000404774_length(amino acids)=267AA_BP=12 MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERTGSCVQFLRGEACPKAGTACLPARYKL -------------------------------------------------------------- >12040_12040_3_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000401401_length(transcript)=2262nt_BP=170nt GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACA AAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAAC CACCGAGTCCCTGCCCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGC ATCCTGGGCAGCTCCAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTC TTCGTGGTGTCCACTGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATG GTCATCTATTTCTTCATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTC TGGATTATGGCTTCCGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGC TTCTTCCCCGCCCTGGTCATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATG GTCTTCTTCAAGAGTGACGGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCC ATCTGGAGGTACCTCTATCTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGG AGTGGAGCACGTTTCTGTGAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGG TGACTTCTGGTGACAGCCAGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTA ATGTGTTTCTATTTTAGATGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGG AATGACGGGCCAATCTGTGTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCC TCTCTGTTACCAAAGTCCAGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTG TGACCATGGCAGACATCACCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATC AATTTGGCACTCATGATGGGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAA TGGGCATTTGCATGCCTATCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAG GCGCACACCCATGCAGCCCCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTC TTCCCATCTCCAAAAATCCAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCAT ACTTAAGGTTTGTGATGCCAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGG CACATGGATCTGGGGCGACTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCA GCCCCCGTCAGGGCGGGGCCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGA ATTGGAATCTCAGATTCTCTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAG ACAGGATGCCTTATGCTTATCTCTAGCACATTCCAGGGGGTTCCAGGGTTCCTGCACCTGGAATCCAGTGTGTCCAAGCCAGTATTAAAT >12040_12040_3_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000401401_length(amino acids)=243AA_BP=12 MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERYKLVELLCYVVMGFFPALVILSMPNTE -------------------------------------------------------------- >12040_12040_4_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000404774_length(transcript)=2343nt_BP=170nt GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACA AAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAAC CACCGAGTCCCTGCCCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGC ATCCTGGGCAGCTCCAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTC TTCGTGGTGTCCACTGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATG GTCATCTATTTCTTCATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTC TGGATTATGGCTTCCGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGAACAGGGAGCTGTGTGCAGTTTCTTCGTGGGGAGGCATGT CCTAAGGCCGGCACGGCTTGTCTTCCTGCCAGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCTGGTC ATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAGTGAC GGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCTCTAT CTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTTCTGT GAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGACAGCC AGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTTTAGA TGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAATCTGT GTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAAGTCC AGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGACATCA CCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCATGATG GGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATGCCTA TCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGCAGCC CCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAAAATC CAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTGATGC CAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGGGCGA CTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGCGGGG CCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGATTCT CTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTATGCTT ATCTCTAGCACATTCCAGGGGGTTCCAGGGTTCCTGCACCTGGAATCCAGTGTGTCCAAGCCAGTATTAAATTATCTCAACACATTCCAC >12040_12040_4_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000404774_length(amino acids)=267AA_BP=12 MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERTGSCVQFLRGEACPKAGTACLPARYKL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C7orf50-MMD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C7orf50-MMD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C7orf50-MMD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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