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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C7orf60-ADAMTS14 (FusionGDB2 ID:12047)

Fusion Gene Summary for C7orf60-ADAMTS14

check button Fusion gene summary
Fusion gene informationFusion gene name: C7orf60-ADAMTS14
Fusion gene ID: 12047
HgeneTgene
Gene symbol

C7orf60

ADAMTS14

Gene ID

154743

140766

Gene namebase methyltransferase of 25S rRNA 2 homologADAM metallopeptidase with thrombospondin type 1 motif 14
SynonymsC7orf60|SAMTOR-
Cytomap

7q31.1

10q22.1

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine sensor upstream of mTORC1UPF0532 protein C7orf60probable methyltransferase BMT2 homologprobable methyltransferase BTM2 homologA disintegrin and metalloproteinase with thrombospondin motifs 14a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000297145, ENST00000485446, 
ENST00000373207, ENST00000373208, 
Fusion gene scores* DoF score3 X 4 X 2=243 X 9 X 3=81
# samples 49
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/81*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C7orf60 [Title/Abstract] AND ADAMTS14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC7orf60(112579645)-ADAMTS14(72489049), # samples:1
C7orf60(112579646)-ADAMTS14(72489050), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC7orf60

GO:0034198

cellular response to amino acid starvation

29123071

HgeneC7orf60

GO:1904262

negative regulation of TORC1 signaling

29123071


check buttonFusion gene breakpoints across C7orf60 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAMTS14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8631-01AC7orf60chr7

112579646

-ADAMTS14chr10

72489050

+
ChimerDB4STADTCGA-FP-8631C7orf60chr7

112579645

-ADAMTS14chr10

72489049

+


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Fusion Gene ORF analysis for C7orf60-ADAMTS14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000297145ENST00000373207C7orf60chr7

112579646

-ADAMTS14chr10

72489050

+
In-frameENST00000297145ENST00000373207C7orf60chr7

112579645

-ADAMTS14chr10

72489049

+
In-frameENST00000297145ENST00000373208C7orf60chr7

112579646

-ADAMTS14chr10

72489050

+
In-frameENST00000297145ENST00000373208C7orf60chr7

112579645

-ADAMTS14chr10

72489049

+
intron-3CDSENST00000485446ENST00000373207C7orf60chr7

112579646

-ADAMTS14chr10

72489050

+
intron-3CDSENST00000485446ENST00000373207C7orf60chr7

112579645

-ADAMTS14chr10

72489049

+
intron-3CDSENST00000485446ENST00000373208C7orf60chr7

112579646

-ADAMTS14chr10

72489050

+
intron-3CDSENST00000485446ENST00000373208C7orf60chr7

112579645

-ADAMTS14chr10

72489049

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297145C7orf60chr7112579645-ENST00000373207ADAMTS14chr1072489049+47163263533127924
ENST00000297145C7orf60chr7112579645-ENST00000373208ADAMTS14chr1072489049+47253263533136927
ENST00000297145C7orf60chr7112579646-ENST00000373207ADAMTS14chr1072489050+47163263533127924
ENST00000297145C7orf60chr7112579646-ENST00000373208ADAMTS14chr1072489050+47253263533136927

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297145ENST00000373207C7orf60chr7112579645-ADAMTS14chr1072489049+0.0106192380.9893807
ENST00000297145ENST00000373208C7orf60chr7112579645-ADAMTS14chr1072489049+0.0094985520.9905014
ENST00000297145ENST00000373207C7orf60chr7112579646-ADAMTS14chr1072489050+0.0106192380.9893807
ENST00000297145ENST00000373208C7orf60chr7112579646-ADAMTS14chr1072489050+0.0094985520.9905014

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Fusion Genomic Features for C7orf60-ADAMTS14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C7orf60chr7112579645-ADAMTS14chr1072489049+1.32E-060.9999987
C7orf60chr7112579645-ADAMTS14chr1072489049+1.32E-060.9999987
C7orf60chr7112579645-ADAMTS14chr1072489049+1.32E-060.9999987
C7orf60chr7112579645-ADAMTS14chr1072489049+1.32E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C7orf60-ADAMTS14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:112579645/chr10:72489049)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAMTS14chr7:112579645chr10:72489049ENST000003732073221100_12212901224.0Compositional biasNote=Pro-rich
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322608_7292901224.0Compositional biasNote=Cys-rich
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322875_8782901224.0Compositional biasNote=Poly-Arg
TgeneADAMTS14chr7:112579645chr10:72489049ENST000003732083221100_12212901227.0Compositional biasNote=Pro-rich
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322608_7292901227.0Compositional biasNote=Cys-rich
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322875_8782901227.0Compositional biasNote=Poly-Arg
TgeneADAMTS14chr7:112579646chr10:72489050ENST000003732073221100_12212901224.0Compositional biasNote=Pro-rich
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322608_7292901224.0Compositional biasNote=Cys-rich
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322875_8782901224.0Compositional biasNote=Poly-Arg
TgeneADAMTS14chr7:112579646chr10:72489050ENST000003732083221100_12212901227.0Compositional biasNote=Pro-rich
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322608_7292901227.0Compositional biasNote=Cys-rich
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322875_8782901227.0Compositional biasNote=Poly-Arg
TgeneADAMTS14chr7:112579645chr10:72489049ENST000003732073221059_10972901224.0DomainPLAC
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322461_5512901224.0DomainNote=Disintegrin
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322552_6072901224.0DomainTSP type-1 1
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322847_9072901224.0DomainTSP type-1 2
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322908_9672901224.0DomainTSP type-1 3
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322968_10222901224.0DomainTSP type-1 4
TgeneADAMTS14chr7:112579645chr10:72489049ENST000003732083221059_10972901227.0DomainPLAC
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322461_5512901227.0DomainNote=Disintegrin
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322552_6072901227.0DomainTSP type-1 1
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322847_9072901227.0DomainTSP type-1 2
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322908_9672901227.0DomainTSP type-1 3
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322968_10222901227.0DomainTSP type-1 4
TgeneADAMTS14chr7:112579646chr10:72489050ENST000003732073221059_10972901224.0DomainPLAC
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322461_5512901224.0DomainNote=Disintegrin
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322552_6072901224.0DomainTSP type-1 1
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322847_9072901224.0DomainTSP type-1 2
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322908_9672901224.0DomainTSP type-1 3
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322968_10222901224.0DomainTSP type-1 4
TgeneADAMTS14chr7:112579646chr10:72489050ENST000003732083221059_10972901227.0DomainPLAC
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322461_5512901227.0DomainNote=Disintegrin
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322552_6072901227.0DomainTSP type-1 1
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322847_9072901227.0DomainTSP type-1 2
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322908_9672901227.0DomainTSP type-1 3
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322968_10222901227.0DomainTSP type-1 4
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322730_8462901224.0RegionNote=Spacer
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322730_8462901227.0RegionNote=Spacer
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322730_8462901224.0RegionNote=Spacer
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322730_8462901227.0RegionNote=Spacer

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373207322259_4602901224.0DomainPeptidase M12B
TgeneADAMTS14chr7:112579645chr10:72489049ENST00000373208322259_4602901227.0DomainPeptidase M12B
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373207322259_4602901224.0DomainPeptidase M12B
TgeneADAMTS14chr7:112579646chr10:72489050ENST00000373208322259_4602901227.0DomainPeptidase M12B


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Fusion Gene Sequence for C7orf60-ADAMTS14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12047_12047_1_C7orf60-ADAMTS14_C7orf60_chr7_112579645_ENST00000297145_ADAMTS14_chr10_72489049_ENST00000373207_length(transcript)=4716nt_BP=326nt
AATCAGTTTGCACTTTTGGGTGAGGGTCCACCTCCAAGGCTGTCGCTCCGGTTCCTCTGCCTCCTCTGGCTGCTGCCTCCGCAGCTCCCT
CCTCCTACCCCACCTCCTCCATCTGGGGAGCGTCTGCGGGGGCCTGAGGGGCGGCGGCGGCGGCGGCGGCTGCGATATGGAGCCAGGGGC
CGGCGGCCGAAATACTGCTCGTGCGCAGAGGGCCGGGTCCCCGAACACTCCGCCGCCCCGGGAGCAGGAGCGGAAACTGGAGCAGGAGAA
GCTCTCCGGTGTGGTGAAGAGCGTCCACCGGCGGCTCCGCAAGAAGTACCGAGAAGGTAGATGAGATTTACCACGATGAGTCCCTGGGGG
TTCATATAAATATTGCCCTCGTCCGCTTGATCATGGTTGGCTACCGACAGTCCCTGAGCCTGATCGAGCGCGGGAACCCCTCACGCAGCC
TGGAGCAGGTGTGTCGCTGGGCACACTCCCAGCAGCGCCAGGACCCCAGCCACGCTGAGCACCATGACCACGTTGTGTTCCTCACCCGGC
AGGACTTTGGGCCCTCAGGGTATGCACCCGTCACTGGCATGTGTCACCCCCTGAGGAGCTGTGCCCTCAACCATGAGGATGGCTTCTCCT
CAGCCTTCGTGATAGCTCATGAGACCGGCCACGTGCTCGGCATGGAGCATGACGGTCAGGGGAATGGCTGTGCAGATGAGACCAGCCTGG
GCAGCGTCATGGCGCCCCTGGTGCAGGCTGCCTTCCACCGCTTCCATTGGTCCCGCTGCAGCAAGCTGGAGCTCAGCCGCTACCTCCCCT
CCTACGACTGCCTCCTCGATGACCCCTTTGATCCTGCCTGGCCCCAGCCCCCAGAGCTGCCTGGGATCAACTACTCAATGGATGAGCAGT
GCCGCTTTGACTTTGGCAGTGGCTACCAGACCTGCTTGGCATTCAGGACCTTTGAGCCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACA
ACCCGTACTTCTGCAAGACCAAGAAGGGGCCCCCGCTGGATGGGACTGAGTGTGCACCCGGCAAGTGGTGCTTCAAAGGTCACTGCATCT
GGAAGTCGCCGGAGCAGACATATGGCCAGGATGGAGGCTGGAGCTCCTGGACCAAGTTTGGGTCATGTTCGCGGTCATGTGGGGGCGGGG
TGCGATCCCGCAGCCGGAGCTGCAACAACCCCTCCCCAGCCTATGGAGGCCGCCTGTGCTTAGGGCCCATGTTCGAGTACCAGGTCTGCA
ACAGCGAGGAGTGCCCTGGGACCTACGAGGACTTCCGGGCCCAGCAGTGTGCCAAGCGCAACTCCTACTATGTGCACCAGAATGCCAAGC
ACAGCTGGGTGCCCTACGAGCCTGACGATGACGCCCAGAAGTGTGAGCTGATCTGCCAGTCGGCGGACACGGGGGACGTGGTGTTCATGA
ACCAGGTGGTTCACGATGGGACACGCTGCAGCTACCGGGACCCATACAGCGTCTGTGCGCGTGGCGAGTGTGTGCCTGTCGGCTGTGACA
AGGAGGTGGGGTCCATGAAGGCGGATGACAAGTGTGGAGTCTGCGGGGGTGACAACTCCCACTGCAGGACTGTGAAGGGGACGCTGGGCA
AGGCCTCCAAGCAGGCAGGAGCTCTCAAGCTGGTGCAGATCCCAGCAGGTGCCAGGCACATCCAGATTGAGGCACTGGAGAAGTCCCCCC
ACCGCATTGTGGTGAAGAACCAGGTCACCGGCAGCTTCATCCTCAACCCCAAGGGCAAGGAAGCCACAAGCCGGACCTTCACCGCCATGG
GCCTGGAGTGGGAGGATGCGGTGGAGGATGCCAAGGAAAGCCTCAAGACCAGCGGGCCCCTGCCTGAAGCCATTGCCATCCTGGCTCTCC
CCCCAACTGAGGGTGGCCCCCGCAGCAGCCTGGCCTACAAGTACGTCATCCATGAGGACCTGCTGCCCCTTATCGGGAGCAACAATGTGC
TCCTGGAGGAGATGGACACCTATGAGTGGGCGCTCAAGAGCTGGGCCCCCTGCAGCAAGGCCTGTGGAGGAGGGATCCAGTTCACCAAAT
ACGGCTGCCGGCGCAGACGAGACCACCACATGGTGCAGCGACACCTGTGTGACCACAAGAAGAGGCCCAAGCCCATCCGCCGGCGCTGCA
ACCAGCACCCGTGCTCTCAGCCTGTGTGGGTGACGGAGGAGTGGGGTGCCTGCAGCCGGAGCTGTGGGAAGCTGGGGGTGCAGACACGGG
GGATACAGTGCCTGCTGCCCCTCTCCAATGGAACCCACAAGGTCATGCCGGCCAAAGCCTGCGCCGGGGACCGGCCTGAGGCCCGACGGC
CCTGTCTCCGAGTGCCCTGCCCAGCCCAGTGGAGGCTGGGAGCCTGGTCCCAGTGCTCTGCCACCTGTGGAGAGGGCATCCAGCAGCGGC
AGGTGGTGTGCAGGACCAACGCCAACAGCCTCGGGCATTGCGAGGGGGATAGGCCAGACACTGTCCAGGTCTGCAGCCTGCCCGCCTGTG
GAGGAAATCACCAGAACTCCACGGTGAGGGCCGATGTCTGGGAACTTGGGACGCCAGAGGGGCAGTGGGTGCCACAATCTGAACCCCTAC
ATCCCATTAACAAGATATCATCAACGGAGCCCTGCACGGGAGACAGGTCTGTCTTCTGCCAGATGGAAGTGCTCGATCGCTACTGCTCCA
TTCCCGGCTACCACCGGCTCTGCTGTGTGTCCTGCATCAAGAAGGCCTCGGGCCCCAACCCTGGCCCAGACCCTGGCCCAACCTCACTGC
CCCCCTTCTCCACTCCTGGAAGCCCCTTACCAGGACCCCAGGACCCTGCAGATGCTGCAGAGCCTCCTGGAAAGCCAACGGGATCAGAGG
ACCATCAGCATGGCCGAGCCACACAGCTCCCAGGAGCTCTGGATACAAGCTCCCCAGGGACCCAGCATCCCTTTGCCCCTGAGACACCAA
TCCCTGGAGCATCCTGGAGCATCTCCCCTACCACCCCCGGGGGGCTGCCTTGGGGCTGGACTCAGACACCTACGCCAGTCCCTGAGGACA
AAGGGCAACCTGGAGAAGACCTGAGACATCCCGGCACCAGCCTCCCTGCTGCCTCCCCGGTGACATGAGCTGTGCCCTGCCATCCCACTG
GCACGTTTACACTCTGTGTACTGCCCCGTGACTCCCAGCTCAGAGGACACACATAGCAGGGCAGGCGCAAGCACAGACTTCATTTTAAAT
CATTCGCCTTCTTCTCGTTTGGGGCTGTGATGCTCTTTACCCCACAAAGCGGGGTGGGAGGAAGACAAAGATCAGGGAAAGCCCTAATCG
GAGATACCTCAGCAAGCTGCCCCCGGCGGGACTGACCCTCTCAGGGCCCCTGTTGGTCTCCCCTGCCAAGACCAGGGTCAACTATTGCTC
CCTCCTCACAGACCCTGGGCCTGGGCAGGTCTGAATCCCGGCTGGTCTGTAGCTAGAAGCTGTCAGGGCTGCCTGCCTTCCCGGAACTGT
GAGGACCCCTGTGGAGGCCCTGCATATTTGGCCCCTCTCCCCAGAAAGGCAAAGCAGGGCCAGGGTAGGTGGGGGACTGTTCACAGCCAG
GCCGAGAGGAGGGGGGCCTGGGAATGTGGCATGAGGCTTCCCAGCTGCAGGGCTGGAGGGGGTGGAACACAAGGTGATCGCAGGCCCAGC
TCCTGGAAGCCAAGAGCTCCATGCAGTTCCACCAGCTGAGGCCAGGCAGCAGAGGCCAGTTTGTCTTTGCTGGCCAGAAGATGGTGCTCA
TGGCCATACTCTGGCCTTGCAGATGTCACTAGTGTTACTTCTAGTGACTCCAGATTACAGACTGGCCCCCCAATCTCACCCCAGCCCACC
AGAGAAGGGGGCTCAGGACACCCTGGACCCCAAGTCCTCAGCATCCAGGGATTTCCAAACTGGCGCTCACTCCCTGACTCCACCAGGATG
GCAACTTCAATTATCACTCTCAGCCTGGAAGGGGACTCTGTGGGACACAGAGGGAACACGATTTCTCAGGCTGTCCCTTCAATCATTGCC
CTTCTCCGAAGATCGCTCCTGCTGGAGTCGGACATCTTCATCTTCTACCTGGCTCAAGCTGGGCCAGAGTGTGTGGTTCTCCCAGGGGTG
GTTGGACCCCAGGACTGAGGACCAGAGTCCACTCATAGCCTGGCCCTGGAGATGACAAGGGCCACCCAGGCCAAGTGCCCCAGGGCAGGG
TGCCAGCCCCTGGCCTGGTGCTGGAGTGGGGAAGACACACTCACCCACGGTGCTGTAAGGGCCTGAGCTGTGCTCAGCTGCCGGCCATGC
TACCTCCAAGGGACAGGTAACAGTCTTAGATCCTCTGGCTCTCAGGAAGTGGCAGGGGGTCCCAGGACACCTCCGGGGTCTTGGAGGATG
TCTCCTAAACTCCTGCCAGGTGATAGAGGTGCTTCTCACTTCTTCCTTCCCCAAGGCAAAGGGGCTGTTCTGAGCCAGCCTGGAGGAACA
TGAGTAGTGGGCCCCTGGCCTGCAACCCCTTTGGAGAGTGGAGGTCCTGGGGGGCTCCCCGCCCTCCCCCTGTTGCCCTCCCCTCCCTGG
GATGCTGGGGCACACGCGGAGTCATTCCTGTGAGAACCAGCCTGGCCTGTGTTAAACTCTTGTGCCTTGGAAATCCAGATCTTTAAAATT

>12047_12047_1_C7orf60-ADAMTS14_C7orf60_chr7_112579645_ENST00000297145_ADAMTS14_chr10_72489049_ENST00000373207_length(amino acids)=924AA_BP=
MGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDG
FSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMD
EQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCG
GGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVV
FMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEK
SPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSN
NVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQ
TRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLP
ACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPT
SLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVP

--------------------------------------------------------------
>12047_12047_2_C7orf60-ADAMTS14_C7orf60_chr7_112579645_ENST00000297145_ADAMTS14_chr10_72489049_ENST00000373208_length(transcript)=4725nt_BP=326nt
AATCAGTTTGCACTTTTGGGTGAGGGTCCACCTCCAAGGCTGTCGCTCCGGTTCCTCTGCCTCCTCTGGCTGCTGCCTCCGCAGCTCCCT
CCTCCTACCCCACCTCCTCCATCTGGGGAGCGTCTGCGGGGGCCTGAGGGGCGGCGGCGGCGGCGGCGGCTGCGATATGGAGCCAGGGGC
CGGCGGCCGAAATACTGCTCGTGCGCAGAGGGCCGGGTCCCCGAACACTCCGCCGCCCCGGGAGCAGGAGCGGAAACTGGAGCAGGAGAA
GCTCTCCGGTGTGGTGAAGAGCGTCCACCGGCGGCTCCGCAAGAAGTACCGAGAAGGTAGATGAGATTTACCACGATGAGTCCCTGGGGG
TTCATATAAATATTGCCCTCGTCCGCTTGATCATGGTTGGCTACCGACAGTCCCTGAGCCTGATCGAGCGCGGGAACCCCTCACGCAGCC
TGGAGCAGGTGTGTCGCTGGGCACACTCCCAGCAGCGCCAGGACCCCAGCCACGCTGAGCACCATGACCACGTTGTGTTCCTCACCCGGC
AGGACTTTGGGCCCTCAGGTATGCAAGGGTATGCACCCGTCACTGGCATGTGTCACCCCCTGAGGAGCTGTGCCCTCAACCATGAGGATG
GCTTCTCCTCAGCCTTCGTGATAGCTCATGAGACCGGCCACGTGCTCGGCATGGAGCATGACGGTCAGGGGAATGGCTGTGCAGATGAGA
CCAGCCTGGGCAGCGTCATGGCGCCCCTGGTGCAGGCTGCCTTCCACCGCTTCCATTGGTCCCGCTGCAGCAAGCTGGAGCTCAGCCGCT
ACCTCCCCTCCTACGACTGCCTCCTCGATGACCCCTTTGATCCTGCCTGGCCCCAGCCCCCAGAGCTGCCTGGGATCAACTACTCAATGG
ATGAGCAGTGCCGCTTTGACTTTGGCAGTGGCTACCAGACCTGCTTGGCATTCAGGACCTTTGAGCCCTGCAAGCAGCTGTGGTGCAGCC
ATCCTGACAACCCGTACTTCTGCAAGACCAAGAAGGGGCCCCCGCTGGATGGGACTGAGTGTGCACCCGGCAAGTGGTGCTTCAAAGGTC
ACTGCATCTGGAAGTCGCCGGAGCAGACATATGGCCAGGATGGAGGCTGGAGCTCCTGGACCAAGTTTGGGTCATGTTCGCGGTCATGTG
GGGGCGGGGTGCGATCCCGCAGCCGGAGCTGCAACAACCCCTCCCCAGCCTATGGAGGCCGCCTGTGCTTAGGGCCCATGTTCGAGTACC
AGGTCTGCAACAGCGAGGAGTGCCCTGGGACCTACGAGGACTTCCGGGCCCAGCAGTGTGCCAAGCGCAACTCCTACTATGTGCACCAGA
ATGCCAAGCACAGCTGGGTGCCCTACGAGCCTGACGATGACGCCCAGAAGTGTGAGCTGATCTGCCAGTCGGCGGACACGGGGGACGTGG
TGTTCATGAACCAGGTGGTTCACGATGGGACACGCTGCAGCTACCGGGACCCATACAGCGTCTGTGCGCGTGGCGAGTGTGTGCCTGTCG
GCTGTGACAAGGAGGTGGGGTCCATGAAGGCGGATGACAAGTGTGGAGTCTGCGGGGGTGACAACTCCCACTGCAGGACTGTGAAGGGGA
CGCTGGGCAAGGCCTCCAAGCAGGCAGGAGCTCTCAAGCTGGTGCAGATCCCAGCAGGTGCCAGGCACATCCAGATTGAGGCACTGGAGA
AGTCCCCCCACCGCATTGTGGTGAAGAACCAGGTCACCGGCAGCTTCATCCTCAACCCCAAGGGCAAGGAAGCCACAAGCCGGACCTTCA
CCGCCATGGGCCTGGAGTGGGAGGATGCGGTGGAGGATGCCAAGGAAAGCCTCAAGACCAGCGGGCCCCTGCCTGAAGCCATTGCCATCC
TGGCTCTCCCCCCAACTGAGGGTGGCCCCCGCAGCAGCCTGGCCTACAAGTACGTCATCCATGAGGACCTGCTGCCCCTTATCGGGAGCA
ACAATGTGCTCCTGGAGGAGATGGACACCTATGAGTGGGCGCTCAAGAGCTGGGCCCCCTGCAGCAAGGCCTGTGGAGGAGGGATCCAGT
TCACCAAATACGGCTGCCGGCGCAGACGAGACCACCACATGGTGCAGCGACACCTGTGTGACCACAAGAAGAGGCCCAAGCCCATCCGCC
GGCGCTGCAACCAGCACCCGTGCTCTCAGCCTGTGTGGGTGACGGAGGAGTGGGGTGCCTGCAGCCGGAGCTGTGGGAAGCTGGGGGTGC
AGACACGGGGGATACAGTGCCTGCTGCCCCTCTCCAATGGAACCCACAAGGTCATGCCGGCCAAAGCCTGCGCCGGGGACCGGCCTGAGG
CCCGACGGCCCTGTCTCCGAGTGCCCTGCCCAGCCCAGTGGAGGCTGGGAGCCTGGTCCCAGTGCTCTGCCACCTGTGGAGAGGGCATCC
AGCAGCGGCAGGTGGTGTGCAGGACCAACGCCAACAGCCTCGGGCATTGCGAGGGGGATAGGCCAGACACTGTCCAGGTCTGCAGCCTGC
CCGCCTGTGGAGGAAATCACCAGAACTCCACGGTGAGGGCCGATGTCTGGGAACTTGGGACGCCAGAGGGGCAGTGGGTGCCACAATCTG
AACCCCTACATCCCATTAACAAGATATCATCAACGGAGCCCTGCACGGGAGACAGGTCTGTCTTCTGCCAGATGGAAGTGCTCGATCGCT
ACTGCTCCATTCCCGGCTACCACCGGCTCTGCTGTGTGTCCTGCATCAAGAAGGCCTCGGGCCCCAACCCTGGCCCAGACCCTGGCCCAA
CCTCACTGCCCCCCTTCTCCACTCCTGGAAGCCCCTTACCAGGACCCCAGGACCCTGCAGATGCTGCAGAGCCTCCTGGAAAGCCAACGG
GATCAGAGGACCATCAGCATGGCCGAGCCACACAGCTCCCAGGAGCTCTGGATACAAGCTCCCCAGGGACCCAGCATCCCTTTGCCCCTG
AGACACCAATCCCTGGAGCATCCTGGAGCATCTCCCCTACCACCCCCGGGGGGCTGCCTTGGGGCTGGACTCAGACACCTACGCCAGTCC
CTGAGGACAAAGGGCAACCTGGAGAAGACCTGAGACATCCCGGCACCAGCCTCCCTGCTGCCTCCCCGGTGACATGAGCTGTGCCCTGCC
ATCCCACTGGCACGTTTACACTCTGTGTACTGCCCCGTGACTCCCAGCTCAGAGGACACACATAGCAGGGCAGGCGCAAGCACAGACTTC
ATTTTAAATCATTCGCCTTCTTCTCGTTTGGGGCTGTGATGCTCTTTACCCCACAAAGCGGGGTGGGAGGAAGACAAAGATCAGGGAAAG
CCCTAATCGGAGATACCTCAGCAAGCTGCCCCCGGCGGGACTGACCCTCTCAGGGCCCCTGTTGGTCTCCCCTGCCAAGACCAGGGTCAA
CTATTGCTCCCTCCTCACAGACCCTGGGCCTGGGCAGGTCTGAATCCCGGCTGGTCTGTAGCTAGAAGCTGTCAGGGCTGCCTGCCTTCC
CGGAACTGTGAGGACCCCTGTGGAGGCCCTGCATATTTGGCCCCTCTCCCCAGAAAGGCAAAGCAGGGCCAGGGTAGGTGGGGGACTGTT
CACAGCCAGGCCGAGAGGAGGGGGGCCTGGGAATGTGGCATGAGGCTTCCCAGCTGCAGGGCTGGAGGGGGTGGAACACAAGGTGATCGC
AGGCCCAGCTCCTGGAAGCCAAGAGCTCCATGCAGTTCCACCAGCTGAGGCCAGGCAGCAGAGGCCAGTTTGTCTTTGCTGGCCAGAAGA
TGGTGCTCATGGCCATACTCTGGCCTTGCAGATGTCACTAGTGTTACTTCTAGTGACTCCAGATTACAGACTGGCCCCCCAATCTCACCC
CAGCCCACCAGAGAAGGGGGCTCAGGACACCCTGGACCCCAAGTCCTCAGCATCCAGGGATTTCCAAACTGGCGCTCACTCCCTGACTCC
ACCAGGATGGCAACTTCAATTATCACTCTCAGCCTGGAAGGGGACTCTGTGGGACACAGAGGGAACACGATTTCTCAGGCTGTCCCTTCA
ATCATTGCCCTTCTCCGAAGATCGCTCCTGCTGGAGTCGGACATCTTCATCTTCTACCTGGCTCAAGCTGGGCCAGAGTGTGTGGTTCTC
CCAGGGGTGGTTGGACCCCAGGACTGAGGACCAGAGTCCACTCATAGCCTGGCCCTGGAGATGACAAGGGCCACCCAGGCCAAGTGCCCC
AGGGCAGGGTGCCAGCCCCTGGCCTGGTGCTGGAGTGGGGAAGACACACTCACCCACGGTGCTGTAAGGGCCTGAGCTGTGCTCAGCTGC
CGGCCATGCTACCTCCAAGGGACAGGTAACAGTCTTAGATCCTCTGGCTCTCAGGAAGTGGCAGGGGGTCCCAGGACACCTCCGGGGTCT
TGGAGGATGTCTCCTAAACTCCTGCCAGGTGATAGAGGTGCTTCTCACTTCTTCCTTCCCCAAGGCAAAGGGGCTGTTCTGAGCCAGCCT
GGAGGAACATGAGTAGTGGGCCCCTGGCCTGCAACCCCTTTGGAGAGTGGAGGTCCTGGGGGGCTCCCCGCCCTCCCCCTGTTGCCCTCC
CCTCCCTGGGATGCTGGGGCACACGCGGAGTCATTCCTGTGAGAACCAGCCTGGCCTGTGTTAAACTCTTGTGCCTTGGAAATCCAGATC

>12047_12047_2_C7orf60-ADAMTS14_C7orf60_chr7_112579645_ENST00000297145_ADAMTS14_chr10_72489049_ENST00000373208_length(amino acids)=927AA_BP=
MGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGMQGYAPVTGMCHPLRSCALNH
EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINY
SMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSR
SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTG
DVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEA
LEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLI
GSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKL
GVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVC
SLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDP
GPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPT

--------------------------------------------------------------
>12047_12047_3_C7orf60-ADAMTS14_C7orf60_chr7_112579646_ENST00000297145_ADAMTS14_chr10_72489050_ENST00000373207_length(transcript)=4716nt_BP=326nt
AATCAGTTTGCACTTTTGGGTGAGGGTCCACCTCCAAGGCTGTCGCTCCGGTTCCTCTGCCTCCTCTGGCTGCTGCCTCCGCAGCTCCCT
CCTCCTACCCCACCTCCTCCATCTGGGGAGCGTCTGCGGGGGCCTGAGGGGCGGCGGCGGCGGCGGCGGCTGCGATATGGAGCCAGGGGC
CGGCGGCCGAAATACTGCTCGTGCGCAGAGGGCCGGGTCCCCGAACACTCCGCCGCCCCGGGAGCAGGAGCGGAAACTGGAGCAGGAGAA
GCTCTCCGGTGTGGTGAAGAGCGTCCACCGGCGGCTCCGCAAGAAGTACCGAGAAGGTAGATGAGATTTACCACGATGAGTCCCTGGGGG
TTCATATAAATATTGCCCTCGTCCGCTTGATCATGGTTGGCTACCGACAGTCCCTGAGCCTGATCGAGCGCGGGAACCCCTCACGCAGCC
TGGAGCAGGTGTGTCGCTGGGCACACTCCCAGCAGCGCCAGGACCCCAGCCACGCTGAGCACCATGACCACGTTGTGTTCCTCACCCGGC
AGGACTTTGGGCCCTCAGGGTATGCACCCGTCACTGGCATGTGTCACCCCCTGAGGAGCTGTGCCCTCAACCATGAGGATGGCTTCTCCT
CAGCCTTCGTGATAGCTCATGAGACCGGCCACGTGCTCGGCATGGAGCATGACGGTCAGGGGAATGGCTGTGCAGATGAGACCAGCCTGG
GCAGCGTCATGGCGCCCCTGGTGCAGGCTGCCTTCCACCGCTTCCATTGGTCCCGCTGCAGCAAGCTGGAGCTCAGCCGCTACCTCCCCT
CCTACGACTGCCTCCTCGATGACCCCTTTGATCCTGCCTGGCCCCAGCCCCCAGAGCTGCCTGGGATCAACTACTCAATGGATGAGCAGT
GCCGCTTTGACTTTGGCAGTGGCTACCAGACCTGCTTGGCATTCAGGACCTTTGAGCCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACA
ACCCGTACTTCTGCAAGACCAAGAAGGGGCCCCCGCTGGATGGGACTGAGTGTGCACCCGGCAAGTGGTGCTTCAAAGGTCACTGCATCT
GGAAGTCGCCGGAGCAGACATATGGCCAGGATGGAGGCTGGAGCTCCTGGACCAAGTTTGGGTCATGTTCGCGGTCATGTGGGGGCGGGG
TGCGATCCCGCAGCCGGAGCTGCAACAACCCCTCCCCAGCCTATGGAGGCCGCCTGTGCTTAGGGCCCATGTTCGAGTACCAGGTCTGCA
ACAGCGAGGAGTGCCCTGGGACCTACGAGGACTTCCGGGCCCAGCAGTGTGCCAAGCGCAACTCCTACTATGTGCACCAGAATGCCAAGC
ACAGCTGGGTGCCCTACGAGCCTGACGATGACGCCCAGAAGTGTGAGCTGATCTGCCAGTCGGCGGACACGGGGGACGTGGTGTTCATGA
ACCAGGTGGTTCACGATGGGACACGCTGCAGCTACCGGGACCCATACAGCGTCTGTGCGCGTGGCGAGTGTGTGCCTGTCGGCTGTGACA
AGGAGGTGGGGTCCATGAAGGCGGATGACAAGTGTGGAGTCTGCGGGGGTGACAACTCCCACTGCAGGACTGTGAAGGGGACGCTGGGCA
AGGCCTCCAAGCAGGCAGGAGCTCTCAAGCTGGTGCAGATCCCAGCAGGTGCCAGGCACATCCAGATTGAGGCACTGGAGAAGTCCCCCC
ACCGCATTGTGGTGAAGAACCAGGTCACCGGCAGCTTCATCCTCAACCCCAAGGGCAAGGAAGCCACAAGCCGGACCTTCACCGCCATGG
GCCTGGAGTGGGAGGATGCGGTGGAGGATGCCAAGGAAAGCCTCAAGACCAGCGGGCCCCTGCCTGAAGCCATTGCCATCCTGGCTCTCC
CCCCAACTGAGGGTGGCCCCCGCAGCAGCCTGGCCTACAAGTACGTCATCCATGAGGACCTGCTGCCCCTTATCGGGAGCAACAATGTGC
TCCTGGAGGAGATGGACACCTATGAGTGGGCGCTCAAGAGCTGGGCCCCCTGCAGCAAGGCCTGTGGAGGAGGGATCCAGTTCACCAAAT
ACGGCTGCCGGCGCAGACGAGACCACCACATGGTGCAGCGACACCTGTGTGACCACAAGAAGAGGCCCAAGCCCATCCGCCGGCGCTGCA
ACCAGCACCCGTGCTCTCAGCCTGTGTGGGTGACGGAGGAGTGGGGTGCCTGCAGCCGGAGCTGTGGGAAGCTGGGGGTGCAGACACGGG
GGATACAGTGCCTGCTGCCCCTCTCCAATGGAACCCACAAGGTCATGCCGGCCAAAGCCTGCGCCGGGGACCGGCCTGAGGCCCGACGGC
CCTGTCTCCGAGTGCCCTGCCCAGCCCAGTGGAGGCTGGGAGCCTGGTCCCAGTGCTCTGCCACCTGTGGAGAGGGCATCCAGCAGCGGC
AGGTGGTGTGCAGGACCAACGCCAACAGCCTCGGGCATTGCGAGGGGGATAGGCCAGACACTGTCCAGGTCTGCAGCCTGCCCGCCTGTG
GAGGAAATCACCAGAACTCCACGGTGAGGGCCGATGTCTGGGAACTTGGGACGCCAGAGGGGCAGTGGGTGCCACAATCTGAACCCCTAC
ATCCCATTAACAAGATATCATCAACGGAGCCCTGCACGGGAGACAGGTCTGTCTTCTGCCAGATGGAAGTGCTCGATCGCTACTGCTCCA
TTCCCGGCTACCACCGGCTCTGCTGTGTGTCCTGCATCAAGAAGGCCTCGGGCCCCAACCCTGGCCCAGACCCTGGCCCAACCTCACTGC
CCCCCTTCTCCACTCCTGGAAGCCCCTTACCAGGACCCCAGGACCCTGCAGATGCTGCAGAGCCTCCTGGAAAGCCAACGGGATCAGAGG
ACCATCAGCATGGCCGAGCCACACAGCTCCCAGGAGCTCTGGATACAAGCTCCCCAGGGACCCAGCATCCCTTTGCCCCTGAGACACCAA
TCCCTGGAGCATCCTGGAGCATCTCCCCTACCACCCCCGGGGGGCTGCCTTGGGGCTGGACTCAGACACCTACGCCAGTCCCTGAGGACA
AAGGGCAACCTGGAGAAGACCTGAGACATCCCGGCACCAGCCTCCCTGCTGCCTCCCCGGTGACATGAGCTGTGCCCTGCCATCCCACTG
GCACGTTTACACTCTGTGTACTGCCCCGTGACTCCCAGCTCAGAGGACACACATAGCAGGGCAGGCGCAAGCACAGACTTCATTTTAAAT
CATTCGCCTTCTTCTCGTTTGGGGCTGTGATGCTCTTTACCCCACAAAGCGGGGTGGGAGGAAGACAAAGATCAGGGAAAGCCCTAATCG
GAGATACCTCAGCAAGCTGCCCCCGGCGGGACTGACCCTCTCAGGGCCCCTGTTGGTCTCCCCTGCCAAGACCAGGGTCAACTATTGCTC
CCTCCTCACAGACCCTGGGCCTGGGCAGGTCTGAATCCCGGCTGGTCTGTAGCTAGAAGCTGTCAGGGCTGCCTGCCTTCCCGGAACTGT
GAGGACCCCTGTGGAGGCCCTGCATATTTGGCCCCTCTCCCCAGAAAGGCAAAGCAGGGCCAGGGTAGGTGGGGGACTGTTCACAGCCAG
GCCGAGAGGAGGGGGGCCTGGGAATGTGGCATGAGGCTTCCCAGCTGCAGGGCTGGAGGGGGTGGAACACAAGGTGATCGCAGGCCCAGC
TCCTGGAAGCCAAGAGCTCCATGCAGTTCCACCAGCTGAGGCCAGGCAGCAGAGGCCAGTTTGTCTTTGCTGGCCAGAAGATGGTGCTCA
TGGCCATACTCTGGCCTTGCAGATGTCACTAGTGTTACTTCTAGTGACTCCAGATTACAGACTGGCCCCCCAATCTCACCCCAGCCCACC
AGAGAAGGGGGCTCAGGACACCCTGGACCCCAAGTCCTCAGCATCCAGGGATTTCCAAACTGGCGCTCACTCCCTGACTCCACCAGGATG
GCAACTTCAATTATCACTCTCAGCCTGGAAGGGGACTCTGTGGGACACAGAGGGAACACGATTTCTCAGGCTGTCCCTTCAATCATTGCC
CTTCTCCGAAGATCGCTCCTGCTGGAGTCGGACATCTTCATCTTCTACCTGGCTCAAGCTGGGCCAGAGTGTGTGGTTCTCCCAGGGGTG
GTTGGACCCCAGGACTGAGGACCAGAGTCCACTCATAGCCTGGCCCTGGAGATGACAAGGGCCACCCAGGCCAAGTGCCCCAGGGCAGGG
TGCCAGCCCCTGGCCTGGTGCTGGAGTGGGGAAGACACACTCACCCACGGTGCTGTAAGGGCCTGAGCTGTGCTCAGCTGCCGGCCATGC
TACCTCCAAGGGACAGGTAACAGTCTTAGATCCTCTGGCTCTCAGGAAGTGGCAGGGGGTCCCAGGACACCTCCGGGGTCTTGGAGGATG
TCTCCTAAACTCCTGCCAGGTGATAGAGGTGCTTCTCACTTCTTCCTTCCCCAAGGCAAAGGGGCTGTTCTGAGCCAGCCTGGAGGAACA
TGAGTAGTGGGCCCCTGGCCTGCAACCCCTTTGGAGAGTGGAGGTCCTGGGGGGCTCCCCGCCCTCCCCCTGTTGCCCTCCCCTCCCTGG
GATGCTGGGGCACACGCGGAGTCATTCCTGTGAGAACCAGCCTGGCCTGTGTTAAACTCTTGTGCCTTGGAAATCCAGATCTTTAAAATT

>12047_12047_3_C7orf60-ADAMTS14_C7orf60_chr7_112579646_ENST00000297145_ADAMTS14_chr10_72489050_ENST00000373207_length(amino acids)=924AA_BP=
MGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDG
FSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMD
EQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCG
GGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVV
FMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEK
SPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSN
NVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQ
TRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLP
ACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPT
SLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVP

--------------------------------------------------------------
>12047_12047_4_C7orf60-ADAMTS14_C7orf60_chr7_112579646_ENST00000297145_ADAMTS14_chr10_72489050_ENST00000373208_length(transcript)=4725nt_BP=326nt
AATCAGTTTGCACTTTTGGGTGAGGGTCCACCTCCAAGGCTGTCGCTCCGGTTCCTCTGCCTCCTCTGGCTGCTGCCTCCGCAGCTCCCT
CCTCCTACCCCACCTCCTCCATCTGGGGAGCGTCTGCGGGGGCCTGAGGGGCGGCGGCGGCGGCGGCGGCTGCGATATGGAGCCAGGGGC
CGGCGGCCGAAATACTGCTCGTGCGCAGAGGGCCGGGTCCCCGAACACTCCGCCGCCCCGGGAGCAGGAGCGGAAACTGGAGCAGGAGAA
GCTCTCCGGTGTGGTGAAGAGCGTCCACCGGCGGCTCCGCAAGAAGTACCGAGAAGGTAGATGAGATTTACCACGATGAGTCCCTGGGGG
TTCATATAAATATTGCCCTCGTCCGCTTGATCATGGTTGGCTACCGACAGTCCCTGAGCCTGATCGAGCGCGGGAACCCCTCACGCAGCC
TGGAGCAGGTGTGTCGCTGGGCACACTCCCAGCAGCGCCAGGACCCCAGCCACGCTGAGCACCATGACCACGTTGTGTTCCTCACCCGGC
AGGACTTTGGGCCCTCAGGTATGCAAGGGTATGCACCCGTCACTGGCATGTGTCACCCCCTGAGGAGCTGTGCCCTCAACCATGAGGATG
GCTTCTCCTCAGCCTTCGTGATAGCTCATGAGACCGGCCACGTGCTCGGCATGGAGCATGACGGTCAGGGGAATGGCTGTGCAGATGAGA
CCAGCCTGGGCAGCGTCATGGCGCCCCTGGTGCAGGCTGCCTTCCACCGCTTCCATTGGTCCCGCTGCAGCAAGCTGGAGCTCAGCCGCT
ACCTCCCCTCCTACGACTGCCTCCTCGATGACCCCTTTGATCCTGCCTGGCCCCAGCCCCCAGAGCTGCCTGGGATCAACTACTCAATGG
ATGAGCAGTGCCGCTTTGACTTTGGCAGTGGCTACCAGACCTGCTTGGCATTCAGGACCTTTGAGCCCTGCAAGCAGCTGTGGTGCAGCC
ATCCTGACAACCCGTACTTCTGCAAGACCAAGAAGGGGCCCCCGCTGGATGGGACTGAGTGTGCACCCGGCAAGTGGTGCTTCAAAGGTC
ACTGCATCTGGAAGTCGCCGGAGCAGACATATGGCCAGGATGGAGGCTGGAGCTCCTGGACCAAGTTTGGGTCATGTTCGCGGTCATGTG
GGGGCGGGGTGCGATCCCGCAGCCGGAGCTGCAACAACCCCTCCCCAGCCTATGGAGGCCGCCTGTGCTTAGGGCCCATGTTCGAGTACC
AGGTCTGCAACAGCGAGGAGTGCCCTGGGACCTACGAGGACTTCCGGGCCCAGCAGTGTGCCAAGCGCAACTCCTACTATGTGCACCAGA
ATGCCAAGCACAGCTGGGTGCCCTACGAGCCTGACGATGACGCCCAGAAGTGTGAGCTGATCTGCCAGTCGGCGGACACGGGGGACGTGG
TGTTCATGAACCAGGTGGTTCACGATGGGACACGCTGCAGCTACCGGGACCCATACAGCGTCTGTGCGCGTGGCGAGTGTGTGCCTGTCG
GCTGTGACAAGGAGGTGGGGTCCATGAAGGCGGATGACAAGTGTGGAGTCTGCGGGGGTGACAACTCCCACTGCAGGACTGTGAAGGGGA
CGCTGGGCAAGGCCTCCAAGCAGGCAGGAGCTCTCAAGCTGGTGCAGATCCCAGCAGGTGCCAGGCACATCCAGATTGAGGCACTGGAGA
AGTCCCCCCACCGCATTGTGGTGAAGAACCAGGTCACCGGCAGCTTCATCCTCAACCCCAAGGGCAAGGAAGCCACAAGCCGGACCTTCA
CCGCCATGGGCCTGGAGTGGGAGGATGCGGTGGAGGATGCCAAGGAAAGCCTCAAGACCAGCGGGCCCCTGCCTGAAGCCATTGCCATCC
TGGCTCTCCCCCCAACTGAGGGTGGCCCCCGCAGCAGCCTGGCCTACAAGTACGTCATCCATGAGGACCTGCTGCCCCTTATCGGGAGCA
ACAATGTGCTCCTGGAGGAGATGGACACCTATGAGTGGGCGCTCAAGAGCTGGGCCCCCTGCAGCAAGGCCTGTGGAGGAGGGATCCAGT
TCACCAAATACGGCTGCCGGCGCAGACGAGACCACCACATGGTGCAGCGACACCTGTGTGACCACAAGAAGAGGCCCAAGCCCATCCGCC
GGCGCTGCAACCAGCACCCGTGCTCTCAGCCTGTGTGGGTGACGGAGGAGTGGGGTGCCTGCAGCCGGAGCTGTGGGAAGCTGGGGGTGC
AGACACGGGGGATACAGTGCCTGCTGCCCCTCTCCAATGGAACCCACAAGGTCATGCCGGCCAAAGCCTGCGCCGGGGACCGGCCTGAGG
CCCGACGGCCCTGTCTCCGAGTGCCCTGCCCAGCCCAGTGGAGGCTGGGAGCCTGGTCCCAGTGCTCTGCCACCTGTGGAGAGGGCATCC
AGCAGCGGCAGGTGGTGTGCAGGACCAACGCCAACAGCCTCGGGCATTGCGAGGGGGATAGGCCAGACACTGTCCAGGTCTGCAGCCTGC
CCGCCTGTGGAGGAAATCACCAGAACTCCACGGTGAGGGCCGATGTCTGGGAACTTGGGACGCCAGAGGGGCAGTGGGTGCCACAATCTG
AACCCCTACATCCCATTAACAAGATATCATCAACGGAGCCCTGCACGGGAGACAGGTCTGTCTTCTGCCAGATGGAAGTGCTCGATCGCT
ACTGCTCCATTCCCGGCTACCACCGGCTCTGCTGTGTGTCCTGCATCAAGAAGGCCTCGGGCCCCAACCCTGGCCCAGACCCTGGCCCAA
CCTCACTGCCCCCCTTCTCCACTCCTGGAAGCCCCTTACCAGGACCCCAGGACCCTGCAGATGCTGCAGAGCCTCCTGGAAAGCCAACGG
GATCAGAGGACCATCAGCATGGCCGAGCCACACAGCTCCCAGGAGCTCTGGATACAAGCTCCCCAGGGACCCAGCATCCCTTTGCCCCTG
AGACACCAATCCCTGGAGCATCCTGGAGCATCTCCCCTACCACCCCCGGGGGGCTGCCTTGGGGCTGGACTCAGACACCTACGCCAGTCC
CTGAGGACAAAGGGCAACCTGGAGAAGACCTGAGACATCCCGGCACCAGCCTCCCTGCTGCCTCCCCGGTGACATGAGCTGTGCCCTGCC
ATCCCACTGGCACGTTTACACTCTGTGTACTGCCCCGTGACTCCCAGCTCAGAGGACACACATAGCAGGGCAGGCGCAAGCACAGACTTC
ATTTTAAATCATTCGCCTTCTTCTCGTTTGGGGCTGTGATGCTCTTTACCCCACAAAGCGGGGTGGGAGGAAGACAAAGATCAGGGAAAG
CCCTAATCGGAGATACCTCAGCAAGCTGCCCCCGGCGGGACTGACCCTCTCAGGGCCCCTGTTGGTCTCCCCTGCCAAGACCAGGGTCAA
CTATTGCTCCCTCCTCACAGACCCTGGGCCTGGGCAGGTCTGAATCCCGGCTGGTCTGTAGCTAGAAGCTGTCAGGGCTGCCTGCCTTCC
CGGAACTGTGAGGACCCCTGTGGAGGCCCTGCATATTTGGCCCCTCTCCCCAGAAAGGCAAAGCAGGGCCAGGGTAGGTGGGGGACTGTT
CACAGCCAGGCCGAGAGGAGGGGGGCCTGGGAATGTGGCATGAGGCTTCCCAGCTGCAGGGCTGGAGGGGGTGGAACACAAGGTGATCGC
AGGCCCAGCTCCTGGAAGCCAAGAGCTCCATGCAGTTCCACCAGCTGAGGCCAGGCAGCAGAGGCCAGTTTGTCTTTGCTGGCCAGAAGA
TGGTGCTCATGGCCATACTCTGGCCTTGCAGATGTCACTAGTGTTACTTCTAGTGACTCCAGATTACAGACTGGCCCCCCAATCTCACCC
CAGCCCACCAGAGAAGGGGGCTCAGGACACCCTGGACCCCAAGTCCTCAGCATCCAGGGATTTCCAAACTGGCGCTCACTCCCTGACTCC
ACCAGGATGGCAACTTCAATTATCACTCTCAGCCTGGAAGGGGACTCTGTGGGACACAGAGGGAACACGATTTCTCAGGCTGTCCCTTCA
ATCATTGCCCTTCTCCGAAGATCGCTCCTGCTGGAGTCGGACATCTTCATCTTCTACCTGGCTCAAGCTGGGCCAGAGTGTGTGGTTCTC
CCAGGGGTGGTTGGACCCCAGGACTGAGGACCAGAGTCCACTCATAGCCTGGCCCTGGAGATGACAAGGGCCACCCAGGCCAAGTGCCCC
AGGGCAGGGTGCCAGCCCCTGGCCTGGTGCTGGAGTGGGGAAGACACACTCACCCACGGTGCTGTAAGGGCCTGAGCTGTGCTCAGCTGC
CGGCCATGCTACCTCCAAGGGACAGGTAACAGTCTTAGATCCTCTGGCTCTCAGGAAGTGGCAGGGGGTCCCAGGACACCTCCGGGGTCT
TGGAGGATGTCTCCTAAACTCCTGCCAGGTGATAGAGGTGCTTCTCACTTCTTCCTTCCCCAAGGCAAAGGGGCTGTTCTGAGCCAGCCT
GGAGGAACATGAGTAGTGGGCCCCTGGCCTGCAACCCCTTTGGAGAGTGGAGGTCCTGGGGGGCTCCCCGCCCTCCCCCTGTTGCCCTCC
CCTCCCTGGGATGCTGGGGCACACGCGGAGTCATTCCTGTGAGAACCAGCCTGGCCTGTGTTAAACTCTTGTGCCTTGGAAATCCAGATC

>12047_12047_4_C7orf60-ADAMTS14_C7orf60_chr7_112579646_ENST00000297145_ADAMTS14_chr10_72489050_ENST00000373208_length(amino acids)=927AA_BP=
MGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGMQGYAPVTGMCHPLRSCALNH
EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINY
SMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSR
SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTG
DVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEA
LEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLI
GSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKL
GVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVC
SLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDP
GPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPT

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Fusion Gene PPI Analysis for C7orf60-ADAMTS14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C7orf60-ADAMTS14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C7orf60-ADAMTS14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource